Mu rubanza no gutanga umusaruro wa Nifedip, kurekura ibinini, ibinini byo kuboneza urubyaro, ibinini byubwiza, ibinini bya Ferromedil, ibinini bya Ferromedil, nibindi, dukoreshaHydroxyPropyl Methylcellse (HPMC)amazi, hydroxypropyl methylcellse na aside polyacryclulase na polAcryclus amazi, opadry (yatanzwe na ticecon yakoreshejena na tekinoroji yakoresheje muri firime, ariko yahuye nibibazo. Nyuma yibibazo bimwe bya tekiniki, ubu tuvugana na bagenzi bacu kubibazo nibisubizo rusange mubikorwa byo gusohoza film.
Mu myaka yashize, ikoranabuhanga ryo gusohora film ryakoreshejwe cyane mugutegura bikomeye. Icyubahiro cya firime kirashobora kurinda ibiyobyabwenge kumucyo, ubuhehere no mu kirere kugirango wongere umutekano wibiyobyabwenge; Hisha uburyohe bwibiyobyabwenge kandi byorohereza umurwayi kubifata; kugenzura urubuga rwo kurekura no kurekura umuvuduko wibiyobyabwenge; irinde guhindura ibiyobyabwenge; Kunoza isura ya tablet utegereze. Ifite kandi ibyiza byimikorere mike, igihe gito, gukoresha ingufu nke, hamwe nuburemere buke. Ubwiza bwibinini bya firime byibanze biterwa nibigize kandi ubwiza bwa tablet Core, Ibisabwa byamazi, Ibipapuro hamwe nibikorwa byububiko, nibindi byiza byingenzi bigaragarira cyane Mubikoresho bifatika bya tablet Core, abababayeho ni isura, gukomera, ibice byoroheje, hamwe na tablet ya tablet ya tablet yibanze. Gushiraho amazi ya toote mubisanzwe birimo polemer nyinshi, plastizers, dyes, ibisasu, nibindi bikoresho byo kwipimisha ni ugumanura hamwe nibikoresho byo kumena.
1.None-kuruhande Aburamu, Filime Crotes
Gukomera kw'isonga hejuru ya tablet core ni ntoya, kandi hagamijwe gucika intege mugihe cyo gupfuka, hamwe no guhagarika ifu imwe cyangwa ibice byimpande zombi cyangwa kumesa hejuru ya Ikibaho cyibanze, kikaba cyambaye uruhande rumwe, cyane cyane hamwe na firime yanditse. Igice kitishoboye cyane cya firime muri tablet ya firime ni inguni. Iyo ibirori cyangwa imbaraga za firime bidahagije, guswera no gukuramo impande za firime birashobora kubaho. Ni ukubera ko gukoraho guhindagurika bitera film kugabanuka, hamwe no kwagura cyane filime yo gukwirakwira hamwe na core yongera imihangayiko yimbere ya firime, irenze imbaraga za kanseri ya firime ya filime.
1.1 Gusesengura impamvu nyamukuru
Ku bijyanye na Chip Core, impamvu nyamukuru nuko ireme rya Chip Core atari ryiza, kandi ubutoni nubunini ni bito. Mugihe cyo gutora, tablet nyamukuru ikorerwa amakimbirane akomeye mugihe azunguruka isafuriya, kandi biragoye kwihanganira imbaraga nkizo zihagije, zijyanye nuburyo bwo gukomera, bifitanye isano nuburyo bwo gutegura hamwe na tablet. Mugihe twapakiye nifedip, kurekura ibinini bikomeza, kubera ubukana buto bwa tablet core, ifu yagaragaye kuruhande rumwe, bikavamo kuri pore, hamwe na pore ya tablet ya firime ntabwo yoroshye kandi yagaragaye nabi kandi yagaragaye nabi kandi afite isura mbi kandi yagaragaye nabi kandi yari agaragara nabi kandi afite isura mbi kandi yagaragaye nabi kandi yari agaragara nabi kandi afite isura mbi kandi yagaragaye nabi kandi yari agaragara nabi kandi afite isura mbi kandi yagaragaye nabi kandi yari agaragara nabi kandi afite isura mbi kandi yagaragaye nabi kandi yari agaragara nabi kandi afite isura mbi kandi yagaragaye nabi kandi yari agaragara nabi kandi afite isura mbi kandi yagaragaye nabi kandi yari agaragara nabi kandi afite isura mbi kandi yagaragaye nabi kandi yari agaragara nabi kandi afite isura mbi kandi yagaragaye nabi kandi yari agaragara nabi kandi afite isura mbi kandi yagaragaye nabi kandi yari agaragara nabi kandi afite isura mbi kandi yagaragaye nabi. Byongeye kandi, aya mashanyarazi akubiyemo kandi afitanye isano n'ubwoko bwa tablet. Niba firime itamerewe neza, cyane cyane niba film ifite ikirango ku ikamba, iruta kwambara uruhande rumwe.
