Gutegura hydroxyethyl selulose

Hydroxyethyl selulose (HEC) ni polymer idafite ionic, amazi ashonga amazi akomoka kuri selile, polymer karemano iboneka murukuta rw'utugingo ngengabuzima. Ikoreshwa cyane mu nganda zinyuranye, zirimo imiti, amavuta yo kwisiga, amarangi, hamwe n’ibiti, kubera ubunini bwayo buhebuje, gukora firime, hamwe n’imiterere. Gutegura hydroxyethyl selulose bikubiyemo etherifike ya selile hamwe na okiside ya Ethylene mubihe bya alkaline. Iyi nzira irashobora kugabanywamo intambwe nyinshi zingenzi: kweza selile, alkalisation, etherification, kutabogama, gukaraba, no gukama.

1. Kwezwa kwa selile
Intambwe yambere mugutegura hydroxyethyl selulose ni ugusukura selile, mubisanzwe biva mubiti cyangwa ibiti by'ipamba. Cellulose yuzuye irimo umwanda nka lignin, hemicellulose, nibindi bivoma bigomba gukurwaho kugirango ubone selile nziza cyane ikwiranye n’imiti.

Intambwe zirimo:

Gutunganya imashini: Cellulose mbisi itunganijwe muburyo bwo kugabanya ubunini bwayo no kongera ubuso bwayo, byoroshe kuvura imiti.
Ubuvuzi bwa Shimi: Cellulose ivurwa hakoreshejwe imiti nka sodium hydroxide (NaOH) na sodium sulfite (Na2SO3) kugirango isenye lignin na hemicellulose, hanyuma ikarabe kandi ihumura kugirango ikureho umwanda usigaye kandi ubone selile yera, fibrous selile.

2. Alkalisation
Cellulose isukuye noneho irahinduka kugirango ikore kugirango etherification reaction. Ibi bikubiyemo kuvura selile hamwe numuti wamazi wa hydroxide ya sodium.

Igisubizo:
Cellulose + NaOH → Alkali selile

Inzira:

Cellulose ihagarikwa mumazi, hanyuma sodium hydroxide ikongerwamo. Ubushuhe bwa NaOH mubusanzwe buri hagati ya 10-30%, kandi reaction ikorwa mubushyuhe buri hagati ya 20-40 ° C.
Uruvange rushyutswe kugirango harebwe alkali imwe, biganisha kuri selile ya alkali. Hagati aho iritabira cyane okiside ya Ethylene, ikorohereza inzira ya etherification.

3. Kwiyongera
Intambwe yingenzi mugutegura hydroxyethyl selulose ni etherification ya alkali selulose hamwe na okiside ya Ethylene. Iyi reaction itangiza amatsinda ya hydroxyethyl (-CH2CH2OH) mumugongo wa selile, bigatuma amazi ashonga.

Igisubizo:
Alkali selulose + Oxide ya Ethylene → Hydroxyethyl selulose + NaOH

Inzira:

Okiside ya Ethylene yongewe kuri alkali selulose, haba mubice cyangwa inzira ikomeza. Igisubizo gikorerwa muri autoclave cyangwa reaction ya reaction.
Imiterere yimyitwarire, harimo ubushyuhe (50-100 ° C) hamwe nigitutu (1-5 atm), bigenzurwa neza kugirango hasimburwe neza amatsinda ya hydroxyethyl. Urwego rwo gusimbuza (DS) no gusimbuza umubyimba (MS) nibintu byingenzi bigira ingaruka kumiterere yibicuruzwa byanyuma.

4. Kutabogama
Nyuma ya reaction ya etherification, imvange irimo hydroxyethyl selulose na hydroxide ya sodium isigaye. Intambwe ikurikiraho ni ukutabogama, aho alkali irenze itabangamiwe hakoreshejwe aside, ubusanzwe aside acike (CH3COOH) cyangwa aside hydrochloric (HCl).

