HydroxyPropyl methylcellse (HPMC) ni polymer itandukanye ikoreshwa cyane mubikorwa bya farumasi nka bunder, mubindi bikorwa. Bunders igira uruhare rukomeye mugukora ibinini bya farumasi, byemeza ko ifu mugihe cyo guturika muburyo bukomeye.
1. Guhuza uburyo buhuza:
HPMC ifite amazi yombi na hydrophobike kubera imiterere yacyo, igizwe na methyl na hydroxyPropyl amatsinda yometse kuri selile. Mugihe cya tablet Tarsion, HPMC ikora filime ifatika, ihindagurika iyo ihura namazi cyangwa ibisubizo bitangaje, bityo bihuza ibikoresho byifu hamwe. Iyi miterere ifatika ivuka kubushobozi bwa hydrogen yitsinda rya hydroxyl muri HPMC, yorohereza imikoranire nibindi molekile.
2. Igishushanyo mbonera:
HPMC SIDA ishinga ishinga rya Agglometes mukurema ibiraro hagati yingingo zabantu. Nkuko Granules Granules ihagaritswe, molekile ya HPMC irahagurukira no kuvuga hagati yibice, guteza imbere ibikoresho. Uku gugGlomera yongera imbaraga zubukanishi nubusugire bwa tablet.
3. Kugenzura igipimo cy'ibisebe:
Ibyatsi byo gukemura HPMC bigira ingaruka ku gipimo cy'ibipimo bya tablet no kurekura ibiyobyabwenge. Muguhitamo amanota akwiye no kwibanda kuri HPMC, abashinzwe gushishikazi birashobora guhuza umwirondoro wo gusebanya wa Tablet kugirango ugere ku biyobyabwenge ibiyobyabwenge. Icyiciro cyo hejuru cya HPMC mubisanzwe bivamo ibiciro bidasubirwaho kubera ko gel yiyongera.
4. Ikwirakwizwa rimwe:
HPMC imfashanyo mu ikwirakwizwa rya farumasi ikora ya farumasi (APIS) n'abari mubyo muri tablet Matrix. Binyuze mu bikorwa byayo, HPMC ifasha gukumira itandukaniro ry'ingingo, kubuza ibiyobyabwenge ndetse n'ibiyobyabwenge bihamye muri buri tablet.
5. Guhuza ibikoresho bifatika:
HPMC ni inert ya chimique kandi ihujwe nigipimo kinini cyibikoresho byimiti ya farumasi, bigatuma bikwiranye no gushyiraho ibiyobyabwenge bitandukanye. Ntabwo yitwara ibiyobyabwenge cyangwa ngo itere ibiyobyabwenge byinshi, kubungabunga umutekano wabo no gukora neza mubuzima bwa miniyoni yibinini.
6. Yagabanije umukungugu:
Mugihe cya tablet Pronctions, HPMC irashobora gukora nkumushyitsi wumukungugu, kugabanya ibisekuru byikirere. Uyu mutungo wongera umutekano wumukozi kandi ukomeza ibidukikije byo gukora isuku.
7. Kubyimba kwa phi:
HPMC yerekana imyitwarire ishingiye kuri PH-yigometse, aho amazi yacyo azamuka hamwe numutungo wa Gel utandukanye na PH. Ibi biranga birashobora kuba byiza kubungabunga imikorere igenzurwa-dosiye igenewe kurekura ibiyobyabwenge kuruhande rwihariye ku rupapuro rwihariye.
8. Kwemera kugenzura:
HPMC yemerwa cyane ninzego zishinzwe kugenzura nkibiryo byo muri Amerika n'ibiyobyabwenge (FDA) n'ibiyobyabwenge by'ibihugu by'Uburayi (EMA) bikoreshwa imiti. Urutonde rwa Pharmacopeya rutandukanye kandi rurubahiriza ibipimo ngenderwaho bifite imico myiza, tubike umutekano ibicuruzwa ndetse no gukora neza.
9. Guhinduka mugutegura:
HPMC itanga guhinduka, kuko ishobora gukoreshwa wenyine cyangwa ihuriweho nabandi bicers, filers, hamwe no gusenya kugirango tugere kumiterere ya tablet yifuzwa. Ubu buryo bwo kwerekana abamuhuza kubahuza kugirango bubahiriza ibisabwa byibiyobyabwenge.
10. Bio
HPMC ni Biocompble, idafite uburozi, kandi ntabwo allergenic, bigatuma bikwiranye nuburyo bwo gutanga umusaruro. Irimo gusesa byihuse munzira ya gastrointestinal idateje uburakari cyangwa ingaruka mbi, bigira uruhare kuri profill yumutekano rusange yibinini bya farumasi.
HydroxyPropyl Methylcellse Imikorere nka farumasi mugutezimbere guhuriza hamwe, kugenzura ibipimo bisenyuka, kandi bitanga guhinduka, no gutanga ibisobanuro byumutekano no kugenzura. Umutungo wacyo wihariye uyigira ikintu cyingenzi mugutezimbere ibinini byiza byo gutanga ibiyobyabwenge.
Igihe cya nyuma: Gicurasi-25-2024