Kodi kuipa kwa HPMC ndi chiyani?

Hydroxypropyl methylcellulose (HPMC)ndi mankhwala omwe amagwiritsidwa ntchito kwambiri m'mafakitale ambiri monga zomangamanga, mankhwala, zakudya ndi zodzoladzola. Komabe, ngakhale HPMC ili ndi zinthu zambiri zabwino kwambiri, monga kukhuthala, emulsification, kupanga mafilimu, ndi machitidwe oyimitsidwa okhazikika, ilinso ndi zovuta zina ndi zolephera.

1. Nkhani zosungunuka

Ngakhale HPMC akhoza kusungunuka m'madzi ndi zosungunulira organic, kusungunuka kwake kumakhudzidwa ndi kutentha. Imasungunuka pang'onopang'ono m'madzi ozizira ndipo imafuna kugwedezeka kokwanira kuti isungunuke, pamene ikhoza kupanga gel osakaniza m'madzi otentha kwambiri, ndikupangitsa kuti ikhale yosabalalika. Khalidweli litha kubweretsa zovuta zina pazantchito zina (monga zida zomangira ndi mankhwala), ndipo njira zapadera zosungunulira kapena zowonjezera zimafunikira kuti muthe kukhathamiritsa.

2. Mtengo wapamwamba

Poyerekeza ndi zowuma zachilengedwe kapena zopangira, mtengo wopangira HPMC ndiwokwera. Chifukwa cha zovuta zake zokonzekera, zomwe zimaphatikizapo masitepe angapo monga etherification ndi kuyeretsedwa, mtengo wake ndi wapamwamba kuposa zowonjezera zina, monga hydroxyethyl cellulose (HEC) kapena carboxymethyl cellulose (CMC). Mukagwiritsidwa ntchito pamlingo waukulu, zinthu zamtengo wapatali zimatha kukhala chifukwa chofunikira chochepetsera kugwiritsidwa ntchito kwake.

3. Kukhudzidwa ndi pH mtengo

HPMC ili ndi kukhazikika kwabwino pansi pamitundu yosiyanasiyana ya pH, koma imatha kutsika pansi pazikhalidwe za pH (monga asidi amphamvu kapena maziko olimba), zomwe zimakhudza kukhuthala kwake ndi kukhazikika kwake. Chifukwa chake, kugwiritsidwa ntchito kwa HPMC kumatha kukhala kochepa muzochitika zina zomwe zimafunikira pH yowopsa (monga makina apadera a mankhwala).

4. Kuchepa kwa biodegradability

Ngakhale kuti HPMC imatengedwa kuti ndi chinthu chokonda zachilengedwe, zimatenga nthawi yayitali kuti iwonongeke kwathunthu. M'chilengedwe, chiwopsezo cha HPMC chimachepa, chomwe chingakhudze chilengedwe. Pazogwiritsa ntchito zomwe zili ndi zofunikira zoteteza zachilengedwe, kuwonongeka kwa HPMC sikungakhale chisankho chabwino kwambiri.

5. Mphamvu zochepa zamakina

Pamene HPMC imagwiritsidwa ntchito ngati filimu kapena gel osakaniza, mphamvu zake zamakina zimakhala zochepa ndipo zimakhala zosavuta kuthyola kapena kuwonongeka. Mwachitsanzo, m'makampani opanga mankhwala, pamene HPMC imagwiritsidwa ntchito popanga makapisozi, imakhala yovuta kwambiri poyerekeza ndi makapisozi a gelatin, ndipo vuto la fragility likhoza kukhudza kukhazikika kwa kayendetsedwe ka kayendetsedwe kake ndi kusungirako. M'makampani omanga, HPMC ikagwiritsidwa ntchito ngati thickener, ngakhale imatha kupititsa patsogolo matope, imakhala ndi gawo lochepa pa mphamvu yamakina ya chinthu chomaliza.

6. Hygroscopicity

HPMC ali ndi digiri inayake ya hygroscopicity ndipo mosavuta zimatenga chinyezi mu mkulu chinyezi chilengedwe, zomwe zingakhudze ntchito yake. Mwachitsanzo, muzakudya kapena kukonzekera mankhwala, kuyamwa kwa chinyezi kungayambitse kufewetsa kwa piritsi komanso kusintha kwa magwiridwe antchito, zomwe zimakhudza kukhazikika kwazinthuzo. Choncho, posungira ndikugwiritsa ntchito, chinyezi cha chilengedwe chiyenera kuyendetsedwa kuti chiteteze ntchito yake kuti isawonongeke.

7. Zotsatira za bioavailability

M'makampani opanga mankhwala, HPMC nthawi zambiri imagwiritsidwa ntchito popanga mapiritsi otulutsidwa nthawi zonse kapena owongolera, koma amatha kukhudza kutulutsidwa kwa mankhwala ena. Mwachitsanzo, mankhwala hydrophobic, pamaso pa HPMC akhoza kuchepetsa Kutha mlingo wa mankhwala mu thupi, potero zimakhudza bioavailability ake. Choncho, popanga mapangidwe a mankhwala, zotsatira za HPMC pa kutulutsidwa kwa mankhwala ziyenera kuyesedwa mosamala, ndipo zowonjezera zowonjezera zingafunikire kuti mankhwala azigwira ntchito bwino.

8. Kukhazikika kwamafuta

HPMC imatha kutsitsa kapena kusintha magwiridwe antchito pamatenthedwe apamwamba. Ngakhale kuti HPMC imakhala yosasunthika pamtundu wa kutentha, ikhoza kutsika, kutayika, kapena kusokoneza ntchito pa kutentha kwakukulu kuposa 200 ° C, zomwe zimalepheretsa kugwiritsidwa ntchito kwake pakutentha kwambiri. Mwachitsanzo, m'mapulasitiki ena kapena kukonza labala, kukana kutentha kwa HPMC kungayambitse kuchepa kwa zinthu.

9. Zogwirizana ndi zosakaniza zina

Popanga ntchito, HPMC imatha kuchita moyipa ndi ma cationic surfactants ena kapena ayoni achitsulo, zomwe zimapangitsa kuti pakhale turbidity kapena coagulation yankho. Izi zitha kukhudza mtundu ndi mawonekedwe a chinthu chomaliza muzinthu zina (monga zodzoladzola, mankhwala kapena mankhwala), zomwe zimafuna kuyesedwa kogwirizana ndi kukhathamiritsa kwa kapangidwe kake.

NgakhaleMtengo wa HPMCndi zinthu zogwiritsidwa ntchito kwambiri zomwe zimagwiritsidwa ntchito kwambiri ndi kukhuthala bwino kwambiri, kupanga mafilimu ndi kukhazikika, zimakhalanso ndi zovuta monga kusungunuka kochepa, kukwera mtengo, kuchepa kwa biodegradability, mphamvu zochepa zamakina, hygroscopicity yamphamvu, zotsatira za kutulutsidwa kwa mankhwala, komanso kutentha kosasunthika. Zolepheretsa izi zitha kukhudza kugwiritsa ntchito HPMC m'mafakitale ena. Choncho, posankha HPMC ngati zopangira, m'pofunika kuti momveka bwino kuganizira ubwino wake ndi kuipa ndi konza osakaniza zofunika ntchito.