Ingaruka za HydroxyPropyl Ibirimo kuri HPMC Gel Ubushyuhe

HydroxyPropyl Methylcellse (HPMC) ni umwuga ukoreshwa mu mazi, ukoreshwa cyane muri farumasi, kwisiga, ibiryo n'imirima ingana, cyane cyane mugutegura uruseli. Imitungo yacyo yumubiri hamwe nimyitwarire isenyuka bigira ingaruka zikomeye kumikoranire muburyo butandukanye. Ubushyuhe bwa Gel Pel ni kimwe mu bintu by'ingenzi byayo, bigira ingaruka ku buryo butaziguye mu myiteguro itandukanye, nko kugenzurwa, gushiraho firime, gutuza, nibindi, nibindi, nibindi.

1. Imiterere n'imitungo ya HPMC

HPMC ni polymer-yoroshye amazi yabonetse mu kumenyekanisha abasimbuye babiri, hydroxypropyl na methyl, muri skelect molecular. Imiterere yayo ikubiyemo ubwoko bubiri bwasimbuye: hydroxypropyl (-ch2chohch3) na methyl (-ch3). Ibintu nkibihorane bitandukanye, urwego rwa metthylation, nurwego rwa polymerizira bizagira ingaruka zikomeye kubashaka, imyitwarire ya selling, hamwe nubukanishi bwa HPMC.

Mu bisubizo bitangaje, SlowlfyhpmC ikora ibisubizo bya colloidal ihamye ya hydrogen hamwe na molekile y'amazi kandi isabana na skeleton ishingiye kuri selile. Iyo ibidukikije byo hanze (nkubushyuhe, Imbaraga za Ioonic, nibindi) Impinduka, imikoranire hagati ya molekile ya HPMC izahinduka, bikavamo ifaranga.

2. ibisobanuro n'ibiringira ibintu by'ubushyuhe bwa gelale

Ubushyuhe bwa Gelale (Ubushyuhe bwa Gelalay, T_GEL) bivuga ubushyuhe aho igisubizo cya HPMC gitangira guhinduka mumazi kugirango gikomere mugihe runaka. Kuri ubu bushyuhe, kugenda kwinyungu za HPMC bizabumburwa, bigize imiterere yimiyoboro itatu, bikaviramo ibintu nka gel.

Ubushyuhe bwa Gelale bwaho bwa HPMS bugira ingaruka kubintu byinshi, kimwe mubintu byingenzi ni ibiryo bya hydroxyPropyle. Usibye HydroxyPropyle, izindi mpamvu zigira ingaruka ku bushyuhe bwa gel zirimo uburemere bwa molekile, igisubizo cya PH, ubwoko bwa PH, ubwoko bwa possi, etic.

3. Ingaruka za HydroxyPropyl Ibirimo kuri HPMC Gel ubushyuhe bwa HPMC

3.1 Kwiyongera muri HydroxyPropyl Ibirimo biganisha ku kwiyongera k'ubushyuhe bwa gel

Ubushyuhe bwa Gelale bwa HPMC bufitanye isano rya bugufi nurwego rwibisimbuza hydroxyPropyl gusimburwa molekile. Nkuko ibirimo bya hydroxypropyle byiyongera, umubare wibisimbura hydrophilic kumurongo wa HPMC wiyongera, bikavamo imikoranire yongerewe hagati ya molekile namazi. Iyi mikoranire itera iminyururu ya molekile kurambura ibindi, bityo bigabanya imbaraga zimikoranire hagati yiminyururu ya molekile. Muburyo runaka bwo kwibanda, kongera ibirimo bya hydroxyPropyl bifasha kuzamura urwego rwimikorere kandi biteza imbere gahunda yo gutunganya iminyururu ya molekile, kugirango imiterere y'urusobe ishobore ku bushyuhe bwo hejuru. Kubwibyo, ubushyuhe bwa gelale bukunze kwiyongera hamwe na hydroxyPropyl irazamuka hamwe nibirimo.

HPMC hamwe na hydroxyPropyl ibirimo (nka HPMC K15m) ikunda kwerekana ubushyuhe bwo hejuru ugereranije no kwibanda kuri Divinthp hamwe na hydroxyPropyl (nka hpmc k4m). Ni ukubera ko hydroxyPropyl ibirimo bigorana cyane kuri molekile zikorana nubushyuhe bwo hasi, bisaba ubushyuhe bwo hejuru kugirango utsinde iyi syration hanyuma ushyireho ubushyuhe bwo hejuru kugirango utsinde iyi hydration kandi ushyire imbere imikoranire yimikorere yo gukora imiterere yimiyoboro itatu. .

3.2 Isano iri hagati ya hydroxyPropyl Ibirimo nibisubizo

Igisubizo cyikibazo nacyo nicyo kintu cyingenzi kigira ingaruka ku bushyuhe bwa pelale ya HPMC. Muburyo bwo hejuru bwa HPMC, imikoranire yimikorere ikomeye, bityo ubushyuhe bwa gelala bushobora kuba hejuru nubwo hydroxyPropyle ibirimo. Mugihe gito, imikoranire hagati ya molekile ya HPMC irakomeye, kandi igisubizo birashoboka cyane ko ufata ubushyuhe bwo hasi.

Iyo ibirimo bya hydroxyPropyl byiyongera, nubwo hydrophility yiyongera, ubushyuhe bwo hejuru buracyasabwa kugirango bugire gel. Cyane cyane mubihe bike byibandaho, ubushyuhe bwa pelale bwiyongera cyane. Ibi ni ukubera ko HPMC ifite hydroxyProppopyle iragoye cyane gutera imikoranire hagati yiminyururu ya molekiri binyuze mumitsi igira ubushyuhe, kandi inzira ya gelati isaba imbaraga zubushyuhe kugirango utsinde ingaruka zibyumba.

3.3 Ingaruka za HydroxyPropyl Ibirimo Kuri Geurlation

Muburyo runaka bwibiryo bya hydroxyproppopyl, inzira ya gelale yiganjemo imikoranire hagati ya hydration hamwe ninkunga ya molekile. Iyo hydroxypropyle ibirimo muri molekile ya HPMC iri hasi, hydration irakomeye, imikoranire iri hagati ya molekile irakomeye, kandi ubushyuhe bwo hasi burashobora guteza imbere imiterere ya Gel. Iyo hydroxyPropyl ibirimo biri hejuru, hazamurwa cyane, imikoranire hagati yiminyururu ya molekili irasa intege, kandi ubushyuhe bwa pelale bwiyongera.

Ibirimo byinshi bya hydroxyPropyl birashobora kandi kuganisha ku kwiyongera muri viscosiya igisubizo cya HPMC, impinduka rimwe na rimwe zongera ubushyuhe bwa Onset.

HydroxyPropyl Ibirimo bifite ingaruka zikomeye kubushyuhe bwa gelale yaHpmc. Nkuko ibirimo bya hydroxyPropyle byiyongera, hydrophilitity ya HPMC yiyongera kandi imikoranire hagati yiminyururu ya molekile iracika intege, bityo ubushyuhe bwa pelelayo bukunze kwiyongera. Iyi ngingo irashobora gusobanurwa nuburyo buhuza hagati ya hydration na molekile. Muguhindura hydroxyproppepleppopyle ibiri muri HPMC, igenzura neza yubushyuhe bwa pelale irashobora kugerwaho, bityo inoze imikorere ya HPMC muri farumasi, ibiryo nibindi bikorwa byinganda.