Kupaka filimu ndi njira yofunika kwambiri popanga mankhwala, momwe polima wopyapyala amapaka pamwamba pa mapiritsi kapena makapisozi. Kupaka uku kumagwira ntchito zosiyanasiyana, kuphatikiza kuwongolera mawonekedwe, kubisa kukoma, kuteteza zomwe zimagwira ntchito pamankhwala (API), kuwongolera kumasulidwa, ndikuthandizira kumeza. Hydroxypropyl Methylcellulose (HPMC) ndi amodzi mwa ma polima omwe amagwiritsidwa ntchito kwambiri popaka filimu chifukwa cha zinthu zake zosiyanasiyana.
1.Katundu wa HPMC:
Hydroxypropyl Methylcellulose (HPMC) ndi semi-synthetic polima yochokera ku cellulose. Amadziwika ndi kusungunuka kwamadzi, luso lopanga mafilimu, komanso kugwirizana kwambiri ndi zinthu zosiyanasiyana za mankhwala. The zimatha HPMC akhoza ogwirizana ndi kusintha magawo monga molecular kulemera, digiri ya m'malo, ndi mamasukidwe akayendedwe.
Kutha Kupanga Mafilimu: HPMC ili ndi zida zabwino kwambiri zopangira mafilimu, zomwe zimapangitsa kuti pakhale yunifolomu komanso zokutira zosalala pamwamba pamitundu yamankhwala.
Kusungunuka kwamadzi: HPMC imawonetsa kusungunuka kwamadzi, kulola kusungunuka kwa polima munjira zamadzimadzi panthawi yopaka. Katunduyu amatsimikizira kugawa yunifolomu kwa polima komanso kumathandizira kupanga wosanjikiza wosanjikiza.
Kumamatira: HPMC imawonetsa kumamatira kwabwino pamwamba pa mapiritsi kapena makapisozi, zomwe zimapangitsa zokutira zolimba zomwe zimamamatira bwino gawo lapansi.
Zolepheretsa: HPMC imapereka chotchinga motsutsana ndi zinthu zachilengedwe monga chinyezi, mpweya, ndi kuwala, potero zimateteza kukhulupirika kwa mawonekedwe a mlingo ndikukulitsa bata.
2. Malingaliro Opanga:
Popanga njira yopaka filimu pogwiritsa ntchito HPMC, pali zinthu zingapo zomwe ziyenera kuganiziridwa kuti zikwaniritse zomwe mukufuna komanso magwiridwe antchito.
Polima Concentration: Kuchuluka kwa HPMC mu njira yokutira kumakhudza makulidwe ndi makina amakanema afilimuyo. Kuchulukira kwa polima kumapangitsa kuti zokutira zokulirapo zomwe zimakhala ndi zotchingira zowonjezera.
Plasticizers: Kuphatikizika kwa plasticizers monga polyethylene glycol (PEG) kapena propylene glycol (PG) kungapangitse kusinthasintha ndi kusungunuka kwa zokutira, zomwe zimapangitsa kuti zisawonongeke komanso zisawonongeke.
Zosungunulira: Kusankha zosungunulira zoyenera ndikofunikira kuti zitsimikizire kusungunuka kwa HPMC komanso kupanga filimu yoyenera. Zosungunulira wamba zimaphatikizapo madzi, ethanol, isopropanol, ndi zosakaniza zake.
Pigment ndi Opacifiers: Kuphatikizika kwa pigment ndi opacifir mu kapangidwe ka zokutira kumatha kupereka mtundu, kuwongolera mawonekedwe, ndikupereka chitetezo chopepuka kwa mankhwala omwe akumva bwino.
3.Magwiritsidwe a HPMC mu Kupaka Mafilimu:
Zovala zochokera ku HPMC zimapeza ntchito zambiri m'mafakitale azamankhwala ndi zakudya zopatsa thanzi chifukwa cha kusinthasintha kwake komanso kukwanira kwamitundu yosiyanasiyana yamankhwala.
Zovala Zotulutsa Mwamsanga: Zopaka za HPMC zitha kugwiritsidwa ntchito kuti apereke kutulutsidwa kwamankhwala mwachangu poyang'anira kuwonongeka ndi kusungunuka kwa mapiritsi kapena makapisozi.
Zopaka Zotulutsidwa Zosinthidwa: Mapangidwe opangidwa ndi HPMC amagwiritsidwa ntchito nthawi zambiri mumitundu yotulutsidwa, kuphatikiza kumasulidwa kotalikirapo komanso zokutidwa ndi enteric. Mwa kusintha mamasukidwe akayendedwe ndi makulidwe a zokutira, mawonekedwe omasulidwa a mankhwalawa amatha kukonzedwa kuti akwaniritse kumasulidwa kokhazikika kapena kolunjika.
Kulawa Kubisala: Zopaka za HPMC zimatha kubisa kukoma kosasangalatsa kwa mankhwala, kuwongolera kutsata kwa odwala komanso kuvomereza mafomu a mlingo wapakamwa.
Chitetezo cha Chinyezi: Zopaka za HPMC zimapereka chitetezo chokwanira cha chinyezi, makamaka kwa mankhwala a hygroscopic omwe amatha kuwonongeka akakumana ndi chinyezi.
Kupititsa patsogolo Kukhazikika: Zovala za HPMC zimapereka chotchinga chotchinga kuzinthu zachilengedwe, potero zimakulitsa kukhazikika komanso moyo wa alumali wazinthu zamankhwala.
Hydroxypropyl Methylcellulose (HPMC) imagwira ntchito yofunika kwambiri pakuyika mafilimu pamakampani opanga mankhwala. Makhalidwe ake apadera, kuphatikiza luso lopanga filimu, kusungunuka kwamadzi, kumamatira, ndi zotchinga, zimapangitsa kukhala chisankho choyenera kupanga zokutira ndi magwiridwe antchito osiyanasiyana. Pomvetsetsa malingaliro opangira ndi kugwiritsa ntchito kwa HPMC mu zokutira filimu, opanga mankhwala akhoza kupanga mafomu a mlingo ndi ntchito yowonjezereka, kukhazikika, ndi kuvomereza kwa odwala.
Nthawi yotumiza: Mar-07-2024