Hydroxypropylmethylcellulose (hpmc) ndi polymer polymer omwe amagwiritsidwa ntchito kwambiri m'makampani ogulitsa mankhwala. Ndi wa gulu la ethel etheul ndipo limachokera ku cellulose wachilengedwe. HPMC imapangidwa ndi kuchiritsa cellulose ndi ma propelyn oxide ndi methyl chloride, zomwe zimapangitsa kuti mafuta osungunuka bwino ndi zinthu zina zofunika. Kutulutsa kwa mankhwala kumeneku kumagwiritsidwa ntchito kwambiri pakupanga mitundu yosiyanasiyana ya misasa, kuphatikiza mapiritsi, makapisozi, kukonzekera kwa ophthalmic ndi makina otulutsidwa-mankhwala osokoneza bongo.
Kuyamba kwa hydroxypropyl methylcellulose:
Kapangidwe ka mankhwala ndi katundu:
Hydroxypypyl methylcellulose ndi zopanga, chonde, sungunuka madzi. Kapangidwe kake kamaphatikizira hydroxypyl ndi methoxy magulu omwe amaphatikizidwa ndi msana wam'madzi. Kuchuluka kwa izi kumatha kusiyanasiyana, kumapangitsa magawo osiyanasiyana a hpmc ndi mitundu yosiyanasiyana. Kulowetsa cholowa m'malo kumakhudza magawo monga mafakisoni, kusakoloka, ndi gel.
Kupanga:
Kupanga kwa HPMC kumaphatikizapo kusinthika kwa cellulose ndi ma propylene oxide ndi methyl chloride. Mulingo wa zolowa m'malo mwa hydroxypyl ndi methoxy amatha kuwongoleredwa pa kaphatikizidwe, kulola kuvomerezana ndi zinthu za HPMC ku zofunikira za mankhwala osokoneza bongo.
Mapulogalamu omwe ali mu malonda ogulitsa:
Ma Baner piriki:
HPMC imagwiritsidwa ntchito kwambiri ngati chingwe cholumikizira cha piritsi. Mphamvu yake yomanga imathandizira kupondereza ufa mu mapiritsi olimba. Kutulutsidwa kwa mankhwala osokoneza bongo (apis) amatha kupezeka pogwiritsa ntchito mafilimu enieni a HPMC yokhala ndi mafayilo oyenera komanso milingo yokhazikika.
Woombeza filimu:
HPMC imagwiritsidwa ntchito ngati othandizira mafilimu mapiritsi ndi magalamu. Imaperekanso zokutira yoteteza bwino yomwe imakulitsa mawonekedwe, kulawa masking ndi kukhazikika kwa mitundu. Kuphatikiza apo, zokutira za HPMC zitha kusintha mafakitale omasulidwa.
Kusungidwa ndi kulamulidwa:
Mphamvu ya hydrophilic ya polymer iyi imapangitsa kuti ikhale yoyenera kugwiritsa ntchito mapangidwe omasulidwa komanso omasulidwa. Matrix a HPMC amalola kuti amasulidwe mankhwalawa nthawi yayitali, kukuthandizani kutsatira wodwala komanso kuchepetsa kuchuluka kwa dosing.
Kukonzekera kwa ophthalmic:
Mu ophthalmic kapangidwe kake, HPMC imagwiritsidwa ntchito kuwonjezera mafayilo amaso, potero amapereka nthawi yokhazikika pamtunda wa ocular. Izi zimathandizira biaavailability ya mankhwala ndi othandizira.
Chingwe Chotsatsa:
HPMC imagwiritsidwa ntchito ngati thicker ndi kusungunuka m'madzi ndi miziki yolimba monga ma gels, mafuta ndi kuyimitsidwa. Imatipatsa mafayilo ku mapangidwe awa ndikusintha mphamvu zawo zonse za matenda.
Mawonekedwe a HPMC:
Kusungunuka:
HPMC imasungunuka m'madzi ndikupanga njira yomveka bwino. Kuchuluka kwa kuwonongeka kumakhudzidwa ndi kuchuluka kwa malo osokoneza bongo ndi kalasi ya mafayilo.
Makulidwe:
Makutu a HPMC mayankho a HPMC ndiyofunikira posankha magwiridwe awo pazogwiritsa ntchito zosiyanasiyana. Masukulu osiyanasiyana amapezeka ndi ma viscosies osiyanasiyana, amalola kuwongolera kwanyengo kwazinthu.
Mafuta owombera:
Makulidwe ena a HPMC amawonetsa katundu wa pormogulling, ndikupanga ma gels pamatenthedwe kwambiri. Katunduyu amagwiritsidwa ntchito kukulitsa mapangidwe owoneka bwino.
Kugwirizana:
HPMC imagwirizana ndi mitundu yosiyanasiyana ya mankhwala ndi apis, ndikupangitsa kuti ikhale chisankho choyamba. Sizitengera kapena kunyoza zambiri zosakaniza.
Zovuta ndi Maganizo:
Hygroscopicity:
HPMC ndi hygroscopic, kutanthauza kuti imatenga chinyezi kuchokera chilengedwe. Izi zimakhudza kukhazikika ndi mawonekedwe a kapangidwe, malo osungira bwino amafunikira.
Kuphatikizidwa ndi Zofunikira Zina:
Ngakhale kuti nthawi zambiri amakhala ogwirizana, opanga ayenera kuganizira kuchuluka kwa hpmc ndi ena ofunikira kuti apewe kuyanjana komwe kungakhudze magwiridwe antchito.
Zotsatira za chisinthiko chopindika:
Kusankha kwa kalasi ya HPMC kungakhudze kwambiri mbiri yosokoneza mankhwalawa. Forcetor amayenera kusankha mosamala kalasi yoyenera kuti akwaniritse mawonekedwe omwe mukufuna.
Maganizo oyang'anira:
HPMC imavomerezedwa kwambiri ngati njira yotetezeka komanso yothandiza. Imakwaniritsa miyezo yosiyanasiyana yovomerezeka ndipo imaphatikizidwa mu pharmacopoeas padziko lonse lapansi. Opanga ayenera kutsatira machitidwe abwino opanga (gmp) kuonetsetsa kuti mtundu wa mankhwala okhala ndi hpmc.
Pomaliza:
Hydroxypropylmethylcelulosese (hpmc), monga momwe amagwiritsidwira ntchito komanso kugwiritsidwa ntchito kwambiri, amagwira ntchito yofunika kwambiri m'makampani ofananira. Malo ake apadera amapangitsa kuti ikhale yoyenera kugwiritsa ntchito mitundu yosiyanasiyana ya mapiritsi, kuphatikiza mapiritsi, makapisozi ndi kukonzekera kwa ophthalmic. Opanga amapindula chifukwa chokhoza kuwongolera katundu wa HPMC kuti akwaniritse zofunika mwatsatanetsatane, monga kumasulidwa ndikukhazikika. Ngakhale panali zovuta zina, hpmc zimakhalabe zofunikira pakupanga zinthu zapamwamba za mankhwala ogulitsa, zomwe zimathandizira chitetezo chambiri.
Post Nthawi: Dis-15-2023