Hydroxypropyl methylcellulose (HPMC), izwi kandi nka hypromellose, ni polymer itandukanye ikoreshwa cyane mu nganda zimiti. Nibice bya sintetike, inert, viscoelastic polymer ikomoka kuri selile, polyisikaride isanzwe. HPMC ihabwa agaciro kubera gukomera kwayo mumazi, imiterere idafite uburozi, nubushobozi bwayo bwo gukora firime na geles.
1. Guhuza muburyo bwa Tablet
Bumwe mu buryo bwibanze bwa HPMC muri farumasi ni nkuguhuza ibinini. HPMC ikoreshwa kugirango ibiyigize biri mu bisate bifatanye kandi bigume bihamye kugeza igihe byinjiye. Ibikoresho byayo bihuza imbaraga za tekinike ya tableti, bigatuma idakunda gucika cyangwa kumeneka mugihe cyo gupakira, gutwara, no gukora. Byongeye kandi, imiterere ya HPMC itari ionic iremeza ko idakora hamwe nibindi bikoresho, igakomeza ituze hamwe ningirakamaro yibikoresho bikora imiti (APIs).
2. Kugenzurwa Kurekura Matrix
HPMC ningirakamaro mugutezimbere kurekurwa kugenzurwa (CR) no kurekura kuramba (SR). Iyi mikorere yashizweho kugirango irekure imiti ku gipimo cyagenwe, igumane urugero rw’ibiyobyabwenge mu maraso mu gihe kinini. HPMC ifite ubushobozi bwo gukora gel iyo ihuye na gastrointestinal fluid ituma biba byiza kubwiyi ntego. Ikora geli igaragara neza ikikije tablet, igenzura ikwirakwizwa ryibiyobyabwenge. Ibi biranga ingirakamaro cyane cyane kubiyobyabwenge bifite igipimo gito cyo kuvura, kuko gifasha mukugumya kwifata rya plasma, bityo bikongera imbaraga kandi bikagabanya ingaruka.
3. Gufata amashusho
Ubundi buryo bukomeye bwa HPMC ni muri firime ya tablet na capsules. HPMC ishingiye ku kurinda ibinini ibintu bidukikije nk'ubushuhe, urumuri, n'umwuka, bishobora gutesha agaciro ibintu bikora. Ipitingi ya firime kandi yongerera ubwiza ubwiza bwibinini, ikanonosora uburyohe, kandi irashobora gukoreshwa mukurinda ibyinjira, kwemeza ko imiti irekurwa mubice bimwe na bimwe byigifu. Byongeye kandi, HPMC ishobora gutwikwa kugirango ihindure umwirondoro w’ibiyobyabwenge, ifasha muri sisitemu yo gutanga.
4. Umukozi wo kubyimba
HPMC ikora nk'umubyimba mwiza muburyo bwo kwisukamo nka sirupe no guhagarikwa. Ubushobozi bwayo bwo kongera ububobere butarinze guhindura cyane indi miterere yibihingwa ni byiza mugukwirakwiza ibiyobyabwenge kimwe mumazi, kwirinda kugabanuka kwimitsi ihagaritswe, no gutanga umunwa wifuzwa. Uyu mutungo ni ingenzi cyane muburyo bwo kuvura abana no gukura, aho korohereza ubuyobozi ari ngombwa.
5. Stabilisateur mu ngingo zifatika
Mubisobanuro byingenzi nka cream, geles, namavuta, HPMC ikora nka stabilisateur na emulifier. Ifasha kugumya guhuzagurika no gutuza kwifata, kwemeza ko ibikoresho bikora bigabanijwe neza. HPMC itanga kandi uburyo bworoshye, butezimbere ikoreshwa no kwinjiza ibicuruzwa kuruhu. Kamere yacyo idatera uburakari ituma ikoreshwa muburyo bwo gukora uruhu rworoshye.
6. Imyiteguro y'amaso
HPMC ikoreshwa cyane mubikorwa byubuvuzi bwamaso, nkamarira yubukorikori hamwe nigisubizo cya lens ibisubizo. Imiterere ya viscoelastic yigana firime yamosozi isanzwe, itanga amavuta nubushuhe kumaso. Ibitonyanga byamaso bishingiye kuri HPMC ni ingirakamaro cyane kubantu bafite syndrome yumaso yumye, bitanga uburuhukiro bwo kurakara no kutamererwa neza. Byongeye kandi, HPMC ikoreshwa muri sisitemu yo gutanga imiti ya ocular, aho ifasha mukwongerera igihe cyo guhura nibiyobyabwenge nubuso bwa ocular, byongera imbaraga zo kuvura.
7. Gutegura Capsule
HPMC nayo ikoreshwa mugukora capsules ikomeye kandi yoroshye. Ikora nk'uburyo bwa gelatine, itanga ibikomoka ku bimera kuri capsule shells. HPMC capsules ikundwa kubintu biri munsi yubushuhe, bikaba byiza kumiti yangiza. Zitanga kandi umutekano muke mubidukikije bitandukanye kandi ntibishobora guhuzwa, ikibazo rusange hamwe na capsules ya gelatine ishobora kugira ingaruka kumwirondoro wo gusohora ibiyobyabwenge.
8. Kuzamura ibinyabuzima
Mubisobanuro bimwe, HPMC irashobora kongera bioavailable yimiti idashonga. Mugukora matelike ya gel, HPMC irashobora kongera umuvuduko wo gusesa ibiyobyabwenge mumitsi yigifu, byoroha kwinjizwa neza. Ibi ni ingenzi cyane cyane ku biyobyabwenge bifite amazi make, kuko kumeneka neza bishobora kugira ingaruka zikomeye kumiti.
9. Porogaramu ya Mucoadhesive
HPMC yerekana imitungo ya mucoadhesive, bigatuma ikwirakwizwa na sisitemu yo gutanga imiti ya buccal na sublingual. Izi sisitemu zisaba imiti gukomera kumitsi, itanga kurekura igihe kirekire no kwinjirira mumaraso, bikarenga metabolism ya mbere. Ubu buryo ni ingirakamaro ku biyobyabwenge bitesha agaciro aside aside yo mu gifu cyangwa bifite bioavailable yo mu kanwa.
Ubwinshi bwa hydroxypropyl methylcellulose (HPMC) muburyo bwa farumasi ntibushobora kuvugwa. Porogaramu zayo kuva kuri tablet guhuza hamwe no gutwikisha firime kugeza kubyimbye no gutuza ibintu muburyo butandukanye. Ubushobozi bwa HPMC bwo guhindura imyirondoro irekura ibiyobyabwenge, kongera bioavailable, no gutanga mucoadhesion birashimangira akamaro kayo mugutezimbere uburyo bwogutanga imiti igezweho. Mu gihe uruganda rukora imiti rukomeje gutera imbere, uruhare rwa HPMC rushobora kwaguka, bitewe n’ubushakashatsi bukomeje gukorwa n’iterambere bigamije kunoza itangwa ry’ibiyobyabwenge n’ibisubizo by’abarwayi.
Igihe cyo kohereza: Jun-05-2024