Kodi Hydroxypropyl methyl cellulose HPMC ndi chiyani?

Hydroxypropyl methyl cellulose HPMC ndi cellulose yopanda ionic yosakanikirana ndi ether mumitundu yosiyanasiyana komanso ionic methyl carboxymethyl cellulose ether yosakanikirana, sichita ndi zitsulo zolemera. Mpweya umodzi wa okosijeni chifukwa cha hydroxypropyl methyl cellulose komanso magawo osiyanasiyana a hydroxypropyl ndi viscosity, zidakhala mitundu yodziwika bwino pakugwirira ntchito, mwachitsanzo, kuchuluka kwa methoxyl komanso kutsika kwamitundu ya hydroxypropyl, magwiridwe ake ali pafupi ndi methyl cellulose komanso kutsika kwa methoxyl komanso magwiridwe antchito apamwamba amtundu wa hydroxypropy ndi methylpropyl hydroxypropyl. cellulose amapangidwa. Koma aliyense zosiyanasiyana, ngakhale lili pang'ono hydroxypropyl kapena pang'ono methoxy, ndi solubility mu zosungunulira organic kapena flocculation kutentha mu amadzimadzi njira, pali kusiyana kwakukulu.
 
1, hydroxypropyl methyl cellulose solubility
Hydroxypropyl methyl cellulose m'madzi osungunuka a hydroxypropyl methyl cellulose kwenikweni ndi mtundu wa propylene oxide (methyl oxypropyl ring) yosinthidwa methyl cellulose, kotero imakhalabe yofanana ndi methyl cellulose madzi ozizira osungunuka ndi madzi otentha osasungunuka. Komabe, kutentha kwa gelation kwa modified hydroxy propyl ndikokwera kwambiri kuposa kwa methyl cellulose m'madzi otentha. Mwachitsanzo, kukhuthala kwa hydroxypropyl methylcellulose aqueous solution yokhala ndi 2% methoxy content DS=0.73 ndi hydroxypropyl content MS=0.46 ndi 500 mpa pa 20℃. Kutentha kwa gel opangidwa ndi S kuli pafupi ndi 100 ℃, pomwe methyl cellulose ya kutentha komweko ndi pafupifupi 55 ℃. Ponena za kusungunuka kwake m'madzi, komanso bwino kwambiri, mwachitsanzo, pambuyo pa kuphwanya kwa hydroxypropyl methylcellulose (tirigu mawonekedwe 0.2 ~ 0.5mm pa 20 ℃ 4% kukhuthala kwamadzimadzi a 2pA? S mankhwala amatha kusungunuka m'madzi popanda kuziziritsa kutentha.
 
(2) Hydroxypropyl methyl cellulose mu organic solvents solubility wa hydroxypropyl methyl cellulose mu organic solvents solubility, ndi bwino kuposa methyl cellulose, methyl cellulose zosowa mu methoxy m'malo digiri ya 2.1 kapena kuposa mankhwala, ndipo lili hydroxypropyl MS = 1.5 ~ 1.100 metho DS = 1.5 ~ 1.80 High vit. hydroxypropyl methyl cellulose yokhala ndi digirii yolowa m'malo yonse pamwamba pa 1.8 imasungunuka mu mankhwala a anhydrous methanol ndi ethanol, ndipo imakhala ndi thermoplastic ndi kusungunuka kwamadzi. Amasungunukanso mu ma hydrocarboni a chlorine monga dichloromethane ndi trichloromethane, komanso zosungunulira za organic monga acetone, mowa wa isopropyl, ndi mowa wa diacetone. Kusungunuka kwake mu zosungunulira za organic kumaposa kusungunuka kwamadzi.
 
2, hydroxypropyl methyl cellulose viscosity ya zinthu zomwe zimakhudza
Hydroxypropyl methylcellulose mamasukidwe akayendedwe zinthu hydroxypropyl methylcellulose muyezo mamasukidwe akayendedwe kutsimikiza, ndi mapanelo ena ether ndi yemweyo, ali pa 20 ℃ ndi 2% amadzimadzi yankho monga muyezo kutsimikiza. The mamasukidwe akayendedwe a chinthu chomwecho, ndi kuwonjezeka ndende ndi kuwonjezeka, yemweyo ndende zosiyanasiyana maselo kulemera mankhwala, maselo kulemera kwa mankhwala ndi mkulu mamasukidwe akayendedwe. Ubale wake ndi kutentha ndi wofanana ndi wa methyl cellulose. Kutentha kumakwera, kukhuthala kumayamba kuchepa, koma ikafika kutentha kwina, kukhuthala kumatuluka mwadzidzidzi ndipo gelation imachitika. Kutentha kwa gelation kwa zinthu zokhala ndi mamasukidwe otsika ndikokwera kuposa kwa zinthu zomwe zimakhala ndi mamasukidwe apamwamba. Mulingo wa gel osakaniza mfundo, kuwonjezera kukhuthala kwapamwamba ndi otsika kwa ether, komanso ndi ether methoxy ndi hydroxypropyl gulu zikuchokera chiŵerengero ndi okwana digiri ya m'malo zimagwirizana. Tiyenera kuzindikira kuti hydroxypropyl methylcellulose ndi pseudoplastic; yankho lake limakhala lokhazikika pamene lisungidwa kutentha kwa firiji ndipo silisonyeza kuwonongeka kwa mamasukidwe akayendedwe kupatula kuthekera kwa kuwonongeka kwa enzymatic.
 
