HPMC (Hydroxypropyl Methylcellulose) ndi nonionic cellulose ether yomwe imagwiritsidwa ntchito kwambiri muzamankhwala, chakudya, zomangamanga ndi zodzoladzola. Osiyana kalasi ya HPMC makamaka m'gulu malinga ndi kapangidwe kawo mankhwala, katundu thupi, mamasukidwe akayendedwe, digiri ya m'malo ndi ntchito zosiyanasiyana.
1. Kapangidwe ka mankhwala ndi digiri ya m'malo
Mapangidwe a maselo a HPMC amakhala ndi magulu a hydroxyl pa unyolo wa cellulose ndikusinthidwa ndi magulu a methoxy ndi hydroxypropoxy. The thupi ndi mankhwala katundu wa HPMC zimasiyanasiyana malinga ndi mlingo wa m'malo methoxy ndi hydroxypropoxy magulu. Mlingo wolowa m'malo umakhudza mwachindunji kusungunuka, kukhazikika kwamafuta ndi ntchito yapamtunda ya HPMC. Makamaka:
HPMC yokhala ndi zinthu zambiri za methoxy imakonda kuwonetsa kutentha kotentha kwa gelation, komwe kumapangitsa kuti ikhale yoyenera kwambiri pazogwiritsa ntchito zosagwirizana ndi kutentha monga kukonzekera kumasulidwa kwa mankhwala.
HPMC ndi mkulu okhutira hydroxypropoxy ali bwino madzi solubility, ndi Kusungunuka ndondomeko sakhudzidwa ndi kutentha, kupanga izo oyenera ntchito mu malo ozizira.
2. Kukhuthala kwa kalasi
Viscosity ndi chimodzi mwa zizindikiro zofunika HPMC kalasi. HPMC ili ndi ma viscosities osiyanasiyana, kuchokera ku centipoise pang'ono mpaka makumi masauzande a centipoise. Gulu la viscosity limakhudza kugwiritsidwa ntchito kwake pazinthu zosiyanasiyana:
Low mamasukidwe akayendedwe HPMC (monga 10-100 centipoise): Izi kalasi ya HPMC ntchito makamaka ntchito amafuna m'munsi mamasukidwe akayendedwe kukhuthala ndi mkulu fluidity, monga ❖ kuyanika filimu, zomatira piritsi, etc. Ikhoza kupereka mlingo wina wa mphamvu yomangira popanda kukhudza fluidity ya kukonzekera.
Sing'anga mamasukidwe akayendedwe HPMC (monga 100-1000 centipoise): Ambiri ntchito mu chakudya, zodzoladzola ndi mankhwala ena kukonzekera mankhwala, akhoza kuchita monga thickener ndi kusintha kapangidwe ndi bata la mankhwala.
High viscosity HPMC (monga pamwamba pa 1000 centipoise): Gulu la HPMC limagwiritsidwa ntchito kwambiri pamapulogalamu omwe amafunikira kukhuthala kwakukulu, monga zomatira, zomatira ndi zomangira. Amapereka mwayi wabwino kwambiri wokulitsa komanso kuyimitsa.
3. Zinthu zakuthupi
The thupi katundu HPMC, monga solubility, gelation kutentha, ndi madzi mayamwidwe mphamvu, komanso zimasiyana ndi kalasi:
Kusungunuka: Ma HPMC ambiri amakhala ndi kusungunuka kwabwino m'madzi ozizira, koma kusungunuka kwake kumachepa pamene zinthu za methoxy zikuwonjezeka. Makalasi ena apadera a HPMC amathanso kusungunuka mu zosungunulira za organic pazogwiritsa ntchito m'mafakitale.
Kutentha kwa Gelation: Kutentha kwa gelation kwa HPMC mu njira yamadzimadzi kumasiyanasiyana ndi mtundu ndi zomwe zili m'malo. Nthawi zambiri, HPMC yokhala ndi zinthu zambiri za methoxy imakonda kupanga ma gels pa kutentha kwambiri, pomwe HPMC yokhala ndi hydroxypropoxy yapamwamba imawonetsa kutentha kochepa.
