HydroxyPropyl MethylcellAllLese (HPMC) ni igice cya siyoka-synthique polymeti ikoreshwa cyane munganda nyinshi, cyane cyane mumwanya wa farumasi. HPMC yabaye intangarugero mu myiteguro ya farumasi kubera biocompaget, idasobanutse hamwe nindahiro yumubiri na shimi.
(1) Ibiranga ibyingenzi byicyiciro cya farumasi hpmc
HPMC ni ubumwe butari ether fillese bwateguwe na selile ya selile hamwe na proploride ya proparlene na methyl chloride mubihe bya alkaline. Imiterere yayo idasanzwe itanga HPMC nziza cyane, kubyimba, gushiraho firime no guhindagura imitungo. Ibikurikira nibiranga HPMC:
Amazi yoroheje na PH kwishingikiriza: HPMC irashonga mumazi akonje kandi ikora igisubizo gisobanutse. Kugaragaza igisubizo byayo bifitanye isano no kwibanda nuburemere bwa moleki, kandi bifite imbaraga zikomeye kuri PH kandi birashobora kuguma zihagaze mubidukikije byombi na alkaline.
Ibiranga TheRogel: HPMC yerekana ibintu bidasanzwe bya TherMogel iyo ashyushye. Irashobora gukora gel iyo yuzuye ubushyuhe runaka hanyuma ugaruke muburyo bwamazi nyuma yo gukonja. Uyu mutungo ni ngombwa cyane mubiyobyabwenge byiteguye.
Bioquatishes hamwe nuburozi: Kubera ko HPMC ari urwara na selile kandi nta kiguzi kandi ntazabyitwaramo nibindi bikoresho, bifite biocompat kandi bitazashyirwa mu mubiri. Ni igihano kitari uburozi.
(2) Gusaba HPMC mumiti
HPMC ikoreshwa cyane mu nganda za farumasi, itwikiriye imirima myinshi nkimvune yo mu kanwa, imiti yibanze kandi yimbitse. Icyerekezo cyacyo nyamukuru gikoreshwa nkibi:
1. Ibikoresho byo gukora firime mubinini
HPMC ikoreshwa cyane muburyo bwo gutora bwibinini nkibikoresho byo gukora firime. Gutwika Tablet ntibishobora kurinda ibiyobyabwenge gusa ibidukikije byo hanze, nkubushuhe n'umucyo, ariko nanone bihimbaza ibiyobyabwenge kandi uburyohe bwibiyobyabwenge, bityo uburyo bwo kwizihiza ibiyobyabwenge. Filime yakozwe na HPMC ifite amazi meza n'imbaraga, bishobora kwagura neza ubuzima bwibiyobyabwenge.
Muri icyo gihe, HPMC irashobora kandi gukoreshwa nk'ibigize byinshi bigenzurwa-birekura imikorere yo gukora neza kandi bigenzurwa-birekurwa. Ubushyuhe bwa Gel butuma ibiyobyabwenge birekurwa mumubiri mugipimo cyateganijwe cyo kurekura, bityo tugera ku ngaruka zo kuvura imiti miremire. Ibi ni ngombwa cyane cyane mu kuvura indwara zidakira, nk'ibiti birebire bisaba abarwayi barwaye diyabete na hypertension.
2. Nk'umukozi urekurwa
HPMC ikoreshwa cyane nkumukozi ushinzwe kurekura mugutegura ibiyobyabwenge. Kuberako ishobora gukora gel mumazi kandi pal layel ishonga buhoro buhoro nkuko ibiyobyabwenge birekuwe, birashobora kugenzura neza umubare wibiyobyabwenge. Iyi porogaramu ni ingenzi cyane mu biyobyabwenge bisaba kurekurwa igihe kirekire, nka insuline, antidepressresses, nibindi
Mu bihe bikomeye, igice cya GPMC gishobora kugenzurira igipimo cyo kurekura ibiyobyabwenge, twirinda gusohora ibiyobyabwenge mu gihe gito, bityo bikagabanya ingaruka nkeya no kurengerera ingaruka. Iyi mitungo irambye ibereye cyane kuvura ibiyobyabwenge bisaba kwibanda ku biyobyabwenge bihamye, nka antibiyotike, ibiyobyabwenge byo kurwanya igicuri, nibindi.
3. Nka binder
HPMC ikunze gukoreshwa nka binder muri tablet. Wongeyeho HPMC kubice byibiyobyabwenge cyangwa ifu, amazi yacyo no kumeneka birashobora kunozwa, bityo bigatuma ingaruka zo kwikuramo n'imbaraga za tablet. Uburozi no gutuza kwa HPMC bituma bifata neza mubinini, granules na capsules.
4. Nkumukunzi wawe na stilizer
Mu myiteguro y'amazi, HPMC ikoreshwa cyane nk'umubyimba n'intangarugero mu mazi atandukanye yo mu kanwa, ibitonyanga by'amaso n'amavuta y'ijisho. Umutungo wacyo wijimye urashobora kongera ubushishozi bwibiyobyabwenge, irinde kubyutsa ibiyobyabwenge cyangwa imvura, kandi urebe kimwe cyo gukwirakwiza ibiyobyabwenge. Muri icyo gihe, amavuta ahinnye na gatoya ya HPMC bishoboza kugabanya neza ibintu bitameze neza mubyo bigabanuka bikabije kandi birinda amaso kurakara hanze.
5. Ikoreshwa muri capsules
Nk'ibihingwa biva mu gihingwa, HPMC ifite biocompaget nziza, ikabigira ibikoresho byingenzi byo gukora capsules. Ugereranije na Capsules gakondo Gelatin Capsules, HPMC Capsules ifite umutekano mwiza, cyane cyane mubushyuhe bwinshi nubushuhe buke, kandi ntabwo byoroshye kubyutsa cyangwa gushonga. Byongeye kandi, Capsules ya HPMC irakwiriye kubakomoka ku bimera n'abarwayi ballergique kuri Gelatin, bagura urugero rw'ibiyobyabwenge bya capsule.
(3) Ibindi bikorwa by'ibiyobyabwenge bya HPMC
Usibye gusaba ibiyobyabwenge byavuzwe haruguru, HPMC irashobora kandi gukoreshwa mumirima runaka yibiyobyabwenge. Kurugero, nyuma yo kubaga Ophthalmic, HPMC ikoreshwa mumaso yijisho nkinyoni yo kugabanya guterana amagambo hejuru yijisho ryijisho no guteza imbere gukira. Byongeye kandi, HPMC irashobora kandi gukoreshwa mu mavuta na gels kugira ngo uteze imbere gukurura ibiyobyabwenge no kunoza imikorere ibiyobyabwenge.
Icyiciro cya Farumasi HPMC gifite uruhare runini mugutegura ibiyobyabwenge bitewe numubiri na shimi. Nkigitumbuzi cyimiti myinshi, HPMC ntishobora guteza imbere ibiyobyabwenge gusa no kugenzura irekurwa ryibiyobyabwenge, ariko kandi bizamura imiti ifata ibiyobyabwenge no kongera umurwayi. Hamwe no gutera imbere kwikoranabuhanga rya farumasi, umurima usaba HPMC uzaba nini kandi ukine uruhare runini mugutezimbere ibiyobyabwenge.
Igihe cyo kohereza: Sep-19-2024