Hydroxypropyl methylcellulose (HPMC) ni polimeri ikoreshwa cyane mumazi, ikoreshwa cyane mumiti, imiti yo kwisiga, ibiryo ninganda, cyane cyane mugutegura geles. Imiterere yumubiri nimyitwarire yo gusesa bigira ingaruka zikomeye kumikorere mubikorwa bitandukanye. Ubushyuhe bwa gelation ya gel ya HPMC nimwe mubintu byingenzi byingenzi bifatika, bigira ingaruka ku mikorere yayo mu myiteguro itandukanye, nko gusohora kugenzura, gukora firime, gutuza, nibindi.
1. Imiterere n'imiterere ya HPMC
HPMC ni polymer yamashanyarazi iboneka mugutangiza ibintu bibiri, hydroxypropyl na methyl, muri selile ya molekile ya selile. Imiterere ya molekile yayo irimo ubwoko bubiri bwinsimburangingo: hydroxypropyl (-CH2CHOHCH3) na methyl (-CH3). Ibintu nkibintu bitandukanye bya hydroxypropyl, urugero rwa methylation, nurwego rwa polymerisation bizagira ingaruka zikomeye kumashanyarazi, imyitwarire ya gell, hamwe nubukanishi bwa HPMC.
Mubisubizo byamazi, AnxinCel®HPMC ikora ibisubizo bihamye bya colloidal muguhuza hydrogène hamwe na molekile zamazi no gukorana na skeleton yayo ishingiye kuri selile. Iyo ibidukikije byo hanze (nkubushyuhe, imbaraga za ionic, nibindi) bihindutse, imikoranire hagati ya molekile ya HPMC izahinduka, bivamo gelation.
2. Ibisobanuro no guhindura ibintu byubushyuhe bwa gelation
Ubushyuhe bwa Gelation (Ubushyuhe bwa Gelation, T_gel) bivuga ubushyuhe aho igisubizo cya HPMC gitangira kuva mumazi kijya gukomera mugihe ubushyuhe bwumuti buzamutse kurwego runaka. Kuri ubu bushyuhe, urujya n'uruza rw'iminyururu ya HPMC ruzagabanywa, rukore imiterere y'urusobe rw'ibice bitatu, bivamo ibintu bimeze nka gel.
Ubushyuhe bwa gelation ya HPMC bwibasiwe nibintu byinshi, kimwe mubintu byingenzi ni hydroxypropyl. Usibye ibirimo hydroxypropyl, ibindi bintu bigira ingaruka kubushyuhe bwa gel harimo uburemere bwa molekile, kwibanda kumuti, agaciro ka pH, ubwoko bwa solvent, imbaraga za ionic, nibindi.
3. Ingaruka yibintu bya hydroxypropyl kubushyuhe bwa HPMC
3.1 Ubwiyongere bwa hydroxypropyl butera kwiyongera k'ubushyuhe bwa gel
Ubushyuhe bwa gelation ya HPMC bufitanye isano rya bugufi nurwego rwo gusimbuza hydroxypropyl muri molekile yayo. Mugihe hydroxypropyl irimo kwiyongera, umubare wibisimbura hydrophilique kumurongo wa molekile ya HPMC wiyongera, bigatuma habaho imikoranire myiza hagati ya molekile namazi. Iyi mikoranire itera urunigi rwa molekile kurambura kurushaho, bityo bikagabanya imbaraga zimikoranire hagati yiminyururu. Mubice bimwe byo kwibandaho, kongera hydroxypropyl ibirimo bifasha kuzamura urwego rwamazi kandi bigateza imbere imikoranire yiminyururu ya molekile, kugirango imiterere y'urusobekerane rushobore gushingwa mubushyuhe bwinshi. Kubwibyo, ubushyuhe bwa gelation mubusanzwe bwiyongera hamwe na hydroxypropyl izamuka hamwe nibirimo.
HPMC ifite hydroxypropyl iri hejuru (nka HPMC K15M) ikunda kwerekana ubushyuhe bwo hejuru bwa gelation ku gipimo kimwe ugereranije na AnxinCel®HPMC ifite hydroxypropyl yo hasi (nka HPMC K4M). Ni ukubera ko hydroxypropyl iri hejuru ituma bigora cyane molekile gukorana no gukora imiyoboro yubushyuhe bwo hasi, bisaba ubushyuhe bwo hejuru kugirango tuneshe ayo mazi kandi biteze imbere imikoranire hagati yimikorere kugirango habeho urwego rwimiterere itatu. .
3.2 Isano iri hagati ya hydroxypropyl nibisubizo byibanda
Gukemura ibibazo nabyo ni ikintu cyingenzi kigira ingaruka ku bushyuhe bwa HPMC. Mubisubizo byinshi bya HPMC ibisubizo, imikoranire ya intermolecular irakomeye, bityo ubushyuhe bwa gelation burashobora kuba hejuru nubwo hydroxypropyl iba iri hasi. Mugihe gito, imikoranire ya molekile ya HPMC irakomeye, kandi igisubizo kirashobora kuza mubushyuhe buke.
Iyo hydroxypropyl irimo kwiyongera, nubwo hydrophilique yiyongera, ubushyuhe bwo hejuru buracyasabwa gukora gel. Cyane cyane mubihe bito byo kwibandaho, ubushyuhe bwa gelation bwiyongera cyane. Ni ukubera ko HPMC ifite hydroxypropyl nyinshi cyane biragoye cyane gutera imikoranire hagati yiminyururu ya molekile binyuze mumihindagurikire yubushyuhe, kandi inzira ya gelation isaba ingufu zumuriro kugirango zitsinde ingaruka zamazi.
3.3 Ingaruka yibintu bya hydroxypropyl kumikorere ya gelation
Murwego runaka rwibintu bya hydroxypropyl, inzira ya gelation yiganjemo imikoranire hagati yimyunyu ngugu. Iyo hydroxypropyl iboneka muri molekile ya HPMC iba mike, hydrata iba idakomeye, imikoranire hagati ya molekile irakomeye, kandi ubushyuhe bwo hasi burashobora gutuma habaho gel. Iyo hydroxypropyl iri hejuru, hydrata ibayongereye cyane, imikoranire hagati yiminyururu ya molekile igacika intege, nubushyuhe bwa gelation bukiyongera.
Ibirungo byinshi bya hydroxypropyl birashobora kandi gutuma habaho kwiyongera kwijimye ryumuti wa HPMC, impinduka rimwe na rimwe ikongera ubushyuhe bwo gutangira bwa gelation.
Hydroxypropyl ibirimo bigira ingaruka zikomeye kubushyuhe bwa gelation yaHPMC. Mugihe hydroxypropyl yibirimo byiyongera, hydrophilicity ya HPMC iriyongera kandi imikoranire hagati yiminyururu ya molekile igabanuka, bityo ubushyuhe bwayo bwa gelation bukiyongera. Iki kintu gishobora gusobanurwa nuburyo bwimikoranire hagati yimyunyu ngugu. Muguhindura hydroxypropyl yibigize HPMC, kugenzura neza ubushyuhe bwimiterere ya gelation birashobora kugerwaho, bityo bigahindura imikorere ya HPMC mumiti, ibiryo nibindi bikorwa byinganda.
Igihe cyo kohereza: Mutarama-04-2025