Abaterankunga b'imiti ni abababaye kandi bashingiye ku bikorwa bikoreshwa mu gukora imiti no gushyiraho ibivugwa, kandi nibice byingenzi byimyiteguro ya farumasi. Nkuko polymer isanzwe ikomokaho, ether ether ifite ibiranga ibiranganya, bidafite uburozi, nigiciro gito, methyl carboxymethyl methypropyl methyppepy,Abahanga muri CelefoniNka hydroxyyeryl selile na Ethyl selile bafite agaciro gakomeye muri pharsipients. Kugeza ubu, ibicuruzwa byimikorere myinshi yo murugo bikoreshwa cyane cyane murwego rwo hagati kandi hasi-hasi-yinyuma yinganda, kandi agaciro kongerewe ntabwo ari hejuru. Inganda zikeneye byihutirwa guhinduka no kuzamura no kunoza ibyifuzo byimikorere yo hejuru.
Abavandimwe ba farumasi bafite uruhare runini mugutezimbere no gutanga umusaruro. Kurugero, mu myiteguro ihamye, ibikoresho bya polymer nka bashiraho selile bikoreshwa nk'abantu ba farumasi mu guhashya, haragusohora amarozi, arekura capsules, ikureho muri kappeles, kandi irakomeza-kurekura ibiyobyabwenge. Imyiteguro n'imyiteguro irambye isohora ikoreshwa cyane. Muri iyi sisitemu, polymers nka bahanga muri selile muri rusange ikoreshwa nkabatwara ibiyobyabwenge kugirango barebe ibiyobyabwenge mu mubiri ku kigero mugihe runaka kugirango ugere ku ntego yo kwivuza neza.
Dukurikije imibare y'ubutegetsi n'ubushakashatsi, hari ubwoko bw'abantu 500 ku isoko mu gihugu cyanjye, ariko ugereranije na Amerika (ubwoko burenga 15000, kandi ubwoko buracyari buto. Abaterankunga bo mu gihugu cyanjye cy'iterambere ry'ubushobozi bwo guteza imbere isoko ni binini. Byumvikane ko abantu icumi ba mbere ba farumasi mu isoko ry'igihugu cyanjye ari imyumbati y'igihugu, Surose, ibinyamisogwe, PVP, HPMCLEXPropyl Methylcellse (HPMC), na Microcrystalline fibre fibre. Ibikomoka ku bimera, HPC, gutabwaho.
"Ubugari bwa Cellus Ether ni ijambo rusange ry'uruhererekane rw'uruhererekane rw'ubugaririro bwa selile ryakozwe na TOLKOLECOLE. Ibicuruzwa byimiti yimiti ahanini biri mubice byimbere kandi byinyuma byinganda kandi bifite agaciro gakomeye. Birashobora kuvugwa ko hashobora kubaho agaciro ka farumasi. Birashobora kandi kugorana Harakomeje-Kurekura ibinini bya Matrix, ibikoresho byo gufunga bikabije, harakomeza-kurekura microCapsule Ibikoresho byo gupakira MicroCapsule, ibikoresho byarangije ibiyobyabwenge, nibindi
Sodium Carboxymethyl Cellulose (CMC-NA) ni selile ether hamwe nibisohoka byinshi no gukoresha murugo no mumahanga. Ni selile ionic ether ether yakozwe mu ipamba n'ibiti binyuze muri alkalisation no gutahura aside ya chloroacetic. Cmc-na nigikoresho gikunze gukoreshwa imiti. Bikoreshwa cyane nka binder kugirango imyiteguro ikomeye kandi imeze nkigibyimba, kubyimba no guhagarika umukozi kugirango yitegure amazi. Irashobora kandi gukoreshwa nka matrix ihujwe namazi hamwe nibikoresho byo gukora firime. Bikoreshwa kenshi nkibintu byarakaye-birekura ibikoresho bya firime kandi bikomeza-Kurekura Matrix tablet irambye (igenzurwa) kurekura.
Usibye sodium carboxymethyl selile selileulose nkabababarira ba farumasi, sodium ya Croscarmellose nayo irashobora kandi gukoreshwa nka farumasi. Carboxymethyl sodium ya selile (CCMC-NA) ni ibintu bidashoboka. Umukozi wa Scass arashobora kuba plycol, anccicique anhydride, anhydride male anIC, anhydride, adipic anhydride, nibindi nkibyo. Sodium ya Croscarmellose ikoreshwa nkugutandukanya ibinini, capsules na granules mu myiteguro yo mu kanwa. Yishingikiriza kuri capillary kandi ikabyimba ingaruka kugirango ugere ku gusenyuka. Ifite uburyo bwiza no gusenyuka. Ubushakashatsi bwerekanye ko urwego rwo kubyimba sodium ya Croscarmellose mumazi aruta iyo sodium nkeya na sodium yambuwe na selileymethyl na hydds microcrystalline.