Igisubizo: NaOH + HCl → NaCl + H2O

Inzira:

Acide yongewemo buhoro buhoro kuvanga reaction mubihe bigenzurwa kugirango birinde ubushyuhe bukabije kandi birinde kwangirika kwa hydroxyethyl selile.
Uruvangitirane rudafite aho ruhuriye noneho rushobora guhindurwa pH kugirango rwemeze ko ruri murwego rwifuzwa, mubisanzwe hafi ya pH (6-8).
5. Gukaraba
Nyuma yo kutabogama, ibicuruzwa bigomba gukaraba kugirango bikuremo umunyu nibindi bicuruzwa. Iyi ntambwe ningirakamaro mu kubona hydroxyethyl selile.

Inzira:

Uruvangitirane rwa reaction ruvangwa namazi, na hydroxyethyl selulose itandukanijwe no kuyungurura cyangwa centrifugation.
Hydroxyethyl selulose yatandukanijwe yogejwe kenshi namazi ya deioniyo kugirango ikureho imyunyu isigaye numwanda. Igikorwa cyo gukaraba kirakomeza kugeza amazi yo gukaraba ageze ku cyerekezo cyihariye, byerekana gukuraho umwanda ushonga.
6. Kuma
Intambwe yanyuma mugutegura hydroxyethyl selulose iruma. Iyi ntambwe ikuraho amazi arenze, itanga umusaruro wumye, ifu ikwiranye nibisabwa bitandukanye.

Inzira:

Hydroxyethyl selile yogejwe ikwirakwizwa kumurongo wumye cyangwa ikanyuzwa mumurongo wumye. Ubushyuhe bwo kumisha bugenzurwa neza kugirango birinde kwangirika kwubushyuhe, mubisanzwe kuva kuri 50-80 ° C.
Ubundi, kumisha spray birashobora gukoreshwa vuba kandi neza. Mu kumisha spray, igisubizo cyamazi ya hydroxyethyl selulose yomekwa mumatonyanga meza hanyuma akumishwa mumazi ashyushye, bikavamo ifu nziza.
Igicuruzwa cyumye noneho gisya kugeza ku bunini bwifuzwa hanyuma gipakirwa kubika no kugabura.
Kugenzura Ubuziranenge na Porogaramu
Mubikorwa byose byo kwitegura, ingamba zikomeye zo kugenzura ubuziranenge zishyirwa mubikorwa kugirango habeho ireme hamwe nubwiza bwa hydroxyethyl selulose. Ibipimo byingenzi nkubukonje, urwego rwo gusimburwa, ibirimo ubuhehere, nubunini bwibice bikurikiranwa buri gihe.

Porogaramu:

Imiti ya farumasi: Ikoreshwa nkibikoresho byibyimbye, binder, na stabilisateur muburyo bwa tableti, guhagarikwa, namavuta.
Amavuta yo kwisiga: Atanga ibishishwa hamwe nibicuruzwa nka cream, amavuta yo kwisiga, na shampo.
Irangi hamwe na Coatings: Ibikorwa nkibibyimbye na rheologiya ihindura, kunoza imiterere yimikorere no gutuza kwamabara.
Inganda zikora ibiryo: Imikorere nkibibyimbye, stabilisateur, na emulisiferi mubicuruzwa bitandukanye byibiribwa.

Gutegura hydroxyethyl selulose ikubiyemo urukurikirane rwimikorere isobanutse neza yimiti nubukanishi bigamije guhindura selile kugirango itangize amatsinda ya hydroxyethyl. Buri ntambwe, uhereye kuri selile ya selile kugeza yumye, nibyingenzi mukumenya ubuziranenge nibikorwa byibicuruzwa byanyuma. Hydroxyethyl selulose yibintu byinshi ituma iba ingirakamaro ntangarugero mu nganda nyinshi, ikagaragaza akamaro ko gukora neza kugirango ihuze ibisabwa byihariye mubikorwa bitandukanye.