Mubikorwa byo gupfukirana, bitinda cyane kwihuta hamwe no gufata umwuka mwinshi cyangwa ubushyuhe bwikirere bukabije buzatera umuvuduko wihuta, gutinda kwa firime yibinini bya tablet, igihe kirekire cyo kurambagiza tablet. Icya kabiri, igitutu cyo kwishyingiranwa ni kinini, viscosiyani yamazi yambaye hasi, ibitonyanga mu kigo cyihutirwa kirahuzwa, kandi umuti uhishe nyuma yo guhangayika imbere; Mugihe kimwe, guterana amagambo hagati yimpande imwe nayo yongera imihangayiko yimbere ya firime kandi yihutisha film. Kumeneka.
Mubyongeyeho, niba umuvuduko wo kuzunguruka wasaga arihuta cyane cyangwa igenamiterere rya kaffle ridakwiye, imbaraga zidahwitse zidakwirakwira neza, kuburyo amazi azaba akomeye, kandi igenamiterere rya firime ridakwirakwira neza, kandi gushiraho film bizatinda, bizatera kwambara impande zombi.
Kuva mumazi yambayeho, biterwa ahanini no guhitamo polymer mumashanyarazi hamwe nubushyuhe buke (kwibanda) byamazi yambaye, hamwe na tablet ikennye.
1.2 Igisubizo
Imwe ni uguhindura imiterere cyangwa inzira yumusaruro ya tablet kugirango utezimbere gukomera kwa tablet core. HPMC nigikoresho gikunze gukoreshwa. Amarozi y'abavandimwe ba tablet afitanye isano n'amatsinda ya hydroxyl kuri molekile yibanze, kandi amatsinda ya hydroxyl ashimangira amatsinda ya hydrogen hamwe nitsinda rinini rya HPMC kugirango ritange ibinyoma byinshi; Imyitozo iracika intege, kandi uruhande rumwe kandi film yo hejuru ikunda gutandukana. Umubare w'amatsinda ya hydroxyl kumurongo wa molekile ya microcrystalline ni muremure, kandi ifite imbaraga nyinshi, kandi ibinini byateguwe kuva muri Lactose hamwe nandi masuji bifite imbaraga zifatika. Gukoresha amavuta, cyane cyane hbéphaphobike nka aside iriya, magnesium irimo, kandi glyceryl ihindagurika hagati ya tablet core na polymer mubisubizo bigabanuka, bigatuma ingufu zigabanuka, kandi ziyongera ko amafaranga ariyongereye, Ingabo zidashidikanyeho buhoro buhoro. Mubisanzwe, niko umubare w'amahoro, niko kumeneka biracika intege. Byongeye kandi, muguhitamo ubwoko bwa tablet, ubwoko bwa tablet ya biconvex bigomba gukoreshwa muburyo bushoboka bwo gupfunga, bushobora kugabanya ibintu bibaho.
Iya kabiri ni uguhindura inyandiko yamazi yimpimbano, ongera ibintu bikomeye mumazi yambaye cyangwa virusi ya firime no kunoza film yo gutwikira, nuburyo bworoshye bwo gukemura ikibazo. Mubisanzwe, ibintu bikomeye muri sisitemu yo gupfukirana ni 12%, nibintu bikomeye muri sisitemu ofline ni 5% kugeza 8%.
