Hydroxypropyl cellulose (HPC) imagwiritsidwa ntchito kwambiri mu gawo la pharmaceutical ndi magwiridwe antchito osiyanasiyana. Amagwiritsidwa ntchito makamaka kukonzekera molimba monga mapiritsi ndi makapisozi. Monga ma cellulose opanga cellose, hpc imapangidwa poyambitsa ma hydroxypyl ma geleulose moleculation kapangidwe ka mu cellulose
1. Otsatsa ndi omanga
HPC, ngati thicker ndi binder, imatha kuthandiza tinthu tating'onoting'ono ndi mawonekedwe nthawi yonyowa. Ili ndi zomatira kwambiri ndipo zimatha kutsatsa tinthu tating'onoting'ono tomwe timakhala ndi mapangidwe onyowa kuti mupange tinthu tating'onoting'ono ndikusinthasintha komanso kutchuka. Tinthu tosiyanasiyana ndiosavuta kupanga ndipo kukhala ndi kusiyana kosiyana ndi mapiritsi, zomwe zimapangitsa mapiritsi apamwamba. Panjira yokonzekera yokonzekera, kuphatikiza kwa omanga kumatha kuonetsetsa kuuma, kukana kuphwanya ndi kuphwanya mapiritsi.
2. Omwe Akutulutsidwa
Kutulutsa kovomerezeka kwa HPC m'mapiritsi ndi chimodzi mwazofunikira kwambiri. Chifukwa cha kutupa kwake ndi mafakisoni amadzi, hpc amatha kupanga filimu ya hydration pamtunda wa mapiritsi, kuchepetsa kumasulidwa kwa mankhwalawa, potero pofika pakuchedwa kumasula mankhwala. M'mapiritsi olamulidwa, hpc amatha kusintha bwino kuchuluka kwa mankhwala pogwiritsa ntchito kuchuluka kwake ndi kuchuluka kwake, kumachepetsa pafupipafupi mankhwala osokoneza bongo, ndikuwonjezera kutsatira wodwala. Kusanja kwa hydrate kumasungunuka pang'ono pakapita nthawi, ndipo kumasulidwa kwa mankhwalawa kumakhala kosalekeza, ndikupanga kukhala ndi chiyembekezo chabwino pakugwiritsa ntchito mapiritsi oletsedwa.
3. Mthandizi Wopanga Mafilimu
Katundu wa filimu ya HPC imapangitsa kuti ikhale yogwiritsidwa ntchito kwambiri pa zokutira za piritsi, makamaka zosungunuka madzi. Kukuta piritsi ndi filimu ya HPC imatha kupanga chotsekemera komanso chofiyira chokha, chomwe sichingangophimba kuwawa kwa mankhwalawa ndikusintha kukoma, komanso kuteteza mankhwalawa ndikuwonjezera kukhazikika kwa mankhwalawa. Chifukwa HPC ili ndi kuwonekera bwino komanso kusinthasintha, filimuyo imakhala yunifolomu komanso yosalala, ndipo imapangitsa kuti pakhale mawonekedwe a piritsi. Kuphatikiza apo, kanema wa HPC ali ndi kusungunuka bwino m'mimba ndipo sadzakhala ndi zovuta pa bioavailability wa mankhwala.
4. Stabilizer
Mphamvu ya HPC ndiyofunikira kwambiri pakugwiritsa ntchito mapiritsi, makamaka kwa mankhwalawa omwe amakhudzidwa ndi kuwala komanso chinyezi. HPC imatha kudzipatula bwino mphamvu ya mpweya ndi chinyezi, ndikuletsa mankhwalawa kuti aziwonongeka kapena maximactative, chifukwa cha chinyontho chifukwa cha chinyezi. Makamaka piritsi yokutidwa ndi okhazikika, kukhazikika ndi kusakhazikika kwa mankhwala kwa HPC siyilepheretse kuphatikizika kwa mankhwala, potero onetsetsani kuti alumaliyo ndi moyo wa mankhwala.
5. Kuzindikira
Ngakhale HPC imagwiritsidwa ntchito makamaka ngati othandizira kumasulira, imatha kugwiritsidwanso ntchito ngati disctigrance m'mapiritsi ena atulutsidwe. Kutsitsa kotsika kwa HPC kumatha kusungunuka mwachangu ndi kutukwana mutalumikizana ndi madzi, chifukwa chosinthana ndi piritsi, potero kumalimbikitsa chisudzo cha m'mimba. Kugwiritsa ntchito ndi koyenera kwa mankhwala ena omwe amafunikira kuchita mwachangu. HPC imatha kukwaniritsa mikhalidwe yosiyanasiyana ya piritsi yosiyanasiyana posintha ma celecular kulemera, kuwonjezera zina ndi zina.
6. Kugwiritsa ntchito m'mapiritsi a pakamwa
Kusungunuka kwamadzi ndi kukweza kwa HPC kumawonetsanso zabwino m'mapiritsi a pakamwa (ODT). Mu piritsi lino, hpc amatha kukulitsa chiboliboli cha piritsi mu mkamwa, kupangitsa kuti lisakhale losavuta kwa odwala, makamaka okalamba kapena ana, kumeza. Kusungunuka kwamadzi kwa HPC kumathandizira kusungunuka ndikusiya nthawi yochepa, pomwe ma viscket ake amatsimikizira kuti piritsi ya piriki ndikuchiletsa.
7. Synergy ndi ena ofunikira
HPC ilinso ndi kugwirizana kwa piriki ndipo kumatha kusokoneza ena (monga ma micbocystalline cellulose, carboxymethyl cellulose, etc.) kukulitsa magwiridwe a piritsi. Mwachitsanzo, mukamagwiritsidwa ntchito limodzi ndi microcrystalline cellulose, hpc amatha kusintha madzi ndi kufanana ndi piritsi pomwe likuwonetsa kuuma kwa piritsi; Akagwiritsidwa ntchito limodzi ndi zomatira zina, zimatha kukulitsa chitsarichi cha piritsi, kusintha njira yabwino komanso yosokoneza.
8. Zochititsa chidwi ndi malire
Ngakhale HPC ili ndi maubwino ambiri m'mapiritsi, kugwiritsa ntchito mphamvu zambiri zimakhudzidwanso ndi zinthu zambiri, zolemera molecular, ndi chinyezi, komanso mphamvu yakuwongolera kuchuluka kwa mankhwala osokoneza bongo; Nthawi yomweyo, chinyezi chambiri chinyezi chimatha kupangitsa piritsi kuti itenge chinyezi, kukhudza kukhazikika kwake. Chifukwa chake, mukamagwiritsa ntchito HPC, ndikofunikira kusankha zochita zoyenera kuonetsetsa kuti zotsatira zabwino za piritsi.
Hydroxypropyl amagwira ntchito zambiri pazenera, kuphatikizapo Thicker, Bander, wovomerezeka, filimu yokhazikika, yomwe imatha kusintha mapiritsi ndi kusamalira mankhwala. Malinga ndi mankhwalawa a mankhwala ndi zofuna za mapangidwe, zolemera zolemera zam'madzi za HPC zimatha kusintha mafayilo, kusakhazikika ndi kumasula kwa mapiritsi, kupangitsa kukhala ndi phindu lofunikira pamakampani ogulitsa mankhwala.
Post Nthawi: Nov-04-2024