HydroxyPropyl Methylcellse (HPMC)Ese polymer itandukanye ikoreshwa ikoreshwa muburyo butandukanye, harimo na farumasi, ibikomoka ku biryo, kwisiga, kwisiga, no gukoresha inganda. Ubwiza bwa HPMC burashobora gutandukana bitewe nibintu nkibiro bya molekile, visositity, urwego rwo gusimbuza (DS), nubuziranenge, bugira ingaruka muburyo butaziguye mubikorwa byayo muburyo bwihariye.
Ibintu by'ingenzi bireba ubwiza bwa hydroxyproppopyl methylcellse
Uburemere bwa molekile
Uburemere bwa molekila (MW) bivuga ubunini bwa molekile yamaganya yamaganya kandi igira uruhare runini muguhitamo viscosity kandi bakegure. Uburemere bwo hejuru bwa moleclar HPMC bukunda kugira ubushishozi bwo hejuru, bufite akamaro mubisabwa nko kurekura ibiyobyabwenge cyangwa nkumukozi wijimye muburyo butandukanye.
Uburemere buke bwa molecular (LMW): Gusenya byihuse, visosity stcosity, bikwiranye nibisabwa nkibikota no gushiraho film.
Uburemere bwo hejuru (HMW): Ndasekeje cyane, ubushyuhe bwinshi, bukwiriye kubyimba, kurimbuka, no kugenzurwa na sisitemu yo kurekura ibiyobyabwenge.
Urwego rwo gusimbuza (DS)
Urwego rwo gusimbuza bivuga urugero amatsinda ya hydroxyl kuri selile ya selile yasimbuwe na methyl na hydroxyProppoxy. Iki kintu kigira ingaruka kumuntu wo kwikebanyagurika na moomerdie ya polymer.
Hasi ds: Yagabanije amazi yonyine, imbaraga za Gel.
DS ndende: Kongera amazi yonyine, yagabanije imbaraga za gel, kandi agenzurwa neza aharemagarwa muri faruceuticals.
Vicosity
Ibyatsi ni ikintu cyingenzi muguhitamo uburyo hpmc ishobora gukora neza, guhungabana, no gusabana. Isubukuru yo hejuru HPMC ikoreshwa mubisabwa nkamagana, guhagarikwa, na hydrogeneyel, mugihe amanota make yinyoni ni meza kubiryo nibikorwa bya farumasi.
Uburakari buke: Mubisanzwe bikoreshwa mubiryo, ubwitonzi bwumuntu, hamwe nibikorwa bya farumasi byo gushiraho firime no guhambira.
Viscosity: Ikoreshwa muri farumasi igenzurwa-arekura imitwe, gels-imbaraga nyinshi, nkabari mubicuruzwa byinganda.
Ubuziranenge
Urwego rwumwanda, nkibisigisigi bisigaye, umunyu wa anorurnic, hamwe nabandi banduye, birashobora kugira ingaruka zikomeye kumikorere ya Slowl®hpmc. Amanota yo gukusanya akunze gukenerwa muri pfamacetical na Porogaramu y'ibiryo.
Amanota ya farumasi: Isuku yo hejuru, akenshi iherekejwe no kugenzura ubukana kubisigisigisigi bisigaye.
Icyiciro cy'inganda: Isuku ryo hasi, ryemewe kubitekerezo bidakoreshwa cyangwa bitavunika.
Kudashoboka
Kudakemurwa na HPMC mumazi biterwa nuburemere bwayo bwa moleki nubusa. Mubisanzwe, HPMC irashonje mumazi akonje, ikabihindura neza kubisabwa bitandukanye bisaba ibikoresho bishingiye kumazi.
Kudakemuke: Gukuramo bike, bikoreshwa muri sisitemu yo kugenzurwa.
Kwishyurwa cyane: Gukuramo byinshi, byiza kubisabwa bisaba gusenywa byihuse.
Ubushyuhe
Umutekano wa Lurmal wa HPMC ni ikintu cyingenzi, cyane cyane munganda zirimo gutunganya ubushyuhe bwo hejuru. Umutekano wo mu bushyuhe urashobora kuba ngombwa mubisabwa nka tablet bihuriye no mu nganda.
GEL Imbaraga
GEL Imbaraga zivuga ubushobozi bwa HPMC kugirango ikore gel iyo ivanze namazi. Imbaraga zo hejuru za gel zifuzwa mubisabwa nka sisitemu yo gutanga ibiyobyabwenge, kandi imbaraga nke za gel zikundwa mubisabwa nkihagarikwa no kumara kumara.