3, hydroxypropyl methyl cellulose acid ndi kukana zamchere
Hydroxypropyl methylcellulose asidi alkali hydroxypropyl methylcellulose asidi ndi zamchere, zambiri ndi khola, mu ph PH2 ~ 12 osiyanasiyana si anakhudzidwa, akhoza kupirira kuchuluka kwa asidi kuwala, monga asidi formic, asidi asidi, citric asidi, succinic asidi, phosphoric asidi, asidi boric acid, ndi viscocentric acid. Alkali monga caustic soda, caustic potaziyamu ndi madzi a mandimu alibe mphamvu pa izo, koma zotsatira za kuwonjezeka pang'ono kukhuthala kwa yankho kudzachepa pang'onopang'ono m'tsogolomu.
 
4, hydroxypropyl methyl cellulose imatha kusakanikirana
Hydroxypropyl methyl cellulose solution imatha kusakanikirana ndi mankhwala osungunuka a polima osungunuka ndi madzi, ndikukhala njira yowonekera yofananira yokhala ndi kukhuthala kwapamwamba. Maselo apamwambawa ndi polyethylene glycol, polyvinyl acetate, polysilicone, polymethyl vinyl siloxane ndi hydroxyethyl cellulose ndi methyl cellulose, etc. Natural polima mankhwala monga chingamu Arabic, dzombe chingamu, minga mtengo chingamu ndi zina zotero amakhalanso ndi kusakaniza bwino ndi yankho lake. Hydroxypropyl methyl cellulose amathanso kusakanikirana ndi stearic acid kapena palmitic acid mannitol ester kapena sorbitol ester, komanso ndi glycerol, sorbitol ndi mannitol, mankhwalawa angagwiritsidwe ntchito ngati hydroxypropyl methyl cellulose plasticizer.
 
5, hydroxypropyl methyl cellulose osasungunuka madzi sungunuka
Hydroxypropyl methyl cellulose insoluble water-soluble cellulose ether, imatha kukhala pamtunda wolumikizana ndi aldehydes, ndikupanga ether yosungunuka m'madziyi kuti isungunuke munjira, kukhala yosasungunuka m'madzi. Ndipo kupanga hydroxypropyl methylcellulose insoluble aldehyde, formaldehyde, glyoxal, succinaldehyde, dialdehyde, etc., ntchito formaldehyde ayenera kulabadira PH mtengo wa yankho, imene glyoxal anachita mofulumira, kotero mu kupanga mafakitale ambiri ntchito glyoxal monga cholumikizira cholumikizira. Mlingo wamtunduwu wa crosslinking agent mu yankho ndi 0.2% ~ 10% ya ether mass, yabwino kwambiri ndi 7% ~ 10%, monga kugwiritsa ntchito glyoxal ndi 3.3% ~ 6% ndiyoyenera kwambiri. Kutentha kwamankhwala ambiri ndi 0 ~ 30 ℃, nthawi ndi 1 ~ 120min. Kuphatikizika kolumikizana kuyenera kuchitika pansi pa acidic. Nthawi zambiri, asidi amphamvu kapena organic carboxylic acid amawonjezedwa ku yankho kuti asinthe PH ya yankho kukhala pafupifupi 2 ~ 6, makamaka pakati pa 4 ~ 6, kenako ma aldehydes amawonjezedwa kuti agwirizane. Zidulo zomwe zimagwiritsidwa ntchito ndi hydrochloric acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, hydroxy acetic acid, succinic acid kapena citric acid, zomwe zimakhala ndi formic acid kapena acetic acid, pomwe formic acid ndi yabwino kwambiri. Ma Acid ndi aldehydes amathanso kuwonjezeredwa nthawi imodzi kuti alole kuti yankho lidulidwe mumtundu wa PH womwe mukufuna. Izi nthawi zambiri zimagwiritsidwa ntchito pomaliza kukonza ma cellulose ether, kuti cellulose ether zisasungunuke, zosavuta kugwiritsa ntchito 20 ~ 25 ℃ madzi kutsuka ndi kuyeretsa. Mankhwalawa akagwiritsidwa ntchito, zinthu zamchere zimatha kuwonjezeredwa ku yankho la mankhwalawa kuti zisinthe PH ya yankho kuti ikhale yamchere, ndipo mankhwalawa amasungunuka mwachangu mu yankho. Njirayi ingagwiritsidwenso ntchito pamene njira ya cellulose ether ikugwiritsidwa ntchito popanga filimu ndiyeno filimuyo imapangidwa kuti ipange filimu yosasungunuka.
 
