1. Imiterere y'ibanze ya HPMC
HYPROMMELLOSE, izina ryicyongereza HydroxyPropyl Methylcellse, Alias HPMC. Formulala yayo ni c8h15o8- (c10hl8o6) n-c8hl5o8, nuburemere bwa moleki ni 86.000. Iki gicuruzwa nikintu cya kimwe cya kabiri cya simic, kikaba kiri mu itsinda rya methyl na igice cya polyhydroxyPropyl ether ya selile. Irashobora gukorwa nuburyo bubiri: imwe igomba gufata methyl selile yitsinda rikwiye hamwe na naoh, hanyuma ukitange hamwe na prodeylene munsi yubushyuhe bwinshi no guhatira cyane. Igihe cyimyitwarire kigomba gukomeza kwemerera methyl na hydroxppepyl amatsinda yo guhuza na ether. Imiterere ya ihujwe nimpeta ya anhydroglucose ya selile, kandi irashobora kugera kurwego rwifuzwa; Ibindi nukuvura ipamba cyangwa iparu yimbaho hamwe na soda ya Caustic, hanyuma ubone mubyitwaramo metaniside hamwe na programne hamwe na producene hamwe na programne HPMC ni ibintu bitandukanye bya selile, kandi ni byiza cyane imiti, ifite inkomoko yagutse. Kugeza ubu, ikoreshwa cyane murugo no mumahanga, kandi nimwe mubaruta imiti ifite igipimo cyo gukoresha hejuru mubiyobyabwenge.
Ibara ryiki gicuruzwa ni cyera kugeza amata yera yera, adafite uburozi kandi utaryoshye, kandi ni ifu ya granular cyangwa fibrouches. Birahagaze neza muburyo bworoshye bworoshye kandi buhebuje. Byarabyimba mumazi akonje kugirango ukore amata yera ya colloidal yumweru hamwe nurwego runaka rwabasura. Ibitekerezo bya Sol-gel guhuza ibintu birashobora kubaho kubera guhindura ubushyuhe bwimyumvire runaka yibisubizo. Biroroshye cyane gushonga muri 70% inzoga cyangwa Dimethyl Ketone, kandi ntuzashonga muri Anhydrous Inzoga, Chloroform cyangwa Ethoxyhane.
Hypromellose ifite umutekano mwiza mugihe PH iri hagati ya 4.0 na 8.0, kandi irashobora kubaho muburyo butandukanye 3.0 na 11.0. Nyuma yo kubika iminsi 10 ku bushyuhe bwa 20 ° C hamwe nubushuhe bugereranije bwa 80%, uburyo buhebuje bwa HPMC ni 6.2%.
Kubera itandukaniro mubikubiye mubisimbuzi bibiri muburyo bwa hyppimellose, uburyo na hydroxypropyl, ubwoko butandukanye bwibicuruzwa byagaragaye. Muburyo bwihariye, ubwoko butandukanye bwibicuruzwa bifite ubushyuhe bwihariye nubushyuhe bwumuriro, rero, bifite ibintu bitandukanye kandi birashobora gukoreshwa mumigambi itandukanye. PharmacoPoEas y'ibihugu bitandukanye ifite ibisobanuro hamwe nimvugo zitandukanye kubitekerezo: Farumaniya ishingiye ku manota atandukanye ya virusire zitandukanye hamwe na gahunda zitandukanye zo gusimbuza ibicuruzwa ku isoko. Bigaragazwa nicyiciro wongeyeho umubare. Igice ni MPA • s. Nyuma yo kongeramo imibare 4 kugirango yerekane ibirimo nubwoko bwa buri wese mu gusimbuza 2208, Imibare ibiri yambere igereranya ijanisha ryitsinda, imibare ibiri yanyuma igereranya hydroxyPropyl ijanisha ryimanza.
2.Uburyo bwo gushonga HPMC mumazi
2.1 Uburyo bwamazi ashyushye
Kubera ko hypromellose idashonga mumazi ashyushye, irashobora gutatana rimwe mumazi ashyushye mugihe cyambere, hanyuma iyo bikonje, uburyo bubiri busanzwe busobanurwa ngo:
(1) Shyira umubare ukenewe wamazi ashyushye muri kontineri no gushyuha kugeza kuri 70 ℃. Buhoro buhoro ongeraho ibicuruzwa bidatinze. Ku ntangiriro, ibicuruzwa bireremba hejuru y'amazi, hanyuma buhoro buhoro bitera gutandukana. Gukonja.
