Abatamenya bifitanye isano murugo no mumahanga mugutegura abababaye ba farumasi hydroxypropyl methylcellse, isesengura ryamazi, kandi igenzurwa no kohereza amazi, igenzurwa no kwitegura kurekura, itegurwa rya Capsu, Gusaba mu murima w'amafi mashya nko gukora ibifatika na bioadheslaves. Kubera itandukaniro muri uburemere bwa molekile ugereranije na HPMC, ifite ibiranga kandi ikoresha umwirondoro, kumeneka, kubyimba, gukomera, guhagarika no gukora firime. Bikoreshwa cyane mu myiteguro ya farumasi kandi bizagira uruhare runini mu rwego rwo kwitegura. Hamwe ninyigisho yimbitse yimitungo yayo no kunoza ikoranabuhanga rya formation, HPMC izakoreshwa cyane mubushakashatsi bushya hamwe na sisitemu nshya yo gutanga ibiyobyabwenge, bityo iteza imbere iterambere ryimirire.
hydroxypropyl methylcellse; imyigire ya farumasi; abababaye imiti.
Abavandimwe ba farumasi ntabwo ari ishingiro ryimiterere gusa yo gushiraho ibiyobyabwenge Ifishi ya dosage n'inzira nshya z'ubuyobozi. Bifitanye isano rya hafi. Kuzamuka kwabantu bashya bya farumasi akenshi biteza imbere kuzamura imico yitegura hamwe niterambere ryimiterere mishya. HydroxyPropyl MethylcellALese (HPMC) nimwe mubantu benshi bazwi cyane murugo ndetse no mumahanga. Kubera uburemere bwayo butandukanye nubunini bwa molekile hamwe nibyishimo, bifite imirimo yo guhindagura, guhambira, kubyimba, kubyimba, no gukandagira. Ibiranga no gukoresha nka coagulation na firime bikoreshwa cyane mubukoranabuhanga bwa farumasi. Iyi ngingo isuzuma cyane cyane gusaba HydroxyProppeyl methylcellse (HPMC) mubikorwa mumyaka yashize.
1.Ibintu by'ibanze bya HPMC
HydroxyPropyl Methyl Cellulose (HPMC), formulaire ya molekile ni c8h15o8- ya selile. Irashobora gukorwa muburyo bubiri: imwe ni uko methyl selile yinzabibu ikwiye ifatwa na Nahh hanyuma igatwara hamwe na prodeylene munsi yubushyuhe bwo hejuru no guhatira cyane. Igihe cyimyitwarire kigomba kumara igihe kinini kugirango twemere methyl na hydroxyproppopYl kugirango ikore neza, ihujwe na anhroglucose impeta ya selile muburyo bwa selile, kandi irashobora kugera kurwego rwifuzwa; Ibindi ni ugufata ipamba cyangwa fibre yimbaho hamwe na soda ya Caustic, hanyuma witondere metani ya chlonad na programne hamwe na propane ya produnated hamwe na okidelene ukurikirana, hanyuma ukomeze kunonosora. , yajanjaguwe mu ifu nziza kandi yambaye imyenda cyangwa granules.
Ibara ryiki gicuruzwa ni cyera kugeza amata yera, impumuroya kandi itaryoshye, kandi ifishi ni granular cyangwa fibrous-ifu yoroshye. Iki gicuruzwa kirashobora gushonga mumazi kugirango gikore amakuru yera ya colloidal yera yera hamwe na virusi. Ibitekerezo bya Sol-gel bihuza kubera guhindura ubushyuhe bwimiti kubitekerezo runaka.
Kubera itandukaniro mubikubiye muri ibi bisimbura byombi muburyo bwa icyuma na hydroxyProppopyl, ubwoko butandukanye bwibicuruzwa byagaragaye. Mubisobanuro byihariye, ubwoko butandukanye bwibicuruzwa bifite ibintu byihariye. Ubushyuhe bwa Style hamwe nubushyuhe bwamabuye, rero bafite imitungo itandukanye kandi irashobora gukoreshwa mubikorwa bitandukanye. Farmacopoeia yibihugu bitandukanye ifite amabwiriza nuburyo butandukanye hamwe nicyerekezo cyicyitegererezo: Farumaniya ishingiye ku manota atandukanye hamwe na gahunda zitandukanye zo gusimbuza ibicuruzwa, kandi igice ni "MPA S ". Muri Pharmacopoea muri Amerika, imibare 4 yongeyeho nyuma yizina rusange kugirango yerekane ibirimo nubwoko bwa buri gusimbuza hydroxypropyl methylcellse 2208. Imibare ibiri yambere igereranya agaciro ka sisitemu. Ijanisha, imibare ibiri yanyuma igereranya ijanisha rya HydroxyPropyl.
