Hydroxypropyl methylcellulose (HPMC)ikoreshwa nka kimwe mu bikoresho binini bya farumasi mu gihugu no hanze yacyo. HPMC irashobora gukoreshwa nkibikorwa byo gukora firime, gufatira hamwe, gusohora kuramba, umukozi uhagarika, emulsifier, agent gusenya, nibindi.
Ibikoresho bya farumasi ni igice cyingenzi cyimyiteguro yimiti, kandi uruhare rwabo ni ukureba niba imiti ijyanwa mu myanya mu buryo runaka no mu buryo runaka, ku buryo imiti irekurwa mu mubiri ku muvuduko runaka no mu gihe runaka. Kubwibyo, guhitamo ibicuruzwa bikwiye ni kimwe mubintu byingenzi byerekana ingaruka zo kuvura imiti yimiti.
1 Ibyiza bya HPMC
HPMC ifite ibintu byinshi biranga izindi nyungu zidafite. Ifite amazi meza cyane mumazi akonje. Igihe cyose yongewe mumazi akonje hanyuma ikabyutsa gato, irashobora gushonga mugisubizo kiboneye. Ibinyuranye na byo, ntigishobora gushonga mumazi ashyushye hejuru ya 60E kandi irashobora gushonga gusa. Nibintu bitari ionic selulose ether, igisubizo cyacyo ntigifite ionic charge, numunyu wicyuma cyangwa ionic organic compound, kugirango harebwe niba HPMC ititabira nibindi bikoresho bibisi mugutegura umusaruro. Hamwe na anti-sensitivite ikomeye, hamwe no kwiyongera kwimiterere ya molekuline yurwego rwo gusimburwa, anti-sensitivite nayo irashimangirwa, ukoresheje HPMC nkibiyobyabwenge byongera, ugereranije no gukoresha indi miti gakondo (krahisi, dextrin, ifu yisukari), ubwiza bwigihe cyiza burahamye. Ifite inertia metabolike. Nkibikoresho bifasha imiti, ntibishobora guhindurwa cyangwa kwinjizwa, ntabwo rero bitanga karori mubuvuzi nibiryo. Ifite umwihariko udasanzwe ku giciro gito cya calorifique, imiti idafite umunyu nubuvuzi butari allergique nibiryo bikenerwa nabarwayi ba diyabete. HPMC ihagaze neza kuri acide na alkali, ariko niba irenze pH2 ~ 11 kandi ikorerwa ubushyuhe bwinshi cyangwa igihe cyo kubika ni kirekire, ububobere buzagabanuka. Igisubizo cyamazi gitanga ibikorwa byubuso kandi kigaragaza impagarike yuburinganire buringaniye hamwe nindangagaciro zingirakamaro. Ifite emulisiyasi nziza muri sisitemu y'ibyiciro bibiri kandi irashobora gukoreshwa nka stabilisateur ikora neza kandi ikingira colloid. Igisubizo cyamazi gifite imiterere myiza ya firime kandi nikintu cyiza cyo gutwikira ibinini n'ibinini. Filime yakozwe nayo ntabwo ifite ibara kandi irakomeye. Plastike yayo nayo irashobora kwiyongera mugushyiramo glycerol.
2.Gukoresha HPMC mubikorwa bya tablet
2.1 Kunoza iseswa
Ukoresheje igisubizo cya HPMC Ethanol cyangwa igisubizo cyamazi nkibikoresho byo guhanagura granulation, mugutezimbere iseswa ryibinini, ingaruka ziratangaje, kandi ukanda muri firime ubukana nibyiza, kugaragara neza. Gukemura ibinini bya Renimodipine: gukomera kwifata byari 17.34% na 28.84% mugihe ibifata byari 40% Ethanol, 5% polyvinylpyrrolidone (40%) umuti wa Ethanol, 1% sodium dodecyl sulfate (40%) umuti wa Ethanol, 3% HPMC ushonga 10% ibinyamisogwe, 3% HPMC igisubizo, 5% HPMC igisubizo. 30.84%, 75.46%, 84.5%, 88%. Igipimo cyo gusohora ibinini bya aside irike: iyo ibifata ari 12% Ethanol, 1% HPMC (40%) igisubizo cya Ethanol, 2% HPMC (40%) igisubizo cya Ethanol, 3% HPMC (40%) igisubizo cya Ethanol, igipimo cyo gusesa ni 80.94% , 86.23%, 90.45%, 99,88%. Igipimo cyo gusesa ibinini bya Cimetidine: mugihe ibifatika byari 10% bya krahisi na 3% HPMC (40%) igisubizo cya Ethanol, igipimo cyo gusesa cyari 76.2% na 97.54%.
Duhereye ku makuru yavuzwe haruguru, birashobora kugaragara ko igisubizo cya Ethanol nigisubizo cyamazi cya HPMC gifite ingaruka zo kunoza iseswa ryibiyobyabwenge, ibyo bikaba ahanini biva mubikorwa byo guhagarika no gukora ibikorwa bya HPMC, bikagabanya ubukana bwubuso hagati yumuti na ibiyobyabwenge bikomeye, byongera ubushuhe, bifasha gusesa ibiyobyabwenge.
2.2 Kunoza ubwiza bwo gutwikira
HPMC nka firime ikora ibikoresho, ugereranije nibindi bikoresho byo gukora firime (resin acrylic resin, polyethylene pyrrolidone), inyungu nini nukubura amazi kwayo, ntukeneye ibishishwa kama, gukora neza, byoroshye. KandiHPMCifite ibintu bitandukanye byihariye bya viscosity, guhitamo bikwiye, gutwikira film nziza, isura ni nziza kuruta ibindi bikoresho. Ciprofloxacin hydrochloride ibinini ni ibinini byera byanditseho inyuguti ebyiri. Ibi binini byo gutwika firime yoroheje biragoye, binyuze mubigeragezo, hitamo ubukonje bwa 50 mpa # s ya plasitike ya elegitoronike, irashobora kugabanya imihangayiko yimbere ya firime yoroheje, gutwikira tablet idafite ikiraro / ibyuya 0, 0, 0, 0 / orange ibishishwa / amavuta ya permeability, 0 / igikoma, nkikibazo cyiza, gutwikira firime ya firime ikora, gufatana neza, no kuzana ijambo impande zidasohoka, zisomeka, Imwe - uruhande rwiza, rwiza. Ugereranije na gakondo ya coating fluid, iyi resept iroroshye kandi yumvikana, kandi igiciro kiragabanuka cyane.
Igihe cyo kohereza: Apr-25-2024