. Kumazi ashyushye asinziriye mu buryo butunguranye, akonje kuvanga nyuma yo gukangura.
Uburyo bwo kuvanga.
Ifu ya powder hamwe nibindi bintu by'ifu bingana cyangwa bike byatatanye byuzuye no kuvanga byumye, hanyuma amazi yongewe gushonga. Muri iki gihe, hypromellose irashobora gushonga nta magglomeration.
3. Ibyiza bya HPMC
3.1 Amazi akonje
Birashonje mumazi akonje munsi ya 40 ° C cyangwa 70% ethanol. Ahanini ni uguhangana mumazi ashyushye hejuru ya 60 ° C, ariko birashobora gutontoma.
3.2 Indorerezi yimiti
HYPROMMELLOSE (HPMC) ni ubwoko bwa selile idahwitse. Igisubizo cyayo ntigifite ionic kandi kidakorana ninyungu zumunyu cyangwa ibintu kama. Kubwibyo, abandi bababarira ntibabyitwaramo mugihe cyo kwitegura.
3.3 Guhagarara
Biratangaje cyane aside na alkali, kandi birashobora kubikwa igihe kirekire hagati ya PH 3 kugeza 1L, kandi uruzinduko rwarwo ntirufite impinduka zigaragara. Igisubizo cyamazi ya hypromellose (HPMC) gifite ingaruka zirwanya kandi zirashobora gukomeza umutekano mwiza mugihe cyo kubika igihe kirekire. Abavandimwe ba farumasi bakoresheje HPMC bafite umutekano mwiza kuruta abatsinze abatsinze gakondo (nka dextrin, ibisimba, nibindi).
3.4 Guhindura vicosity
Ibiryo bitandukanye bya HPMC birashobora kuvangwa muburyo butandukanye, kandi ubushyuhe bwayo burashobora guhinduka ukurikije amategeko runaka, kandi afite umubano mwiza, bityo birashobora gutorwa ukurikije ibisabwa.
3.5 Metabolic Inetia
HPMC ntabwo yinjijwe cyangwa yakandagira mumubiri, kandi ntabwo itanga karori, niko bitewe neza ni imyiteguro yubuvuzi.
3.6 Umutekano
Muri rusange bizera ko HPMC ari ibintu bitari uburozi kandi bidatera uburakari. Igipimo cya Median cyica kuri imbeba ni 5g / kg, hamwe na median yica ingano yimbeba ni 5.2g / kg. Dosage ya buri munsi ntacyo itwaye kumubiri wumuntu.
4. Gusaba HPMC mu myiteguro
4.1 Byakoreshejwe nkibikoresho byo guhora hamwe na firime
Hypromellose (HPMC) ikoreshwa nkibikoresho bya tablet. Ugereranije nibisate gakondo byinkoko nkibinini byinkoko, ibinini byanditse nta nyungu bigaragara muguhisha uburyohe no kugaragara, no gukomera, gusebanya, gusebanya, ibipimo byubuzima nibyiza nibyiza nibyiza nibyiza nibyiza. Icyiciro gito cyo hejuru cyibicuruzwa gikoreshwa nka firime yo gukosora amazi yibinini nibinini, hamwe nicyiciro kinini cyo hejuru gikoreshwa nkibikoresho byo gupfukirana kuri sisitemu ofline sisitemu ya simver. Gukoresha kwibanda mubisanzwe ni 2.0% -20%.
4.2 Nkinder na distergrant
Icyiciro cyo hasi cyiki gicuruzwa kirashobora gukoreshwa nkainder kandi zidasobanutse kubinini, ibinini, na granules, hamwe nicyiciro kinini cyo gukoreshwa cyane nkurwego. Ibipimo biratandukanye hamwe nibisabwa bitandukanye. Mubisanzwe, umubare wa binder ukoreshwa mubinini byumye ni 5%, kandi umubare wa binder ukoreshwa mubinini bya granulation ya granulation ni 2%.
4.3 Nkumukozi wahagaritswe
Guhagarika umukozi ni ibintu byasukuye hamwe na hydrophileity. Gukoresha umukozi wahagaritswe mu guhatira umuvuduko w'imigenzo y'ibice, kandi birashobora kwizirika ku bice byo gukumira ibice bitandukanye no kugereranya muri misa. Guhagarika abakozi bafite uruhare runini muguhagarika guhagaritse. Hpmc nubutandukanye buhebuje bwo guhagarika. Igisubizo cya colloidal cyasheshwe gishobora kugabanya impagarara z'imikoreshereze y'amazi n'imbaraga z'ubuntu ku bice bito bikomeye, bityo bikamura umutekano wa sisitemu yo gutatanya ubuyobe. Iki gicuruzwa ni uscosity yo hejuru-suscosity imyiteguro y'amazi yateguwe nkumukozi wahagaritswe. Ifite ingaruka nziza, byoroshye gusubiramo, kudahanika, hamwe nigice cyiza cyoroshye. Amafaranga asanzwe ni 0.5% kuri 1.5%.
