Ibintu bireba umusaruro wa viscosity wa hydroxypropyl methylcellse

HydroxyPropyl Methylcellse (HPMC)Ese polymer ikoreshwa cyane mu nganda zitandukanye, harimo imiti, ibiryo, kubaka, no kwisiga. Uburiri bwayo bufite uruhare rukomeye mugusaba. Gusobanukirwa ibintu bigira ingaruka kumusaruro wa HPMC ni ngombwa kugirango utezimbere imikorere yayo mubice bitandukanye. Mu buryo bwumvikana gusesengura ibi bintu, abafatanyabikorwa barashobora gukoresha neza imiterere ya HPMC kugirango bahuze ibisabwa.

Intangiriro:
HydroxyPropyl MethylcellllALese (HPMC) ni polymer itandukanye hamwe na porogaramu nyinshi zitunze bikunze, harimo no kwishyurwa n'amazi, ubushobozi bwo gukora firime, na biocompat. Kimwe mubipimo bikomeye bigira ingaruka kumikorere yayo ni urusyo. Ibyamamare bya Ibisubizo bya HPMC bigira ingaruka ku myitwarire yayo muri porogaramu zitandukanye, nko kubyimba, gutenguha, gupfukirana, no gusohora firime, no gusohora firime muri farumasi. Gusobanukirwa ibintu bigenga ibisaruro bya HPMC biratangaje kubona imikorere yacyo munganda zitandukanye.

Ibintu bigira ingaruka kumusaruro wa HPMC:

Uburemere bwa molekile:
Uburemere bwa molekile yaHpmcIngaruka zikomeye kuba vicosity yayo. Uburemere bwo hejuru bwa molemers muri rusange byerekana vicosi yisumbuye kubera urunigi rwiyongera. Ariko, uburemere bukabije bukabije burashobora kuganisha kubibazo byo gutegura no gutunganya. Kubwibyo, guhitamo ibiro bikwiye bya molecular ni ngombwa kugirango mbogamire vinoment ibisabwa nibitekerezo bifatika.

Urwego rwo gusimbuza (DS):
Urwego rwo gusimbuza bivuga impuzandengo ya HydroxyProppopyl na FlingextroperProppopy na Methanks kuri Anhydroblucose Igice cya Collilose. Indangagaciro za DS zisanzwe zivamo ubuyobe buhasure kubera hydrophilitity yiyongereye kandi imikoranire. Ariko, gusimburwa gukabije birashobora kuganisha ku kugabanya intege nke no kugabanuka. Kubwibyo, guhitamo DS ni ngombwa kugirango ugere kuri virusi yifuzwa mugihe ukomeje kwikeba no gutunganya.

Kwibanda:
HPMC viccosity igereranya itaziguye kubitekerezo byayo mubisubizo. Nkuko kwibanda kwa polymer byiyongera, umubare wa polymer yiminyururu kuri buri gice yiyongera, yiyongera, biganisha ku rubavu rwongerewe urunigi rwinshi kandi rukomeye. Ariko, mubihe byinshi cyane, viscosity irashobora gucapa cyangwa kugabanuka kubera imikoranire ya polymer-polymer-polymex. Kubwibyo, hitamo ibitekerezo ni ngombwa kugirango ugere kuri virusi yifuzwa utabangamiye igisubizo gihamye.

Ubushyuhe:
Ubushyuhe bugira ingaruka zikomeye kuri viscosiya ibisubizo bya HPMC. Mubisanzwe, viscosity igabanuka kwiyongera kwiyongereye kubera kugabanya imikoranire ya polymer-polymer kandi yongerewe imbaraga za molecular. Ariko, iyi ngaruka irashobora gutandukana bitewe nibintu nkibitekerezo bya polymer, uburemere bwa moleclar, hamwe nuburyo bwihariye na politike cyangwa inyongeramusaruro. Ubushyuhe bujyanye nubushyuhe bugomba gusuzumwa mugihe bateranya ibicuruzwa bya HPMC kugirango habeho imikorere ihamye kubushyuhe butandukanye.

PH:
PH of igisubizo kigira ingaruka kuri vicosity ya HPMC binyuze mubikorwa byayo kuri Polymer Kubogama no kubahiriza. HPMC irashonje cyane kandi igaragaza ubushyuhe ntarengwa muri acide nkeya kuri phi iringaniye. Gutandukana kuva kuri iyi PH Rame birashobora kuganisha ku kugabanya ibibazo no kureba kubera impinduka muri polymer ihuza n'imikoranire hamwe na molekile. Kubwibyo, kubungabunga ibintu byiza p PH ni ngombwa kugirango ubone vicosity yoroheje HPMC mu gisubizo.

Inzoti:
Inyongeramuzi zitandukanye, nk'ubwinyungo, surfactints, hamwe n'amasezerano, birashobora kugira ingaruka kuri vicosity ya HPMC mu guhindura umuti hamwe n'imikoranire ya Polymer. Kurugero, umunyu urashobora gutera imbaraga za vicosity ukoresheje ingaruka mbi, mugihe ibyiciro bishobora kugirira nabi impagarara zubutaka na polymer. Co-Po-Polly irashobora guhindura polilatique yamasezerano no kuzamura polymer kwikebanukira no gusya. Ariko, guhuza n'imikoranire hagati ya HPMC n'inyongera bigomba gusuzumwa neza kugirango birinde ingaruka zitifuzwa kuri viscosiya hamwe n'imikorere y'ibicuruzwa.

Ese polymer itandukanye ikoreshwa cyane muri farumasi, ibiryo, kubaka, no kwisiga. Ibyamamare bya Ibisubizo bya HPMC bigira uruhare runini mu kugena imikorere yacyo muburyo butandukanye. Gusobanukirwa ibintu bigira ingaruka ku musaruro wa HPMC, harimo uburemere bwa molekile, urwego rwo gusimbuza, kwibanda, ubushyuhe, PH, hamwe n'inyongera, ni ngombwa mu guhitamo imikorere n'imikorere yayo. Mugukoresha witonze ibi bintu, abafatanyabikorwa barashobora kudoda imitungo yo kubahiriza ibisabwa neza. Ubundi bushakashatsi mu kigo kiri hagati yizi ngingo bizakomeza gutera gusobanukirwa no gukoresha HPMC mumirenge itandukanye yinganda.