Hydroxypropyl methylcellulose (HPMC)ni ibisanzwe bikoreshwa mumazi ya elegitoronike ya polymer, ikoreshwa cyane muri farumasi, ibiryo, ibikoresho byubaka, kwisiga nizindi nzego. HPMC ifite ibisubizo byiza kandi biranga ubukonje kandi irashobora gukora igisubizo gihamye, bityo igira uruhare runini mubikorwa byinshi. Kugirango utange umukino wuzuye kumikorere ya HPMC, uburyo bwiza bwo gusesa ni ngombwa cyane.
1. Uburyo busanzwe bwo gusesa amazi
HPMC irashobora gushonga mumazi akonje, ariko mubisanzwe harakenewe ubuhanga kugirango wirinde guhuriza hamwe. Kugirango tunoze ingaruka zo gusesa, intambwe zikurikira zirashobora gukoreshwa:
Intambwe ya 1: Ongeramo HPMC mumazi
Ku bushyuhe bwicyumba, banza usukemo HPMC kuringaniza hejuru yamazi kugirango wirinde gusuka HPMC nyinshi mumazi icyarimwe. Kuberako HPMC ari uruganda rwa polymer, kongeramo ubwinshi bwa HPMC bizatera kwinjiza amazi no kubyimba vuba mumazi kugirango bibe ibintu bimeze nka gel.
Intambwe ya 2: Kangura
Nyuma yo kongeramo HPMC, komeza ubyuke neza. Kuberako HPMC ifite ibice byiza, izabyimba nyuma yo gukuramo amazi kugirango ibe ikintu kimeze nka gel. Gukangura bifasha kurinda HPMC guhurira hamwe.
Intambwe ya 3: Hagarara hanyuma ukangure
Niba HPMC idasesekaye rwose, igisubizo kirashobora gusigara gihagaze umwanya muto hanyuma ugakomeza kubyutsa. Mubisanzwe bizaseswa rwose mumasaha make.
Ubu buryo burakwiriye mugihe ubushyuhe budakenewe, ariko bisaba igihe kirekire kugirango HPMC isenywe burundu.
2. Uburyo bwo gushonga amazi ashyushye
HPMC ishonga vuba mumazi ashyushye, bityo gushyushya ubushyuhe bwamazi birashobora kwihutisha cyane inzira yo gusesa. Ubushuhe bwamazi akunze gukoreshwa ni 50-70 but, ariko hejuru cyane ubushyuhe (nka hejuru ya 80 ℃) bushobora gutuma HPMC igabanuka, bityo ubushyuhe bugomba kugenzurwa.
Intambwe ya 1: Gushyushya amazi
Shyushya amazi kugeza kuri 50 ℃ kandi uhore uhoraho.
Intambwe ya 2: Ongeraho HPMC
Kunyunyuza HPMC buhoro buhoro mumazi ashyushye. Kubera ubushyuhe bwinshi bwamazi, HPMC izashonga byoroshye, bigabanye agglomeration.
Intambwe ya 3: Kangura
Nyuma yo kongeramo HPMC, komeza ukangure igisubizo cyamazi. Gukomatanya gushyushya no gukurura birashobora guteza imbere iseswa ryihuse rya HPMC.
Intambwe ya 4: Komeza ubushyuhe kandi ukomeze kubyutsa
Urashobora kugumana ubushyuhe runaka hanyuma ugakomeza kubyutsa kugeza HPMC isheshwe burundu.
3. Uburyo bwo Kurandura Inzoga
HPMC irashobora gushonga atari mumazi gusa, ariko no mumashanyarazi amwe n'amwe (nka Ethanol). Inyungu nyamukuru yuburyo bwo gusesa inzoga nuko ishobora guteza imbere gukomera no gukwirakwiza HPMC, cyane cyane kuri sisitemu ifite amazi menshi.
Intambwe ya 1: Hitamo umusemburo ukwiye
Umuti wa alcool nka Ethanol na isopropanol ukoreshwa kenshi kugirango ushonga HPMC. Muri rusange, 70-90% igisubizo cya Ethanol gifite ingaruka nziza mugusenya HPMC.
Intambwe ya 2: Iseswa
Buhoro buhoro usuka HPMC mumashanyarazi ya alcool, ukurura mugihe wongeyeho kugirango HPMC itatanye rwose.