4.4 Byakoreshejwe nka Blocker, gahoro kandi bigenzurwa numukozi ushinzwe kurekura hamwe numukozi wa Pore
Icyiciro cyo hejuru cyiki gicuruzwa gikoreshwa mugutegura Hydrophilic Gel Matrix yakomeje-kurekura ibinini, redirgers hamwe nabakozi bagenzurwa na matrix ikomeje-kurekura ibikoresho. Ifite ingaruka zo gutinza irekurwa ryibiyobyabwenge. Gukoresha kwibanda ni 10% ~ 80% (w / w). Icyiciro gito cya virusire gikoreshwa nkumukozi wa Pore kubwo gusohora cyangwa kugenzurwa kurekura. Igipimo cyambere gisabwa kugirango ingaruka zimpeshyi zubu bwoko bwa tablet zirashobora kugerwaho vuba, hanyuma ingaruka zikomeza cyangwa zigenzurwa, kandi kwibanda ku mibiri myiza birakomeza mumubiri. Hypromellose hydrate kugirango ikore gel igice iyo iterana namazi. Uburyo bwo kurekura ibiyobyabwenge kuri tablet ya Matrix ahanini ni ugutandukanya igice cya gel hamwe nisuri yigice cya gel.
4.5 gukingira gukingira byakoreshejwe nka Thickener na Colloid
Iyo iki gicuruzwa gikoreshwa nkuwabyimbye, kwibanda bisanzwe ni 0.45% ~ 1.0%. Iki gicuruzwa kirashobora kandi kongera imbaraga za slue ya hydrophobike, kora colloide ikingira, irinda akarere no guhuriza hamwe no gukusanya, bityo ugabuza imiterere yimyanda. Ibisanzwe byayo ni 0.5% ~ 1.5%.
4.6 ikoreshwa nkibikoresho bya capsule
Mubisanzwe, ibikoresho bya capsule ibikoresho bya capsule ni gelatin. Igikorwa cyo gutanga umusaruro kiboze igikonoshwa kiroroshye, ariko hari ibibazo hamwe nibibazo nkibintu bibi bigabanya ibiyobyabwenge byubushuhe, byagabanije gusenya ibiyobyabwenge na ogisijeni, kandi bigabanya gusenya ibiyobyabwenge Kubwibyo, Hyppimellose ikoreshwa nkumusimbura wibikoresho bya capsule mugutegura capsules, itezimbere kwibasirwa no gukoresha ingaruka za capsule, kandi yazamuwe cyane murugo no mumahanga.
4.7 Nka biolhesive
Ikoranabuhanga rya BioAdhesive, Gushyira mu bikorwa abarizwa muri bioalmes, mu gukurikiza Mucosa y'ibinyabuzima, byongera ubukana hagati y'imyiteguro na Mucosa kwivuza. Byakoreshejwe cyane ubu birakoreshwa mugufata indwara zubwato bwamazuru na Mucosa Oral. Ikoranabuhanga rya Gastrointestinal Bioadhesion nuburyo bushya bwo gutanga ibiyobyabwenge byateye mumyaka yashize. Ntabwo ari ugukiza igihe cyo gutura ibiyobyabwenge gusa munzira y'ibiyobyabwenge, ariko kandi bizanakaza imikorere yimiti ifite ibiyobyabwenge hamwe na selile yurubuga rwinjira kandi ihindura amazi ya selile. Imbaraga zinjira mubiyobyabwenge kuri selile yinyandiko zamabato ntoya zongerewe imbaraga, bityo utezimbere ibinyabuzima byabiyobyabwenge.
4.8 Nka gel yibanze
Nkitegura imyifatire y'uruhu, Gel ifite urukurikirane rwinyungu nkumutekano, ubwiza, isuku yoroshye, igiciro gito, gahunda yo kwitegura, no guhuza neza nibiyobyabwenge. Mu myaka yashize, yatsinzwe cyane kandi yabaye iterambere ryurukundo rwimyiteguro yo hanze. icyerekezo.
4.9 Nkayo inyote muri sisitemu enye
Igihe cyohereza: Ukuboza-16-2021