HydroxyPropyl methylcellse ifite urukurikirane 3, aribwo e seriveri, f serukurikirane na k urukurikirane, buri rukurikirane rufite moderi zitandukanye zo guhitamo. E urukurikirane rukoreshwa ahanini nka firime, zikoreshwa mubiti bya tablet, bifunga ibinini bya tablet; E, f urukurikirane rukoreshwa nka virusire no kurekura abakozi bidindiza kwitegura kwa Ophthalmic, guhagarika abakozi, ibinini byo kwitegura kwamazi, ibinini na binders bya granules; K Urukurikirane rukoreshwa cyane nko kurekura ibibuza hamwe na hydrophilic ibikoresho bya matrix yimyiteguro yihuse kandi igenzurwa.
Abakora murugo cyane harimo fuzhou No 2 Uruganda rwumuti, ibiryo bya huzhou, Ltd., Shandong Ruitai Ibikoresho byiza bya Chiicaine Co., Ltd. .
2.Ibyiza bya HPMC
HPMC yabaye umwe mubakuru ba farumasi cyane murugo no mumahanga, kuko HPMC ifite ibyiza abandi bibarirwa badafite.
2.1 Amazi akonje
Gushonga mumazi akonje munsi ya 40 ℃ cyangwa 70% ethanol, bidahwitse mumazi ashyushye hejuru ya 60 ℃, ariko birashoboka ko gel.
2.2 inert ya shimi
HPMC nubu bwoko bwa selile idafite ishingiro, igisubizo cyacyo ntigikora ishinga amategeko kandi ntabwo gikorana ninyungu zamagana cyangwa ibinyabuzima byose bidakira mugihe cyo gukora.
2.3 Guhagarara
Birahagaze neza kuri aside hamwe na alkali, kandi irashobora kubikwa igihe kirekire hagati ya PH 3 na 11 nta mpinduka zikomeye muri viscosity. Igisubizo cya HPMC cya HPMC gifite ingaruka zo kurwanya mildew kandi zikomeza umutekano mwiza mugihe cyo kubika igihe kirekire. Abavandimwe ba farumasi bakoresheje HPMC bafite umutekano mwiza kuruta abatsinze abatsinze gakondo (nka dextrin, ibisimba, nibindi).
2.4 Ibyahishuwe
Ibiryo bitandukanye bya HPMC birashobora kuvangwa muburyo butandukanye, kandi ubuyobe bwayo burashobora guhinduka ukurikije amategeko runaka, kandi ifite umubano mwiza wumurongo, niko umubare ushobora gutorwa ukurikije ibikenewe.
2.5 Intertness
HPMC ntabwo yinjijwe cyangwa metabolize mumubiri, kandi ntabwo itanga ubushyuhe, niko imyiteguro yumutima itekanye. 2.6 Umutekano muri rusange ufatwa ko HPMC ari ibintu bitari uburozi kandi bidakaje, igipimo cya Median cyica ku rubi ni 5. 2 G · kg - 1. Igipimo cya buri munsi ntacyo kitwaye kumubiri wumuntu.
3.Gusaba HPMC mubitera
3.1 Nka firime yo gutwikira ibikoresho nibikoresho byo gukora firime
Gukoresha HPMC nkibikoresho bya tablet ya firime, ibinini byanditse nta nyungu bigaragara muguhishurira uburyohe no kugaragara ugereranije nibinini byinkoko, ariko gukomera kwayo, gukomera, impamyabumenyi, impamyabumenyi, impamyabumenyi, impamyabumenyi, impamyabumenyi. , Gukunda ibiro hamwe nibindi bipimo byiza nibyiza. Icyiciro cyo hasi cyiki gicuruzwa gikoreshwa nkigikoresho cyo gukosora amazi yibinini nibinini, hamwe nicyiciro kinini cya sisitemu yo gutoranya sisitemu yamashanyarazi, mubisanzwe mugihe cya 2% kugeza 20 %.
