Hydroxypropyl methylcellulose (hpmc)Amagwiritsa ntchito ma cellulose omwe amagwiritsidwa ntchito kwambiri ndi mapulogalamu osiyanasiyana, makamaka m'minda ya mankhwala opangira mankhwala, zodzoladzola, chakudya, ndi zida zomangira. Sizosungunulira, koma polymer yosungunuka madzi omwe amatha kusungunuka m'madzi ndikupanga yankho lowonekera la colloidal. Kusungunuka kwa kudandaula ®hpmc kumadalira nambala ndi udindo wa methyl ndi hydroxypropyl m'malo mwake kapangidwe kake.
1. Zoyambira zoyambira za hydroxypropyll methylcellulose
Hydroxypropyll methylcellulose imapezeka ndi methylation ndi hydroxyproproproproproplation ya cellulose. Cellulose palokha ndi polysacular yoopsa kwambiri yomwe ilipo mumakhomedwe a cell. Kapangidwe ka mankhwala kwa HPMC kumapangidwa makamaka kwa mayunitsi a glucose, omwe ndi mamolekyulu a nthawi yayitali omwe amalumikizidwa ndi β-1,4 glycosiidic. Mu kapangidwe kake kake, magulu ena a hydroxyl amasinthidwa ndi methyl (-och₃) ndi hydroxypropyl (-Ch₃h₇h), ndikupereka solix ina ndi mankhwala ena.
Kusungunuka kwa HPMC kumakhudzidwa ndi mawonekedwe a maselo ndipo nthawi zambiri amakhala ndi izi:
Kusungunuka kwamadzi: hpmc amatha kupanga njira yothetsera ma viscous m'madzi ndikusungunula mwachangu. Kusungunuka kwake kumakhala kogwirizana kwambiri ndi kutentha kwa madzi ndi maselo olemera a HPMC.
Chisoni chachikulu: Pochita chidwi winawake, yankho la HPMC limawonetsa ma viccect apamwamba, makamaka pamlingo wolemera kwambiri komanso wokhazikika kwambiri.
Kukhazikika kwamafuta: hpmc kumakhala ndi bata yabwino pamitundu ina yotentha ndipo sikophweka kuwola, motero imakhala ndi matenthedwe ake.
2. Solubility ya HPMC
HPMC ndi chinthu chosungunuka madzi, koma sichisungunuka ndi ma solver. Chikhalidwe chake chimagwirizana ndi polarity ya zosungunulira ndi kulumikizana pakati pa mamonanunu a solvent ndi mamolekyu a HPMC.
Madzi: HPMC imatha kusungunuka m'madzi. Madzi ndi zosungunulira zake kwambiri, ndipo mkati mwa mamolekyulu osungunuka, mamolekyulu a nkhawa. Kuchuluka kwa kuwonongeka kumakhudzidwa ndi zinthu monga momwe zimapangidwira kwa HPMC, kuchuluka kwa methylation ndi hydroxyproproproproproprops, kutentha, ndi mtengo wamadzi. Nthawi zambiri, kusungunuka kwa HPMC ndikoyenera kwambiri pakuchita zinthu zakale.
Ordontals: HPMC imatha kukhala yopanda mphamvu m'malo okhazikika okhazikika, monga mowa, ers, ndi ma hydrocarbons. Izi ndichifukwa choti mawonekedwe ake a hydrophilic hydroxyl hydroxyl ndi lipophic methyl ndi ma hydroxypyl. Ngakhale zili ndi zokhudzana ndi madzi, zimakhala ndi kugwirizana kwambiri ndi ma solntic ambiri.
Kusungunuka kwamadzi otentha: M'madzi ofunda (nthawi zambiri 40 ° C mpaka 70 ° C), HPMC imasungunuka mwachangu komanso njira yosungunuka imawonetsa kuwoneka bwino. Pamene kutentha kumawonjezeka, kusungunuka kwa chibadwa ndi kusandulika kumakulirakulira, koma kutentha kwambiri, mawonekedwe a yankho atha kukhudzidwa.
3. Kugwiritsa ntchito HPMC
Chifukwa cha madzi ake abwino osungunuka, zoopsa zochepa, komanso mawonekedwe osinthika, hpmc imagwiritsidwa ntchito kwambiri m'mafakitale osiyanasiyana.
Makampani ogulitsa mankhwala: M'makampani opanga mankhwala, HPMC imagwiritsidwa ntchito pokonza mankhwala osokoneza bongo, mapiritsi amawumba, ma gels, ndi onyamula mankhwala. Imatha kuthandiza mankhwala osokoneza bongo amasungunuka m'madzi ndikuwongolera kuchuluka kwa mankhwala.
Makampani ogulitsa zakudya: hpmc, monga chowonjezera cha chakudya, chimagwiritsidwa ntchito pochita emulsization, kukula, komanso kunyowa. M'zinthu zophika, zimatha kusintha duckity ndi kukhazikika kwa mtanda. Nthawi zambiri amagwiritsidwa ntchito mu ayisikilimu, zakumwa zakumwa zonenepa kwambiri.
Makampani omanga: M'makampani omanga, hpmc nthawi zambiri amagwiritsidwa ntchito ngati chotsirizira matope, chomwe chimatha kusintha matope omanga, kusungidwa kwamadzi ndi mphamvu yamatope.
Zodzikongoletsera: Mu zodzikongoletsera, kudandaula ®hptc imagwiritsidwa ntchito ngati thiccener, kuyimitsa wothandizi, ndipo amagwiritsidwa ntchito kwambiri m'mabatani monga amakumana ndi ma gelses.
Hpmcndi kusungunuka kwamadzi komanso kuwoneka bwino kwa cellose komwe kumatha kupanga njira yowonekera ya colloidal. Sizosungunulira, koma patali kwambiri molecular yomwe imasungunuka m'madzi. Kusungunuka kwake kumaonekera makamaka mu kusungunuka bwino m'madzi, koma osakhazikika m'malo okhazikika. Makhalidwe awa a HPMC amagwiritsidwa ntchito kwambiri m'mafakitale ambiri, kuphatikizapo mankhwala, chakudya, zomanga, ndi zodzoladzola.
Post Nthawi: Feb-17-2025