Kugeza ubu, ibikoresho fatizo bikuze bya capsules ni hydroxypropyl methylcellulose (HPMC) na pullulan, na hydroxypropyl krahisi nayo ikoreshwa nkibikoresho fatizo.
Kuva mu ntangiriro ya za 2010,HPMCYashyizwe mu nganda mu nganda zikora inganda za capsule mu Bushinwa, kandi ishingiye ku mikorere yayo myiza, HPMC hollow capsules yafashe umwanya ukomeye ku isoko rya capsule, byerekana ko bikenewe cyane mu myaka icumi ishize.
Nk’uko imibare y’inganda ibigaragaza, mu mwaka wa 2020, igurishwa ry’imbere mu gihugu rya capsules zuzuye zizaba hafi miliyari 200 za capsules (inganda z’imiti n’ubuzima zikomatanyirijwe hamwe), muri zo igurishwa rya capsules ya HPMC rizaba hafi miliyari 11.3 (harimo no kohereza ibicuruzwa hanze) , kwiyongera kwa 4.2% muri 2019.%, bingana na 5.5%. Inganda zidafite imiti zingana na 93.0% by’ikoreshwa rya capsules ya HPMC mu Bushinwa, kandi izamuka ry’inganda zita ku buzima zitera kugurisha capsules ya HPMC.
Kuva muri 2020 kugeza 2025, CAGR ya capsules ya HPMC ifite imiti ya gelling iteganijwe kuba 6.7%, ibyo bikaba birenze umuvuduko wubwiyongere bwa 3.8% kuri capsules ya gelatine. Byongeye kandi, icyifuzo cya capsules ya HPMC mu nganda zita ku buzima bwo mu rugo kiri hejuru kuruta iyo mu nganda zikora imiti.HPMCcapsules irashobora gufasha mubibazo byandikirwa no guhuza imico nimirire yabaguzi kwisi yose. Nubwo ubu ibyifuzo bya capsules ya HPMC bikiri hasi cyane ugereranije na capati ya gelatine, umuvuduko wubwiyongere bwibisabwa urenze uw'imitsi ya gelatine.
1) Iterambere ryimikorere nibikorwa, nta gelling agent; ifite ibisubizo byiza, imyitwarire ihoraho yo gusesa mubitangazamakuru bitandukanye, ntabwo byatewe nimbaraga za pH nimbaraga za ionic, kandi byujuje ibisabwa na farumasi y'ibihugu bikomeye n'uturere;
2) Kubintu bya alkaline nkeya, ongera bioavailable kandi utezimbere dosiye nziza;
3) Kugaragara ni byiza, kandi guhitamo amabara ni byinshi.
Capsule yoroshye ni imyiteguro ikorwa mugushiraho amavuta cyangwa guhagarikwa gushingiye kumavuta mugikonoshwa cya capsule, kandi imiterere yacyo irazengurutse, imeze nka olive, ifi ntoya, ifata ibitonyanga, nibindi. Irangwa no gushonga cyangwa guhagarika ibikoresho bikora muri amavuta, afite umuvuduko wibikorwa byihuse hamwe na bioavailable nyinshi kuruta gukora ibintu bimwe bikora mubinini, kandi byakoreshejwe cyane mugutegura ibicuruzwa byubuzima n’imiti. Muri iki gihe, capsules yoroshye ifite ibintu bitandukanye nka enteric-coated, chewable, osmotic pompe, irekura-irekuye, hamwe nibitekerezo byoroshye bimaze kugurishwa. Igikonoshwa cyoroshye capsule igizwe na colloid ninyongera zingirakamaro. Muri byo, colloide nka gelatine cyangwa amase y'imboga ni byo bintu by'ingenzi, kandi ubuziranenge bwabwo bugira ingaruka ku mikorere ya capsules yoroshye. Kurugero, capsule shell yamenetse, adhesion, kwimuka kwibintu, gusenyuka buhoro, no gusesa capsules yoroshye bibaho mugihe cyo kubika Ibibazo nko kutubahiriza bifitanye isano nayo.
Kugeza ubu, ibyinshi mu bikoresho bya capsule ya farumasi yoroheje ya capsules mu gihugu cyanjye ni gelatine y’inyamanswa, ariko hamwe n’iterambere ryimbitse no gushyira mu bikorwa byimbitse ya gelatine yoroshye, ibitagenda neza n’ibitagenda neza byagaragaye cyane, nk’amasoko akomeye y’ibikoresho fatizo, kandi byoroshye guhuza reaction hamwe na aldehyde ivanze Ibibazo byiza nkigihe cyo kubika igihe gito n "“ imyanda itatu ”ikorwa mugikorwa cyo gutunganya gelatine bigira uruhare runini mukurengera ibidukikije. Byongeye kandi, hari n'ikibazo cyo gukomera mu gihe cy'itumba, bigira ingaruka mbi ku bwiza bw'imyiteguro. Kandi imboga zumye za capsules zifite ingaruka nke kubidukikije. Hamwe n’indwara zanduye zikomoka ku nyamaswa ku isi hose, umuryango mpuzamahanga uhangayikishijwe cyane n’umutekano w’ibikomoka ku nyamaswa. Ugereranije na capsules yinyamanswa, capsules yibimera bifite ibyiza byingenzi mubisabwa, umutekano, umutekano, no kurengera ibidukikije.
Ongerahohydroxypropyl methylcellulosekuvomera no gutatanya kugirango ubone igisubizo A; ongeramo imiti ya gelling, coagulant, plasitike, opacifier hamwe namabara kumazi hanyuma ukwirakwiza kugirango ubone igisubizo B; vanga ibisubizo A na B, hanyuma ushushe kugeza kuri 90 ~ 95 ° C, koga kandi ugumane ubushyuhe kuri 0.5 ~ 2h, ukonje kugeza kuri 55 ~ 70 ° C, komeza ushyushye kandi uhagarare kubeshya kugirango ubone kole;
Nigute ushobora kubona vuba amazi ya kole, inzira rusange nugushuha buhoro mumasafuriya ya reaction igihe kirekire,
Bamwe mubakora ibicuruzwa banyura vuba muruganda rwa koleo binyuze mumashanyarazi
Igihe cyo kohereza: Apr-25-2024