Intambwe ya 3: Guhagarara no gukangura
Inzira yo kunywa inzoga zishonga HPMC irihuta cyane, kandi mubisanzwe bifata iminota mike kugirango iseswe burundu.
Uburyo bwo gusesa inzoga mubusanzwe bukoreshwa muburyo bukoreshwa busaba gushonga vuba hamwe n’amazi make.
4. Uburyo bwa solvent-water buvanze uburyo bwo gusesa
Rimwe na rimwe, HPMC ishonga mu ruvange rw'igipimo runaka cy'amazi na solve. Ubu buryo burakwiriye cyane cyane mubihe aho ubwiza bwigisubizo cyangwa igipimo cyo gusesa bigomba guhinduka. Umuti usanzwe urimo acetone, Ethanol, nibindi.
Intambwe ya 1: Tegura igisubizo
Hitamo igipimo gikwiye cyumuti namazi (urugero 50% amazi, 50% solvent) nubushyuhe kubushyuhe bukwiye.
Intambwe ya 2: Ongeraho HPMC
Mugihe ukangura, ongera buhoro buhoro HPMC kugirango urebe ko iseswa rimwe.
Intambwe ya 3: Ibindi byahinduwe
Nkuko bikenewe, igipimo cyamazi cyangwa ibishishwa birashobora kwiyongera kugirango uhindure ibishishwa hamwe nubwiza bwa HPMC.
Ubu buryo burakwiriye mugihe aho ibishishwa kama byongewe kumuti wamazi kugirango uzamure igipimo cyiseswa cyangwa uhindure imiterere yumuti.
5. Ultrasonic-ifashwa nuburyo bwo gusesa
Ukoresheje ingaruka nyinshi zo guhindagurika kwa ultrasound, uburyo bwa ultrasonic bufashijwe no gusesa burashobora kwihutisha inzira yo gusesa HPMC. Ubu buryo burakwiriye cyane cyane kubwinshi bwa HPMC bugomba guseswa vuba, kandi burashobora kugabanya ikibazo cya agglomeration gishobora kubaho mugihe cyo gukurura gakondo.
Intambwe ya 1: Tegura igisubizo
Ongeramo HPMC kumazi akwiye cyangwa igisubizo cyamazi avanze.
Intambwe ya 2: Kuvura Ultrasonic
Koresha ultrasonic isukura cyangwa ultrasonic yamashanyarazi hanyuma uyifate ukurikije imbaraga nigihe cyagenwe. Ingaruka ihindagurika ya ultrasound irashobora kwihutisha cyane inzira yo gusesa HPMC.
Intambwe ya 3: Reba ingaruka zo gusesa
Nyuma yo kuvura ultrasonic, reba niba igisubizo cyasheshwe burundu. Niba hari igice kidakemutse, kuvura ultrasonic birashobora kongera gukorwa.
Ubu buryo bubereye porogaramu zisaba guseswa neza kandi byihuse.
6. Kwitegura mbere yo guseswa
Mu rwego rwo kwirindaHPMCagglomeration cyangwa ingorane zo gushonga, uburyo bumwe bwo kwitegura bushobora gukoreshwa, nko kuvanga HPMC hamwe nandi mashanyarazi make (nka glycerol), kuyumisha mbere, cyangwa guhanagura HPMC mbere yo kongeramo umusemburo. Izi ntambwe zo kwitegura zirashobora kunoza neza gukemura kwa HPMC.
Hariho inzira nyinshi zo gusesa HPMC. Guhitamo uburyo bukwiye bwo gusesa birashobora kunoza cyane imikorere yiseswa nubwiza bwibicuruzwa. Uburyo bwo gusesagura ubushyuhe bwicyumba burakwiriye kubidukikije byoroheje, uburyo bwo gushonga amazi ashyushye burashobora kwihutisha inzira yo gusesa, kandi uburyo bwo gusesa inzoga hamwe nuburyo bwo kuvanga amazi-solvent-amazi bukwiranye no guseswa bikenewe bidasanzwe. Uburyo bwa ultrasonic-bufashijwe bwo gusesa nuburyo bwiza bwo gukemura vuba vuba kwa HPMC. Ukurikije ibisabwa byihariye bisabwa, guhitamo byoroshye uburyo bukwiye bwo gusesa birashobora kwemeza imikorere myiza ya HPMC mubice bitandukanye.
Igihe cyo kohereza: Ukuboza-19-2024