Ibintu by'ingenzi bigira ingaruka ku kugumana amazi ya HPMC

HydroxyPropylmethylcellCellCellsellsellsellsells (HPMCs polymer yakoreshejwe mu nganda za farumasi, ikoreshwa cyane mu bikoresho bya tablet, birakoreshwa cyane mu bikoresho bya tablet, bikoreshwa cyane mu bikoresho bya tablet, bigenzurwa bigenzurwa n'ibindi bikorwa byo gutanga ibiyobyabwenge. Imwe mumitungo yingenzi ya HPMC nubushobozi bwayo bwo kugumana amazi, bigira ingaruka kumikorere yacyo nka farumasi. Muri iki kiganiro, tuzasesengura ibintu by'ingenzi bireba kugumana amazi ya HPMC, harimo n'uburemere bwa molekile, ubwoko bwo gusimbuza, ubwoko bw'intunge, na pH.

uburemere bwa molekile

Uburemere bwa moleki ya HPMC bufite uruhare rukomeye mugukoresha ubushobozi bwayo. Muri rusange, uburemere bwinshi bwa moleclar HPMC ni hydrophilic kurenza uburemere buke hpmc kandi irashobora gukuramo amazi menshi. Ibi ni ukubera ko uburemere bwo hejuru bwa molecland bufite iminyururu minini ishobora kwizirika kandi ikora umuyoboro mubi, kongera amazi ashobora kwinjizwa. Ariko, twakagombye kumenya ko uburemere bwa molecular cyane hpmc buzatera ibibazo nkibirori no gutunganya ingorane.

Ubundi

Ikindi kintu kigira ingaruka kubushobozi bwo kugumana amazi ya HPMC nuburyo bwo gusimburwa. HPMC muri rusange iraza muburyo bubiri: hydroxyPropyl-yasimbuwe na memoxy. Ubwoko bwa hydroxypropyl-bwasimbuwe bufite ubushobozi bwo kwinjiza amazi menshi kurenza ubwoko bwa ecrans. Ni ukubera ko itsinda rya hydroxypropyl rihari muri molekile ya HPMC ni hydrophilic kandi yongera ubumwe bwa HPMC kumazi. Ibinyuranye, ubwoko bwa ecrans-bundi bushya ni hydrophilic bityo rero ifite ubushobozi bwo kugumana kumazi. Kubwibyo, ubundi buryo bwa HPMC bugomba gutoranya neza ukurikije imitungo yifuzwa yibicuruzwa byanyuma.

kwibanda kuri

Kwibanda kuri HPMC nabyo bigira ingaruka kubushobozi bwayo bwo kugumana. Muburyo buke, HPMC ntabwo ikora imiterere isa na gel, kugirango ubushobozi bwo kugumana amazi ari bike. Mugihe kwibanda kuri HPMC byiyongereye, molekile za polymer yatangiye kwizirika, gukora gareke nka gel. Uru rusobe rwa gel rukurura kandi rugumana amazi, kandi ubushobozi bwo kugumana amazi kuri HPMC bwiyongera. Ariko, twakagombye kumenya ko kwibanda cyane HPMC bizatera ibibazo byo gushyingirwa nka viscosiya no gutunganya ingorane. Kubwibyo, kwibanda kuri HPMC byakoreshejwe bigomba guhitamo kugera kubushobozi bwo kugumana amazi wifuza mugihe twirinze ibibazo byavuzwe haruguru.

Agaciro

PH agaciro k'ibidukikije HPMC ikoreshwa nayo igira ingaruka kubushobozi bwo kugumana amazi. Imiterere ya HPMC irimo amatsinda ya ainic (-Co-) amatsinda ya hydrophilic mail (-Oh). Idini rya -coo- Amatsinda ni PH biterwa, kandi impamyabumenyi yabo yiyongera hamwe na PH. Kubwibyo, HPMC ifite ubushobozi bwo kugumana mumazi kuri PH. Kuri Ph nkeya, -COO- Itsinda rirabi kandi hydrofilirity yayo igabanuka, bikaviramo ubushobozi bwo kugumana amazi make. Kubwibyo, PH y'ibidukikije igomba guhitamo kugera ku bushobozi bwo kugumana amazi ya HPMC.

Mu gusoza

Mu gusoza, ubushobozi bwo kugumana amazi ya HPMC ni ikintu cyingenzi kigira ingaruka kumikorere yacyo nka farumasi. Ibintu by'ingenzi bigira ingaruka ku bushobozi bwo kugumana amazi ya HPMC harimo uburemere bwa molekile, ubwoko bwo gusimbuza, gusambirwa na pH. Muguhindura witonze ibyo bintu, ubushobozi bwo kugumana mumazi ya HPMC burashobora guhitamo kugera kubiranga ibicuruzwa byanyuma. Abashakashatsi ba farumasi n'ababikora bagomba kwita cyane kuri ibyo bintu kugirango barebe ubuziranenge n'imikorere myiza y'ibiyobyabwenge bya HPMC.