Itandukaniro muri vinosity ryamazi yimpimbano rigira ingaruka kumuvuduko nurwego rwo kwinjira mu mazi ya pical muri tablet. Iyo hari bike cyangwa nta kwinjira, umuhigo ni muto cyane. Ibyatsi byamazi ya pication hamwe numutungo wa filime yo gutwikira bifitanye isano nuburemere bwa molecular ya polymer muri formulate. Ikigereranyo cyo hejuru yuburemere bwa molekilar, niko gukomera kwa film yo gukwirakwira, gutandukana gato no kurwanya kwambara. Kurugero, Ubucuruzi HPMC ifite amanota atandukanye yo gutoranya kubera itandukaniro muburemere bwa molecular. Usibye imbaraga za polymer, ongeraho plastistizers cyangwa kongera ibikubiye muribirengana birashobora kugabanya imiterere yicyuma, ariko wongeyeho amabara ya film ikoreshwa mu rugero.
Icya gatatu, mubikorwa byo gupfukirana, birakenewe kongera umuvuduko wateye, cyane cyane iyo irushanwa ryatangiye bwa mbere, umuvuduko utera ukwiye kwihuta gato, kugirango tablet nyamukuru itwikiriwe nikihe gihe gito, akina uruhare rwo kurinda tablet Core Core. Kongera igipimo cya Spray nacyo gishobora kugabanya ubushyuhe bwo mu buriri, igipimo cyo guhumeka no gushyuha film, kugabanya imihangayiko yimbere, kandi nanone bigabanya ikibazo cyo gucibwa film. Mugihe kimwe, hindura umuvuduko wo kuzunguruka wisafuriya kuri leta nziza, hanyuma ushireho urujijo muburyo bwo kugabanya guterana no kwambara.
2.Hisi
Mugihe cyo gupfunga, iyo ubumwe bwimikorere hagati yibice bibiri biruta imbaraga zo gutandukana kwa molecular, ibice byinshi (ibice byinshi) bizatandukana muri make hanyuma ugatandukanya. Iyo impirimbanyi hagati ya spray no kumisha ntabwo ari byiza, film iratose cyane, film izakomera kurukuta rwinkono cyangwa gukomera, ariko nanone bitera firime ku bupfura; Muri spray, mugihe ibitonyanga byumye, ibitonyanga bitavunitse bizaguma muri filime yaho, hari ibibyimba bito, kugirango urupapuro rwinzoka ruboneke.
2.1 Gusesengura impamvu nyamukuru
Umwangabumenyi n'indwara y'iziritse cyane biterwa ahanini n'ibihe bifatika, ubusumbane hagati ya spray no kumisha. Umuvuduko wo gutera wihuta cyane cyangwa ingano ya gaze itone ni nini cyane. Umuvuduko wumye uratinda cyane kubera ingano yo hasi yinjira mu kirere cyangwa ubushyuhe buke bwindege nubushyuhe buke bwuburiri. Urupapuro ntabwo rwumye kandi ruri mugihe no kumeneka cyangwa ibituba bibaho. Mubyongeyeho, kubera ingaruka zidakwiye cyangwa intera, cone yakozwe na spray ni nto, kandi amazi yimpimbano yibanda ahantu runaka, bikavamo itose. Hano hari inkono yihuta yihuta, ingabo za Centrifugal ni nto cyane, filime izunguruka ntabwo izatanga umusaruro.
Guhangana kugaragara kwamazi ni binini cyane, nabyo ni imwe mu mpamvu. Imyambarire yambaye imyenda nini nini, byoroshye gukora ibitonyanga byinshi, ubushobozi bwayo bwo kwinjira muri Core ni umukene, ubwikunde bwamwe no kumeneka ni bike. Ariko ibi ntibigira ingaruka nyinshi kumumaro.
Mubyongeyeho, ubwoko bwa firime budakwiye nabyo bigaragara kandi kumeneka. Niba film iringaniye mu nkono yo gutwika ntabwo ari nziza, izarenganya hamwe, biroroshye gutera film ebyiri cyangwa nyinshi. Mu misaruro yacu yo gutanga urugamba rwa Buflomechloride, ibice byinshi birengana byagaragaye mu nkono rusange yo gupfuka inkono kubera inkono.
2.2 Ibisubizo
Ari kugirango uhindure spray kandi wumisha umuvuduko kugirango ugere kuringaniza. Mugabanye umuvuduko wa spray, ongera umuzingo windege hamwe nubushyuhe bwikirere, ongera ubushyuhe buri mucurara wumye. Ongera ubupfura bwa spray, kugabanya impuzandengo yikigereranyo cyo gutera cyangwa guhindura intera iri hagati yimbunda nigitanda cyigihe gito kigabanuka hamwe no guhindura intera iri hagati yimbunda nigitanda.
