Hydroxypropyl yambuwe na FOLLECHULOSE (L-HPC) ni ukomoka kuri selile, polymer karemano iboneka mu rukuta rw'ibimera. L-HPC yahinduwe kugirango yongere ikibazo cyoroshye nindi mitungo, ikabigira ibikoresho bifatika hamwe na porogaramu nyinshi muri farucetique, ibiryo, nibikoresho byo kwisiga.
Hydroxypropylceppeppoulose (L-HPC) ni ugusimburana hasi ya selile yahinduwe cyane cyane kugirango utezimbere ibibazo byayo mumazi nibindi bicuruzwa. Cellulose ni Umurongo Polsaccharide igizwe n'ibice bya glucose bimaze muri kamere kandi nibice byubatswe byinkuta zamababi. L-HPC irimo kwifashisha imiti ihinduranya imiti, itangiza amatsinda ya hydroxyPropyle kugirango yongere umusaruro wacyo mugihe ukomeza ibintu bimwe na bimwe byifuzwa bya selile.
Imiterere yimiti ya hydroxy oflexyll selile
Imiterere yimiti ya L-HPC igizwe na selile ya selile hamwe nitsinda rya hydroxypropyl ryiziritse kuri hydroxyl (yewe) itsinda ryishami rya glucose. Urwego rwo gusimbuza (DS) bivuga impuzandengo y'amatsinda ya hydroxyPropyl kuri glucose ishami rya selile. Muri L-HPC, DS irabikwa nkana kuringaniza kumera neza hamwe no kubungabunga imitungo yimbere ya selile ya selile.
Synthesis ya Hydroxypropyl selile
Synthesis ya L-HPC ikubiyemo reaction ya selile hamwe na propaylene oxide imbere ya catalyst ya alkaline. Iyi myitwarire iva mu ntangiriro yamatsinda ya hydroxyPropyles muminyururu ya selile. Igenzura ryitondewe kubihe, harimo ubushyuhe, igihe cyimyitwarire, hamwe nubusambanyi, ningirakamaro kugirango ugere ku rwego rwo gusimbuza.
Ibintu bireba Kudakemurwa
1. Impamyabumenyi yo gusimbuza (DS):
Kudakemurwa bya L-HPC bigira ingaruka kuri ds yayo. Nkuko DS yiyongera, hydrophiliti yitsinda rya hydroxypropyl iravugwa cyane, bityo yongerera imbere mubintu byamazi na polar.
2. Uburemere bwa molekile:
Uburemere bwa L-HPC ni ikindi kintu gikomeye. Uburemere bwo hejuru bwa molecular l-hpc irashobora kwerekana kunanirwa kwikekuru kubera kongera imikoranire yimikorere hamwe ningendo.
3. Ubushyuhe:
Ubusanzwe ubwitonzi bwiyongera ubushyuhe kuko ubushyuhe bwo hejuru butanga imbaraga nyinshi kugirango ucire imbaraga ziterabwoba kandi utezimbere imikoranire ya polymer-.
4. PH agaciro k'igisubizo:
PH yumuti wibisubizo bigira ingaruka kuri ionisation yamatsinda ya hydroxyProppoyleyle. Rimwe na rimwe, guhindura ph birashobora kongera ibibazo bya L-HPC.
5. Ubwoko bwa sorvent:
L-HPC igaragaza neza cyane mumazi na polan zitandukanye. Guhitamo ibicuruzwa biterwa na porogaramu yihariye hamwe nibicuruzwa byifuzwa byibicuruzwa byanyuma.
Gukoresha HYDROXY YA LYRDROXYL YASOHOTSE
1. Ibiyobyabwenge:
L-HPC ikoreshwa cyane mu nganda za farumasi nkurugomo, rusukuye kandi rugenzurwa kandi rugenzurwa n'umukozi urekurwa muri Tablet. Kudakemurwa kwayo mumazi ya gastrointestinal bituma bikwiranye no gutanga ibiyobyabwenge.
2. Inganda zibiribwa:
Mu nganda zibiribwa, L-HPC ikoreshwa nkuwabyimbye kandi ikigata mubicuruzwa bitandukanye. Ubushobozi bwayo bwo gukora gel yerekana uburyohe cyangwa ibara ryibicuruzwa bigira agaciro mubiryo.
3. Amavuta yo kwisiga:
L-HPC ikoreshwa mumyidagaduro yo kwisiga kubijyanye na firime no kunyeganyega. Ifasha kunoza umutekano nuburyo bwo kwisiga nka cream, amavuta na gels.
4.
L-HPC irashobora gukoreshwa nkibikoresho byo gutwikira film muri farumasi n'ibiribwa kugirango utange urwego rukingire ibinini cyangwa ibikomoka ku bicuruzwa.
Hydroxypropyl Trapleyl selilese ni polymer yo mu mibereho myinshi hamwe no kongera intege nke zikomoka kuri selile isanzwe iboneka mu bimera. Umutungo wacyo wihariye ugira agaciro mu nganda zinyuranye harimo imiti, ibiryo n'amavuta yo kwisiga. Gusobanukirwa ibintu bigira ingaruka ku kuntu kwikebada ni ngombwa kugirango utezimbere ikoreshwa muburyo butandukanye. Nkuko ubushakashatsi bwa siyanse niterambere bukomeza, L-HPC hamwe na selile isa na selile isa ishobora kubona porogaramu nshya kandi idushya murwego rwimirima.
Igihe cyohereza: Ukuboza-26-2023