Abahanga muri Celefoni bashinzwe kurekurwa ibiyobyabwenge muri sisitemu ya matrix

Abami ba selile, cyane cyaneHydroxyPropyl Methylcellse (HPMC), bakoreshwa cyane mubutaka bwo kurekurwa ibiyobyabwenge byagenzuwe muri sisitemu ya mari ya hydrophilic. Kurekura ibiyobyabwenge ni ngombwa kugirango utegure umusaruro wa Therapeutic, kugabanya ingaruka zifatika, no kuzamura inararibonye. Dore uburyo etalralese ikorera muri sisitemu ya marif ya hydrophilic kugirango irekurwe ibiyobyabwenge:

1. Sisitemu ya hydrophilic sisitemu:

• Igisobanuro: Sisitemu ya hydrophilic ni sisitemu yo gutanga ibiyobyabwenge aho ibintu bikora bya farumasi (API) bitatanye cyangwa byinjijwe mumagambo ya hydrophilic matrix.
• Intego: Matrix igenzura irekurwa ryabanyamiti mugutandukanya ibitandukanye binyuze muri polymer.

2. Uruhare rwa bahanga muri selile (urugero, HPMC):

• Viccosity na gel - imitungo yo gukora:
  • HPMC izwiho ubushobozi bwo gukora gels no kongera ubukwe bwibisubizo bitangaje.
  • Muri sisitemu ya Matrix, HPMC igira uruhare mu gushiraho matrix ya gelatinous ikwirakwiza ibiyobyabwenge.
• Imiterere ya Hydrophilic:
  • HPMC ni hydrophilic, zororoka imikoranire n'amazi munzira ya gastrointestinal.
• Kugenzurwa nabi:
  • Iyo uhuye n'amazi yo gusoza, matrix ya hydrophilic yabyimbye, ikora gel igice kizengurutse ibiyobyabwenge.
• Gutandukanya ibiyobyabwenge:
  • Ibiyobyabwenge ntabwo byatatanye cyangwa bikubiye muri matrix ya Gel.

3. Uburyo bwo Kugenzurwa:

• Gutandukanya kandi isuri:
  • Kugenzurwa bibaho binyuze muburyo bwo gukwirakwiza no gukomera.
  • Amazi yinjira muri matrix, biganisha kuri Gel kubyimba, kandi ibiyobyabwenge bikwirakwiza ibiyobyabwenge binyuze kuri Gel.
• Kurekura zeru:
  • Umwirondoro wagenzuwe usanga usanzwe ukurikira zeru-perique, itanga igipimo cyo kurekura ibiyobyabwenge bihamye kandi byateganijwe mugihe.

4. Ibintu bigira ingaruka Kurekura ibiyobyabwenge:

• Polymer kwibanda:
  • Kwibanda kuri HPMC muri matrix bigira ingaruka ku gipimo cyo kurekura ibiyobyabwenge.
• Uburemere bwa moleki ya HPMC:
  • Ibyiciro bitandukanye bya HPMC hamwe nuburemere bwa moleking bufite burashobora gutoranywa kugirango bukore umwirondoro urekura.
• Ibiyobyabwenge
  • Kukesha ibiyobyabwenge muri matrix bigira ingaruka kumiterere yacyo.
• Matrix Poroisity:
  • Urwego rwa Gel kubyimba kandi matrix poroisity ingaruka kubiyobyabwenge.

5. Ibyiza bya selire ya selile muri sisitemu ya matrix:

• Biocompaget: Abakoresha selile muri rusange barionodatible kandi bahanganira neza muri tract ya Gastrointestinal.
• Guhinduranya: amanota atandukanye ya elitural arashobora guhitamo kugera kumwirondoro wifuza.
• Guhagarara: Abahanga ba selile batanga umutekano kuri sisitemu ya matrix, kugirango birebe ibiyobyabwenge mugihe runaka.

6. Gusaba:

• Gutanga ibiyobyabwenge mu kanwa: Sisitemu ya marike ya hydrophilic ikoreshwa mu mibare yo mu kanwa, itanga irekurwa rirambye kandi rigenzurwa.
• Ibintu bidakira: Nibyiza kubiyobyabwenge bikoreshwa mubintu bidakira aho kurekura ibiyobyabwenge bifatika.

7. ICYIZA:

• Kwemeza Optimisation: Gutegura bigomba kuba byiza kugera kumyanda yifuza kurekura ibiyobyabwenge bishingiye ku bisabwa biyobyabwenge.
• Kumenyekanisha Ubuyobozi: Abashiraho selile bakoreshwaga muri farumasi bagomba kubahiriza ibipimo ngenderwaho.

Gukoresha Abashiraho selile muri sisitemu ya mari ya hydrophilique yerekana akamaro kayo muri farumasi, itanga uburyo bworoshye kandi bwiza bwo kugera ku biyobyabwenge.