HydroxyPropyl MethylcellllAlose (HPMC) ni polymer itandukanye yakoreshejwe cyane munganda ziva muri farurisi mubwubatsi kubera imitungo yihariye. Ni uterwa na selile, hamwe namatsinda ya hydroxyl yasimbuwe nuburyo hamwe na hydroxyProppoyl amatsinda, yongerera amafaranga yo kwikeba mumazi hamwe nibiti byamarika.
Ibiranga Gukundwa na HPMC
1. Kukecuruza amazi
Hpmc yiganjemo amazi. Kudakemurwa mumazi byatewe nibintu byinshi:
Ubushyuhe: HPMC irashonga mumazi akonje cyangwa ibyumba. Amaze gushyushya, HPMC irashobora gukora gel; Ku gukonjesha, geel yongeye gushonga, bigatuma ihinduka. Iyi pelation yubushyuhe ni ingirakamaro muri porogaramu nko gusohora ibiyobyabwenge muri faruceuticals.
Kwibandaho: Ubushakashatsi buke (0.5-2%) muri rusange bishonga byoroshye. Ibitekerezo byinshi (kugeza 10%) birashobora gusaba byinshi bikurura nigihe.
Ph: Ibisubizo bya HPMC birahagaze neza hejuru ya ph (3-11), kubakora bitandukanye mubijyanye nuburyo butandukanye.
2. Amashanyarazi
Mugihe ahanini hashowe amazi, HPMC irashobora kandi gushonga mubintu bimwe na bimwe, cyane cyane abafite urwego runaka rwibiranga. Harimo:
Inzoga: HPMC yerekana koroheje cyane muri alcool yo hepfo nka methanol, ethanol, na isopropanol. Inzoti zo hejuru ntizikora kubera iminyururu yabo ya hydrophobic.
Glycols: Propylene Glycol na Polyethylene Glycol (Peg) irashobora gushonga HPMC. Ibi bicuruzwa bikunze gukoreshwa muguhuza amazi cyangwa alcool kugirango utezimbere gucika intege no gukemura ibibazo.
Ketones: Ketone nka Acetone na Methyl Ethyl Ketone irashobora gusesa HPMC, cyane cyane iyo ivanze namazi.
3. Uruvange
HPMC irashobora kandi gushonga muburyo budasanzwe. Kurugero, guhuza amazi hamwe na alcool cyangwa glycols birashobora kuzamura ibyokuntu. Imbaraga hagati yumutima irashobora kugabanya kwibanda kubisabwa byose, uburyo bwo gusenya.
Uburyo bwo gusenya
Iseswa rya HPMC muri Stills rikubiyemo kumena imbaraga ziterabwoba hagati yinyungu za HPMC kandi zigakora imikoranire mishya hamwe na molekile. Ibintu bigira ingaruka kuri iyi nzira harimo:
Amarira ya hydrogen: HPMC ikora hydrogen ingwate n'amazi nandi mashanyarazi, byorohereza kwikeba.
Imikoranire ya Polymer-Solvery: Ubushobozi bwa molekile ya soleventi kugirango yinjire kandi igakora iminyururu ya HPMC igira ingaruka ku mikorere yo gusebanya.
Guhagarika imashini: Gukomera bifasha mugutandukana kandi biteza imbere iseswa rimwe.
Ibitekerezo bifatika byo gushonga HPMC
1. Uburyo bwo kuvugurura
Kubwo gusesa neza, kurikiza izi ntambwe:
Buhoro buhoro: Buhoro buhoro ongeraho HPMC kuri solive hamwe no guhora ukomera kugirango wirinde guhubuka.
Kugenzura Ubushyuhe: Gushonga HPMC mumazi akonje kugirango wirinde pelation imburagihe. Kubintu bimwe, ubushyuhe buke burashobora gufasha.
Guvanga tekinike: Koresha ubukana bwa mashini cyangwa abashongezi kugirango uvange neza, cyane cyane mubihe byinshi.
2. Kwibanda no guscosity
HPMC Yibanda ku myumvire ya viscosiya:
Ubushishozi buke: Ibisubizo muburyo buke-buke, bukwiye kubisabwa nko kwikuramo cyangwa guhuza.
Kwibanda cyane: Gukora igisubizo-hejuru-virusi cyangwa gel, ingirakamaro mubutaka bwo kurekurwa.
3. Guhuza
Iyo ukoresheje HPMC mubikorwa, menya neza nibindi bikoresho:
PH Guhagarara: Kugenzura niba ibindi bigize bidahindura PH birenze urugero rwa HPMC.
Ubushyuhe bumva: Reba imitungo ya gelation yubushyuhe mugihe ushushanya inzira zirimo impinduka zubushyuhe.
Gusaba ibisubizo bya HPMC
Ibisubizo bya HPMC bikoreshwa mu nganda zitandukanye kubera imitungo yabo idasanzwe:
1..
HPMC ikora nka bunder, firime yahozeho, kandi igenzurwa numukozi urekura:
Ibinini na Capsules: Ibisubizo bya HPMC ubufasha mu guhuza ibikoresho no gukora firime zo kurekura ibiyobyabwenge.
Gels: ikoreshwa mubitera byingenzi kugirango inyeganyega kandi ikongerera ibintu.
2. Inganda zibiri
Nkibiryo byongeweho, HPMC ikoreshwa mu guhungabana kandi ikabije:
Abarimbyi: biteza imbere imiterere no gutuza mu sogo no kwambara.
Gushiraho firime: Gukora firime ziribwa kugirango zihuze na englic.
3. Kubaka
HPMC Ibisubizo byongerera ibintu ibikoresho byubwubatsi:
Sima na minisiteri: ikoreshwa nkumukozi wabana na mazi mubicuruzwa bishingiye kuri sima.
Irangi n'amakoti: Itanga igenzura ryumutima n'umutekano mu gushushanya.
Tekiniki yo gusebanya
1. Ultrasiness
Gukoresha imiraba ya ultrasonic kugirango ishonge hpmc irashobora kuzamura igipimo cyivumburwa no gukora neza mugusenya ibice no guteza imbere gutatanya kimwe.
2. Imisozi miremire
MIXES-YISANZWE AGATANGA Ivanze, Kugabanya Igihe cyo Kwica no Kunoza Ubushitsi, cyane cyane muburyo bwo hejuru.
Ibidukikije n'umutekano
1. Biodedaditabishoboye
HPMC ni biodegradament, bigatuma iba inshuti. Itesha agaciro ibice bisanzwe, kugabanya ingaruka zishingiye ku bidukikije.
2. Umutekano
HPMC ntabwo ari uburozi kandi ifite umutekano kugirango ikoreshwe mu biribwa, imiti, no kwisiga. Nyamara, impapuro zumutekano (SDS) zigomba gusubirwamo mugukora no kubika.
Gushonga HPMC neza bisaba gusobanukirwa ibiranga ikibazo cyayo no guterana hamwe nubushakashatsi butandukanye. Amazi akomeza gupfobya, mugihe aconts, glycols, na retelven ibyuma bitanga ubundi buryo bwo gusaba. Ubuhanga bukwiye nibitekerezo byemeza neza, guhitamo ibikoresho bya HPMC bikoreshwa munganda.
Igihe cya nyuma: Jun-14-2024