Hydroxypropyl Methylcellulose (HPMC) ni polymer itandukanye ikoreshwa cyane mu nganda kuva mu miti kugeza ku bwubatsi kubera imiterere yihariye. Nibikomoka kuri selile, hamwe nitsinda rya hydroxyl ryasimbujwe na mikorobe na hydroxypropyl, bikongerera imbaraga mumazi hamwe na solge zimwe na zimwe.
Ibiranga ibisubizo bya HPMC
1. Amazi meza
HPMC yiganjemo amazi. Gukomera kwayo mumazi biterwa nibintu byinshi:
Ubushyuhe: HPMC ishonga mumazi akonje cyangwa icyumba cy'ubushyuhe. Iyo ushyushye, HPMC irashobora gukora gel; ku gukonjesha, gel irongera gushonga, bigatuma ihinduka. Iyi mashanyarazi yumuriro ningirakamaro mubikorwa nko gusohora imiti igenzurwa muri farumasi.
Kwishyira hamwe: Ibitekerezo bike (0.5-2%) mubisanzwe bishonga byoroshye. Kwibanda cyane (kugeza 10%) birashobora gusaba gukurura igihe.
pH: Ibisubizo bya HPMC birahamye murwego rugari rwa pH (3-11), bigatuma bihinduka muburyo butandukanye.
2. Umuti wumuti
Mugihe cyane cyane amazi ashonga, HPMC irashobora kandi gushonga mumashanyarazi amwe, cyane cyane afite urwego runaka ruranga polar. Muri byo harimo:
Inzoga: HPMC yerekana gukemura neza muri alcool yo hasi nka methanol, Ethanol, na isopropanol. Inzoga nyinshi ntizikora neza kubera iminyururu ndende ya hydrophobique.
Glycol: Propylene glycol na polyethylene glycol (PEG) irashobora gushonga HPMC. Iyi mashanyarazi ikoreshwa kenshi hamwe namazi cyangwa alcool kugirango bitezimbere kandi bikemuke.
Ketone: Ketone zimwe na zimwe nka acetone na methyl etyl ketone irashobora gushonga HPMC, cyane cyane iyo ivanze namazi.
3. Imvange
HPMC irashobora kandi gushonga muruvange rwa solvent. Kurugero, guhuza amazi na alcool cyangwa glycol birashobora kongera imbaraga. Imikoranire hagati yumuti irashobora kugabanya kwibanda kubisabwa byose, guhitamo gusesa.
Uburyo bwo gusesa
Iseswa rya HPMC mumashanyarazi bikubiyemo guca imbaraga hagati yiminyururu hagati yiminyururu ya HPMC no gukora imikoranire mishya na molekile ikora. Ibintu bigira uruhare muriki gikorwa birimo:
Guhuza hydrogène: HPMC ikora hydrogène ihuza amazi nandi mashanyarazi ya polar, byoroha gukomera.
Imikoranire ya Polymer-Solvent: Ubushobozi bwa molekile ya solvent yo kwinjira no gukorana numunyururu wa HPMC bigira ingaruka kumikorere.
Imyitozo ya Mechanical: Gukangura bifasha mugucamo ibice kandi bigatera gusesa kimwe.
Ibitekerezo bifatika byo gusesa HPMC
1. Uburyo bwo gusesa
Kugira ngo iseswa neza, kurikiza izi ntambwe:
Buhoro buhoro Wongeyeho: Buhoro buhoro ongeramo HPMC kumuti hamwe no guhora ukangura kugirango wirinde guhuzagurika.
Kugenzura Ubushyuhe: Kuramo HPMC mumazi akonje kugirango wirinde gusohora imburagihe. Kumashanyarazi amwe, ubushyuhe buke burashobora gufasha.
Ubuhanga bwo kuvanga: Koresha imashini zikoresha imashini cyangwa homogenizers kugirango uvange neza, cyane cyane murwego rwo hejuru.
2. Kwibanda no Kwishishanya
Kwibanda kwa HPMC bigira ingaruka kumyumvire yumuti:
Kwishyira hamwe kwinshi: Ibisubizo mubisubizo buke-bwibisubizo, bikwiranye nibisabwa nka coatings cyangwa binders.
Kwibanda cyane: Gukora igisubizo cyinshi-cyiza cyangwa gel, bifite akamaro mumiti ya farumasi kugirango irekurwe.
3. Guhuza
Mugihe ukoresheje HPMC mubisobanuro, menya guhuza nibindi bikoresho:
pH Guhagarara: Kugenzura ko ibindi bice bidahindura pH kurenza urwego ruhamye rwa HPMC.
Ubushyuhe bukabije: Reba imitunganyirize yumuriro mugihe ushushanya inzira zirimo ihindagurika ryubushyuhe.
Porogaramu ya HPMC Ibisubizo
Ibisubizo bya HPMC bikoreshwa mu nganda zitandukanye bitewe n'imiterere yihariye:
1. Imiti
HPMC ikora nka binder, firime yahoze, kandi igenzurwa nogusohora:
Ibinini na Capsules: Ibisubizo bya HPMC bifasha muguhuza ibikoresho no gukora firime zo gusohora ibiyobyabwenge.
Gels: Yifashishijwe muburyo bwibanze kugirango ibyimbye kandi ituze.
Inganda zikora ibiribwa
Nkinyongera yibiribwa, HPMC ikoreshwa muburyo bwo gutuza no kwigana:
Inkoko: Itezimbere imiterere no gutuza mumasosi no kwambara.
Imiterere ya Firime: Gukora firime ziribwa zifatika hamwe na encapsulations.
3. Ubwubatsi
Ibisubizo bya HPMC byongera imiterere yibikoresho byubwubatsi:
Isima na Mortar: Byakoreshejwe nkibikoresho byongera amazi yo kubika ibicuruzwa bishingiye kuri sima.
Irangi hamwe na Coatings: Itanga kugenzura imvugo no gutuza mumabara.
Ubuhanga buhanitse bwo gusesa
1. Ultrasonication
Gukoresha imirasire ya ultrasonic kugirango ushonga HPMC irashobora kongera umuvuduko wo gusesa no gukora neza mugucamo ibice no guteza imbere gutandukana.
2. Kuvanga cyane-Shear
Imvange-shear nyinshi itanga kuvanga cyane, kugabanya igihe cyo gusesa no kunoza ubutinganyi, cyane cyane muburyo bwo kwiyegereza cyane.
Ibidukikije n'umutekano
1. Kubora ibinyabuzima
HPMC irashobora kwangirika, itangiza ibidukikije. Yangirika mubice bisanzwe, bigabanya ingaruka zibidukikije.
2. Umutekano
HPMC ntabwo ari uburozi kandi ifite umutekano kugirango ikoreshwe mu biribwa, imiti, no kwisiga. Ariko, impapuro zumutekano (SDS) zigomba gusubirwamo kugirango zikorwe nubuyobozi bwo kubika.
Gusenya HPMC bisaba gusobanukirwa neza ibiranga gukemura no gukorana hamwe na solde zitandukanye. Amazi akomeza kuba umusemburo wibanze, mugihe alcool, glycol, hamwe nuruvange rwumuti bitanga ibisubizo byubundi buryo bwihariye. Tekinike ikwiye hamwe nibitekerezo byemeza ko iseswa neza, bigahindura imikoreshereze ya HPMC mu nganda.
Igihe cyo kohereza: Jun-14-2024