Guhitamo neza kwa hydroxypropyl methylcellulose

Hydroxypropyl methylcellulose (HPMC) ni polymer itandukanye ikoreshwa cyane mu nganda zitandukanye kubera imiterere yihariye. Nkibikomoka kuri selile, HPMC ikomoka kuri selile isanzwe kandi ifite hydroxypropyl na methyl matsinda ifatanye numugongo wa selile. Iri hinduka riha HPMC imitungo yifuzwa, bigatuma ikoreshwa muburyo butandukanye, harimo imiti, ubwubatsi, ibiryo, nibicuruzwa byawe bwite.

Guhitamo icyiciro gikwiye cya HPMC ningirakamaro kugirango ugere kubikorwa bisabwa mubisabwa byihariye. Ibintu byinshi bigira ingaruka kumahitamo ya HPMC, harimo ubukonje, imikorere ya hydroxypropyl, ubwoko bwo gusimbuza, nubunini bwibice. Muri iki kiganiro, tuzareba neza kuri ibi bintu tunasuzume uburyo bigira ingaruka kumahitamo ya HPMC kubikorwa bitandukanye.

1. Viscosity:

Kimwe mubitekerezo byingenzi muguhitamo HPMC nubwiza bwayo. Viscosity bivuga kurwanya amazi atemba. Muri HPMC, viscosity ni igipimo cy'ubunini cyangwa guhuza igisubizo. BitandukanyePorogaramu isaba amanota atandukanye ya HPMC. Urugero:

Imiti ya farumasi: Muburyo bwa farumasi, HPMC ikoreshwa nkumubyimba kandi utera. Guhitamo ibipimo bya viscosity biterwa nuburyo bwifuzwa bwibicuruzwa byanyuma, byaba ibinini, capsules cyangwa amavuta meza.

Ubwubatsi: Mu nganda zubaka, HPMC ikoreshwa cyane mumashanyarazi yumye. Ubukonje bwa HPMC bugira ingaruka ku gufata amazi, gukora no guhangana na minisiteri. Porogaramu ihagaritse muri rusange ihitamo amanota yo hejuru cyane kugirango wirinde sag.

2. Methoxy na hydroxypropyl ibirimo:

Urwego rwo gusimbuza (DS) rwa HPMC bivuga urwego rwo gusimbuza hydroxypropyl hamwe na matsinda ya mikorobe kumurongo wa selile kandi ni ikintu cyingenzi. Indangagaciro zitandukanye za DS zirashobora kuyobora to impinduka mubisubizo, gelation, nibindi bintu. Ibitekerezo birimo:

Ipitingi ya firime muri farumasi: HPMC ifite vitamine yo hasi ikunze gukundwa kubijyanye na firime muri farumasi kuko itezimbere imiterere ya firime kandi igabanya sensititivite ku bidukikije.

3. Ubundi buryo:

Ubwoko bwo gusimbuza ikindi kintu cyingenzi. HPMC irashobora gushonga vuba (nanone yitwa "hydration yihuta") cyangwa gushonga buhoro. Guhitamo biterwa numwirondoro wo kurekura usabwa muri farumasi. Urugero:

Kugenzura kurekurwa kugenzurwa: Kubisohoka bigenzurwa, amanota atinda ya HPMC arashobora guhitamo kugera kurekurwa kurambye kwimiti ikora imitidient.

4. Ingano y'ibice:

Ingano yingirakamaro igira ingaruka ku gutatanya no gukemuka kwa HPMC mugukemura. Uduce duto duto dukunda gushonga byoroshye, bigira ingaruka kumikorere rusange mubikorwa bitandukanye:

Inganda zibiribwa: Mu nganda zibiribwa, HPMC ikoreshwa mubikorwa nko kubyimba no gutuza. Ingano nzizaed HPMC ikunze gutoneshwa kubwihuta bwayo no gukwirakwiza ibintu mubiryo.

5. Guhuza nibindi bikoresho:

Ubwuzuzanye bwa HPMC nibindi bikoresho mubitegura ni ingenzi kubikorwa byayo muri rusange. Ibi birimo guhuza nibikoresho bikora bya farumasi (APIs) mumiti cyangwa guhuza nibindi byongewe mubikoresho byubaka.

Ibicuruzwa byibiyobyabwenge: HPMC igomba be bihujwe na API kugirango tumenye ituze hamwe nogukwirakwiza kimwe muburyo bwa dosiye.

6. Kubahiriza amabwiriza:

Kubikorwa bya farumasi nibiribwa, kubahiriza amabwiriza ni ngombwa. Icyiciro cya HPMC cyatoranijwe kigomba kubahiriza imiti ya farumasi cyangwa ibipimo byongera ibiryo.

Ibiyobyabwenge nibiryo: Kubahiriza ibipimo ngenderwaho (urugero, USP, EP, JP) cyangwa ibiryo byongera ibiryons (urugero, amabwiriza ya FDA) ni ngombwa kugirango umutekano urusheho kugenda neza.

7. Ibiciro:

Igiciro nigitekerezo gifatika mubikorwa byose byinganda. Iyo uhisemo icyiciro cyiza cya HPMC, kuringaniza ibisabwa nibikorwa no gutekereza kubiciro ni ngombwa.

Inganda zubwubatsi: Mu nganda zubwubatsi, HPMC ikoreshwa cyane muburyo bwo kuvanga byumye, aho gukora neza ari ikintu cyingenzi.

Guhitamo neza hydroxypropyl methylcellulose bisaba gusuzuma witonze ibintu bitandukanye, birimo viscosity, mitoxy na hydroxypropyl, ubwoko bwasimbuwe, ingano yingirakamaro, guhuza nibindi bikoresho, kubahiriza amabwiriza nigiciro. Buri porogaramu ifite ibisabwa byihariye, kandi guhitamo icyiciro cyiza cya HPMC byerekana imikorere myiza nibiranga ibicuruzwa byanyuma. Birasabwa gukorana nabatanga ibicuruzwa nababikora bashobora gutanga ubufasha bwa tekiniki nubuyobozi bugufasha guhitamo icyiciro cya HPMC gikwiranye nibisabwa byihariye.