HydroxyPropyl Methylcellse (HPMC) ni ahantu hatari iolic y'amazi ya polymer yabonetse kubijyanye na chimique ya selile karemano. Bikoreshwa cyane mu biryo, ubuvuzi, kwisiga no kwisiga no kubaka, cyane cyane nk'ibironge, ubudozi, kumarana no guhagarika umukozi mu myiteguro y'imiti. Mubikorwa byo gusaba, ibiranga viscosity yo gukemura HPMC igisubizo nibyingenzi mubikorwa byayo mumirima itandukanye.
1. Imiterere n'imitungo ya hydroxypropyl methylcellse
Imiterere ya HPMC ikubiyemo amatsinda abiri asimbuye, HydroxyPropyl (-ch₂Chohch₃) na methyl (-umukono₃), bituma bigira amazi meza no guhindura ubushobozi. Urunigi rwa HPMC rufite imiterere mibi, ariko irashobora kandi gukora imiyoboro itatu-yimiyoboro itatu mu gisubizo gitangaje, bikavamo kwiyongera muri vino. Uburemere bwayo bwa molekile, ubwoko bwumusimbuzi nurwego rwo gusimbuza (ni ukuvuga urwego rwa hydroxyPropyl na methyl gusimbuza igice cya buri gice) kugira uruhare rukomeye kuri vino.
2. Ibiranga STICIQUTIQUE BIKORWA BIKURIKIRA
Ibiranga viscosity Igisubizo cya HPMC gifitanye isano rya bugufi nibintu nkibitekerezo, uburemere bwa molecular, ubushyuhe na ph agaciro ka solive. Mubisanzwe, viscosiyani igisubizo cya HPMC cyiyongera hamwe no kwiyongera kwayo. Uburakari bwayo bwerekana imyitwarire itari itomo, ni ukuvuga, kubera ko igipimo cy'imisoro ariyongera, visosity yo gukemuka igabanuka buhoro buhoro, igaragaza imisatsi yoroheje.
(1) ingaruka zo kwibanda
Hariho umubano runaka hagati ya viscozetity ya HPMC igisubizo cyamazebwe no kwibanda. Mugihe kwibanda kuri HPMC yiyongera, imikoranire ya molecular mugisubizo cyibitangaje, kandi kwishora no guhuza iminyururu imubumba byinshi, bikavamo kwiyongera muri vino. Kumwanya muto, ubukuru bwa HPMC Ibisubizo bya HPMC byiyongera birinze umurongo hamwe no kwibandaho, ariko mubihe byibanze, imikurire yo kwibandaho ikunda kuba igorofa kandi igera ku gaciro gahamye.
(2) ingaruka zuburemere bwa molekile
Uburemere bwa Molekolar ya HPMC bugira ingaruka kuburyo butaziguye igisubizo cyacyo gitangaje. HPMC ifite uburemere bwo hejuru bwa molecular ifite iminyururu ndende kandi irashobora gukora uruganda runini-rwigipimo cyimiyoboro itatu mugisubizo cyibitekerezo, bikavamo ubushishozi bwo hejuru. Ibinyuranye, HPMC hamwe nuburemere bwa molecular bufite umuyoboro wa molecseser hamwe na vino yo hepfo kubera iminyururu ya molekile. Kubwibyo, mugihe usaba, ni ngombwa cyane guhitamo HPMC hamwe nuburemere bukwiye bwo kugera ku ngaruka nziza za virusi.
(3) ingaruka z'ubushyuhe
Ubushyuhe nikintu cyingenzi kigira ingaruka kuri viscosiya igisubizo cya HPMC. Mugihe ubushyuhe bwiyongera, kugenda kwa molekile y'amazi bikanga kandi viscositity yumuti mubisanzwe igabanuka. Ni ukubera ko igihe ubushyuhe buzamutse, ubwisanzure bwinyungu za HPMC byiyongera kandi imikoranire iri hagati ya molekile iragabanya, bityo ikagabanya ubukuru bwigisubizo. Ariko, igisubizo cya HPMC kuva ibisimba bitandukanye cyangwa ibirango kubushyuhe birashobora no gutandukana, bityo imiterere yubushyuhe igomba guhinduka ukurikije ibisabwa.