Zhang jixing et al. Byakoreshejwe uburyo bwo hejuru kugirango utegure premix forelation hamwe na HPMC nkuko firime ikunda. Gufata ibikoresho byo gukora firime HPMC, ingano ya polyvinyle na plastikilene glycol nkibikorwa bya tensiyo, imbaraga za firime hamwe nimbaraga za firime hamwe nubusabane hagati yubugenzuzi Ironderero hamwe nibikoresho byubugenzuzi byasobanuwe nicyitegererezo cyimibare, kandi inzira yo gutereta agaciro irarangwa. Ikoreshwa ryayo rifite umuhango wo gukora firime hydroxyPropyl methylcellellse (HPMCE5) 11.88 G, Inzoga Polyitylene Glycol 13.12 G, Ububiko bwa Poltiny ni 20.00 g, ubushishozi bwa polyiley ni 20. . Zhang Yuan yazamuye inzira yo kwitegura, yakoresheje HPMC nka fagitire yo gusimbuza ibinyamisogwe, maze ahindura ibinini bya litiro kugeza ku miterere yacyo kugira ngo iteze imbere ireme ry'imyiteguro yacyo, yonone ibisate byayo, byoroshye n'ibindi bibazo, kuzamura ibinini bituje. Gahunda yo gushyiraho neza yagenwa nubushakashatsi bwa orthogonal, ni ukuvuga ubushishozi bukabije bwari 2% mu gisubizo cya 70% mugihe cyo gupfuka, kandi umwanya ushimishije mugihe cya Granulation yari 15 min. Ibisubizo bya firime ya rezoua byateguwe na filime nshya byateguwe n'imikorere mishya n'imiterere yateye imbere cyane mu isura, igihe cyo gusenyuka no gukomera kuruta ibyo byakozwe n'imikorere y'umwimerere. yageze ku zirenga 95%. Liang Meiyi, Lu Xiaohui, nibindi kandi yakoresheje hydroxypropyl methylcellse nkibikoresho byo gukora firime kugirango bategure ibipimo bya firime ya Parike hamwe na tablet ya matrine. bigira ingaruka ku biyobyabwenge. Huang Yunran yateguye ibinini byamaraso ya dragon, kandi ashyira mu bikorwa HPMC ku gisubizo cyo gucengero cyo kubyimba, kandi agace kayo kari 5%. Birashobora kugaragara ko HPMC ishobora gukoreshwa cyane muburyo bwo gutanga ibiyobyabwenge.
HydroxyPropyl Methylcellse ntabwo ari ibintu byiza byo guhinga film gusa, ariko nanone birashobora gukoreshwa nkibikoresho bigize film muri firime. Wang Tongshin nibindi birategurwa kugeza kubyorezo bya zinc. Propaylene Glycol yujuje ibisabwa kugirango arekurwe kandi umutekano, kandi irashobora gukoreshwa nkimyiteguro yo kwitegura film.
3.2 Nka Binder no Gutandukanya
Icyiciro gito cya virusire kirashobora gukoreshwa nkainder kandi zidasobanutse kubinini, ibinini na granules, hamwe nicyiciro kinini cya virusire gishobora gukoreshwa gusa nkurwego. Ibipimo biratandukanye hamwe nibisabwa bitandukanye. Mubisanzwe, dosage ya binder kubinini byumye ni 5%, hamwe nigipimo cya binder kubinini bya granulation itose ni 2%.