Methyl selile (MC) ni mokotele itari iporike ikozwe mu ipamba n'ibiti binyuze muri alkalisation na methyl chloride. Methyl selile ifite amazi meza kandi arahamye muri pH amanota ya 2.0 kugeza 13.0. Bikoreshwa cyane mubababayeho, kandi ikoreshwa mubisate bikabije, inshinge zidasanzwe, imyiteguro yo mu magambo, capsules yo mu kanwa, ibinini byo mu kanwa, imyiteguro yo mu kanwa. Byongeye kandi, mu buryo burambye-kurekura, MC irashobora gukoreshwa nka hydrophilic gel matrix yakomeje-kurekura ibikoresho byo gupakira microCapsule, hazakuza-ibikoresho bya firime, nibindi.
HydroxyPropyl methylcellsellse (HPMC) ni selile itari ionic ivanze kuva ipamba ikozwe mu ipamba n'ibiti binyuze muri alkalisation no guhinduranya ibyatsi bya proploride na methyl chloride. Nibintu bidasanzwe, bidafite uburyohe, bidafite uburozi, gushonga mumazi akonje, na gels mumazi ashyushye. HydroxyPropyl methylcellse ni umuhanga uvanze ibintu bitandukanye bitandukanye byiyongera cyane mu mikorere, gukoresha no kumera mu myaka 15 ishize. Numwe mubakuru benshi ba farumasi bikoreshwa murugo no mumahanga. Byakoreshejwe nkibintu bya farumasi hafi yimyaka 50. Imyaka yamateka. Kugeza ubu, ikoreshwa rya HPMC rigaragarira ahanini mu ngingo eshanu zikurikira:
Imwe ni nk'abinde kandi ikanyura. HPMC nka binder irashobora gutuma ibiyobyabwenge byoroshye bitose, kandi birashobora kwagura inshuro amagana nyuma yo gukuramo amazi, bityo birashobora kunoza cyane iseswa cyangwa irekurwa rya tablet. HPMC ifite ubushyuhe bukomeye, kandi irashobora kuzamura urujijo no kunoza ibikoresho fatizo hamwe na crisp cyangwa imiterere ikomeye. HPMC ifite ubushyuhe buke burashobora gukoreshwa nka bunder na dintegrant, na HPMC hamwe na viscosity yo hejuru irashobora gukoreshwa gusa nkainder.
Icya kabiri, ikoreshwa nk'ibikoresho bikomejwe kandi bigenzurwa no kwitegura mu kanwa. HPMC nigikoresho gikunze gukoreshwa hydrogel matrix yimyiteguro irambye. HPMC yicyiciro gito cya virusi (5 ~ 50MPA · s) irashobora gukoreshwa nka bunder, vicosity yongera umukozi kandi igahagarara mu cyiciro cya capsules na hydrophilic HPMC irashonje amazi ya Gastrointestinal, ifite ibyiza byo kwiyumvisha neza, amazi meza, ubushobozi bukomeye bwo gupima ibiyobyabwenge nibiranga ibiyobyabwenge bitatewe na PH. Nibintu byingenzi byingenzi bya hydrophilique muri sisitemu yo kwitegura guhora kandi akenshi ikoreshwa nka hydrophilic petrix yitegura irambye, kandi ikoreshwa mugutegura ibiyobyabwenge bireremba kandi bikaba birekuye ibikoresho byo gufasha ibiyobyabwenge.
Iya gatatu ni nkumukozi wa firime.Hpmcifite imitungo myiza ya firime. Filime yakozwe na ni imwe imwe, isobanutse, kandi ikomeye, kandi ntibyoroshye kubahiriza mugihe cyo gutanga umusaruro. Cyane cyane kubiyobyabwenge byoroshye gukuramo ubushuhe kandi ntibihungabana, kubikoresha nkurwego rwo kwigunga rushobora kuzamura cyane ibiyobyabwenge kandi bikabuza firime ihindura ibara. HPMC ifite ibisobanuro bitandukanye bya stacosity. Niba byatoranijwe neza, ubuziranenge no kugaragara bwibinini byanditse biruta ibindi bikoresho, kandi kwibanda kwacyo ni 2% kugeza 10%.