(4) ingaruka za PH agaciro
HPMC ubwayo ni ikigo kitari ionic, kandi viscosiya igisubizo cyacyo cyumva impinduka muri PH. Nubwo HPMC yerekana ibintu bihamye byagaragaye muri aside icide cyangwa kutabogama, kwikebana no gukurura HPMC bizagira ingaruka mubidukikije bikabije cyangwa alkaline. Kurugero, munsi ya acide ikomeye cyangwa imiterere ikomeye ya alkaline, molekile ya HPMC irashobora kuba yarangiritse igice, bityo bigabanya ubukuru bwikibazo cyacyo.
3. Isesengura rya rohologiya ibiranga viccosity igisubizo cya HPMC
Imyitwarire yuburyo bwa HPMC yumuti wibitangaje mubisanzwe yerekana ibiranga amazi ya Newtonian, bivuze ko urusyo rwayo rudafitanye isano gusa nibintu byo gukemura hamwe nuburemere bwa moleki, ariko nuburemere bwa moleki, ariko nuburemere bwa moleki, ariko nuburemere bwa moleki, ariko nuburemere bwo gupfobya. Muri rusange, ku gipimo cy'iminsi mike, HPMC, yerekana ubushishozi bwo hejuru, mu gihe nk'ibipimo byo kwiyongera, vicosity iragabanuka. Iyi myitwarire yitwa "kogosha inkono" cyangwa "guhogosha" kandi ni ngombwa cyane mubisabwa byinshi bifatika. Kurugero, mubice birimo ibiparira, imyiteguro ya farumasi, gutunganya ibiryo, nibindi biranga inkombe bya HPMC birashobora kwemeza ko ubushyuhe bwo hejuru bubikwa mugihe gito cyane.
4. Ibindi bintu bireba viscosity igisubizo cya HPMC
(1) ingaruka z'umunyu
Kwiyongera k'umunyu (nka sodium chloride) birashobora kongera vicosity ya HPMC. Ni ukubera ko umunyu ushobora kuzamura imikoranire hagati ya molekile uhindura imbaraga za ionic zimbaraga, kuburyo molekile ya HPMC ikora imiterere yumuyoboro wuzuye, bityo bikongera urusobe rworoshye, yongera vino. Ariko, ingaruka zubwoko bwumunyu no kwibanda kuri viscozetity kandi bigomba guhindurwa ukurikije ibihe byihariye.
(2) ingaruka zizindi zinyongera
Ongeraho izindi nyandiko (nka surpacts, polymers, nibindi) kuri HPMC igisubizo cyibitangaza nacyo bizagira ingaruka kuri viszo. Kurugero, abarisiweho barashobora kugabanya visosity ya HPMC, cyane cyane iyo kwibanda kubagwa neza ari byinshi. Byongeye kandi, polymers zimwe cyangwa ibice birashobora kandi gusabana na HPMC kandi uhindure ibintu byimitima yumuti wacyo.
Ibiranga viscosity byahydroxypropyl methylcellse Igisubizo gitangaje kigira ingaruka kubintu byinshi, harimo kwibanda, uburemere bwa moleki, ubushyuhe bwa PH mubisanzwe bigaragarizanya ibintu bitari bishya bya Newtologiya, kandi bikoreshwa cyane mubyiciro bitandukanye nibikorwa bitandukanye nibikorwa bitandukanye nibikorwa bitandukanye nibikorwa bitandukanye ninganda ninganda. Gusobanukirwa no gutanga ibiranga viscosity bizafasha kunoza ikoreshwa rya HPMC muburyo butandukanye. Mubikorwa bifatika, ubwoko bwa HPMC bukwiye bwa HPMC bugomba gutorwa ukurikije ibikenewe byihariye kugirango babone ubuyobe bwiza na motelelogiya.
Igihe cyohereza: Werurwe-01-2025