Gusenya Hydroxypropyl Methylcellulose (HPMC) mumazi ni ibintu bisanzwe mubikorwa bitandukanye, harimo imiti, ibiryo, amavuta yo kwisiga, nubwubatsi. HPMC ni inkomoko ya selile ikora igisubizo kiboneye, kitagira ibara, kandi kigaragara iyo kivanze namazi. Igisubizo cyerekana ibintu byihariye nko kubyimba, guhuza, gukora firime, no gukomeza kurekura ibintu bikora. Uburyo bwo gusesa HPMC mumazi burimo intambwe zihariye kugirango habeho gutatana neza no guhuza.
Intangiriro kuri HPMC:
Hydroxypropyl Methylcellulose (HPMC) ni selile idafite ionic selile ikomoka kuri polymer selile. Ihinduranya mukuvura selile hamwe na okiside ya propylene na methyl chloride. HPMC ikoreshwa cyane mu nganda zitandukanye bitewe nuburyo bwiza bwo gukora firime, kubyimba, gutuza, no kubika amazi. Porogaramu y'ibanze ya HPMC irimo:
Imiti ya farumasi: Ikoreshwa nka binder, firime yahoze, ihindura viscosity, hamwe na agent-igenzura-kurekura ibinini, capsules, amavuta, hamwe no guhagarikwa.
Inganda zikora ibiribwa: Zikoreshwa nkibyimbye, stabilisateur, emulisiferi, hamwe nububiko bwo kubika neza mubicuruzwa byibiribwa nka sosi, amata, nibicuruzwa bitetse.
Ubwubatsi: Bikora nk'umukozi wo kubika amazi, gufatisha, no kubyimbye mu bikoresho bishingiye kuri sima, plaque ishingiye kuri gypsumu, hamwe na tile.
Amavuta yo kwisiga: Imikorere nkibyimbye, firime yambere, hamwe na stabilisateur ya emulsiyo mumavuta yo kwisiga, amavuta, shampo, nibicuruzwa byawe bwite.
Iseswa rya HPMC mumazi:
Gusenya HPMC mumazi bikubiyemo intambwe nyinshi zingenzi kugirango tugere ku gisubizo kimwe kandi gihamye:
Guhitamo Icyiciro cya HPMC: Hitamo icyiciro gikwiye cya HPMC ukurikije ubwiza bwifuzwa, ingano yingingo, nurwego rwo gusimbuza. Ibyiciro bitandukanye bitanga impamyabumenyi zitandukanye zo kwiyegeranya no kwikemurira ibibazo.
Gutegura Amazi: Koresha amazi asukuye cyangwa yatoboye kugirango utegure igisubizo. Ubwiza bwamazi burashobora kugira ingaruka zikomeye muburyo bwo gusesa hamwe nigisubizo cyanyuma. Irinde gukoresha amazi akomeye cyangwa amazi arimo umwanda ushobora kubangamira iseswa.
Gupima no gupima: Gupima neza ingano isabwa ya HPMC ukoresheje uburinganire bwa digitale. Ibyifuzo bya HPMC mumazi biratandukanye bitewe nibisabwa. Mubisanzwe, kwibanda kuri 0.1% kugeza 5% w / w birasanzwe mubisabwa byinshi.
Icyiciro cya Hydration: Kunyanyagiza HPMC yapimwe buhoro kandi buringaniye hejuru y'amazi mugihe ukomeje. Irinde kongeramo HPMC mubice binini kugirango wirinde kwibibyimba cyangwa agglomerates. Emerera HPMC kuyobora no gukwirakwiza buhoro buhoro mumazi.
Kuvanga no guhagarika umutima: Koresha ibikoresho bikwiye byo kuvanga nka magnetiki stirrer, imashini ivanga imashini, cyangwa imashini yivanga cyane kugirango byorohereze ikwirakwizwa rya HPMC mumazi. Komeza uburakari bworoheje kugirango wirinde kubira ifuro ryinshi cyangwa guhumeka ikirere.
Kugenzura Ubushyuhe: Gukurikirana no kugenzura ubushyuhe mugihe cyo gusesa. Mu bihe byinshi, ubushyuhe bwicyumba (20-25 ° C) burahagije kugirango ushonga HPMC. Ariko, kugirango iseswa ryihuse cyangwa formulaire yihariye, ubushyuhe bwo hejuru burashobora gukenerwa. Irinde gushyuha cyane, kuko bishobora gutesha polymer kandi bikagira ingaruka kumuti.
Igihe cyo gusesa: Iseswa ryuzuye rya HPMC rishobora gufata amasaha menshi, bitewe nurwego, ingano y'ibice, hamwe nubukangurambaga bukabije. Komeza kubyutsa kugeza igisubizo kiboneye, kiboneye, kandi kitarangwamo ibice cyangwa agglomerates.
pH Guhindura (nibiba ngombwa): Mubisobanuro bimwe, ihinduka rya pH rirashobora kuba nkenerwa kugirango uhindure ituze nimikorere yumuti wa HPMC. Koresha ibikoresho bikwiye cyangwa uhindure pH ukoresheje acide cyangwa base nkuko bisabwa byihariye.
