Hydroxypropyl methyl selulose nkibikoresho bya farumasi

Hydroxypropyl methyl selulose (HPMC)ni imiti itandukanye yimiti ikoreshwa cyane muburyo butandukanye bwa dosiye kubera imiterere yihariye. Iyi selile ikomoka kuri selile ikomoka kuri selile, polimeri isanzwe iboneka mu bimera, kandi ihindurwa hakoreshejwe imiti kugirango ibone ibiranga ibyifuzo. Mubikorwa bya farumasi, HPMC ikora imirimo myinshi, harimo binder, firime yahoze, kubyimbye, stabilisateur, hamwe nogukora-kurekura. Ikoreshwa ryinshi ningirakamaro mubikorwa bya farumasi bisaba gusobanukirwa byimazeyo imiterere yabyo, imikoreshereze, ninyungu.

HPMC yo kwikuramo no kwiyegeranya bituma ihitamo neza kugenzura irekurwa ryibiyobyabwenge muburyo bukomeye. Ikora matelike ya gel kuri hydration, ishobora kubuza kurekura ibiyobyabwenge ikwirakwizwa binyuze muri geli yabyimbye. Ubukonje bwa gel buterwa nibintu nkuburemere bwa molekile, urugero rwo gusimburwa, hamwe nubunini bwa HPMC muburyo bwo gukora. Muguhindura ibipimo, abahanga mu bya farumasi barashobora guhuza imyirondoro yo gusohora imiti kugirango bagere ku musaruro wifuzwa, nko kurekurwa ako kanya, kurekurwa bikabije, cyangwa kurekurwa.

HPMC isanzwe ikoreshwa nka binder mugutegura ibinini kugirango itange ubumwe kandi itezimbere imbaraga za mashini za tableti. Nka binder, iteza imbere uduce duto duto hamwe na granule mugihe cyo kwikuramo ibinini, bikavamo ibinini birimo ibiyobyabwenge kimwe hamwe numwirondoro uhoraho. Byongeye kandi, imiterere ya firime ya HPMC ituma ibera ibinini bisize, bikora ibintu bitandukanye nko guhisha uburyohe, kurinda ubushuhe, no gusohora ibiyobyabwenge.

Usibye impapuro zifatika zo mu kanwa, HPMC isanga ikoreshwa mubindi bikoresho bya farumasi, harimo ibisubizo byamaso, geles yibanze, imiti ya transdermal, hamwe ninshinge zirekurwa. Mu bisubizo by'amaso, HPMC ikora nk'umukozi wongera ubwiza, utezimbere igihe cyo gutura kwa formulaire hejuru ya ocular no kongera ibiyobyabwenge. Muri geles yibanze, itanga igenzura rya rheologiya, ryemerera gukoreshwa byoroshye no kongera uruhu rwinjira mubintu bikora.

HPMC-bishingiye kuri transdermal yamashanyarazi atanga uburyo bworoshye bwo gutanga ibiyobyabwenge kubuvuzi bwa sisitemu cyangwa bwaho. Matrix matrix igenzura irekurwa ryibiyobyabwenge binyuze muruhu mugihe kinini, bikomeza imiti ivura mumaraso mugihe bigabanya ihindagurika. Ibi nibyiza cyane kubiyobyabwenge bifite idirishya rivura cyangwa risaba ubuyobozi buhoraho.

HPMC ya biocompatibilité hamwe nubusembure bituma ikwiriye gukoreshwa muburyo bwababyeyi nkumukozi uhagarika cyangwa uhindura viscosity. Mu gutera inshinge zirekurwa, microsperes ya HPMC cyangwa nanoparticles irashobora gukingira molekile zibiyobyabwenge, bigatanga irekurwa rirambye mugihe kinini, bityo bikagabanya inshuro nyinshi no kunoza kubahiriza abarwayi.

HPMC yerekana imitungo ya mucoadhesive, ikagira akamaro mumikorere yagenewe gutanga imiti ya mucosal, nka firime ya buccal na spray yamazuru. Mu kwizirika hejuru ya mucosal, HPMC yongerera igihe cyo gutura ibiyobyabwenge, bigatuma ibiyobyabwenge byiyongera kandi bikaboneka.

Muri rusange HPMC izwi nk’umutekano (GRAS) n’inzego zishinzwe kugenzura nk’ikigo cy’Amerika gishinzwe ibiryo n’ibiyobyabwenge (FDA), bigatuma gikoreshwa mu miti y’imiti igenewe kurya abantu. Ibinyabuzima byangiza ibidukikije hamwe nubumara butarimo uburozi bikomeza kugira uruhare mu kwiyambaza imiti ya farumasi.

Hydroxypropyl methyl selulose (HPMC)ni imiti itandukanye ya farumasi hamwe nibisabwa bitandukanye muburyo butandukanye. Imiterere yihariye, harimo kwikemurira ibibazo, kwiyegeranya, ubushobozi bwo gukora firime, hamwe na biocompatibilité, bituma iba ikintu cyingirakamaro mu gutegura ibiyobyabwenge bigamije kugera ku ntego zihariye zo kuvura. Mugihe ubushakashatsi bwa farumasi bukomeje kugenda bwiyongera, HPMC irashobora gukomeza kuba umusingi wibanze mugutezimbere uburyo bwo gutanga imiti mishya.