Hydroxypropyl methylcellulose na hydroxyethyl selulose byombi ni selile

Hydroxypropyl methylcellulose (HPMC)na hydroxyethyl selulose (HEC) nibikomoka kuri selile ebyiri zingenzi zikoreshwa cyane mubikorwa bitandukanye kubera imiterere yihariye. Mugihe byombi bikomoka kuri selile, bifite imiterere yimiti itandukanye kandi byerekana ibintu bitandukanye nibisabwa.

1. Intangiriro kubikomoka kuri Cellulose:
Cellulose ni polyisikaride isanzwe iboneka mu rukuta rw'utugingo ngengabuzima, igizwe n'iminyururu igaragara y'imirongo ya glucose ihujwe na β (1 → 4) glycosidic. Inkomoko ya selile iboneka muguhindura imiti ya selile kugirango yongere imitungo yihariye cyangwa itangire imikorere mishya. HPMC na HEC ni bibiri bikomokaho bikoreshwa cyane mu nganda kuva imiti n’ubwubatsi.

2. Synthesis:
HPMC ihindurwamo reaction ya selile hamwe na okiside ya propylene kugirango itangize amatsinda ya hydroxypropyl hanyuma methyl chloride kugirango itangire amatsinda ya methyl. Ibi bivamo gusimbuza amatsinda ya hydroxyl mumurongo wa selile, gutanga umusaruro hamwe no gukemuka neza hamwe no gukora firime.

Ku rundi ruhande, HEC ikorwa no gukora selile hamwe na okiside ya Ethylene kugirango yinjizemo amatsinda ya hydroxyethyl. Urwego rwo gusimbuza (DS) muri HPMC na HEC rushobora kugenzurwa no guhindura imiterere yimikorere, bigira ingaruka kumitungo yabo nko kwijimisha, kwikemurira ibibazo, hamwe nimyitwarire ya gelation.

3. Imiterere yimiti:
HPMC na HEC biratandukanye muburyo bwamatsinda asimburana yometse kumugongo. HPMC ikubiyemo hydroxypropyl na methyl matsinda, mugihe HEC irimo hydroxyethyl. Ibisimburwa bitanga ibiranga byihariye kuri buri nkomoko, bigira ingaruka kumyitwarire yabo mubikorwa bitandukanye.

4. Ibyiza byumubiri:
HPMC na HEC byombi ni polimeri zishonga mumazi afite imiterere myiza yo kubyimba. Ariko, bagaragaza itandukaniro mubyiza, ubushobozi bwo kuyobora, hamwe nubushobozi bwo gukora firime. HPMC mubusanzwe ifite ubukonje bwinshi ugereranije na HEC yibitekerezo bihwanye, bigatuma iboneka mubisabwa bisaba kubyimba cyane.

Byongeye kandi, HPMC ikora firime zisobanutse kandi zifatika kubera insimburangingo ya methyl, mugihe HEC ikora firime yoroshye kandi yoroshye. Itandukaniro ryimiterere ya firime rituma buri nkomoko ikwiranye nibisabwa mubikoresho bya farumasi, ibicuruzwa byita kumuntu, ninganda zibiribwa.

5. Gusaba:
5.1 Inganda zimiti:
HPMC na HEC byombi bikoreshwa cyane mubikorwa bya farumasi nka binders, umubyimba, hamwe nubushakashatsi bwa firime. Bitezimbere ubudakemwa bwa tablet, kugenzura irekurwa ryibiyobyabwenge, kandi byongera umunwa muke. HPMC ihitamo uburyo bwo gukomeza kurekura bitewe n’umuvuduko ukabije w’amazi, mu gihe HEC ikoreshwa cyane mu bisubizo by’amaso hamwe n’amavuta yo kwisiga bitewe n’ibisobanutse kandi bihuza n’amazi y’ibinyabuzima.

5.2 Inganda zubaka:
Mu nganda zubaka,HPMCnaHECbakoreshwa nk'inyongeramusaruro mubikoresho bishingiye kuri sima, nka minisiteri, grout, na render. Batezimbere imikorere, kubika amazi, no gufatira hamwe, bikavamo imikorere myiza nigihe kirekire cyibicuruzwa byanyuma. HPMC ikunze gukundwa kubushobozi bwayo bwo gufata amazi menshi, igabanya gucika kandi igateza igihe cyo gushiraho.

5.3 Ibicuruzwa byawe bwite:
Ibikomokaho byombi usanga porogaramu mubicuruzwa byitaweho nka shampo, amavuta yo kwisiga, hamwe na cream nkibintu byiyongera, emulisiferi, na stabilisateur. HEC itanga uburyo bworoshye kandi burabagirana muburyo bwo gukora, bigatuma ibera ibicuruzwa byita kumisatsi hamwe na cream yuruhu. HPMC, hamwe nibikorwa byayo byiza byo gukora firime, ikoreshwa mumirasire yizuba hamwe no kwisiga bisaba kurwanya amazi no kwambara igihe kirekire.

5.4 Inganda zikora ibiribwa:
Mu nganda z’ibiribwa, HPMC na HEC zikora ibintu byongera umubyimba, stabilisateur, hamwe n’imyandikire mu bicuruzwa bitandukanye birimo isosi, imyambarire, hamwe n’ubutayu. Bitezimbere umunwa, birinda syneresis, kandi byongera ibiranga ibyumviro byibiryo. HPMC ikunze gukundwa kubwumvikane bwayo nubushyuhe butajegajega, bigatuma ikoreshwa mubisabwa bisaba gele ibonerana hamwe na emulisiyo ihamye.

6. Umwanzuro:
hydroxypropyl methylcellulose (HPMC) na hydroxyethyl selulose (HEC) ni ibikomoka kuri selile bifite imiterere yimiti itandukanye, imiterere, nibisabwa. Mugihe byombi bitanga uburyo bwiza bwo kubyimba no gukora firime, byerekana itandukaniro mubyiza, ubwiza bwa firime, nimyitwarire ya hydration. Gusobanukirwa itandukaniro nibyingenzi muguhitamo ibikomoka kubikenewe mubikorwa bitandukanye nka farumasi, ubwubatsi, kwita kubantu, nibiribwa. Mugihe ubushakashatsi bukomeje gutera imbere, hateganijwe ko hahindurwa ubundi buryo bwo gukoresha ibikomoka kuri selile, bikagira uruhare runini mu nganda zitandukanye.