Hydroxypropyl selulose isimbuwe cyane (L-HPC) ni inkomoko ya selile, polymer karemano iboneka mu nkuta z’ibimera. L-HPC yahinduwe kugirango yongere imbaraga zayo hamwe nindi mitungo, bituma iba ibintu byinshi hamwe nibisabwa byinshi mubikorwa bya farumasi, ibiryo, no kwisiga.
Hydroxypropylcellulose isimbuwe nkeya (L-HPC) nimbuto ikomoka kuri selulose isimburwa nkeya yahinduwe cyane cyane kugirango irusheho gukomera mumazi nandi mashanyarazi. Cellulose ni umurongo wa polysaccharide ugizwe nibice bya glucose byuzuye muri kamere kandi ni ibintu bigize urukuta rw'ibimera. L-HPC ikomatanyirizwa mu guhindura imiti ya selile, ikazana amatsinda ya hydroxypropyl kugirango yongere imbaraga zayo mugihe ikomeza bimwe mubintu byifuzwa bya selile.
Imiterere yimiti ya hydroxypropyl selulose isimbuwe
Imiterere yimiti ya L-HPC igizwe numugongo wa selile hamwe nitsinda rya hydroxypropyl rifatanije na hydroxyl (OH) itsinda rya glucose. Urwego rwo gusimbuza (DS) bivuga impuzandengo ya hydroxypropyl matsinda ya glucose kuri selile ya selile. Muri L-HPC, DS ibikwa nkana kugirango ibangikanye neza hamwe no gukomeza imiterere ya selile.
Synthesis ya hydroxypropyl selulose isimbuwe
Synthesis ya L-HPC ikubiyemo reaction ya selile hamwe na oxyde ya propylene imbere ya catalizike ya alkaline. Iyi reaction itera kwinjiza hydroxypropyl muminyururu ya selile. Kugenzura neza uko ibintu byifashe, harimo ubushyuhe, igihe cyo kubyitwaramo, hamwe na catalizator yibanze, ni ngombwa kugirango ugere ku ntera yifuzwa yo gusimburwa.
Ibintu bigira ingaruka kumuti
1. Impamyabumenyi yo gusimbuza (DS):
Gukemura kwa L-HPC bigira ingaruka kuri DS yayo. Mugihe DS yiyongera, hydrophilicity yitsinda rya hydroxypropyl irigaragaza cyane, bityo igatera imbaraga mumazi no mumashanyarazi.
2. Uburemere bwa molekile:
Uburemere bwa molekuline ya L-HPC ni ikindi kintu gikomeye. Uburemere buke bwa molekuline L-HPC irashobora kwerekana kugabanuka gukemuka bitewe no kwiyongera kwimikoranire hagati yimikorere no guhuza urunigi.
3. Ubushyuhe:
Ubusanzwe ubwiyongere bwiyongera hamwe nubushyuhe kuko ubushyuhe bwo hejuru butanga imbaraga nyinshi zo guca imbaraga za intermolecular no guteza imbere imikoranire ya polymer-solvent.
4. pH agaciro k'igisubizo:
PH yumuti igira ingaruka kuri ionisation ya hydroxypropyl. Rimwe na rimwe, guhindura pH bishobora kongera imbaraga za L-HPC.
5. Ubwoko bwumuti:
L-HPC yerekana imbaraga nziza mumazi hamwe na polar zitandukanye. Guhitamo ibisubizo biterwa na progaramu yihariye hamwe nibintu byifuzwa byibicuruzwa byanyuma.
Gukoresha hydroxypropyl selulose isimbuwe
1. Ibiyobyabwenge:
L. Gukomera kwayo mumazi ya gastrointestinal bituma bikwiranye no gutanga imiti.
Inganda zikora ibiribwa:
Mu nganda zibiribwa, L-HPC ikoreshwa nkibyimbye na stabilisateur mubicuruzwa bitandukanye. Ubushobozi bwayo bwo gukora gel isobanutse itagize ingaruka kuburyohe cyangwa ibara ryibicuruzwa byibiribwa bituma igira agaciro mubiribwa.
3. Amavuta yo kwisiga:
L-HPC ikoreshwa muburyo bwo kwisiga muburyo bwo gukora firime no kubyimba. Ifasha kunoza ituze hamwe nuburyo bwo kwisiga nka cream, amavuta yo kwisiga hamwe na geles.
4. Gusaba gutwikira:
L-HPC irashobora gukoreshwa nkibikoresho bya firime munganda zimiti n’ibiribwa kugirango itange urwego rukingira ibinini cyangwa ibicuruzwa.
Hydroxypropyl selulose isimbuwe cyane ni polymer ikora cyane hamwe na solubile yongerewe imbaraga ikomoka kuri selile naturel iboneka mubihingwa. Imiterere yihariye itanga agaciro mubikorwa bitandukanye birimo imiti, ibiryo na cosmetike. Gusobanukirwa nibintu bigira ingaruka kubikemura ningirakamaro mugutezimbere imikoreshereze yabyo itandukanye. Mugihe ubushakashatsi bwa polymer nubushakashatsi bikomeje, L-HPC nibindi nkomoko ya selile irashobora kubona ibintu bishya kandi bishya mubikorwa bitandukanye.
Igihe cyo kohereza: Ukuboza-26-2023