Mu rwego rwa farumasi, sodium carboxymethylcellulose (CMC) na hydroxypropyl methylcellulose (HPMC) ni ibintu bibiri bikoreshwa mu bya farumasi bifite imiti n’imikorere itandukanye.
Imiterere yimiti nimiterere
CMC ni amazi akomoka kuri selile yamashanyarazi yabonetse muguhindura igice cyamatsinda ya hydroxyl ya selile mumatsinda ya carboxymethyl. Amazi meza hamwe nubwiza bwa CMC biterwa nurwego rwasimbuwe nuburemere bwa molekile, kandi mubisanzwe yitwara nkibintu byiza byongera umubyimba.
HPMC iboneka mugusimbuza igice cyamatsinda ya hydroxyl ya selile hamwe na methyl na hydroxypropyl. Ugereranije na CMC, HPMC ifite imbaraga nyinshi, irashobora gushonga mumazi akonje kandi ashyushye, kandi ikagaragaza ububobere buhamye kumico itandukanye ya pH. HPMC ikunze gukoreshwa nka firime yahoze, ifata, ikabyimbye kandi igenzurwa nogusohora imiti.
Umwanya wo gusaba
Ibinini
Mu gukora ibinini, CMC ikoreshwa cyane nkibidahwitse kandi bifata. Nkibidahwitse, CMC irashobora gukuramo amazi no kubyimba, bityo bigateza imbere ibinini byangirika no kongera ibiyobyabwenge. Nka binder, CMC irashobora kongera imbaraga za mashini za tableti.
HPMC ikoreshwa cyane nka firime yahoze kandi igenzurwa nogusohora muri tableti. Filime yakozwe na HPMC ifite imbaraga zubukanishi kandi zirwanya kwambara, zishobora kurinda ibiyobyabwenge ingaruka z’ibidukikije. Muri icyo gihe, imiterere ya firime ya HPMC irashobora kandi gukoreshwa mu kugenzura igipimo cy’ibiyobyabwenge. Muguhindura ubwoko na dosiye ya HPMC, irekurwa rirambye cyangwa ingaruka zo kurekura zishobora kugerwaho.
Capsules
Mugutegura capsule, CMC ntabwo ikoreshwa cyane, mugihe HPMC ikoreshwa cyane, cyane cyane mugukora capsules zikomoka ku bimera. Ibikonoshwa bya capsule gakondo bikozwe muri gelatine, ariko kubera ikibazo cyamasoko yinyamanswa, HPMC yahindutse ibikoresho byiza. Igikonoshwa cya capsule gikozwe muri HPMC ntabwo gifite biocompatibilité gusa, ahubwo inahura ibikomoka ku bimera.
Imyiteguro y'amazi
Bitewe nubwiza buhebuje no guhagarika, CMC ikoreshwa cyane mugutegura amazi nkibisubizo byo munwa, ibitonyanga byamaso hamwe nimyiteguro yibanze. CMC irashobora kongera ububobere bwimyiteguro y’amazi, bityo igahagarika ihagarikwa ryimiterere n’ibiyobyabwenge no gukumira ibiyobyabwenge.
Ikoreshwa rya HPMC mugutegura amazi yibanda cyane mubyimbye na emulisiferi. HPMC irashobora kuguma itekanye kurwego runini rwa pH kandi irashobora guhuzwa nibiyobyabwenge bitandukanye bitagize ingaruka kumikorere yibiyobyabwenge. Byongeye kandi, imiterere ya firime ya HPMC nayo ikoreshwa mugutegura ibintu byingenzi, nkingaruka zo gukingira firime mugutonyanga amaso.
Kugenzura imyiteguro yo kurekura
Mugutegurwa kurekurwa kugenzurwa, ikoreshwa rya HPMC riragaragara cyane. HPMC ishoboye gukora umuyoboro wa gel, kandi igipimo cyo kurekura imiti gishobora kugenzurwa no guhindura imiterere n'imiterere ya HPMC. Uyu mutungo wakoreshejwe cyane mumunwa urambye-kurekura ibinini byatewe. Ibinyuranye, CMC ntabwo ikoreshwa cyane mugutegura-kurekura imyiteguro, cyane cyane kubera imiterere ya gel ikora ntabwo ihagaze neza nka HPMC.
Guhagarara no guhuza
CMC ifite umutekano muke kubiciro bitandukanye bya pH kandi bigira ingaruka byoroshye kubidukikije. Byongeye kandi, CMC idafite aho ihuriye nibintu bimwe na bimwe byibiyobyabwenge, bishobora gutera imvura cyangwa kunanirwa.
HPMC yerekana ituze ryiza kurwego rwagutse rwa pH, ntabwo byoroshye kwanduzwa na aside-ishingiro, kandi ifite ubwuzuzanye buhebuje. HPMC irashobora guhuzwa nibintu byinshi byibiyobyabwenge bitagize ingaruka kumutekano no kumikorere yibiyobyabwenge.
Umutekano n'amabwiriza
CMC na HPMC zombi zifatwa nk'ibikoresho bikoreshwa mu bya farumasi kandi byemewe gukoreshwa mu gutegura imiti na farumasi n’ibigo bishinzwe kugenzura ibihugu bitandukanye. Ariko, mugihe cyo kuyikoresha, CMC irashobora gutera allergie reaction cyangwa gastrointestinal, mugihe HPMC idakunze gutera ingaruka mbi.
CMC na HPMC bafite inyungu zabo mubikorwa bya farumasi. CMC ifite umwanya wingenzi mugutegura amazi bitewe nuburyo bwiza cyane bwo kubyimba no guhagarikwa, mugihe HPMC yakoreshejwe cyane mubinini, capsules hamwe nimyiteguro yo kugenzura-gusohora bitewe nuburyo bwiza bwo gukora firime no kugenzura-gusohora. Guhitamo imiti yimiti bigomba gushingira kumiterere yihariye yibiyobyabwenge nibisabwa kugirango utegure, urebye byimazeyo ibyiza nibibi byombi, no guhitamo ibikwiye.
Igihe cyoherejwe: Nyakanga-19-2024