Li Houtao et al yerekanye binder yibinini bya Tinidazole. 8% PolyvinyrPrOroNodone (PVP-K30), 40% Syruurs, 2.0% Ibice bya SthanalPropyl MethylCrollus K4 MethylCrollUll MethylCrollAl Gutegura ibinini bya Tinidazole. Kugaragara bihinduka ibinini bisobanutse hanyuma nyuma yo gutwarwa byarigereranijwe, kandi ibiyobyabwenge, gukomera, gusenya igihe ntarengwa n'uburamburwe bwibisate bitandukanye. Ibisubizo Ibisate byateguwe na HydroxyPropyl Methylcellpirase byari byiza, kandi ibipimo bidakenewe byabonetse hamwe na chenomen, kandi nyuma yo gukomera, isura yari nziza. Kubwibyo, ibinini bya Tinidazole byateguwe hamwe na 2,0% HPMC-K4 na 50% Ethanol nkuko binders byakoreshejwe. Guan Shihai yize inzira yo guterekiranya ibinini bya Fuganning, suzuma ibifuniko, kandi byerekanwe 50%, 15% Ibipimo bya Sthanol na 50% hamwe na Ethanol, no kugereranya, no kumenyekana no gusuzuma. , 5% cmc-na na 15% igisubizo cya HPMC (5 mP). Ibisubizo Impapuro zateguwe na 50% Ethanol, 15% Ibice bya Paste, 10% PVP 50% Igisubizo cya Ethanol na 5% 15% Umuti wa HPMC (5 mp · s), ubuso bwa tablet buroroshye, ibiyobyabwenge byujuje ibisabwa, kandi kubyutsa ni byiza, bishobora kubahiriza ibikenewe. Kubwibyo, HPMC (5 MPA S) yatoranijwe nkiyidimya.
3.3 Nkuguhagarika umukozi
Icyiciro cyo hejuru cyiki gicuruzwa gikoreshwa nkumukozi wahagaritswe kugirango utegure igiteguro cyamazi. Ifite ingaruka nziza, biroroshye gusubiramo, ntabwo akomeza kurukuta, kandi afite ibice byiza. Dosage isanzwe ni 0.5% kuri 1.5%. Indirimbo Tian et al. yakoresheje ibikoresho bisanzwe byakoreshejwe (hydroxypropyl methylcellse, sodium carboxymethylcelllcelllcellAlose, Poliviyo, Xthylcellsellsellse, PolivinlCellllllse, PolivinlCellllllse, PolivinlCellllllse, PolivinlCelcellUlose, PolivinlcellAllllAlose, Polivinone, Xthylcellses, nibindi) nko guhagarika abakozi kugirango bategure ubwoko bwa romontadote. guhagarikwa. Binyuze mu gipimo cy'ibipimo by'ibipimo bitandukanye, indangagaciro zidasanzwe, hamwe n'uburyo, guhagarika ibinyabiziga bya microscopique, kandi gushikama kw'ibiyobyabwenge biri mu iperereza ryihuse naryo ryakozweho iperereza. Ibisubizo Guhagarikwa ryumye byateguwe hamwe na 2% HPMC mugihe umukozi wahagaritswe yari afite inzira yoroshye kandi ituje.
Ugereranije na methyl selile, hydroxypropyl methyl methyl Methyl Methyl Methyl Methyl Methyl Methys ibiranga ibintu bya fibroke bisobanutse, kandi ni bike kandi bikunze gukoreshwa cyane nkumukozi wahagaritswe mumyiteguro ya Ophthalmic mu myiteguro ya Ophthalmic mu myiteguro ya Ophthalmic mu myiteguro ya Ophthalmic mu myiteguro ya Ophthalmic mu myiteguro ya Ophthalmic mu myiteguro ya Ophthalic. Liu jie et al. yakoresheje HPMC, HYDROXYPRAPropyl Twolleapy (HPC), karbomer 940, sodium hlycol (peg), sodium hlyanmic yo gutegura ibisobanuro bya CICLOVIM byatoranijwe nkibipimo byubugenzuzi kugirango bagaragaze umukozi mwiza wahagaritswe. Ibisubizo byerekana ko acyclovir ophthalmic yateguwe na 0.05% ha na 0.05%. Igipimo cy'imiyoboro y'imyanya ni cyo
3.4 Nka Blocker, Buhoro kandi ugenzure umukozi ushinzwe kurekura hamwe numukozi wa Pore
Icyiciro cyo hejuru cyibicuruzwa gikoreshwa mugutegura Gel Gel Matrix yakomeje-kurekura ibinini bya Matrix, kandi bifite ingaruka zo gutinza ibisate. Kwibandaho ni 10% kugeza 80%. Amanota make akoreshwa nka porogens kugirango ikureho cyangwa igenzurwa-igenzurwa. Igipimo cyambere gisabwa kugirango ingaruka zimpeshyi zirashobora kugerwaho vuba, hanyuma hakomezwa cyangwa igenzura-zo kurekura. . HydroxyPropyl methylcellsellse ni hydted kugirango ikore gel urwego iyo yujuje amazi. Uburyo bwo kurekura ibiyobyabwenge muri tablet ya Matrix ahanini ikubiyemo kugabanura igice cya gel hamwe nisuri yigice cya gel. Jung bo shim et al yateguye karvestilol ikomeje-kurekura ibinini hamwe na HPMC nkibikoresho byakomeje kurekura.
