Kugereranya CMC na HPMC mubutaka bwa farumasi

Mu murima wa farumasi, sodium carboxymethylcellslcellse (cmc) na hydroxypropyl methylcellse (HPMC) ni abababarirwa ba farumasi bakunze gukoreshwa hamwe nibikorwa bitandukanye bya shimi hamwe nimirimo itandukanye.

Imiterere yimiti hamwe numutungo
CMC ni uguhindura amazi yabonetse muguhindura igice cyamatsinda ya hydroxyl ya selile mumatsinda ya Carboxymethys. Amazi yoroheje na virusi ya CMC biterwa nurwego rwayo rwo gusimbuza nuburemere bwa molekile, kandi mubisanzwe bitwara nkubwinshi no guhagarikwa.

HPMC iboneka mugusimbuza igice cyamatsinda ya hydroxyl ya selile hamwe na methyl na hydroxyPropyle. Ugereranije na CMC, HPMC ifite ubwitonzi bwagutse, irashobora gushonga mumazi akonje namazi ashyushye, kandi agaragaza ko bigaragara ko victrable ihamye ku ndangagaciro zitandukanye. HPMC ikoreshwa nka firime yabanjirije iyi film, ingirakamaro, yijimye kandi igenzurwa numukozi urekurwa muri faruceuticals.

Porogaramu

Ibinini
Mu gukora ibinini, CMC ikoreshwa cyane nkintangarugero no kumeneka. Nkibintu bitandukanijwe, CMC irashobora gukurura amazi no kubyimba, bityo ateza imbere gusenya ibinini no kongera umubare wibiyobyabwenge. Nka binder, CMC irashobora kongera imbaraga zamashini.

HPMC ikoreshwa cyane nkumukozi wahoze agenzurwa mubisate. Filime yakozwe na HPMC ifite imbaraga nziza zamashini na zambara ihohoterwa, rishobora kurinda ibiyobyabwenge ingaruka zibidukikije byo hanze. Muri icyo gihe, imitungo yo gukora kuri firime ya HPMC irashobora kandi gukoreshwa mu kugenzura igipimo cyo kurekura ibiyobyabwenge. Muguhindura ubwoko na dosiye ya HPMC, gusohora birambye cyangwa bigenzurwa birashobora kugerwaho.

Capsules
Mugutegura Capsule, CMC ntikoreshwa cyane, mugihe HPMC ikoreshwa cyane, cyane cyane mugukora capsules zikomoka ku bimera. Ibishishwa bya capsule gakondo bikozwe muri Gelatin, ariko bitewe nikibazo cyamatungo, HPMC yabaye ibintu byiza. Igikonoshwa cya capsule gikozwe muri HPMC ntabwo ifite biocoke itabimenyekana gusa, ahubwo yujuje ibikenewe byabakomoka ku bimera.

Imyiteguro y'amazi
Kubera ubwinshi bwayo bukabije kandi bukoreshwa cyane, CMC ikoreshwa cyane mugutegura amazi nkibisubizo byo mu kanwa, ibitonyanga byamaso hamwe nimyiteguro yibanze. CMC irashobora kongera viscolity yo gutegura amazi, yonoza ihagarikwa no gutuza ibiyobyabwenge no gukumira imyanda y'ibiyobyabwenge.

Gusaba HPMC mu myiteguro y'amazi byibanze cyane cyane mu bigo no kumara. HPMC irashobora kuguma ihagaze hejuru ya ph nyinshi kandi irashobora guhuzwa nibiyobyabwenge bitandukanye bitagize ingaruka kumibare yibiyobyabwenge. Byongeye kandi, imitungo yo gushinga film ya HPMC ikoreshwa no mu myiteguro y'ibanze, nk'ingaruka zo kurinda film mu zito z'ijisho.

Kugenzurwa Imyiteguro yo kurekura
Mu rwego rwo kugenzura ibicuruzwa byo kurekura, gusaba HPMC biragaragara cyane. HPMC irashobora gukora umuyoboro wa gel, kandi igipimo cyo kurekura ibiyobyabwenge kirashobora kugenzurwa no guhindura ibintu byateganijwe nimiterere ya HPMC. Uyu mutungo wakoreshwaga cyane mu kanwa karakaye-urekuye. Ibinyuranye, CMC ntikoreshwa mu myiteguro igenzurwa, ahanini kubera ko imiterere ya Gel itunganijwe ntabwo ihamye nka HPMC.

Gushikama no guhuza
CMC ifite umutekano mubi ku gaciro gatandukanye ya PH kandi byoroshye bigira ingaruka kuri aside. Byongeye kandi, CMC ifite ihumure ribi nibikoresho bimwe nibiyobyabwenge, bishobora gutera imvura cyangwa gutsindwa.

HPMC yerekana umutekano mwiza kuri prof ya kera, ntabwo yibasiwe byoroshye na aside, kandi ifite guhuza neza. HPMC irashobora guhuza nibiyobyabwenge byinshi bitabangamiye umutekano no gukora neza ibiyobyabwenge.

Umutekano n'amabwiriza
CMC na HPMC bafatwa nkimbabazi zitekanye kandi zemejwe kugirango zikoreshwe mu myiteguro ya farumacopoe ninzego zishinzwe kugenzura mu bihugu bitandukanye. Ariko, mugihe cyo gukoreshwa, CMC irashobora gutera ibisubizo bimwe na bimwe bya allergique cyangwa ibishoboka byose, mugihe HPMC idakunze gutera imbere.

CMC na HPMC bafite ibyiza byabo mubikorwa bya farumasi. CMC ifite umwanya wingenzi mugutegura amazi bitewe numutungo wacyo mwiza kandi uhagarikwa cyane mubinini, mugihe HPMC yakoreshejwe cyane mubinini, capsules no gusohora kwitegura kwitegura firime nziza kandi bigenzurwa-bigenzurwa. Guhitamo imyiteguro ya farumasi bigomba gushingira ku mitungo yihariye y'ibiyobyabwenge n'ibisabwa mu gutegura, ku buryo bumva neza ibyiza n'ibibi bya byombi, no guhitamo icyicaro gikwiye cyane.