HydroxyPropyl MethylcellllAlose (HPMC), uzwi kandi nka hypromellose, ni polymer itandukanye ikoreshwa cyane mu nganda za farumasi. Ni kimwe cya kabiri, inert, polymer polymer yakomotse kuri selile, polysacride isanzwe. HPMC ihabwa agaciro kukesha mu mazi, imiterere itari uburozi, n'ubushobozi bwayo bwo gushinga filime na gels.
1. Binder muri tablet
Imwe mubyiciro byibanze bya HPMC muri farumasi ni nkirideri muri tablet. HPMC ikoreshwa kugirango igaragaze ko ibirungo biri muri tablet byubahiriza kandi biguma bihamye kugeza igihe hagejejwe. Imitungo yayo ihuza kuzamura imbaraga zubukanishi yibisatezo, bigatuma badakunda guswera cyangwa kumena mugihe cyo gupakira, gutwara, no gukora. Byongeye kandi, kamere ya HPMC ntabwo ionic ibyemeza ko ititabira ibindi bikoresho, kubungabunga umutekano, gukomeza umutekano hamwe nibikorwa bikora bya farumasi (APIS).
2. Kugenzurwa Matrix
HPMC ningirakamaro mugutezimbere irekurwa ryagenzuwe (Cr) kandi riragurwa (SR). Izi fomu zateguwe kugirango urekure ibiyobyabwenge mugihe cyagenwe, gukomeza urwego rwibiyobyabwenge bihamye mumaraso mugihe kinini. Ubushobozi bwa gel-pel bufite ubushobozi bwo guhura namazi ya gastrointestinal atuma ari byiza kuriyi ntego. Ikora urusaku rwa gel hafi ya tablet, kugenzura ibiyobyabwenge kubiyobyabwenge. Ibi biranga ni ingirakamaro cyane cyane kubiyobyabwenge nigipimo cya therapetic, kuko gifasha mugukomeza kwibanda ku plasma yifuzwa, bityo bikamura imikorere yibanze kandi bikagabanya ingaruka mbi.
3. Guhinga firime
Ubundi buryo bukoreshwa bwa HPMC burimo gutwika firime hamwe na capsules. Amavuta ashingiye kuri HPMC kurinda ibinini mubidukikije nkubushuhe, urumuri, numwuka, bishobora gutesha agaciro ibintu bikora. IHURIRO RY'AMAFARANGA RYINSHIna kandi ritezimbere ku bushake bwa tablet, biteza imbere kwiyangiza, kandi birashobora gukoreshwa mu rwego rwo kurinda ibintu byinjira, tubikeza ko ibiyobyabwenge birekurwa mu turere twihariye two mu nzira nyabagendwa. Byongeye kandi, aho bireba birashobora gukorerwa kugirango uhindure umwirondoro urekura ibiyobyabwenge, ugana muri sisitemu yo gutanga.
4. Umukozi wijimye
HPMC ikora nkumukozi mwiza wijimye mumashanyarazi nka syrupe no guhagarikwa. Ubushobozi bwayo bwo kongera viscosity nta gusobanura cyane indi mitungo yo kwimenyekanisha ari byiza cyane kugabura ibiyobyabwenge mumazi, gukumira imyanda yahagaritswe, no gutanga umunwa wifuzwa. Uyu mutungo ni ngombwa cyane cyane muri pediatric maremare na geriatric, aho horohewe nubuyobozi bukomeye.
5. Stabilizer mubitera imbere
Muburyo bwimbitse nka cream, gels, namavuta, HPMC ikora nkintandaro na emalisifier. Ifasha gukomeza guhuzagurika no gutuza kwa formulation, kwemeza ko ibigize ibikorwa bikora bigabanywa. HPMC itanga kandi imiterere yoroshye, yongeza ibyifuzo no kwinjiza ibicuruzwa kuruhu. Kamere yacyo idakaze ituma ikwiye gukoreshwa mubishusho byuruhu rworoshye.
6. Imyiteguro yo kwitegura
HPMC ikoreshwa cyane mugutegura ibisasu, nkamarira ahinnye no kuvugana na lens ibisubizo. Umutungo wacyo wa visic wigana filime isanzwe ya tear, zitanga amavuta nubushuhe kumaso. Ibitonyanga byamaso bishingiye kuri HPMC byingirakamaro cyane kubantu bafite syndrome yumye, batanga ubutabazi kurakara no kutamererwa neza. Byongeye kandi, HPMC ikoreshwa muri sisitemu yo gutanga ibiyobyabwenge, aho ifasha mu kurambagizanya igihe cyibiyobyabwenge hamwe nubuso bwa ocular, bituma ubuzima bwa oculatic.
7. AMAFARANGA YA CAPSUL
HPMC nayo ikoreshwa mugukora capsules ikomeye kandi yoroshye. Ikora nk'ubundi buryo kuri Gelatin, itanga amahitamo akomoka ku bimera kuri capsule ibishishwa. HPMC Capsules ikundwa kubera ibintu byayo byo hepfo, bikaba byiza kubiyobyabwenge. Batanga kandi umutekano mwiza muburyo butandukanye kandi ntibakunze kwambukiranya, ikibazo rusange na Gelatin Capsules ishobora kugira ingaruka kumyirondoro.
8. Kuzamura ibinyabuzima
Muburyo bumwe, HPMC irashobora kuzamura ibinyabuzima ibiyobyabwenge byoroshye. Mugukora Gel Matrix, HPMC irashobora kongera igipimo cyivumburwa cyibiyobyabwenge munzira ya gastrointestinal, yoroshya kwinjiza neza. Ibi ni ngombwa cyane cyane kubiyobyabwenge n'amazi yoroheje, nkuko gusebanya burundu birashobora kugira ingaruka ku buryo bukomeye bwo kuvura imiti.
9. Porogaramu ya Mucoadive
HPMC yerekana imitungo ya Mucoacheds, bigatuma sisitemu yo gutanga ibiyobyabwenge. Sisitemu isaba ibiyobyabwenge kugirango ikore kuri Mucous Membranes, itanga kurekurwa cyane no kwinjizwa mu maraso, kurenga kuri metabolism ya mbere. Ubu buryo ni ingirakamaro kubiyobyabwenge bitesha agaciro acide yigifu cyangwa kugira orawawaibaVAVAiLAbility.
Ibisobanuro bya HydroxyPropyl methylcellse (HPMC) muri farumasi idashobora kurenza urugero. Porogaramu yacyo yakoreshejwe kuri tablet ihuza kandi ifunga film kugirango inyeganyega no guhungabanya abakozi bakomeye muburyo butandukanye. Ubushobozi bwa HPMC bwo guhindura imyirondoro yo kurekura ibiyobyabwenge, yogoshe ibinyabuzima, kandi bitanga urundi Mucoadsion ashimangira akamaro kayo mugutezimbere sisitemu yo gutanga ibiyobyabwenge. Nkuko inganda za farumasi zikomeje guhinduka, uruhare rwa HPMC rushobora kwaguka, guterwa nimbaraga zikomeje ubushakashatsi nimbaraga ziterambere zigamije guhitamo gutanga ibiyobyabwenge no kwihangana.
Igihe cyohereza: Jun-05-2024