Incamake ya HydroxyPropyl Methylcellse (HPMC)

HydroxyPropyl Methylcellse (HPMC)ni syntheulose ukomokamo na kimwe cya kabiri cya simic polymer. Bikoreshwa cyane mu nganda nyinshi nko kubaka, imiti, ibiryo, kwisiga no kwisiga. Nka selile itari ionic ether, hpmc ifite amazi meza yoroheje, imiterere yo gukora firime, umuhisitimba kandi ahisha, bityo afite agaciro gakoreshwa mumirima myinshi.

1. Imiterere yimiti numutungo wa HPMC

Imiterere ya HPMC ya HPMC ikomoka kuri selile karemano. Nyuma yo guhindura imiti, methyl (-och₃) na hydroxyPropyl (-OPH₂₂oh) byitangizwa muri churlilose. Imiterere yimiti yimiti ni izi zikurikira:

Molekile ya selile igizwe n'ibice bya glucose bihujwe na β - 1,4-GLYCOsic Bonds;

Amatsinda ya methyl na hydroxyPropyl yitangijwe muri parikingi ya selile binyuze mubisubizo byo gusimbuza.

Iyi miterere yimiti iha Hpmc ibintu bikurikira:

Gutubakira amazi: Mugenzura urwego rwo gusimbuza methyl na hydroxyPropeyl matsinda, HPMC irashobora guhindura amazi yacyo. Muri rusange, HPMC irashobora gukora igisubizo cya vino mumazi akonje kandi ifite amazi meza.

Guhindura vicosity: viscosity ya HPMC irashobora kugenzurwa neza muguhindura uburemere bwa molekile nurwego rwo gusimbuza kugirango duhuze ibisabwa bitandukanye.

Ubushyuhe: Kubera ko HPMC ari ibintu bya polymer polyplastique, kurwanya ubushyuhe bwayo ni byiza kandi birashobora kugumana imikorere ihamye mubushyuhe runaka.

Biocompaget: HPMC ni ibintu bitari uburozi kandi bidakajeri, bityo biratoneshwa cyane mubuvuzi.

2. Uburyo bwo gutegura HPMC

Uburyo bwo gutegura HPMC burarangiye ahanini na resection ya selile. Intambwe Zihariye ni izi zikurikira:

Disisolution ya Cellulose: Icya mbere, vangal kamere kamere hamwe na solivem (nka chloroform, inzoga kumuti, nibindi) kubicana muburiri bwa selile.

Guhindura imiti: methyl na hydroxyPropyl reagents (nkibi chloromethyl ibice na allyl inzoga) yongewe kumuti kugirango utere reaction.

Neutralization and drying: The pH value is adjusted by adding acid or alkali, and separation, purification and drying are carried out after the reaction to finally obtain hydroxypropyl methylcellulose.

3. Ibisabwa byingenzi bya HPMC

Ibintu bidasanzwe bya HPMC bikoreshwa cyane mumirima myinshi. Ibikurikira ni bimwe mubice byingenzi byasabye:

. Irashobora guteza imbere amazi, kumesa no kugumana amazi yo kuvanga. Cyane cyane kuri minisiteri yumye, HPMC irashobora kunoza imikorere yubwubatsi, yongera amahano ya minisiteri, kandi wirinde ibice muri sima acibwa na sima.

. Nkumukozi ushinzwe film, umubyimba na stabilizer, birashobora kunoza ibiyobyabwenge na bioatseiaility yibiyobyabwenge. Mu bisate, HPMC ntishobora kugenzura gusa ibiyobyabwenge gusa, ariko kandi itezimbere ibiyobyabwenge.

. Kurugero, mubiribwa bike n'ibinure, hpmc irashobora gutanga uburyohe bwiza nuburyo bworoshye kandi wongere umutekano wibicuruzwa. Byakoreshejwe kandi cyane mubiryo byakonje kugirango birinde gutandukana namazi cyangwa urubura Crystal.

. Irashobora kunoza imiterere yo kwisiga, kugirango byoroshye gusaba no gushishoza. Cyane cyane muri cream yuruhu, shampoos, masike ya gahoro hamwe nibindi bicuruzwa, gukoresha HPMC birashobora gutera imbere kumva no gutuza ibicuruzwa.

. Irashobora kandi kuzamura kurwanya amazi no kurwanya imitungo yo kurwanya ipfunyika, kandi yongera gukomera no gukomera no guhimba.

4. Isoko ryisoko niterambere ryiterambere rya HPMC

Mugihe abantu bitondera cyane kurengera ibidukikije n'ubuzima, HPMC, nk'ibikoresho bya polymer n'ibiti bya polymer, bifite uburozi, bifite ibyiringiro byinshi. Cyane cyane muri farumasi, inganda zibiribwa, kwisiga, gusaba HPMC bizakomeza kwagurwa. Mu bihe biri imbere, imikorere yo gukora ya HPMC irashobora kurushaho kuba nziza, kandi kwiyongera kw'ibisohoka no kugabanuka kw'ibiciro bizateza imbere ikoreshwa mu nganda nyinshi.

Hamwe niterambere ryibikoresho byubwenge no kugenzura ikoranabuhanga rishinzwe gusohora, gusaba HPMC muri sisitemu yo gutanga ibiyobyabwenge nabyo bizahinduka hotspot yubushakashatsi. Kurugero, HPMC irashobora gukoreshwa mugutegura abatwara ibiyobyabwenge imikorere igenzurwa kugirango igabanye ikibazo cyo gutanga ibiyobyabwenge no kunoza imikorere.

Hydroxypropyl methylcellseni ibikoresho bya polymer bifite imikorere myiza no gusaba. Hamwe n'amazi meza yoroheje, ubushobozi bwo guhindura visosi na biocompaTubitekerezo byiza, HPMC ifite ibyifuzo byingenzi mubice byinshi nko kubaka, nibindi byifuzo bya siyanse n'ikoranabuhanga rya HPMC birashobora gukomeza kwaguka, hamwe nikoranabuhanga rya Science hamwe niterambere ryigihe kizaza.