HydroxyPropyl Methylcellse nayo ikoreshwa cyane mubinini bya matrix gakondo yubushinwa, nibindi byinshi bikora, ibice bimwe byimiti yubushinwa bikoreshwa. Liu wen et al. yakoresheje 15% hydroxypropyl methylcellellus nkibikoresho bya matrix, 1% lactose na 5% microchesstalline nkuko umucurazi wa jaoches Icyitegererezo ni ikigereranyo cya Higuruchi. Sisitemu yo guhimba kwa formula iroroshye, kwitegura byoroshye, kandi amakuru yo kurekura arahagaze neza, yujuje ibyangombwa bya Pharmacopoeia y'Ubushinwa. Tang Guanguang et al. Yakoresheje saponine zose za astragalus nk'ibiyobyabwenge by'icyitegererezo, byateguwe ibiyobyabwenge bya HPMC, hanyuma ugasuzuma ibintu bireba kurekura ibiyobyabwenge bivuye mu bice bifatika by'ubuvuzi gakondo mu bushinwa. Ibisubizo Nkuko Dosage ya HPM yiyongereye, irekurwa rya Astragalo ryagabanutse, kandi ijanisha ryasohotse ryibiyobyabwenge ryari rifite umurongo uhuza umurongo hamwe nigipimo cyivumburwa cya matrix. Muri Hypplemellose tablet matrix, hariho umubano runaka hagati yo kurekura igice cyiza cyumuti gakondo wubuvuzi hamwe nigipimo cya HPMC, hamwe nuburyo bwa HPMC, hamwe nuburyo bwo kurekura bwa HPDROPHIC, kandi inzira yo kurekura chimique yimiti irasa nayo. HydroxyPropyl Methylcellse ntabwo ikwiriye gusa ibice bya hydrophilic, ariko no mubintu bitari hydrophilic. Liu Guia yakoresheje 17% hydroxypropyl methylcellse (HPMCK15M) nkuko ibikoresho byarangije matrix, kandi byateguye ibikoresho bya matrix, kandi byateguye ibikoresho bya matrix byakomeje-gusohora matrix. Ingaruka zikomeje zagaragaye, kandi inzira yo gutegura yarahagaze neza kandi bishoboka.
HydroxyPropyl Methylcellse ntabwo ikoreshwa gusa ibisate bya Matrix yibikoresho bikora nibice bifatika byubuvuzi gakondo, ariko nanone bikoreshwa mubice gakondo byubuvuzi. Wu Huichao et al. yakoresheje 20% hydroxypropyl methyl methyl Methym (HPMCK4M) nkibikoresho bya matrix, kandi bigakoresha uburyo butaziguye kugirango bategure ibiyobyabwenge Saponin RG1, Ginsenoside RB1 na Panax Nonooginseng Saponin R1 yakoreshejwe nk'ibipimo byo gusuzuma kugira ngo ikore iperereza kuri Vitro, kandi ikigereranyo cyo kurekura ibiyobyabwenge cyashyizwemo ko zize imikoreshereze y'ibiyobyabwenge. Ibisubizo Kurekura Ibiyobyabwenge bihuye na zeru-kuri zetike hamwe na ritger-peppas, aho geniposide yarekuwe ikwirakwizwa ryabanyagatine, hamwe nibice bitatu muri kanax nonoorion.
3.5 gukingira gukingira nka Thickeneri na Colloid
Iyo iki gicuruzwa gikoreshwa nkuwabyibushye, ibisanzwe byibanda kuri 0.45% kuri 1.0%. Irashobora kandi kongera imbaraga za slue ya hydrophobike, kora colloid irinda, irinda uduce duhanganye no gukomera, bityo bikabuza, kubuza gushiraho imyanda. Ijanisha risanzwe ryibanda kuri 0.5% kuri 1.5%.
