Guhitamo neza hydroxypropyl methylcellse

HydroxyPropyl MethylcellAlose (HPMC) ni polymer itandukanye ikoreshwa cyane mu nganda zinyuranye kubera imitungo yihariye. Nkumurongo wa selile, HPMC ikomoka kuri selile karemano kandi ifite amatsinda ya hydroxyPropyl na methyl yometse kuri selile. Iyi formification itanga imitungo yifuzwa na HPMC, bigatuma bishoboka kubisabwa, harimo na farumasi, kubaka, ibiryo, nibicuruzwa byita kugiti cyawe.

Guhitamo icyiciro cyukuri cya HPMC ni ingenzi kugirango ugere kubikorwa bisabwa muburyo bwihariye. Ibintu byinshi bigira ingaruka guhitamo HPMC, harimo vicosity, uburyo na hydroxyPropyl ibirimo, ubwoko bwo gusimbuza, hamwe nubunini. Muri iki kiganiro, tuzareba neza ibi bintu kandi tugashakisha uburyo bigira ingaruka guhitamo HPMC kuri porogaramu zitandukanye.

1. Kugaragaza:

Kimwe mu bitekerezo nyamukuru mugihe cyo guhitamo HPMC ni urujijo rwarwo. Viscosiya bivuga kurwanya amazi atemba. Muri HPMC, viscosiya ni igipimo cyurugero cyangwa guhuza igisubizo. ItandukanyePorogaramu ya et isaba amanota atandukanye ya HPMC. Kurugero:

Imiti yicals: Muri farumasi, HPMC ikunze gukoreshwa nkumunyamanyeza kandi wanguze. Guhitamo icyiciro cya viscosity biterwa nimiterere yifuzwa yibicuruzwa byanyuma, yaba ibinini, capsules cyangwa imiterere y'amazi.

Kubaka: Mu nganda zubwubatsi, HPMC ikoreshwa cyane mu mirire yumye minisiteri. Uruzinduko rwa HPMC rugira ingaruka ku ihohoterwa ry'amazi, ibikorwa n'ibikorwa bya Sag na Sag irwanya minisiteri. Porogaramu ihagaritse ihitamo amanota yo hejuru kugirango wirinde sag.

2. Uburyo na HydroxyProppoxl:

Urwego rwo gusimbuza (DS) rwa HPMC rwerekeza ku rwego rwo gusimbuza hydroxyproppopyle na Methoxy troproppopy na Methoxy of the urunigi nyamukuru kandi ni ikintu cy'ingenzi. Indangagaciro zitandukanye za DS zirashobora kuyobora to Impinduka mubikesha, pelation, nibindi bintu. Ibitekerezo birimo:

Amafilingi muri Faruryasi: HPMC ifite uburyo bwo hasi akenshi ikundwa kubijyanye na film muri farumasi kuko itezimbere imitungo yo gukora firime kandi igabanya ibyumweru byinshiisomo ryibidukikije.

3. Ubwoko bundi:

Ubwoko bwo gusimbuza nikindi kintu cyingenzi. HPMC irashobora gushonga vuba (nayo yitwa "hydration yihuta") cyangwa ishonga buhoro. Guhitamo biterwa numwirondoro urekura usabwa muri porogaramu ya farumasi. Kurugero:

Kugenzurwa Ibicuruzwa: Kugenzurwa bigenzurwa, gucika intege gutinda kuri HPMC birashobora guhitamo kugera kurekura harakaye cyaneubuhanga.

4. Ingano yinshi:

Ingano yinshi igira ingaruka kubitanya no kukecuruzwa na HPMC mu gisubizo. Ibice byiza bikunda gushonga byoroshye, bigira ingaruka kumikorere rusange muburyo butandukanye:

Inganda zibiribwa: Mu nganda zibiribwa, HPMC ikoreshwa mubisabwa nko kubyimba no gutuza. Ingano-inganoED HPMC ikunze gutoneshwa kumashanyarazi yihuse hamwe no gutatanya ibiranga ibiryo.

5. Guhuza nibindi bikoresho:

Guhuza HPMC hamwe nibindi bikoresho muri formulate nibyingenzi mubikorwa rusange. Ibi birimo guhuza nibikoresho bikora bya farumasi (APIS) mumiti cyangwa guhuza nibindi bishyingo mubikoresho byubaka.

Ibiyobyabwenge: HPMC igomba B.e ihuje na API kugirango ikarito ihamye hamwe nibisabwe murwego rwa dosage.

6. Kumenya neza:

Kubisabwa bya farumasi na ibiryo, kubahiriza ibidukikije ni ngombwa. Icyiciro cya HPMC cyatoranijwe kigomba kubahiriza farumacopoeia bireba cyangwa ibipimo ngenderwaho.

Ibiyobyabwenge n'ibiryo: Kubahiriza ibipimo by'Ingano (urugero, USP, EP, JP) cyangwa ibiryo byongeraho ibiryoNS (urugero, amabwiriza ya FDA) ni ngombwa kugirango umutekano ningirakamaro.

7. Ibitekerezo bya soTe:

Igiciro nigitekerezo gifatika mubisabwa byose. Mugihe uhitamo icyiciro cyiza cya HPMC, kuringaniza ibisabwa nibisabwa nibitekerezo bya sof birakomeye.

Inganda zubwubatsi: Mu nganda zubwubatsi, HPMC ikoreshwa cyane mukuma imirongo yumye ivanga imihiro, aho ibicuruzwa byiciro ari ngombwa.

Guhitamo neza hydroxyPropyl methylcellse bisaba gusuzuma neza ibintu bitandukanye, harimo na viscositylePl Buri cyifuzo gifite ibisabwa byihariye, kandi uhitamo icyiciro cyiburyo cya HPMC cyemeza imikorere myiza kandi iranga ibiranga ibicuruzwa byanyuma. Birasabwa gukorana nabatanga ibicuruzwa nababikora bashobora gutanga inkunga nubuyobozi bwo kugufasha guhitamo amanota ya HPMC ikwiranye na porogaramu yawe yihariye.