Ubuhanga bwubushyuhe bwa hydroxypropyl methylcellulose (HPMC)

Hydroxypropyl Methyl Cellulose (HPMC) ni selile ya ionic selile ikoreshwa cyane mubwubatsi, ubuvuzi, ibiryo, impuzu nizindi nganda. Imiterere yihariye yumubiri na chimique itanga ituze ryiza nibikorwa bikora mubushyuhe bwo hejuru. Hamwe nogukenera kwiyongera kubushyuhe bwo hejuru, ubushyuhe bwo hejuru hamwe nubuhanga bwo guhindura HPMC bwagiye buhinduka ubushakashatsi.

1. Ibintu shingiro bya HPMC

HPMC ifite amazi meza yo gukomera, kubyimba, gukora firime, emulisitiya, ituze hamwe na biocompatibilité. Mugihe cy'ubushyuhe bwo hejuru, gukemura, imyitwarire ya gelation hamwe na rheologiya ya HPMC bizagira ingaruka, bityo rero kuzamura tekinoroji yubushyuhe bwo hejuru ni ngombwa cyane kubishyira mu bikorwa.

2. Ibintu nyamukuru biranga HPMC munsi yubushyuhe bwo hejuru

Ubushuhe

HPMC yerekana ibintu bidasanzwe byubushyuhe bwumuriro mubushyuhe bwo hejuru. Iyo ubushyuhe buzamutse bugera ku ntera runaka, ubwiza bwumuti wa HPMC buzagabanuka kandi gelation izaba ku bushyuhe runaka. Iyi mikorere ni ingenzi cyane mubikoresho byubaka (nka sima ya sima, minisiteri yipima) hamwe ninganda zibiribwa. Kurugero, mubihe byubushyuhe bwo hejuru, HPMC irashobora gutanga amazi meza no kugarura amazi nyuma yo gukonja.

Ubushyuhe bwo hejuru

HPMC ifite ubushyuhe bwiza kandi ntabwo byoroshye kubora cyangwa gutandukana kubushyuhe bwinshi. Muri rusange, ubushyuhe bwumuriro bujyanye nurwego rwo gusimbuza urwego rwa polymerisation. Binyuze mu buryo bwihariye bwo guhindura imiti cyangwa guhinduranya uburyo, ubushyuhe bwabwo burashobora kunozwa kuburyo bushobora gukomeza imiterere myiza ya rheologiya nibikorwa mumiterere yubushyuhe bwo hejuru.

Kurwanya umunyu no kurwanya alkali

Mu bushyuhe bwo hejuru, HPMC yihanganira aside, alkalis na electrolytite, cyane cyane irwanya alkali ikomeye, ituma ishobora kunoza imikorere yubwubatsi mubikoresho bishingiye kuri sima kandi bikaguma bihamye mugihe cyo gukoresha igihe kirekire.

Kubika amazi

Kugumana amazi menshi ya HPMC nikintu cyingenzi muburyo bukoreshwa mubikorwa byubwubatsi. Mu bushyuhe bwinshi cyangwa ahantu humye, HPMC irashobora kugabanya neza guhumeka kwamazi, gutinda kwifata rya sima, no kunoza imikorere yubwubatsi, bityo bikagabanya kubyara ibice no kuzamura ubwiza bwibicuruzwa byanyuma.

Igikorwa cyo hejuru no gutandukana

Mugihe cyubushyuhe bwo hejuru, HPMC irashobora gukomeza kwigana neza no gutatanya, guhagarika sisitemu, no gukoreshwa cyane mubitambaro, amarangi, ibikoresho byubaka, ibiryo nizindi mirima.

3. HPMC tekinoroji yo guhindura ubushyuhe bwo hejuru

Mu gusubiza ubushyuhe bukenewe bukenewe, abashakashatsi n’inganda bakoze tekinoroji zitandukanye zo guhindura HPMC kugirango barusheho guhangana n’ubushyuhe no guhagarara neza. Ahanini harimo:

Kongera urwego rwo gusimburwa

Urwego rwo gusimbuza (DS) no gusimbuza amara (MS) ya HPMC bigira ingaruka zikomeye kubirwanya ubushyuhe. Mugukomeza urwego rwo gusimbuza hydroxypropyl cyangwa mikorerexy, ubushyuhe bwayo bwumuriro burashobora kugabanuka neza kandi ubushyuhe bwabwo burashobora kunozwa.

Guhindura kopi

Gukoporora hamwe nizindi polymers, nko guhuza cyangwa kuvanga inzoga za polyvinyl (PVA), aside polyacrylic (PAA), nibindi, birashobora kunoza ubushyuhe bwa HPMC kandi bikagumana imikorere myiza yubushyuhe bwo hejuru.

Guhindura guhuza

Ubushyuhe bwumuriro wa HPMC burashobora kunozwa hakoreshejwe imiti ihuza imiti cyangwa ihuza umubiri, bigatuma imikorere yayo ihagarara neza mugihe cy'ubushyuhe bwinshi. Kurugero, gukoresha silicone cyangwa polyurethane guhindura birashobora kunoza ubushyuhe nimbaraga za HPMC.

Guhindura Nanocomposite

Mu myaka yashize, hiyongereyeho nanomateriali, nka dioxyde ya nano-silicon (SiO₂) na nano-selile, irashobora kongera imbaraga zo guhangana nubushyuhe hamwe nubukanishi bwa HPMC, kugirango ikomeze kugumana imiterere myiza ya rheologiya munsi yubushyuhe bwo hejuru.

4. HPMC ubushyuhe bwo hejuru bwo gusaba

Ibikoresho byo kubaka

Mu bikoresho byo kubaka nka minisiteri yumye, ifata amatafari, ifu yuzuye, hamwe na sisitemu yo kubika urukuta rwo hanze, HPMC irashobora kunoza imikorere yubwubatsi munsi yubushyuhe bwinshi, kugabanya gucika, no kunoza amazi.

Inganda zikora ibiribwa

Nka kongeramo ibiryo, HPMC irashobora gukoreshwa mubiribwa bitetse ubushyuhe bwo hejuru kugirango hongerwe amazi hamwe nuburyo bwimiterere yibiribwa, kugabanya gutakaza amazi, no kunoza uburyohe.

Urwego rwubuvuzi

Mu nganda zikoreshwa mu bya farumasi, HPMC ikoreshwa nkibikoresho bisize ibinini hamwe n’ibikoresho bisohora-bikomeza kugira ngo ubushyuhe bw’imiti bugabanuke, gutinda kurekura ibiyobyabwenge, no kuzamura bioavailable.

Gucukura amavuta

HPMC irashobora gukoreshwa nk'inyongeramusaruro y'amazi yo gucukura amavuta kugirango hongerwe ubushyuhe bwo hejuru bwamazi yo gucukura, kurinda iriba gusenyuka, no kunoza imikorere.

HPMC ifite ubushyuhe budasanzwe, ubushyuhe buhanitse, kurwanya alkali no kugumana amazi munsi yubushyuhe bwo hejuru. Kurwanya ubushyuhe bwarwo birashobora kurushaho kunozwa no guhindura imiti, guhindura cololymerisation, guhuza guhuza no guhindura nano-composite. Ikoreshwa cyane mu nganda nyinshi nk'ubwubatsi, ibiryo, ubuvuzi, na peteroli, byerekana ubushobozi bunini bw'isoko hamwe n'icyerekezo cyo gukoresha. Mugihe kizaza, hamwe nubushakashatsi niterambere ryibikorwa bya HPMC bikora cyane, porogaramu nyinshi mubushyuhe bwo hejuru zizagurwa.