Wang Zhen et al. yakoresheje uburyo bwa L9 orthogonal deptpel igishushanyo kugirango ikore iperereza ku buryo bwo gutegura imiti ifata Carbon Enema. Imiterere nziza yo kugena imiti yanyuma ya Carbon Enema igomba gukoresha 0.5% Carboxymethyl MethyProxyl Methyproxyl Methylcellle Me 11,6%) Guhagarara kwa CARBON YAKORESHEJWE. Zhang ZhiqiAng et al. yateje imbere Ph-Defletives Abalefloxacin hydrochloride ophthalmic yiteguye-gukoresha gel hamwe na gel matrix na hydroxypropyl methylcellse nkumukozi wijimye. Imyitozo Nziza nubushakashatsi, amaherezo ibona uburyo bwiza ni Abalefloxacin Hydrochloride 0.1 g, acide ya hydroxcelll methylcellse, 0,50 g ya sodium , 0.03 G ya Ethyl paraben, kandi amazi yongeweho kugirango akore 100. Mu kizamini, umwanditsi yagenzuye hydroxyPropyl methylcellus urukurikirane rwamabara rwamabara hamwe nibisobanuro bitandukanye (K4m, E5MV) gutegura ibibyimba bitandukanye, kandi ibisubizo byatoranijwe na HPMC e50. Thuckener kuri Ph-Defletives Abalewi Hydrochloride Akanya ako kanya.
3.6 nkibikoresho bya capsule
Mubisanzwe, ibikoresho bya capsule ibikoresho bya capsules ni gelatin. Igikorwa cyo gukora cya capsule shell kiroroshye, ariko hari ibibazo hamwe nibibazo nkibibi nkibibi bibujijwe ubushuhe nububiko bwa ogisijeni, bigabanya gusenya ibiyobyabwenge. Kubwibyo, hydroxyPropyl methylcellse ikoreshwa nkumusimbura wa Gelatin Capsules yo gutegura capsule, itezimbere uburyo bwo gukora capsule, itezwa imbere imbaraga za capsule, kandi yazamuwe murugo no mumahanga.
Gukoresha Theophylline nkibiyobyabwenge byo kugenzura, podczeck et al. Habonetse ko igipimo cyo kuvugwa ibiyobyabwenge cya capsules hamwe na hydroxypropyl methylcellse ibisasu byakururwa na gelatin capsules. Impamvu yo gusesengura ni uko gusenyuka kwa HPMC ni ugusebanya kwa capsule yose icyarimwe, mugihe imyuka ya gelatin capsule ni ukundi kwa capsule yose, hanyuma induru ya capsule yose, nuko HPMC Capsule irakwiriye cyane kubishishwa bya capsule kugirango irekure vuba. Chiwele et al. yabonye kandi imyanzuro isa no kugabana iseswa rya Gelatin, Gelatin / Polyethylene Glycol na SPMC. Ibisubizo byerekanye ko HPMC yashonze vuba muburyo butandukanye bwa PH, mugihe Gelatin Capsules yibasiwe cyane na PH itandukanye PH. Tang Yue et al. Yagaragaje ubwoko bushya bwa capsule igikonoshwa cyibiyobyabwenge-bike byambaye ubusa bya sisitemu yo guhumeka. Ugereranije na capsule igishoro cya hydroxypropyl methylcellse na capsule igikono cya gelatin, hashyizweho ikizamini cy'ifu mu bihe bitandukanye, kandi ikizamini kidakoreshwa cyakorwaga. Ibisubizo byerekana ko ugereranije na Gelatin Capsules, ibishishwa bya HPMC birusheho gutura, bityo bikaba birwanya ifu ya Gelatin Capsule, kandi bikaba bigabanijwe cyane kuri Gelatin Capsule yo guhumeka.
3.7 Nka biolhesive
Ikoranabuhanga rya Bioadhesion rikoresha abababaye hamwe na bioalmes polymers. Mugukurikiza inzu y'ibinyabuzima, yongera gukomeza no gukomera kwimibonano mpuzabitsina hagati yo kwitegura na Mucosa, kugirango imiti irekurwe buhoro buhoro kandi ishingiye kuri Mucosa kugirango igere ku ntego yo kwivuza. Byakoreshejwe cyane muri iki gihe. Kuvura indwara z'amadupapuro ya gastrointestinal, igituba, Mucosa yo mu kanwa nibindi bice.