Imbonerahamwe igereranya: ibintu byiza bya hydroxypropyl methylcellse
| Ikintu | Ubuziranenge bwa HPMC | Ubuziranenge bwa HPMC | Ingaruka ku mikorere |
| Uburemere bwa molekile | Uburemere bwo hasi (lmw) | Uburemere bwo hejuru (HMW) | LMW irashonga vuba, HMW itanga viscosity cyane na gels. |
| Urwego rwo gusimbuza (DS) | Gucisha bugufi DS (gusimbuza) | DS ndende (gusimbuza byinshi) | DS hasi ya DS itanga imbaraga nziza, ds ndende zitezimbere kwikeba. |
| Vicosity | Ubushyuhe buke, gushonga vuba | Viscosity, kubyimba, gel-gushiraho | Ubushyuhe buke bubereye gutaka byoroshye, busasu cyane kugirango bukemure kandi burambye. |
| Ubuziranenge | Inzego nkuru zumunyu (indaya za moturmanic, ibicuruzwa) | Isuku yo hejuru, umwanda usigaye | Isuku yo hejuru iremeza umutekano no gukora neza, cyane cyane muri farucetical n'ibiryo. |
| Kudashoboka | Kukeshagura nabi mumazi akonje | Kudakemuwe neza mumazi akonje | Guke cyane ni ingirakamaro kubijyanye no gutora no kurekura vuba. |
| Ubushyuhe | Umutekano wo hasi | Umutekano wo hejuru | Umutekano muremure watoranijwe mubushyuhe bwo hejuru. |
| GEL Imbaraga | Imbaraga zo hasi | Imbaraga ndende | Imbaraga ndende za gel ikenewe kugirango igenzurwe na sisitemu ya gelling. |
| Isura | Umuhondo cyangwa off-yera, ntangarugero | Cyera kugeza kuri cyera, cyoroshye | Ubwiza bwa HPMC buzaba ifite isura imwe, yerekana guhuza umusaruro. |
Ibitekerezo bishingiye kubitekerezo
Inganda za farumasi: Muri farumasi, ubuziranenge, ubusura, uburemere bwa moleki, hamwe na gel imbaraga ni ibintu byingenzi mubikorwa bya HPMC. Kurekura ibicuruzwa bifatika bya farumasi (APIS) biterwa cyane kumiterere ya HPMC, aho uburemere bwinshi bwa molekilar hamwe nurwego rukwiye rwo gusimbuza kwemerera gukora neza
Inganda: Kubicuruzwa byibiribwa, cyane cyane mubisabwa nkibikoresho byokurya, abashinzwe gutanga ibitekerezo, hamwe na emulsifiers, hpmc ya emalifiers yo hepfo nubusambanyi buciriritse bukunze guhitamo. Icyiciro cyiza-cyiciro HPMC iremeza umutekano w'abaguzi kandi wujuje ibipimo byo kunywa.
Kwisiga no kwita ku muntu ku giti cye: Muri kwisiga, Slowltlfhpmc ikoreshwa mu guhiga, kubyimba, no gukora film. Hano, viscosity no kudukemura ni ngombwa kugirango dukore ibintu bihamye nkibisigazwa, amavuta, nibicuruzwa byimisatsi.
Inganda zikoresha: Mu nganda, nko mu gushushanya, kurokora, no kurera, amanota menshi ya HPMC ikoreshwa mu kwinuba no gushiraho firime. Intumbero kumutekano yubushyuhe, ubuziranenge, na vino nibyingenzi mubikorwa byibicuruzwa byiza mubihe bibi.
Ireme ryaHydroxypropyl methylcellseirashobora guhindura cyane imikorere yayo munganda zitandukanye. Mugusobanukirwa ibintu bigira uruhare mubuzima bwacyo - nkuburemere bwa moleculand, urugero, ubususu, gutuzwa, kandi gutuza, kandi gushikama - urashobora guhitamo urwego rwiburyo kuri buri porogaramu. Niba gukoresha imiti, umusaruro wibiribwa, cyangwa gukora inganda, kureba niba urwego rwiza rwa HPMC rwatoranijwe ruzamura imikorere no gukora neza kubicuruzwa byanyuma.
Igihe cya nyuma: Jan-27-2025