1.Nibikoresho:
Muri farumasi, bibers bafite uruhare runini mu kwemeza ko ubunyangamugayo n'imikorere yimpapuro. Muri sisitemu zitandukanye zinyuranye ziboneka, hydroxypropyl methylcellse (HPMC) igaragara nkigikoresho gisobanutse kandi cyakoreshejwe cyane.
2.Properties ya sisitemu ya HPMC iSINTER:
HPMC, polymer ya semisythertic ikomoka kuri selile, itanga ibintu byiza byibyiza bya farumasi. Harimo:
Guhinduranya: HPMC yerekana amanota yagutse yinzarugero, yemerera abamushinyagurira guhuza imikorere yacyo kumiterere yihariye nibisabwa. Ubu buryo bwo kwagura ibisabwa mu mihigo itandukanye ya farumasi, harimo n'ibisame, capsules, film, hamwe n'imyiteguro y'ibanze.
Binder nogutandukanya: HPMC ikora nk'ibideringe, byorohereza imbaraga mu bisate, kandi nk'interaniro, biteza imbere gusenyuka byihuse no kurekura ibiyobyabwenge. Iyi mikorere ibiri yo kuzamura imikorere kandi yongerera imikorere yimikorere yo mu kanwa, cyane cyane ibisate.
Guhuza: HPMC yerekana guhuza hamwe nigikoresho gitandukanye cyibikoresho byingenzi bya farumasi (APIS) nabababaye, bigatuma bikwiranye no gushyiraho ibice byinshi byibiyobyabwenge. Kamere yacyo no kubura imikoranire hamwe nibice byunvikana neza ko hazamunaniza.
Imiterere yo gukora film: HPMC irashobora gukora firime zitoroshye kandi zikomeye iyo hydred, zikavuga nta makosa mugutezimbere firime zoroheje, ibice bya transdermal, hamwe na sisitemu yo gutanga ibiyobyabwenge. Izi firime zitanga inyungu nka yongerewe kubahiriza, guswera neza, no gufata byihuse ibikorwa.
Kugenzurwa: Mugushiraho icyiciro cya vinosity hamwe no kwibanda kuri HPMC mu miterere, kurekura ibiyobyabwenge ibiyobyabwenge birashobora kuba byiza kugerwaho neza kugira ngo bigerweho, birambye, cyangwa byagutse imyirondoro. Ubu bushobozi bufite akamaro cyane cyane bwo gushyiraho uburyo bwo kugenzura umunwa, aho kubungabunga urwego rwibiyobyabwenge mugihe cyagutse ni ngombwa.
3.Kasaba n'inyungu mu ngamba zo gushyiraho:
Ibitekerezo bya tablet:
HPMC ihuza ibitana neza hamwe numutungo utemba kuri granules, byorohereza inzira nziza.
Imyitwarire yagenzuwe hamwe na Hydration ya HPMC mubibi bigira uruhare mu gusenya ibiyobyabwenge kimwe no guhabwa ibizamura Kinetics, kugirango habeho ingaruka zidasanzwe.
Abashinzwe kuba abamushinyaguzi barashobora guhuza na HPMC hamwe nabandi bababaye kugirango bateze imbere ibinini byinshi bifatika
Amahirwe ya Capsule:
HPMC ikora nka binder itandukanye mumabwiriza ya capsules yumye yifu yuzuyemo ifu yumirwa, igateganyo ibitandukanye bya hydrophilic na hydrophobic apis.
Ubushobozi bwayo bwo gukora firime zikomeye zorohereza kwiteza imbere kandi bihamye-birekura capsule, bizamuka umutekano wa API.
Ibikorwa bishingiye kuri firime:
HPMC-ishingiye kuri firime yoroheje itanga ibyiza byinshi kumpapuro zibipimo gakondo, harimo no gusenyuka byihuse, byatejwe imbere, kandi byatejwe imbere kubahiriza abarwayi n'abaturage.
Ibikoresho bya Transdermal byateguwe na firime ya HPMC itanga ibicuruzwa bigenzurwa nuruhu, gutanga ibitekerezo bya plasma bihamye no kugabanya ingaruka za sisitemu.
Ibigize byinshi:
Mubiterankunga byingenzi nka gels, amavuta, namavuta, hpmc ikora nka romeifier yuburyo, itanga virusire yifuzwa.
Umutungo wacyo wa firime uzamura amarangamutima yibanze ku ruhu, kuramba ku biyobyabwenge no kuborohereza gutanga ibiyobyabwenge.
HydroxyPropyl Methylcellse (HPMC) sisitemu ya Binder itanga inyungu nyinshi mu ngamba zo gushyiraho imiti, zikereka ibintu byabo bitandukanye hamwe na porogaramu yagutse hirya no hino. Kuva ku bisate na capsules kuri firime hamwe n'imikorere y'imikorere, HPMC ituma abamubukira kugira ngo bagenzure neza kurekurwa n'ibiyobyabwenge, kuzamura imihane yo kuzamura, no kunoza umuhanga wo kwihangana. Mugihe inganda za farumasi zikomeje guhinduka, HPMC ikomeje kuba ibuye rikomeza iterambere ryiterambere ryamagana, gutwara udushya no kuzamura umusaruro wa TheRapeutic.
Igihe cya nyuma: Gicurasi-07-2024