Ikoranabuhanga rya bioadhesille ni sisitemu nshya yo gutanga ibiyobyabwenge yateye mumyaka yashize. Ntabwo ari ugukiza igihe cyo guturamo ibiyobyabwenge gusa munzira y'ibiyobyabwenge, ariko kandi bikazana imiti hagati yibiyobyabwenge na membrane ya selile ku rubuga rwa selile, ihindura amazi ya selile, kandi ahindura amazi ya selile, kandi ahindura ibitekerezo bya selile Ingirabuzimafatizo nto zongenga zongerewe imbaraga, bityo zitezimbere ibinyabuzima. Wei KEDAT ET. Yagaragaje tablet yibanze hamwe na dosage ya HPMCK4M na karbomer 940 nkibikoresho byo gukora iperereza, kandi bigakoresha igikoresho cya bioals, kandi gikoresha igikoresho cya bioals kugirango gikene imbaraga zamazi hamwe nubwiza bwamazi mumufuka wa plastiki. , hanyuma amaherezo yahisemo ibikubiye muri HPMCK40 na karbomer 940 kuba 15 na 27.5 mg mukarere ka NCAEBT (nka hydroxyPropyl methylcellse) irashobora kugabanya cyane kunonosora Imyiteguro yo kwitegura ingirangingo.
Imyiteguro yo hagati yacyo nayo ni ubwoko bushya bwa sisitemu yo gutanga ibiyobyabwenge yize cyane mumyaka yashize. Imyiteguro yo mu kanwa irashobora kubahiriza ibiyobyabwenge mu gice cyanduye cy'ubusarure mu kanwa, bidahemba nyuma y'ibiyobyabwenge mu Muco wo mu kanwa muri Mucosa mu kanwa, ariko nanone kandi arinda Mucosa wo mu kanwa. Ingaruka nziza yo kuvuza no kunoza ibiyobyabwenge bioakwaiLaility. XUE Xiaoyan et al. Hindura uburyo bwo gushyiraho ibinini bya insuline, ukoresheje pectine ya Apple, Chitosan, Carboxt, HPMC K392) hamwe nibikoresho bya bioyplicellse (HPMC K392) ibikoresho-byumye kugirango utegure insuline yo mu kanwa. Urupapuro rwibifite. Isum yateguwe mu magambo afatika afatika afite imiterere myiza ya sponge, ikunda kurekura insuline, kandi ifite urwego rurinda hydrophobic, rushobora kwemeza ko ibiyobyabwenge birekura ibiyobyabwenge kandi bikaba bishobora kurekura ibiyobyabwenge kandi birinda gutakaza ibiyobyabwenge. Hao JIFU et al. Biteguye kandi ibishyimbo byumuhondo biri hejuru ukoresheje baiji glue, hpmc na karbomer nkibikoresho bya bioyadi.
Muri sisitemu yo gutanga ibiyobyabwenge, tekinoroji ya bioals nayo yakoreshejwe cyane. ZHA YUTO HTL. yakoresheje karbomer (cp) na hpmc nkibikoresho bifatika kandi bikarisha matrix kugirango bategure clottrimatozo ibipimo bya biodrimatole hamwe nibipimo bitandukanye, kandi bipima igihe cyayo, kumbagera mubidukikije. , inyandiko ikwiye yagenzuwe nka CP-HPMC1: 1, urupapuro rufite ibikoresho rwateguwe rwagize imikorere myiza, kandi inzira yari yoroshye kandi birashoboka.
3.8 nka gel yo hejuru
Nkinzu yo kwitegura, Gel ifite urukurikirane rwinyungu nkumutekano, ubwiza, isuku yoroshye, igiciro gito, gahunda yo kwitegura, no guhuza neza nibiyobyabwenge. Icyerekezo cy'iterambere. Kurugero, gel ya transdermal nuburyo bushya bwa dosage bwize cyane mumyaka yashize. Ntabwo ishobora kwirinda gusenya ibiyobyabwenge gusa munzira ya gastrointestinal kandi igabanya itandukaniro ryinshi ryibanda ku biyobyabwenge, ariko nanone byabaye kimwe muri sisitemu yo kurekura imiti kugirango utsinde ingaruka zibiyobyabwenge. .
