HydroxyPropyl MethylcellUlose (HPMC) yakoreshejwe cyane cyane mu nganda zitandukanye, harimo imiti, kwisiga, kwisiga, ibiryo, no kubaka. Ubushobozi bwayo bwo gukora gels, firime, nibisubizo bituma biha agaciro gusaba byinshi. Hydration ya HPMC nintambwe ikomeye mubikorwa byinshi, kuko bifasha polymer kwerekana imitungo yifuzwa neza.
1. Gusobanukirwa HPMC:
HPMC ni ukomoka kuri selile kandi ni synthesied uvura selile hamwe na proplene okiside na methyl chloride. Irangwa no kwikebagura amazi nubushobozi bwo gukora ibintu bisobanutse, ubushyuhe butangaje. Urwego rwa HydroxyPropyl na Methoxyl verisiyo igira ingaruka kumitungo yacyo, harimo no kwikeba, viccosity, hamwe nimyitwarire ya falale.
2. Akamaro ka Hyalration:
Hydration ni ngombwa kugirango ufungure imikorere ya HPMC. Iyo HPMC yijimye, ikurura amazi kandi ikabyimba, biganisha kumuti wa virusire cyangwa gel, bitewe no kwibanda hamwe nibisabwa. Iri ndwara ya HYDM ifasha HPMC gukora imirimo igenewe, nko kubyimba, gutenguha, gushiraho filimi, no gukomeza kurekura ibiyobyabwenge.
3. Uburyo bwa Hydration:
Hariho uburyo bwinshi bwo gukumira HPMC, bitewe nibisabwa nibisubizo byifuzwa:
a. Gutata amazi akonje:
Ubu buryo bukubiyemo gutatanya ifu ya HPMC mumazi akonje mugihe atera witonze.
Gutatana amazi akonje bikunzwe kugirango birinde guswera no kwemeza ko hamérotion imwe.
Nyuma yo gutatanya, igisubizo mubisanzwe cyemewe kuva cyangwa kurengera ibintu byoroheje kugirango ugere kuri virusi yifuzwa.
b. Gutata amazi ashyushye:
Muri ubu buryo, ifu ya HPMC yatatanye mumazi ashyushye, mubisanzwe ku bushyuhe bwavuzwe haruguru 80 ° C.
Amazi ashyushye yorohereza hydration yihuta hamwe na HPMC ya HPMC, bikaviramo igisubizo gisobanutse.
Kwitonda bigomba kwirinda gushyushya cyane, bishobora gutesha agaciro hpmc cyangwa gutera.
c. Kutabogama:
Porogaramu zimwe zishobora kuba zirimo kugamana ibisubizo bya HPMC hamwe nibikoresho bya alkaline nka sodium hydroxide cyangwa potasiyumu hydroxide.
Kutabogama bihindura PH of igisubizo, gishobora guhindura viscosiya hamwe na pelasiyo ya HPMC.
d. Guhana Solven:
HPMC irashobora kandi gukumira kungurana ibitekerezo, aho yatangijwe mumazi-adasobanutse nka ethanol cyangwa methanol hanyuma ihana amazi.
Guhana gukemurwa birashobora kuba ingirakamaro kubisabwa bisaba kugenzura neza hydration na vicosity.
e. Mbere yo gukundwa:
Mbere-hydration ikubiyemo gusa kuri hpmc mumazi cyangwa kwigana mbere yo kuyishyiramo.
Ubu buryo butuma hydration yuzuye kandi irashobora kuba ingirakamaro kugirango igere kubisubizo bihamye, cyane cyane muburyo bugoye.
4. Ibintu bireba Hydration:
Ibintu byinshi bigira ingaruka kumashanyarazi ya HPMC:
a. Ingano yinshi: ifu ya HPMC nziza yasya impyisi byoroshye kuruta ibice bifatika bitewe no kwiyongera.
b. Ubushyuhe: Ubushyuhe bwo hejuru muri rusange bwihuta ariko burashobora kandi kugira ingaruka kuri virusi n'imyitwarire ya HPMC.
c. PH: PH ya HyDration Medium irashobora kugira ingaruka kumiterere ya HPMC kandi niyo mpamvu hydration kinetike hamwe nimitungo yuburyo.
d. Kuvanga: Kuvanga neza cyangwa guhagarika ni ngombwa kuri hydration imwe no gutatanya ibice bya HPMC muri socieve.
e. Kwibandaho: Kwibanda kuri HPMC muri stdration medium bigira ingaruka kuri viscosiya, imbaraga geel, nibindi bintu byikibazo cyavuyemo cyangwa gel.
5. Porogaramu:
HYDRATED HPMC isanga ikoreshwa ritandukanye mu nganda zitandukanye:
a. Ibikorwa bya farumasi: Muri Tablet Coatings, kugenzurwa-kurekura matrices, ibisubizo by'amasako, no guhagarikwa.
b. Ibicuruzwa byibiribwa: Nkumukunzi, stilizer, cyangwa umukozi wa firime mumasoko, imyambarire, ibikomoka ku mata, na perfectionery.
c. Kwisiga: muri cream, amavuta, gels, hamwe nibindi bitera byo guhindura vitcosiction no kugandukira.
d. Ibikoresho byubwubatsi: Mu bicuruzwa bishingiye ku byaro, tile bifata neza, kandi bitanga kunoza ibikorwa, kugumana amazi, no kumeneka.
6. Igenzura ryiza:
Amazi meza ya HPMC ningirakamaro kubikorwa byimisoro no guhuzagurika. Ingamba zo kugenzura ubuziranenge zishobora kubamo:
a. Isesengura ryinshi ryibice: kwemeza kimwe no gukwirakwiza ibice kugirango ugabanye ibiryo bya hydration kinetics.
b. Gupima viscosity: Gukurikirana vicosity mugihe cya hydtion kugirango ugere ku buryo bwifuzwa kubisabwa.
c. PH Kuri Gukurikirana PH: Kugenzura PH of Spetion medium kugirango uhindure hydration kandi wirinde gutesha agaciro.
d. Isuzuma rya Microscopique: Kugenzura amashusho yintangarugero munsi ya microscope kugirango usuzume ibice bitavuga no kuba inyangamugayo.
7. UMWANZURO:
Hydration ninzira yibanze mugukoresha imitungo ya HPMC kubisabwa bitandukanye. Gusobanukirwa uburyo, ibintu, nuburyo bwiza bwo kugenzura bujyanye na hydration ni ngombwa muguhitamo imikorere yibicuruzwa no guharanira ubudakemu. Mugutegeka HYDMC, abashakashatsi na abamushinyagurira barashobora gufungura ubushobozi bwuzuye hakurya yinganda nini, gutwara udushya no guteza imbere ibicuruzwa.
Igihe cyo kohereza: Mar-04-2024