HPMC ikoreshwa nka farumasi

HydroxyPropyl Methylcellse (HPMC)ikoreshwa nkumwe mubababaye cyane ba farumasi murugo ndetse no mumahanga. HPMC irashobora gukoreshwa nka firime yo gushiraho film, umukozi, ushinzwe kurekura umukozi, umukozi wahagaritswe, Emalifier, emalifier, acukura umukozi, nibindi.

Abavandimwe ba farumasi nigice cyingenzi cyimyiteguro ya farumasi, kandi uruhare rwabo ni ukureba ko ibiyobyabwenge byatoranijwe munzira runaka nuburyo, kugirango imiti irekurwe mumubiri mugihe runaka. Kubwibyo, guhitamo ababikwiriye nimwe mubintu byingenzi byingaruka zo kwitegura imiti.

1 Ibyiza bya HPMC

HPMC ifite ibintu byinshi byabandi bibabazwa bidafite. Ifite amazi meza cyane mumazi akonje. Igihe cyose cyongewe mumazi akonje hanyuma ukangurwa gato, birashobora gushonga mubisubizo biboneye. Ibinyuranye, birashoboka cyane ko bidasubirwaho mumazi ashyushye hejuru ya 60e kandi arashobora gusezerera gusa. Ni selile itari ionic ether, igisubizo cyacyo ntabwo gifite umunyu wibinyabuzima cyangwa ibinyabuzima bya gionic, kugirango tumenye neza ko HPMC ititabira izindi shusho zibitekerezo. Hamwe no kurwanya imbaraga zikomeye, hamwe no kongera imiterere ya moleculation yurwego rwo gusimburwa, kongera imbaraga nabyo, ukoresheje ibiyobyabwenge biduhanishwa, guhuza ibiyobyabwenge, dextrin, ifu ya dextrin) ibiyobyabwenge, Ubwiza bwigihe cyiza burahagaze neza. Ifite INYETITA. Nkibintu bifatika bya farumasi, ntibishobora guhumanya cyangwa guhugukira, bityo ntibitanga karori mubuvuzi nibiryo. Ifite porogaramu yihariye ya kaburimbo gake, imiti idafite umunyu nubuvuzi nibiryo bikenewe na diyabete. HPMC irahamye acide na alkali, ariko niba irenze PH2 ~ 11 kandi itangirwa ubushyuhe bwo hejuru cyangwa igihe cyo kubika ni kirekire, viscosiya izagabanuka. Igisubizo cyamazi gitanga ibikorwa byo hejuru kandi byerekana indangaruhara yubuso ntarengwa hamwe nindangamitungi. Ifite ingendo nziza muri sisitemu yicyiciro cya kabiri kandi irashobora gukoreshwa nkabaterankunga neza kandi urinda Colloid. Igisubizo cyamazi gifite firime nziza yo gushiraho firime kandi ni ibikoresho byiza byo gutwikira ibinini nibinini. Filime yakozwe na ifite ibara kandi irakomeye. Icyubahiro cyacyo birashobora kandi kwiyongera wongeyeho glycerol.

2.Gusaba HPMC mu musaruro wa tablet

2.1 Gutezimbere gusenywa

Gukoresha HPMC Ethanol igisubizo cyangwa igisubizo cyamazi nkabakozi batoboye kuri granulation, kubera kuzamura ibisate, ingaruka ziratangaje, kandi zigaragara muri firime ikomeye, isura yoroshye. Kukesha ibintu bya renimodipine: Kudakemurwa kwamavuza byari 17.34% na 28.84% mugihe ibifatanije byari 40%, 1% 10% Starch, 3% igisubizo cya HPMC, 5% Igisubizo cya HPMC, kimwe. 30.84%, 75.46%, 84.5%, 88%. Igipimo cy'ivumburwa cya Acide Igikoresho cya Pipric: Iyo ibifatika ari 12%, 1%) Igisubizo cya Ethanol, 2%) , 86.23%, 90.45%, 99.88%. Igipimo cy'ibiruhuko cya Cimetidine Clatts: Iyo umugenzuzi yari 10% ya strorry na 3% ya HPMC (40%) igisubizo cya Ethanol, igipimo cy'imisemburo cyari 76.2% na 97.54%.

Duhereye kuri amakuru yavuzwe haruguru, birashobora kugaragara ko Ethanol igisubizo nikibazo cya HPMC gifite ingaruka zo kuzamura ibiyobyabwenge, nibishoboka cyane kubikorwa byo guhagarikwa no kwishora mu butaka hagati yumuti na Ibiyobyabwenge bikomeye, byongera ubushuhe, bufasha gusesa ibiyobyabwenge.

2.2 Kuzamura ireme ryo gupfuka

HPMC nk'ibikoresho byo gukora firime, ugereranije nibindi bikoresho bya firime (Acryclecylene Pyrrodidone), inyungu nini cyane ni amazi yayo, imikorere yumutekano, imikorere yumutekano, yoroshye. KandiHpmcIfite ibisobanuro bitandukanye bya virusire, guhitamo bikwiye, gucengeza film, isura iruta ibindi bikoresho. Ibinini bya Hydrofloride nibinini byera byera hamwe ninyuguti ebyiri. Ibi binini byo gukinisha firime biragoye, binyuze mubushakashatsi, hitamo vino ya 50 msya, irashobora kugabanya imihangayiko yimbere ya firime yoroheje, irashobora kugabanya imikino yoroheje ya firime yoroheje, irashobora kugabanya imihangayiko yimbere ya firime yoroheje, ibirambo byanditseho. Peel / Amavuta akurikiranye, 0 / Gukata, nkibibazo byiza, gukinisha filime ikora, kuroga byiza, kandi bizane ijambo ridafite amajwi, byemewe, byumye. Ugereranije n'amazi gakondo gakondo, iyi nyandiko iroroshye kandi ishyira mu gaciro, kandi ikiguzi kiragabanuka cyane.