Bane ikoreshwa nkibikoresho bya capsule. Mu myaka yashize, hamwe no gutontoma kenshi z'ibitabo ku isi, ugereranije na Gelatin Capsules, capsules y'ibimera byahindutse umukunzi mushya w'inganda. Pfizer yakuyeho HPMC yavuye mu bimera bya kamere kandi yateguwe na VCAPTM imboga imboga. Ugereranije na Capsules ya Gelatin Hollow, Capsules yimboga ifite ibyiza byo guhuza n'imihindagurikire yo guhuza n'imihindagurikire y'ikiruhuko, kandi nta kamaro ko guhuza abantu, no gushikama cyane. Igipimo cyo kurekura ibiyobyabwenge ni gihamye, kandi itandukaniro rya buri muntu ni rito. Nyuma yo gusenyuka mumubiri wumuntu, ntabwo byinjizwa kandi birashobora gusohoka. Yavuye mu mubiri. Kubijyanye n'imiterere y'ibizamini byinshi, hatagaragara ibizamini byinshi, kandi imitungo ya capsule igikonoshwa cyane, kandi indangagaciro zitandukanye za capsules zikabije ntabwo zigira ingaruka. Hamwe no gusobanukirwa nabantu ba Capsules y'ibimera no guhindura imyumvire yubuvuzi rusange murugo no mumahanga, ibyifuzo bya capsules ibihingwa bizakura vuba.
Gatanu ni nk'umukozi uhagarika. Ubwoko bwo guhagarika amazi nigikoresho gikunze gukoreshwa dosiye, nikihe buryo bwo gutatanya ahantu hashobora gutatanya ibiyobyabwenge bikomeye bidakwirakwizwa mubiciriritse. Guhagarara kuri sisitemu bigena ireme ryimiterere yitegura. Umuti wa Colloidal urashobora kugabanya impagarara zikomeye-zidafite ishingiro, kugabanya imbaraga zubusa zingingo zikomeye, kandi zigabanya uburyo bwo gutanika hitera inkunga. Ni umukozi winda cyane. HPMC ikoreshwa nkuwijimye kumato yijisho, hamwe nibirimo 0.45% kuri 1.0%.
HydroxyPropyl Cellulose (HPC) ni Mokoeti itari iportic ikozwe mu ipamba n'ibiti binyuze muri alkalisation hamwe na propaylene. HPC isanzwe ikundwa mumazi munsi ya 40 ° C hamwe numubare munini wa polar, kandi imikorere yacyo ijyanye nibiri muri hydroxyPropyle nurwego rwa polymeri. HPC irashobora guhuzwa nibiyobyabwenge bitandukanye kandi ifite icyerekezo cyiza.
Hydroxypropyl selile(L-HPC)ikoreshwa cyane nkiyi tablet itandukana kandi igahuza. Ibiranga ni: Biroroshye gukanda no gushiraho, gukoreshwa gukomeye, cyane cyane biragoye gukora, ibinini bya plastike nibisobanuro byimbere bya tablet, kandi birashobora kandi kugandukira igipimo cyimbere cya tablet, no kunoza ingaruka zo gukiza.
Hejuru ya hydroxypropyl selile ya selile (H-HPC) irashobora gukoreshwa nkumukozi uhuza ibinini, granules hamwe na granules nziza mumibare ya farumasi. H-HPC ifite imiterere myiza ya firime, hamwe na firime yavuyemo irakomeye kandi ikagereranywa na plastistizers. Mu kuvanga nabandi bakozi barwanya itose, imikorere ya firime irashobora kunonosorwa, kandi akenshi ikoreshwa nkibikoresho byo gupfukirana kubinini. H-HPC irashobora kandi gukoreshwa nkibikoresho bya matrix kugirango utegure matrix harakaye-kurekura ibisate, bikureho-kurekura pellet hamwe niminsi ibiri ikureho ibisate.
Hydroxyyeryl selile (hec) ni mokoeti itari iponese ikozwe mu ipamba n'ibiti binyuze muri alkalisation na Ethylene oxiction. HEC ikoreshwa cyane cyane nkuwabyimbye, umukozi wa Colloidal, acomera, atarasa, stabilizer, guhagarika igent, ibikoresho byo gushinga filimi nibikoresho bitinda mumwanya wubuvuzi. Irashobora gukoreshwa kuri emulsions, amavuta, nijisho ryijisho kubiti. Amazi meza, ibinini bikomeye, capsules nubundi buryo bwo gutanga dosiye. HydroxyAythyl selile yashyizwe muri Farumacopoeia yo muri Amerika / US mu gihugu na Farumaniya y'i Burayi.
