Nigute Hypromellose (HPMC) ikoreshwa muburyo bwagutse-burekura ibinini bya matrix?

Mu nganda zimiti, hypromellose (HPMC, METHOCEL ™) irashobora gukoreshwa nkuwuzuza, binder, tablet coating polymer hamwe ningirakamaro kugirango igenzure ibiyobyabwenge. Hypromellose imaze imyaka irenga 60 ikoreshwa mubinini kandi ni ikintu cyingenzi gikoreshwa cyane muri tableti ya hydrophilique.

Ibigo byinshi bikorerwamo ibya farumasi bifashisha hypromellose mugusohora imiti igenzurwa, cyane cyane mumashanyarazi ya hydrophilique gel matrix. Iyo bigeze ku bicuruzwa bya hypromellose, ushobora kwibaza uburyo wahitamo - cyane cyane niba ushaka ikintu cyiza kandi kirambye ku isoko kubakiriya bawe. Muri iki gitabo, tuzavuga kubintu by'ingenzi ukeneye kumenya kuri hypromellose.

Hypromellose ni iki?

Hypromellose, izwi kandi nkahydroxypropyl methylcellulose (HPMC), ni polymer ikoreshwa nkibikoresho bya farumasi kugirango igenzure irekurwa ryibiyobyabwenge biva mu binini bya hydrophilique gel matrix.

Hypromellose ni igice cya sintetike ikomoka kuri selile, polymer nyinshi cyane muri kamere. Bimwe mubintu bisanzwe bihuriweho harimo:

. gushonga mumazi akonje

. kudashonga mumazi ashyushye

. Nonionic

. Guhitamo gushonga mumashanyarazi kama

. Guhinduranya, imiterere ya gel yumuriro

. Hydrated na viscosity bidashingiye kuri pH

. Surfactant

. idafite uburozi

. Kuryoha no kunuka biroroshye

. Kurwanya Enzyme

. pH (2-13) urwego ruhamye

. Irashobora gukoreshwa nkibibyimbye, emulifier, binder, igenzura igipimo, firime yambere

Hydrophilic Gel Matrix Tablet ni iki?

Hydrophilic gel matrix tablet nuburyo bwa dosiye ishobora kugenzura irekurwa ryibiyobyabwenge biva mugihe kinini.

Hydrophilic gel matrix itegura ibinini:

. ugereranije byoroshye

. Irasaba gusa ibikoresho bisanzwe byo guhunika tablet

. Irinde guta ibiyobyabwenge

. Ntabwo byatewe nubukomezi bwa tablet cyangwa imbaraga zo kwikuramo

. Kurekura ibiyobyabwenge birashobora guhinduka ukurikije urugero rwinshi na polymers

Ikoreshwa rya hypromellose muri hydrophilique gel-matrix ibinini byemewe byemewe n'amategeko, kandi hypromellose iroroshye gukoresha kandi ifite inyandiko nziza z'umutekano, ibyo bikaba byaragaragajwe nubushakashatsi bwinshi. Hypromellose ibaye amahitamo meza kumasosiyete yimiti yiterambere kandi akabyara ibinini bisohora.

Ibintu bigira ingaruka ku irekurwa ryibiyobyabwenge biva muri Matrix:

Mugihe utegura ibinini byasohotse-bisohora, hari ibintu bibiri byingenzi ugomba gusuzuma: gukora no gutunganya. Hariho ibintu bimwe na bimwe ugomba gusuzuma mugihe ugena imiterere nogusohora ibicuruzwa byanyuma byibiyobyabwenge.

Inzira:

Ibintu by'ingenzi ugomba gusuzuma kugirango iterambere ryambere:

1. Polymer (ubwoko bwo gusimbuza, viscosity, ingano nubunini buke)

2. Ibiyobyabwenge (ingano yubunini no gukemuka)

3. Ibikoresho byinshi (solubility and dosage)

4. Ibindi bikoresho (stabilisateur na buffers)

Ubukorikori:

Izi ngingo zijyanye nuburyo imiti ikorwa:

1. Uburyo bwo gukora

2. Ingano ya Tablet nubunini

3. Imbaraga za tableti

4. pH ibidukikije

5. Gufata amashusho

Uburyo imitwe ya skeleton ikora:

Hydrophilic gel matrix ibinini birashobora kugenzura irekurwa ryibiyobyabwenge binyuze murwego rwa gel, harimo uburyo bubiri bwo gukwirakwiza (soluble active ingredient) hamwe nisuri (insuluble active ingredient), bityo ubwiza bwa polymer bugira uruhare runini kumwirondoro wo gusohora. Hifashishijwe hypromellose, uruganda rukora imiti rushobora gukoresha tekinoroji ya hydrophilique gel matrix tablet kugirango ihindure umwirondoro w’ibiyobyabwenge, itange urugero rwiza kandi yubahirize neza abarwayi, bityo bigabanye umutwaro wimiti ku barwayi. Inzira yo gufata imiti rimwe kumunsi birumvikana ko iruta uburambe bwo gufata ibinini byinshi inshuro nyinshi kumunsi.