6, hydroxypropyl methyl cellulose anti-enzyme
Hydroxypropyl methyl cellulose enzyme kukana kwa cellulose zotumphukira mu chiphunzitso, monga aliyense magulu anhydroglucose monga pali olimba osakaniza m`malo magulu, kukokoloka kwa tizilombo ndi satengeke atengeke matenda, koma kwenikweni mankhwala yomalizidwa m`malo mtengo kuposa 1, komanso ndi kuwonongeka kwa puloteni kuwonongeka, uku ndiko kulongosola kwa gulu lililonse yunifolomu m'malo mwa cellulose m'malo amakokoloka pafupi ndi magulu a glucose osalowa m'malo kuti apange shuga, yemwe amatha kuyamwa ndi tizilombo toyambitsa matenda monga chakudya. Choncho, ngati etherification m'malo digiri ya mapadi chiwonjezeke, kukana mapadi etere kuti kukokoloka enzymatic adzakhala patsogolo. Amanenedwa kuti pansi pamikhalidwe yolamulidwa, kukhuthala kotsalira kwa hydroxypropyl methyl cellulose (DS=1.9), methyl cellulose (DS=1.83), methyl cellulose (DS=1.66), ndi hydroxyethyl cellulose (1.7%) inali 13.2%, 7.3%, 3.8%, ndi ulemu. Hydroxypropyl methyl cellulose ili ndi mphamvu yotsutsa ma enzyme. Choncho hydroxypropyl methylcellulose kwambiri odana ndi puloteni, pamodzi ndi kubalalitsidwa bwino, thickening ndi filimu mapangidwe, ntchito mu zokutira emulsion, etc., zambiri safuna kuwonjezera zotetezera. Komabe, pofuna kupewa kusungidwa kwa nthawi yaitali kwa yankho kapena kuipitsidwa kotheka kuchokera kudziko lakunja, zosungirako zingathe kuwonjezeredwa, zomwe kusankha kwawo kungatsimikizidwe malinga ndi zofunikira zomaliza za yankho. Phenylmercuric acetate ndi manganese fluosilicate ndi zoteteza bwino, koma ndizowopsa ndipo ziyenera kugwiritsidwa ntchito mosamala. Kawirikawiri, 1 ~ 5mg phenylmercuric acetate ikhoza kuwonjezeredwa ku lita imodzi ya yankho.
 
7, hydroxypropyl methyl cellulose membrane ntchito
Mafilimu a Hydroxypropyl methyl cellulose a hydroxypropyl methyl cellulose ali ndi filimu yabwino kwambiri, yankho lamadzimadzi kapena organic solvent solution, yokutidwa pa mbale ya galasi, kuyanika kumakhala kopanda mtundu, kowonekera komanso kolimba. Ili ndi kukana kwabwino kwa chinyezi ndipo imakhalabe yolimba pa kutentha kwakukulu. Monga kuwonjezera kwa hygroscopic plasticizer, kumatha kukulitsa kutalika kwake ndi kusinthasintha, kuwongolera kusinthasintha, glycerol ndi sorbitol ndi plasticizer zina ndizoyenera kwambiri. Njira yothetsera ndende ndi 2% ~ 3%, mlingo wa plasticizer ndi 10% ~ 20% ya cellulose ether. Ngati zomwe zili mu plasticizer zili ndi mphamvu, ndiye kuti kuchepa kwa colloid kumatha kuchitika pachinyezi chachikulu. Mphamvu yamphamvu ya filimuyo yowonjezera pulasitiki ndi yaikulu kwambiri kuposa yomwe sinawonjezere, ndipo imawonjezeka ndi kuwonjezeka kwa kuchuluka kwa zowonjezera, monga hygroscopicity ya filimuyi ikuwonjezekanso ndi kuwonjezeka kwa kuchuluka kwa plasticizer.