Hygroscopicity: HPMC ili ndi hygroscopicity yotsika, makamaka magiredi olowa m'malo apamwamba. Izi zimapangitsa kuti zikhale zabwino kwambiri m'malo omwe amafunikira kukana chinyezi.
4. Malo ogwiritsira ntchito
Chifukwa magiredi osiyanasiyana a HPMC ali ndi zinthu zosiyanasiyana zakuthupi ndi zamankhwala, ntchito zawo m'magawo osiyanasiyana ndizosiyananso:
Makampani opanga mankhwala: HPMC imagwiritsidwa ntchito kwambiri pakupaka mapiritsi, kukonzekera kosalekeza, zomatira, ndi zokhuthala. Gulu la mankhwala HPMC liyenera kukwaniritsa miyezo yeniyeni ya pharmacopoeia, monga United States Pharmacopoeia (USP), European Pharmacopoeia (EP), ndi zina zotero.
Makampani azakudya: HPMC imagwiritsidwa ntchito ngati thickener, emulsifier, stabilizer ndi filimu yakale. HPMC yamagulu azakudya nthawi zambiri imafunika kuti ikhale yopanda poizoni, yopanda fungo, yopanda fungo, ndipo imayenera kutsatira malamulo owonjezera pazakudya, monga a US Food and Drug Administration (FDA) ndi European Food Safety Authority (EFSA).
Makampani omanga: Gulu la zomangamanga la HPMC limagwiritsidwa ntchito makamaka muzinthu zopangidwa ndi simenti, zinthu za gypsum ndi zokutira kuti zikhwime, kusunga madzi, kuthira mafuta ndi kukulitsa. HPMC ya magulu osiyanasiyana mamasukidwe akayendedwe zingakhudze operability wa zomangira ndi ntchito yomaliza mankhwala.
5. Miyezo ndi malamulo abwino
Makalasi osiyanasiyana a HPMC alinso ndi miyezo ndi malamulo osiyanasiyana:
Pharmaceutical grade HPMC: iyenera kukwaniritsa zofunikira za pharmacopoeia, monga USP, EP, ndi zina zotero. Njira yake yopangira ndi zofunikira zoyendetsera khalidwe ndizokwera kwambiri kuti zitsimikizire chitetezo ndi mphamvu zake pokonzekera mankhwala.
HPMC yamagulu azakudya: Iyenera kutsatira malamulo ofunikira pazowonjezera zazakudya kuti zitsimikizire chitetezo chake muzakudya. Mayiko ndi madera osiyanasiyana akhoza kukhala ndi mindandanda yazakudya za HPMC.
HPMC yamagulu a mafakitale: HPMC yomwe imagwiritsidwa ntchito pomanga, zokutira ndi madera ena nthawi zambiri sifunika kutsata zakudya kapena mankhwala, komabe imayenera kukwaniritsa miyezo yamakampani, monga miyezo ya ISO.
6. Chitetezo ndi chitetezo cha chilengedwe
HPMC amakalasi osiyanasiyana amasiyananso chitetezo ndi chilengedwe. HPMC yamagulu amankhwala ndi chakudya nthawi zambiri imawunikiridwa mwamphamvu kuti iwonetsetse kuti ilibe vuto m'thupi la munthu. HPMC yamagulu a mafakitale, kumbali ina, imayang'ana kwambiri kuteteza chilengedwe komanso kuwonongeka kwake pakagwiritsidwe ntchito pofuna kuchepetsa kukhudzidwa kwa chilengedwe.
Kusiyanitsa pakati pa magiredi osiyanasiyana a HPMC kumawonekera makamaka mu kapangidwe ka mankhwala, kukhuthala, katundu wakuthupi, madera ogwiritsira ntchito, miyezo yapamwamba komanso chitetezo. Malinga ndi zofunikira pakugwiritsa ntchito, kusankha giredi yoyenera ya HPMC kumatha kupititsa patsogolo magwiridwe antchito ndi mtundu wazinthu. Mukamagula HPMC, izi ziyenera kuganiziridwa mozama kuti zitsimikizire kuti mankhwalawa ndi othandiza.
Nthawi yotumiza: Aug-20-2024