Hindura inyandiko yo gukemura, ongera ibikubiye mu gisubizo cyo guhora, gabanya umubare wo gukemura cyangwa kongera ibitekerezo bya Ethanol muburyo bwa vitcosity; Anti-adhesive irashobora kandi kongerwaho uko bikwiye, nkifu ya talcum, magnesium stearate, ifu ya silica gel cyangwa oxide peptide. Irashobora kunoza neza umuvuduko winkono yinkono, ongera imbaraga zigihugu cyigitanda.
Hitamo urupapuro rukwiye. Ariko, kumabati aringaniye, nkibisate bya hydrochloride, gukinisha byarakozwe nyuma ukoresheje igifungo cyiza cyangwa mugushiraho urusaku rwifuro rusanzwe kugirango uteze imbere urupapuro.
Igihu cya 3. Uruhu rukomeye
Muburyo bwo gupfunga, kuko amazi yambaye adakwirakwira neza, polymer yumye ntabwo ikwirakwizwa, kubitsa bidasanzwe cyangwa gupfuka hejuru ya firime, bikavamo ibara ribi kandi hejuru yubuso butaringaniye. Uruhu rwinkazi ni ubwoko bubi, bukabije bwerekana neza.
3.1 Gusesengura impamvu nyamukuru
Iya mbere ifitanye isano na chip core. Nini cyane ubuso bwambere bukabije bwa core ni, nini nini yubuso bubi bwibicuruzwa bibaho.
Icya kabiri, ifite umubano mwiza na porogaramu yo gukemura. Muri rusange bizera ko uburemere bwa molekile, kwibanda hamwe ninyongera bya polymer mubisubizo byo gutwika bifitanye isano nubuso bwubuso bwa firime. Bakora bareba viscolity yo gukemura ibimenyetso Ibirimo cyane mubisubizo byo gutwika birashobora gutera byoroshye coarsese.
Hanyuma, bifitanye isano nubuzima bwibirori. Umuvuduko wa atome uri hasi cyane cyangwa muremure cyane (Ingaruka zo Gutobora ntabwo ari nziza), idahagije kugirango ikwirakwize ibiryo igihu byose kandi igashyiraho uruhu rwuzuye. Kandi ingano ikabije yindege yumye (umwuka unera ni nini cyane) cyangwa ubushyuhe bwinshi, guhumeka vuba cyane, bitanga eddy kurubu, kandi bigatuma ibitonyanga bikwirakwira ntabwo ari byiza.
3.2
Iya mbere nukuzamura ireme ryibanze. Mugihe cyo kwemeza ireme ryibanze, guhindura igisubizo cya couting no kugabanya uruzitiro (kwibanda) cyangwa ibikubiye mubisubizo byo guhora. Kunywa inzoga cyangwa inzoga-2-2-amazi yo gutoranya arashobora gutoranywa. Noneho hindura imiterere yimikorere, kunoza neza umuvuduko winkono yimpimbano, kora film ucecekere, ongera uterana, kuzamura ikwirakwizwa ryamazi yo gupfukirana. Niba ubushyuhe bwo kuryama ari bwinshi, bugabanye amajwi agaragara no gufata ubushyuhe bwikirere. Niba hari impamvu zitera, igitutu cyo kwishyiriraho kigomba kwiyongera kugirango wihute wihutishe umuvuduko wa Spray, hamwe nimpamyabumenyi iteye imbere hamwe no kunoza ibitonyanga byigihumyo bikwirakwira cyane hejuru yurupapuro, kugirango ukore ibibyimba bigabanuka Impuzandengo ya diameter kandi ibuza kubaho ibitonyanga byinshi, cyane cyane byo guhinga bifite ubushyuhe bunini. Intera iri hagati yimbunda ya spray nurupapuro igikari nabyo birashobora guhinduka. Imbunda ya Spray hamwe na diameter ntoya (015 mm ~ 1.2 mm) hamwe nigipimo kinini cyo gutembera gaze itotorwa. Imiterere ya Spray yahinduwe murwego runini rwa cone inguni yijimye, kugirango ibitonyanga bitatanye mukarere kanini.
