Kodi ma rheological properties a HPMC ndi ati?

Kodi rheological properties ndi chiyaniMtengo wa HPMC?

Hydroxypropyl methylcellulose (HPMC) ndi polima yosunthika yomwe imagwiritsidwa ntchito kwambiri m'mafakitale osiyanasiyana, kuphatikiza mankhwala, zomangamanga, chakudya, ndi zodzoladzola, makamaka chifukwa cha mawonekedwe ake apadera a rheological. Rheology ndikusanthula kayendedwe kazinthu komanso kusinthika kwazinthu, ndipo kumvetsetsa mawonekedwe a HPMC ndikofunikira pakuwongolera magwiridwe antchito osiyanasiyana.

Viscosity: HPMC imawonetsa pseudoplastic kapena kumeta ubweya wa ubweya, kutanthauza kuti kukhuthala kwake kumachepa ndi kuchuluka kwa kumeta ubweya. Katunduyu ndi wofunikira pakugwiritsa ntchito monga mankhwala opangira mankhwala, komwe amalola kupopera kosavuta, kufalikira, ndi kugwiritsa ntchito. Viscosity imatha kusinthidwa ndikusintha kuchuluka kwa m'malo (DS) ndi kulemera kwa maselo a HPMC.

Thixotropy: Thixotropy amatanthauza kusintha kwa gel-sol komwe kumawonetsedwa ndi zinthu zina pansi pa kumeta ubweya wa ubweya. Ma gels a HPMC omwe amapangidwa popumula amatha kusweka ndikumeta ubweya ndikubwezeretsanso mawonekedwe awo a gel pamene kupsinjika kumachotsedwa. Katunduyu ndi wopindulitsa pamagwiritsidwe ntchito ngati utoto, komwe amalepheretsa kugwa pakanthawi kogwiritsa ntchito koma amaonetsetsa kuti zokutira koyenera zikayikidwa.

Hydration: HPMC ndi hygroscopic ndipo imatha kuyamwa madzi, zomwe zimapangitsa kutupa ndi kuwonjezereka kwa viscosity. Kuchuluka kwa hydration kumadalira zinthu monga kutentha, pH, ndi mphamvu ya ionic ya sing'anga yozungulira. Kuthira madzi kumagwira ntchito yofunika kwambiri pakuwongolera kutulutsidwa kwa mankhwala kuchokera ku mankhwala opangidwa ndi mankhwala komanso kusunga chinyezi muzakudya.

Kutengeka kwa Kutentha:Mtengo wa HPMCnjira zimasonyeza kutentha amadalira mamasukidwe akayendedwe, ndi mamasukidwe akayendedwe akuchepa monga kutentha kumawonjezeka. Komabe, izi zimatha kusiyanasiyana kutengera zinthu monga ndende ya polima komanso yankho la pH. Kuzindikira kwa kutentha ndikofunikira pakugwiritsa ntchito ngati zida zomangira, komwe kumakhudza kugwira ntchito komanso kukhazikitsa nthawi.

Kukhudzika Kwa Mchere: Mayankho a HPMC amatha kuwonetsa kukhudzika kwa mchere, ndi mchere wina womwe umayambitsa kukhathamiritsa kwa viscosity ndi zina zomwe zimapangitsa kuchepetsa kukhuthala. Chodabwitsa ichi chimachitika chifukwa cha kuyanjana pakati pa mamolekyu a HPMC ndi ayoni mu yankho. Kukhudzika kwa mchere ndikofunika kwambiri pakupanga mankhwala ndi zakudya zomwe zili ndi mchere ziyenera kuyang'aniridwa mosamala.

Kudalira kwa Shear Rate: The rheological properties of HPMC solutions imadalira kwambiri kumeta ubweya wogwiritsidwa ntchito. Pakumeta ubweya wochepa, kukhuthala kumakhala kokulirapo chifukwa cha kuchuluka kwa mamolekyulu, pomwe kumeta ubweya wambiri, kukhuthala kumachepa chifukwa cha kumeta ubweya. Kumvetsetsa kudalira kumeta ubweya wa ubweya ndikofunikira kwambiri popanga zinthu zogwirira ntchito zosiyanasiyana.

Tinthu Kuyimitsidwa: HPMC akhoza kuchita monga suspending wothandizira kwa particles mu madzi formulations chifukwa thickening ndi stabilizing katundu. Zimathandizira kupewa kukhazikika kwa tinthu tating'onoting'ono, kuwonetsetsa kugawidwa kofanana komanso kusasinthika pazinthu monga utoto, zomatira, ndi kuyimitsidwa kwamankhwala.

Mapangidwe a Gel:Mtengo wa HPMCamatha kupanga ma gels pamiyeso yayikulu kapena pamaso pa othandizira ophatikizira monga ma divalent cations. Ma gels awa amawonetsa mawonekedwe a viscoelastic ndipo amagwiritsidwa ntchito ngati mankhwala oyendetsedwa ndi mankhwala, pomwe kumasulidwa kosalekeza kwa zosakaniza zogwira ntchito kumafunikira.

The rheological zimatha HPMC, kuphatikizapo mamasukidwe akayendedwe, thixotropy, hydration, kutentha ndi mchere tilinazo, kukameta ubweya mlingo kudalira, tinthu kuyimitsidwa, ndi gel osakaniza mapangidwe, amathandiza kwambiri kudziwa mmene ntchito zosiyanasiyana mafakitale ntchito. Kumvetsetsa ndi kuwongolera zinthu izi ndikofunikira pakukonza ndi kukonza zinthu zopangidwa ndi HPMC.