HPMC (HydroxyPropyl methylcellse) ni ibintu byoroshye amazi bikoreshwa cyane mububiko bwubwubatsi, imiti, ibiryo n'imiti ya buri munsi. Ifite ubwinshi, kumarana, gushiraho firime, ikingira colloid hamwe nibindi bintu. Muri sisitemu ya emulsion, HPMC irashobora kugenzura uruzitiro rwa Edulision muburyo butandukanye.
1. Imiterere ya molekile ya HPMC
Uruzinduko rwa HPMC rwibasirwa cyane nuburemere bwayo nubusa. Uburemere bunini bwa molekile, hejuru ya virusire yigisubizo; N'urwego rwo gusimburwa (ni ukuvuga urwego rwo gusimbuza hydroxyproppopy na memoxy troppopy na memoxy trafroppopy na memoxy) bigira ingaruka ku kwitonda na vicositike ya HPMC. By'umwihariko, urwego rwo hejuru rwo gusimbuza, ibyiza byamazi yoroheje ya HPMC, kandi ubukuru bwiyongera. Ubusanzwe abayikora batanga ibicuruzwa bya HPMC hamwe nuburemere butandukanye bwa molekale na dogere byo gusimbuza kugirango babone ibyifuzo bitandukanye.
2. Koresha kwibanda
Kwibanda kuri HPMC mu gisubizo gitangaje ni kimwe mu bintu by'ingenzi bigira ingaruka ku rubyiruko. Muri rusange, hejuru yibanda kuri HPMC, niko virusire yigisubizo. Ariko, viscolity yubwoko butandukanye bwa HPMC mugihe kimwe burashobora gutandukana cyane. Kubwibyo, mubikorwa bifatika, birakenewe guhitamo ibisobanuro bikwiye byigisubizo cya HPMC ukurikije ibisabwa. Kurugero, mubwubatsi, kwibanda kuri HPMC mubisanzwe bigenzurwa hagati ya 0.1% na 1% kugirango utange vicositine ibereye hamwe nimikorere yubwubatsi.
3. Uburyo bwo kuvugurura
Inzira yo gusebanya ya HPMC nayo ifite ingaruka zikomeye kuri viscosity. HPMC biroroshye gutatanya mumazi akonje, ariko igipimo cyo gusebanya kiratinda; Ishonga vuba mumazi ashyushye, ariko biroroshye gutera imbere. Kugirango wirinde agglomeration, uburyo bwongeyeho buhoro buhoro burashobora gukoreshwa, ni ukubanza kongeramo HPMC kumazi akonje, hanyuma ashyuha, ashyuha kugeza ashonga rwose. Byongeye kandi, HPMC irashobora kandi kuba hafi yizindi myanda yumye hanyuma yongera mumazi kugirango ishonge neza ibisebe byo gusenyuka no guterura vicosity.
4. Ubushyuhe
Ubushyuhe bufite ingaruka zikomeye kuri viscosiya ibisubizo bya HPMC. Muri rusange, viscozetity yo gukemura Hpmc igabanuka nkuko ubushyuhe bwiyongera. Ibi ni ukubera ko kuzamuka kwiyongera bizagabanya isuku hydrogène hagati ya molekile, bigatuma urunigi rwa HPMC runyerera byoroshye, bityo bigabanya urujijo rwigisubizo. Kubwibyo, mubisabwa bisaba ubuyobe bukabije, ibisubizo bya HPMC bikoreshwa ahantu hagabanutse. Kurugero, mubutaka bwa farumasi, ibisubizo bya HPMC bikoreshwa mugihe cyubushyuhe bwicyumba kugirango hazengurwa neza nibiyobyabwenge.
5. Agaciro PH
Ibyatsi byo gukemura HPMC nabyo bigira ingaruka ku gaciro ya PH. HPMC ifite ubushyuhe bwinshi mubihe bitabogamye kandi bidafite intege nke, mugihe viscosiya izagabanuka cyane mubihe bikomeye bya acide cyangwa alkaline. Ni ukubera ko indangagaciro zikabije zizasenya imiterere ya HPMC kandi zigabanya ingaruka zacyo. Kubwibyo, mubikorwa bifatika, agaciro ka PH kagomba kugenzurwa no kubungabunga murwego ruhamye rwa HPMC (mubisanzwe PH 3-11) kugirango tumenye neza ingaruka zayo. Kurugero, muri porogaramu zibiribwa, HPMC ikunze gukoreshwa mu biribwa bya acide nka yogurt n'umutobe, kandi virusi nziza irashobora kuboneka muguhindura agaciro PH.
6. IZINDI NTANDUKANYA
Muri sisitemu ya emulsion, viscosity ya HPMC irashobora kandi guhindurwa no kongeramo abandi babyimba cyangwa ibishyurwa. Kurugero, ongeraho umubare ukwiye wumunyu wa moturganic (nka sodium chloride) birashobora kongera vicosiya igisubizo cya HPMC; Mugihe wongeyeho ibiti bya kama nka Ethanol bishobora kugabanya uruzitiro rwayo. Mubyongeyeho, iyo bikoreshejwe hamwe nabandi babyimba (nka xanthan gum, karbomer, nibindi), virusi cyangwa ituze ryamagana naryo rirashobora kunozwa cyane. Kubwibyo, muburyo bufatika, inyongera zikwiye zirashobora gutorwa nkuko bikenewe kugirango utezimbere virusi n'imikorere ya emulision.
HPMC irashobora kugera ku kugenzura neza virusi ya emulsion binyuze mumiterere yabyo, imikoreshereze yakoreshejwe, uburyo bwo kuvugurura, ubushyuhe, agaciro, agaciro. Mubyiciro bifatika, ibi bintu bigomba gufatwa nkibisanzwe guhitamo ubwoko bwa HPMC bukwiye hamwe nuburyo bwo gukoresha kugirango ugere ku ngaruka nziza. Binyuze mu gutegura no kugenzura neza, HPMC irashobora kugira uruhare runini mu mirima y'ubwubatsi, imiti, ibiryo n'imiti ya buri munsi, itanga uburambe bw'imikorere n'umukoresha.
Igihe cya nyuma: Jul-17-2024