4.Ibyanze ikiraro
4.1 Isesengura ryimpamvu nyamukuru
Ibi bibaho mugihe ubuso bwa firime bwaranzwe cyangwa bwashyizweho ikimenyetso. Kuberako imyenda membrane owe ibipimo byumvikana, nka elastique yo hejuru, imbaraga za firime ni umukene, ubukene, nibindi, Kugarura imyenda yongeye kurambika, bikaba byanze bikunze bikaraba, kora Uruhande rumwe rwabuze cyangwa ikirango ntirusobanutse, impamvu zibi ziri mubinyoma mumashyamba ya coute.
4.2 Igisubizo
Hindura ibitabo byo gukemura. Koresha ibiremere bike bya molemer cyangwa firime ndende yo gushushanya gukora; Ongera umubare wa soteve, gabanya uruzitiro rwo gukemura; Ongera umubare wa plastistizer, kugabanya imihangayiko yimbere. Ingaruka zitandukanye za plastistizer ziratandukanye, Polyethylene Glycol 200 iruta Propay Glycol, Glycerin. Irashobora kandi kugabanya umuvuduko wa spray. Ongera ubushyuhe bwikirere, ongera ubushyuhe bwuburiri bwimpapuro, kugirango igikona cyashizwemo gikomeye, ahubwo ni ukubuza kunyeganyega. Byongeye kandi, mugushushanya hapfuye, dukwiye kwitondera ubugari bwinguni yo gutema hamwe nizindi ngingo nziza, kugirango zishobore kubuza ibiraro phenomenon.
5.Girango himbrane Chromatism
5.1 Gusesengura impamvu nyamukuru
Mubisubizo byinshi byo guhinga hari pigment cyangwa ibisigazwa bihagarikwa mubisubizo byo gutwika no kubera ibikorwa bidakwiye, kugabura amabara ntabwo bihurira hagati yibice cyangwa mubice bitandukanye bya sclis. Impamvu nyamukuru nuko umuvuduko winkono yimpinga aritinda cyane cyangwa uburyo bwo kuvanga ari umukene, kandi ingaruka zo gusiga imyenda ntishobora kugerwaho hagati yigihe gisanzwe cya cote; The concentration of pigment or dye in the colored coating liquid is too high or the solid content is too high, or the spraying speed of the coating liquid is too fast, the bed temperature is too high, so that the colored coating liquid is not rolled hanze mugihe; Amahirwe ya firime nayo irashobora guterwa; Imiterere yikibanza ntabwo ikwiye, nkigice kinini, igice cya capsule, kubera kuzunguruka nkigice, nacyo kizatera itandukaniro ryamabara.
5.2 Igisubizo
Ongera umuvuduko wisafuriya cyangwa umubare wa baffle, uhindure leta ikwiye, kugirango urupapuro rurinde. Mugabanye umuvuduko wamazi wihuta, gabanya ubushyuhe bwo kuryama. Mugushushanya inyandiko yo gushushanya amabara, ibipimo cyangwa ibikubiye muri pigment cyangwa irangi bigomba kugabanuka, kandi pigment ifite igifuniko gikomeye igomba gutorwa. Pigment cyangwa irangi igomba kuba byoroshye kandi ibice bigomba kuba bito. Amazi adashongejweho uruta amazi yo gushonga amazi, Amazi adashobora kwimuka n'amazi byoroshye, no kugabanya icyuho cyamazi. Hitamo kandi ubwoko bukwiye. Muburyo bwo gupfunga bwa firime, akenshi hari ibibazo bitandukanye, ariko uko ibintu bimeze, ibintu ari byinshi, birashobora gukemurwa no kunoza ubwiza bwibanze, guhindura imiti no kubahiriza ibikorwa, kugirango ugere kubisabwa byoroshye n'imikorere ya dialetic. Hamwe n'ubuhanga bwo gutwarwara ikoranabuhanga, iterambere no gushyira mu bikorwa ibikoresho bishya byo guhinga hamwe n'ibikoresho byo ku nkombero bya firime bizakundwa cyane, ipfundo rya firime zizagenda neza, ipfundo rya firime zizagenda neza mu gukora imyiteguro ikomeye.
Kohereza Igihe: APR-25-2024