Kurungurura (niba bikenewe): Nyuma yo guseswa burundu, shungura igisubizo cya HPMC ukoresheje icyuma cyiza cya mesh cyangwa urupapuro rwo kuyungurura kugirango ukureho ibice byose bidashonga cyangwa umwanda. Iyi ntambwe yemeza neza igisubizo kimwe no guhuza ibitsina.
Kubika no Guhagarara: Bika igisubizo cyateguwe na HPMC mubikoresho bisukuye, byumuyaga mwinshi kure yizuba ryinshi nubushyuhe bukabije. Ibisubizo bibitswe neza biguma bihamye mugihe kinini nta mpinduka zikomeye zijimye cyangwa indi mitungo.
Ibintu bigira ingaruka ku iseswa rya HPMC:
Impamvu nyinshi zirashobora guhindura inzira yo gusesa hamwe nibisubizo bya HPMC:
Ingano nini na Grade: Ifu nziza ya pome ya HPMC irashonga byoroshye kuruta uduce duto duto bitewe nubuso bwiyongereye hamwe na hydrata yihuta.
Ubushyuhe: Ubushyuhe bwo hejuru bwihutisha umuvuduko wa HPMC ariko birashobora no gutuma habaho gutakaza ubukana cyangwa kwangirika mubihe bikabije.
Umuvuduko wo guhagarika umutima: Imyigaragambyo ikwiye ituma ibice bimwe bya HPMC bikwirakwiza kandi bigatera vuba vuba. Imyivumbagatanyo ikabije irashobora kwinjiza umwuka mubi cyangwa ifuro mubisubizo.
Ubwiza bw’amazi: Ubwiza bw’amazi akoreshwa mu guseswa bugira ingaruka ku bwumvikane, butajegajega, ndetse n’ubukonje bw igisubizo cya HPMC. Amazi asukuye cyangwa yatoboye ahitamo kugabanya umwanda na ion zishobora kubangamira iseswa.
pH: pH yumuti irashobora kugira ingaruka kuri solubilité na stabilite ya HPMC. Guhindura pH murwego rwiza rwicyiciro cyihariye cya HPMC irashobora kongera gusesa no gukora.
Imbaraga za Ionic: Ubwinshi bwumunyu cyangwa ion mubisubizo birashobora kubangamira iseswa rya HPMC cyangwa bigatera gelation. Koresha amazi ya deionisation cyangwa uhindure umunyu mwinshi nkuko bikenewe.
Imbaraga zogosha: Kuvanga cyane cyangwa kuvanga ibintu birashobora kugira ingaruka kumiterere yimikorere nimikorere yumuti wa HPMC, cyane cyane mubikorwa byinganda.
Inama zo gukemura ibibazo:
Niba uhuye ningorane zo gusesa HPMC cyangwa guhura nibibazo bifite ireme ryigisubizo, suzuma inama zikurikira zo gukemura ibibazo:
Ongera Ubukangurambaga: Kongera imbaraga zo kuvanga cyangwa gukoresha ibikoresho byihariye byo kuvanga kugirango uteze imbere no gusesagura ibice bya HPMC.
Hindura Ubushyuhe: Hindura imiterere yubushyuhe murwego rusabwa kugirango byorohereze vuba nta guhungabanya umutekano wa polymer.
Kugabanya Ingano ya Particle: Koresha amanota meza ya HPMC cyangwa ukoreshe tekinike yo kugabanya ingano nko gusya cyangwa micronisation kugirango utezimbere ibikorwa.
pH Guhindura: Reba pH yumuti hanyuma uhindure nkibikenewe kugirango ukomeze ibintu byiza kugirango HPMC ikemuke kandi ihamye.
Ubwiza bw’amazi: Menya neza ubwiza nubwiza bwamazi akoreshwa mugusenyuka ukoresheje uburyo bukwiye bwo kuyungurura cyangwa kweza.
Kwipimisha Guhuza: Kora ubushakashatsi bwuzuzanya hamwe nibindi bikoresho byerekana kugirango umenye imikoranire iyo ari yo yose cyangwa ibidahuye bishobora kugira ingaruka ku iseswa.
Baza Amabwiriza Y’abakora: Reba ibyifuzo byubuyobozi nu murongo ngenderwaho kumanota yihariye ya HPMC kubyerekeranye nuburyo bwo gusesa, intera yibandaho, hamwe ninama zo gukemura ibibazo.
Gusenya Hydroxypropyl Methylcellulose (HPMC) mumazi nintambwe yingenzi mubikorwa bitandukanye byinganda, harimo imiti, ibiryo, ubwubatsi, hamwe no kwisiga. Ukurikije uburyo bwasabwe hanyuma ukareba ibintu byingenzi nkubunini bwibice, ubushyuhe, ubukangurambaga, nubwiza bwamazi, urashobora kugera kumurongo umwe kandi uhamye wa HPMC ufite imiterere ya rheologiya. Byongeye kandi, gukemura ibibazo hamwe ningamba zo gutezimbere birashobora gufasha gutsinda ibibazo no kwemeza ko HPMC iseswa neza kubikorwa bitandukanye. Gusobanukirwa inzira yo gusesa hamwe nayo
Igihe cyo kohereza: Werurwe-09-2024