Hydroxyloppolin (HPMC) ni polymer ikoreshwa cyane mu nganda za farumasi kandi ni formulaire ikomeye. Irakoreshwa cyane nkigiciro cya dosage ikomeye (nkibinini, capsules, hamwe nibice), vicosity yongerewe umukozi no kubora.
Mugutegura ibiyobyabwenge, iseswa ryibintu bifatika ni ngombwa kugirango ugaragaze kandi utange ingaruka zo kuvura. Ariko, iseswa ryibikoresho bikora birashobora kugabungwa na formula. Kubwibyo, ni ngombwa gusobanukirwa imyitwarire isesa na HPMC muri formula itagira ibiyobyabwenge kuko bigira ingaruka kumikorere yubwoko bwa dosage.
Uburyo bwa HPMC
Farumasi ya Amerika (USP) yashyize mu bikorwa uburyo bwo kwipimisha HPMC. Ubu buryo mubisanzwe bukubiyemo gukoresha ibikoresho bishonga, bigereranya kandi bipima ibikuza byubwoko bwa dosage muburyo bwo gukemura. Ikizamini gikubiyemo gushyira icyayi mu gitebo cyangwa paddle, nigitebo cyangwa padi kizunguruka mu kintu kirimo umutingine.
Uburyo bwo kwishyura bugomba gutorwa ukurikije uburyo buteganijwe bwo gukoresha dosiye (nka gastric cyangwa amara). Uburyo busanzwe bwo kwishyurwa muri HPMC burimo amazi, fosifate buffer igisubizo no kwigana gastric gastric to lice (sgf) cyangwa amazi yintara (Sif).
Kugirango tumenye nibasubirwamo no kwisubiraho, ibizamini byikizamini bigomba gutonderwa, nkumuvuduko wo kuzunguruka, ubushyuhe, hamwe nubunini bucana nubunini buciriritse nigihe cyo gutoranya. Noneho koresha uburyo bukwiye bwo gusesengura kugirango usesengure igisubizo cyicyitegererezo cyabonetse mugihe gitandukanye kugirango umenye umubare wa HPMC.
Ingamba zo gukumira mugihe ukora ibizamini bya HPMC
1. Guhitamo Ubushake budahwitse: Guhitamo imitekerereze idahwitse bishingiye kubiteganijwe gukoresha urupapuro rwabigenewe. Guhitamo uburyo bukwiye bwo gusenya ni ngombwa cyane kuko bizagira ingaruka kumyitwarire ya HPMC.
2. Neza neza uburyo bworoshye: kugenzura uburyo bwo kwigunga kugirango umenye neza ko bikwiye kandi ni ngombwa kubahiriza ibisabwa mu kigo ngenzuramikorere. Kugenzura bigomba kuba bikubiyemo gukomera no gusubiramo ibipimo.
3.. Ibipimo ngenderwaho Ibizamini: Ibipimo by'ibizamini, nk'umuvuduko wo kuzunguruka, ubushyuhe, kandi bushongeshejwe umubumbe wo hagati bigira ingaruka ku bigeragezo bisekeje. Kubwibyo, ibipimo bigomba gutonderwa kugirango byongere bigaragara kandi isesengura ryukuri.
4. Icyitegererezo: Gutoranya neza ni ngombwa kubona igereranyo gihagarariye kuva gucika intege. Witondere igihe cyamanota no gutoranya kugirango umenye neza ko icyitegererezo cyegeranijwe mumwanya uhuriweho.
5. Uburyo bwo gusesengura: Hitamo uburyo bwo gusesengura isesengura rizasuzumwa, kandi kigomba kugira ibyiyumvo bikwiye, guhitamo no kuba ukuri.
Muri make, ikizamini gisakuza cya HPMC nigikoresho cyingenzi mubijyanye no guteza imbere ibiyobyabwenge na formula. Laboratwari yo kugenzura ireme ikorwa buri gihe kugirango irekure iboneye ibintu bikora, kandi ibiyobyabwenge bifite umutekano kandi bifite akamaro. Ikosa muburyo bukwiye bwikizamini gishobora gutuma umuntu atumvikana namagambo y'ibinyoma kuri imikorere yibiyobyabwenge. Kubwibyo, ni ngombwa gukurikiza ibipimo n'ingamba zo gukumira mugihe cyo kwipimisha.
Igihe cya nyuma: Jun-29-2023