Ethyl selile (EC) nimwe mubintu byakoreshejwe mumazi-bidahwitse. EC ntabwo ari uburozi, ihamye, idahujwe mumazi, aside cyangwa alkaline ibisubizo, no gushonga mubintu byamarika nka ethanol na methanol. Igitabo gikunze gukoreshwa nigisubizo cya Toluene / Ethanol 4/1 (uburemere). EC ifite byinshi mu myiteguro ihamye ikuramo, kandi ikoreshwa cyane ku batwara na microcapsules, n'ibikoresho bifatika, ibikoresho byo gusiga, n'ibikoresho byo gusiga, n'ibikoresho bifatika byo kurekura. pellet, nkibikoresho byingirakamaro kugirango bitegure microcapsules irambye; Irashobora kandi gukoreshwa cyane nkibikoresho bitwara bikoreshwa mugutegura ibice bikomeye; Birashobora gukoreshwa cyane mubukoranabuhanga bwa farumasi nkuburyo bwo gukora firime hamwe no gukingira firime, kandi birashobora kandi gukoreshwa nka fander kandi byuzuza. Nkumupfumu urinda ibinini, birashobora kugabanya kumva ibisate byubushuhe no kubuza ibiyobyabwenge guhinduka no kwangirika nubushuhe; Irashobora kandi gukora kurekura gahoro gahoro hamwe na microencapite polymer kugirango ikomeze kurekura ibiyobyabwenge.
Muri make, sodium-sodium ya sodium carboxymethyl, Methyl selile ya selile Ibikoresho byo kwitegura mu kanwa, gucengeza abakozi bashinzwe film, ibikoresho bya capsule no guhagarika abakozi. Kureba isi, amasosiyete menshi yo mu rwego rwo mu bihugu by'amahanga (Shin-etsu Ubuyapani, DOW Wolf na Ashland) bamenye ku isoko cyangwa kwiyongera, haba kongera umusaruro cyangwa kwiyongera, bongereye kuboneka muri uyu murima. Ishoramari muri porogaramu. Dow Wolff yatangaje ko bizamura ibitekerezo byateganijwe, ibigize kandi bisaba isoko ryo gutegura imiti yimiti yubushinwa, kandi ubushakashatsi bwabwo buzaharanira kandi kwiyegereza isoko. Igabana rya selile ya Wolff rya Dow Dow Chimique na Stopcon Portwor ya Amerika ryashyizeho Ihuriro rirambye kandi rigenzurwa kwisi. Ifite abakozi barenga 1.200 mumijyi 9, ibigo 15 by'indogobe n'ibigo 6 bya GMP. Gushyira mu bikorwa umwuga w'ubushakashatsi utanga serivisi kubakiriya mubihugu hafi 160. Ashland afite ibibase muri Beijing, Tiajin, Shanghai, Nanjing, Kunshan na JiAghan na Kiagmen, kandi bashora mu bigo by'ubushakashatsi muri Shanghai na Nanjing.
Nk'uko imibare yaturutse ku rubuga rw'ishyirahamwe ry'ubushinwa, muri 2017, umusaruro wo mu gihugu wa TOLUESTION Ether yari toni 373.000 kandi igipimo cy'ibicuruzwa 360. Muri 2017, ingano yo kugurisha ionicCmcyari toni 234.000, ubwiyongere bwa 18.61% umwaka-kumyaka, hamwe nubunini bwa CMC ntabwo bwari toni 126.000, kwiyongera kwumwaka 8.2%. Usibye HPMC (kubaka ibikoresho byo kubaka) Ibicuruzwa bitari ionic,Hpmc. Abatangago wa Cellulose murugo bakuze vuba cyane, kandi umusaruro wabaye iyambere kwisi. Ariko, ibyinshi mu bicuruzwa bya kagari byakabukuru bikoreshwa cyane cyane hagati no hasi yinganda, kandi agaciro kongerewe ntabwo ari hejuru.
Kugeza ubu, ibyinshi mu bihugu byakabukuru byimbere biri mu gihe gikomeye cyo guhinduka no kuzamura. Bagomba gukomeza kongera ibikorwa byubushakashatsi nibikorwa byiterambere, bikomeza gukungahaza burundu Ubushinwa, gukoresha neza ubushinwa, isoko rinini ku isi, no kongera imbaraga zo guteza imbere amasoko yamahanga kugirango bishoboke kuzamuka vuba bishoboka. Uzuza impinduka no kuzamura, winjire hagati kugeza ku nganda ndende, kandi ugere ku iterambere n'icyatsi.
Kohereza Igihe: APR-25-2024