Ibicuruzwa bya sima, nka beto, minisiteri, nibindi bikoresho byubwubatsi, bikoreshwa cyane mumazu agezweho. Ether ya selile (nka hydroxypropyl methylcellulose (HPMC), hydroxyethyl methylcellulose (HEMC), nibindi) ninyongera zingenzi zishobora kuzamura imikorere yibicuruzwa bya sima. Kugirango ugere kuri iyo mico myiza, ni ngombwa kumenya no kugenzura imikorere ya selile.
1. Ibintu shingiro nibikorwa bya selile ethers
Ether ya selile ni icyiciro cyibikomoka ku miti ya selile isanzwe, aho hydroxyl itsinda risimburwa igice na ether binyuze muri reaction ya etherification. Ubwoko butandukanye bwa selile ya selile irashobora guhuzwa ukurikije ubwoko numubare wabasimbuye, kandi buri bwoko bugira uruhare rutandukanye mubicuruzwa bya sima.
Viscosity ya selulose ethers:
Ubukonje bwa selile ya selile bigira ingaruka itaziguye kuri rheologiya no gutuza kwa sima. Ether-selile nyinshi ya selile irashobora kuzamura amazi no guhuza imbaraga za paste, ariko irashobora kugabanya amazi yayo. Ether-viscosity selulose ethers ifasha kunoza imikorere no gutembera.
Impamyabumenyi yo gusimbuza (DS) no gusimbuza umubyimba (MS):
Urwego rwo gusimbuza no gusimbuza amavuta ya selile ya selile igena gukomera kwayo hamwe nubwiza bwumuti. Urwego rwo hejuru rwo gusimbuza no gusimbuza umubyimba mwinshi birashobora guteza imbere gufata neza amazi hamwe na selile ya selile.
Gukemura ibibazo bya selile:
Igipimo cyo gusesa no gukomera kwa selile ya selile bigira ingaruka kuburinganire bwa sima. Ether ya selile ifite imbaraga zo gukemura neza irashobora gukora igisubizo kimwe byihuse, bityo bigatuma uburinganire n'ubwuzuzanye bya paste.
2. Hitamo ethers ikwiye
Porogaramu zitandukanye zikoreshwa zifite imikorere itandukanye ya selile. Guhitamo ubwoko bukwiye nibisobanuro bya selile ether birashobora kunoza cyane imikorere yibicuruzwa bya sima:
Binders:
Mubisabwa nka tile yometse hamwe na pompe ya pompe, ether-selile nyinshi ya selile (nka HPMC) irashobora gutanga neza hamwe nubushuhe burambye, bityo bikazamura imikorere yubwubatsi nimbaraga za nyuma.
Ibikoresho bigumana amazi:
Muri minisiteri yo kwisiga hamwe na sima ishingiye kuri tile, hasabwa ethers ya selile ifite amazi menshi (nka HEMC). Kugumana amazi menshi bifasha kwirinda gutakaza amazi imburagihe, bityo bigatuma habaho hydrata ihagije nigihe kinini cyo gukora.
Ibikoresho bishimangira:
Ether ya selile ikoreshwa mugutezimbere imbaraga zibicuruzwa bya sima bigomba kugira itandukaniro ryiza hamwe nubukonje buringaniye kugirango byongere uburinganire nimbaraga za matrix.
3. Hindura uburyo bwo kongeramo
Kugenzura uburyo bwiyongera bwa selile ya ether mubicuruzwa bya sima nibyingenzi kugirango bigerweho neza. Ibikurikira nuburyo bwinshi busanzwe bwo gutezimbere:
Uburyo bwambere:
Kuvanga selile ya ether nibindi bikoresho byifu byumye mbere. Ubu buryo burashobora kwirinda gushiraho agglomeration ya selulose ether nyuma yo guhura namazi, bityo bigatuma ikwirakwizwa ryayo rimwe.
Uburyo bwo kuvanga amazi:
Ongeramo selile ether kuri sima buhoro buhoro. Ubu buryo bukwiranye nigihe selulose ether ishonga vuba kandi igafasha gukora ihagarikwa rihamye.
Uburyo bwo kongeramo ibice:
Muburyo bwo gutegura sima ya sima, kongeramo selile ya selile mubice bishobora kwemeza ko igabanywa kimwe mugihe cyo kwitegura no kugabanya agglomeration.
4. Kugenzura ibintu byo hanze
Ibintu byo hanze nkubushyuhe, agaciro ka pH, nigipimo gikurura bigira ingaruka zikomeye kumikorere ya selile ether.
Kugenzura ubushyuhe:
Ububasha hamwe nubwiza bwa selulose ether yunvikana cyane nubushyuhe. Ubushyuhe bwo hejuru bufasha selile ether gushonga vuba, ariko birashobora no gutuma ubwiza bwumuti bugabanuka. Ubushuhe bugomba guhindurwa ukurikije porogaramu yihariye kugirango tumenye neza imikorere.
Guhindura pH: Agaciro pH ka sima paste mubusanzwe iri murwego rwo hejuru rwa alkaline, mugihe solubile hamwe nubwiza bwa selulose ether ihindagurika hamwe no guhindura agaciro ka pH. Kugenzura agaciro ka pH murwego rukwiye birashobora guhagarika imikorere ya selile ether.
Igipimo cyo gukurura: Igipimo gikurura kigira ingaruka zo gukwirakwiza selile ya ether muri paste ya sima. Igipimo kinini cyane gishobora kuganisha ku kwinjiza ikirere no kwegeranya selile ya selile, mugihe igipimo giciriritse giciriritse gifasha gukwirakwiza no gushonga ether ya selile.
5. Isesengura ry'imanza n'ibitekerezo bifatika
Binyuze mu isesengura ryukuri, turashobora kurushaho gusobanukirwa ingamba nogutezimbere ingamba za selile ether mubicuruzwa bitandukanye bya sima:
Ibikoresho bifata neza cyane: Iyo isosiyete yakoraga ibyuma bifata neza cyane, byagaragaye ko kugumana amazi yibicuruzwa byumwimerere bidahagije, bigatuma imbaraga zubusabane zigabanuka nyuma yubwubatsi. Mugutangiza HEMC igumana amazi menshi no guhindura umubare wongeyeho nuburyo bwo kongeramo (ukoresheje uburyo bwo kubanziriza), gufata amazi hamwe nimbaraga zo guhuza amatafari byatejwe imbere.
Ibikoresho byo kwisuzumisha hasi: Ibikoresho byo kwipimisha hasi byakoreshejwe mumushinga runaka byari bifite amazi mabi hamwe nubuso bubi nyuma yo kubaka. Muguhitamo HPMC nkeya kandi igahindura igipimo cyogukurikirana no kugenzura ubushyuhe, amazi nubwubatsi bwikibabi biratera imbere, bigatuma ubuso bwanyuma bworoha.
Kugenzura imikorere ya selulose ether mubicuruzwa bya sima nurufunguzo rwo kuzamura imikorere yibikorwa nubwiza bwubwubatsi. Muguhitamo ubwoko bukwiye bwa selile ya selile, guhitamo uburyo bwo kongeramo, no kugenzura ibintu bitera ingaruka, ibintu byingenzi byibicuruzwa bya sima nko kubika amazi, gufatira, hamwe n’amazi birashobora kunozwa cyane. Mubikorwa bifatika, birakenewe guhora tunonosora kandi ugahindura imikoreshereze ya selile ya selile ukurikije ibikenewe hamwe nibisabwa kugirango ugere kubisubizo byiza.
Igihe cyo kohereza: Jun-26-2024