Zhu Jingjie et al. Yize ingaruka za matrices zitandukanye ku irekurwa rya scutellarin gel i vitro, kandi sobanura hamwe na karépropyl methylcellse (HPMPLALPOPLLL MITHYLCELSE (HPMPRYPLEPLULOSE (HPMPRYPLOCELLAS (HPMPLALPLOCELLAS (HPMPLALPLOCELLAS (HPMPLALPLOCELLAPH (HPMPLALFOYOYA (HPMPLALFOYOYL MOTRANIM Gel Matrix ya Scostids Plastide. Ibisubizo byubushakashatsi byerekana ko 1. 0% Carbomer, 1% Carbomer, 1% Carbomer + 1%. 0% . Mu bushakashatsi, wasangaga HPMC ishobora guhindura uburyo bwo kurekura ibiyobyabwenge Gel Matrix ikwiranye no kurekura ibiyobyabwenge, kandi 1.0% HPMC irashobora kunoza matrix 1.0% na 1.5% matrix. Impamvu irashobora kuba ko hpmc yaguka vuba, kandi kwaguka byihuse mugihe cyubushakashatsi bukora icyuho cya fale ya gel nini, bityo twihutisha igipimo cyo kurekura ibiyobyabwenge. Zhao wencui et al. yakoresheje karbomer-934 na hydroxyPropyl methylcellse nkabatwara kugirango bategure gel ya Norfloxacin. Inzira yo kwitegura iroroshye kandi birashoboka, kandi ubuziranenge buhuye na gel ya Ophthalmic ya "Pharmacopoeia y'Ubushinwa" (Edition 2010) ibisabwa.
3.9 Imvura imurikator muri sisitemu yo kwishima
Kwishimangira sisitemu yo gutanga ibiyobyabwenge (Smedds) ni ubwoko bushya bwo gutanga ibiyobyabwenge, ni uruvange rufite ishingiro, ruhamye kandi ruhagaze mu cyiciro cya peteroli, ku mucyo, Emulsifier na CO-EMULSIIER. Ibigize ibyo wanditse biroroshye, kandi umutekano n'umutekano ni byiza. Kubiyobyabwenge cyane, ibikoresho bya fibre ya fibre ya fibre, nka hvmc, polyvinylprirodone (PVP), nibindi, akenshi byongeweho kugirango ibiyobyabwenge bigerweho nibiyobyabwenge bigerweho bigera ku ncapake ya Gastrointestinal, kugirango Ongera ibiyobyabwenge byonyine no kuzamura ibinyabuzima.
Peng Xuan et al. yateguye silibinin yahagaritse kwikuramo uburyo bwo gutanga ibiyobyabwenge (S-sedds). Oxyrateylene Amavuta ya Beorogeted Pator (Cremophor Rh40), 12% Caprylic capric acide polkol glycol glycol glycol glycol glyceider (labrasol) nkamagana, na 50 mp · g-1 hpmc. Ongeraho HPMC kuri SESEDS irashobora gutanga supersurate silibinin kubuntu kugirango ishongesheje s-seds kandi irinde sidibinin kugwa. Ugereranije nubuzima bwimico gakondo, umubare munini wa surfactant usanzwe wongeyeho kugirango wirinde gutandukana kwinshi. Kwiyongera kwa HPMC birashobora kubahiriza ibikesha bya silibinin mu rwego rwo gusebanya ugereranije, bigabanya ingendo mu mishinga miremire. igipimo cyumukozi.
4.conlution
Birashobora kugaragara ko HPMC yakoreshejwe cyane mu myiteguro kubera imitungo yayo, imiti na HPMC ifite kandi amakosa menshi mu myiteguro, nka phenomenon yo kurekura mbere. methyl methacrylate) kugirango utezimbere. Muri icyo gihe, abashakashatsi bagize iperereza ku busabane bw'ibitekerezo bya Osmotic muri HPMC mu gutegura ibinini bikomeza-birekura ibinini bya Verapamil na Verapamil Hydrololoride gukurikiraho ibinini byo kwigira. Mu ijambo, abashakashatsi benshi kandi benshi bakora imirimo myinshi yo gukoresha neza HPMC mu myiteguro, ndetse no kwiga mu buryo bwimbitse bw'ikoranabuhanga ryayo no kunoza ikoranabuhanga ryo gutegura, HPMC izakoreshwa cyane muburyo bushya bwo gutanga dosiye n'imiterere mishya. Mu bushakashatsi bwa sisitemu yimiti, hanyuma utezimbere iterambere rya farumasi.
Igihe cya nyuma: Ukwakira-08-2022