Hydroxy opropyl methylcellse na hydroxyEthyll selile ni selile

HydroxyPropyl Methylcellse (HPMC)na HydroxyAythyl Cellulose (HEC) ni ibigo bibiri by'ingenzi byakago byateguwe cyane mu nganda zitandukanye kubera imitungo yabo idasanzwe. Mugihe bombi bakomoka kuri selile, bafite imiterere yimiti itandukanye kandi bagaragaza ibintu bitandukanye nibisabwa.

1. Kumenyekanisha kuri selile
Cellulose ni PolySacharide Polyspacride iboneka mu rukuta rw'ibimera, igizwe n'iminyururu y'umurongo ya glucose ifitanye isano na β (1 → 4) inyoni. Ibikomoka kuri Cellus biboneka kubishushanyo mbonera bya selile kugirango byongere imitungo yihariye cyangwa itangire imikorere mishya. HPMC na Hec ni bibiri nkibyo bikoreshwa mu nganda ziva muri farumasi kugirango ubwumvikane.

2. Synthesis:
HPMC irimo kunyereza kuri selile hamwe na propaylene kugirango utangire amatsinda ya hydroxyProppoyle hanyuma wa methyl chloride kugirango utangire methyl. Ibi bivamo gusimbuza amatsinda ya hydroxyl muri parikingi ya selile, itanga umusaruro ufite ikibazo cyiza cyoroheje no gukora firime.

Ku rundi ruhande, hec ikorwa mu gufata selile hamwe na selile oxide oxide yo gushiramo amatsinda ya hydroxyyeryy. Urwego rwo gusimbuza (DS) muri HPMC na HS) byombi birashobora kugenzurwa no guhindura uko ibintu bimeze, bigira ingaruka kumitungo yabo nka viscosiya, kudutera imbaraga, hamwe nimyitwarire ya gelation.

3. Imiterere yimiti:
HPMC na HEC itandukanye muburyo bwamatsinda asimbuye yifatanije na selile. HPMC irimo hydroxy osipropyl na methyl matsinda, mugihe hec irimo amatsinda ya hydroxyeryethyl. Aba basimbutse batanga ibimenyetso byihariye kuri buri gihirwa, bigira ingaruka kumyitwarire yabo muburyo butandukanye.

4.
HPMC na hec ni polymes-polymes ifite amazi meza. Ariko, bagaragaza itandukaniro muri viscosiya, ubushobozi bwa syration, hamwe nubushobozi bwa firime. HPMC mubisanzwe ifite ubushishozi bwo hejuru ugereranije na HEC kuri concentration zingana, bigatuma habaho gusaba bisaba kubyimba.

Byongeye kandi, impesi ya HPMC isobanutse kandi ihuza firime zihuriye hamwe na methyl yasimbutse, mugihe hec ikora softer na firime zihinduka. Ibi bitandukanya ibintu bya firime bituma buri gihiro gikwiriye kubisabwa byihariye muri farumasi, ibicuruzwa byita kugiti cyawe, hamwe ninganda zibiribwa.

5. Porogaramu:
5.1 Inganda za farumasi:
HPMC na HEC ikoreshwa cyane mubutaka bwa farumasi nka bunders, abarimbyi, nabakozi bakimwe. Batezimbere ubunyangamugayo bwa TableT, kugenzura kurekura ibiyobyabwenge, no kuzamura umunwa mu miterere y'amazi. HPMC ihitamo kurekura-kurekura igipimo cyihuse cyihuse, mugihe Hec isanzwe ikoreshwa mubisubizo bya Ophthalmic hamwe na creamique yimbere kubera ibisobanuro byayo no guhuza amazi yibinyabuzima.

5.2 Inganda zubwubatsi:
Mu nganda zubwubatsi,HpmckandiHecBakoreshwa nk'inyongera mu bikoresho bya sima bishingiye ku mishinga, nk'imiryango, ibishushanyo, no guhindura. Batezimbere ibikorwa, kugumana amazi, no kumeneka, bikaviramo imikorere yongerewe kandi iramba ryibicuruzwa byanyuma. HPMC ikunze gushimishwa kubushobozi bwayo bwo kugumana amazi, bigabanya gucika no guteza imbere igihe.

5.3 Ibicuruzwa byita kugiti cyawe:
Ibikomokaho byombi bishakisha ibyifuzo mubicuruzwa byitaweho nka Shampoos, amavuta, na cream nkamavuta, emalifiers, na stabilizers. HEC itanga imiterere yoroshye kandi imeze neza kugirango itegure, bigatuma bikwiranye nibicuruzwa byo kwita kumisatsi na cream yuruhu. HPMC, hamwe numutungo wawe wa firime, ukoreshwa mumashusho yizuba hamwe nibitekerezo byimiterere bisaba kurwanya amazi no kwambara igihe kirekire.

5.4 Inganda zibiribwa:
Mu nganda z'ibiryo, HPMC na Hec bakora nk'abakozi babyibushye, abanyagaboga, n'abategura ibicuruzwa mu bicuruzwa bitandukanye birimo isosi, imyambarire, n'ibyoroheje. Batezimbere umunwa, birinda syneresisi, no kuzamura ibintu byumva ibikoresho. HPMC ikunze gushimishwa no gusobanuka no gushikama, bigatuma iba isaba ibyifuzo bisaba gels igendana no kumara kumara kumarana.

6. UMWANZURO:
HydroxyPropyl MethylcellllALese (HPMC) na hydroxyEthyl Mugihe bombi batanze ibintu byiza cyane hamwe na firime yimiterere, bagaragaza itandukaniro muri vinosity, gusobanuka firime, nimyitwarire ya hydtion. Gusobanukirwa itandukaniro ni ngombwa muguhitamo gukomoka kubisabwa mu nganda mu nganda nk'ibiti, kubaka, kwita ku muntu ku giti cyabo, n'ibiryo. Nkuko ubushakashatsi bukomeje gutera imbere, hitabirya hamwe nibisabwa bya selile birateganijwe, bikagira uruhare mubikorwa byabo bikomeje mu mirenge itandukanye yinganda.