HPMC (Hydroxypropyl Methylcellulose) ni selile ya nonionic selile ikoreshwa cyane muri farumasi, ibiryo, ubwubatsi no kwisiga. Ibyiciro bitandukanye bya HPMC byashyizwe mubikorwa ukurikije imiterere yimiti, imiterere yumubiri, viscosity, urwego rwo gusimbuza no gukoresha bitandukanye.
1. Imiterere yimiti nintera yo gusimburwa
Imiterere ya molekulire ya HPMC igizwe nitsinda rya hydroxyl kumurongo wa selile isimbuzwa imikorere ya hydroxypropoxy. Imiterere yumubiri na chimique ya HPMC iratandukanye bitewe nurwego rwo gusimbuza imikorere ya hydroxypropoxy. Urwego rwo gusimbuza rugira ingaruka zitaziguye, ubushyuhe bwumuriro nibikorwa bya HPMC. By'umwihariko:
HPMC ifite vitamine nyinshi ikunda kwerekana ubushyuhe bwo hejuru bwumuriro, ibyo bigatuma bikenerwa cyane nubushyuhe bukabije nko gutegura imiti irekuwe-irekura.
HPMC ifite hydroxypropoxy nyinshi ifite amazi meza, kandi uburyo bwo kuyasesa ntibwatewe nubushyuhe, bigatuma bukoreshwa ahantu hakonje.
Icyiciro cya Viscosity
Viscosity nimwe mubimenyetso byingenzi byurwego rwa HPMC. HPMC ifite ubunini bwinshi, kuva kuri centipoise nkeya kugeza kuri centipoise ibihumbi icumi. Urwego rwa viscosity rugira ingaruka kumikoreshereze yabyo itandukanye:
Ubukonje buke HPMC (nka 10-100 centipoise): Iki cyiciro cya HPMC gikoreshwa cyane mubisabwa bisaba ubukonje buke no gutembera cyane, nko gutwikisha firime, gufata ibinini, n'ibindi. Birashobora gutanga urugero runaka rwimbaraga zidafite ingaruka amazi meza yo kwitegura.
Hagati ya viscosity HPMC (nka 100-1000 centipoise): Bikunze gukoreshwa mubiribwa, kwisiga no gutegura imiti imwe n'imwe, birashobora gukora nk'ibyimbye kandi bigateza imbere imiterere n'ibicuruzwa.
Ubukonje bukabije HPMC (nko hejuru ya 1000 centipoise): Iki cyiciro cya HPMC gikoreshwa cyane mubisabwa bisaba ubukonje bwinshi, nka kole, ibifunga nibikoresho byubaka. Zitanga ubushobozi bwiza bwo kubyimba no guhagarika.
3. Imiterere yumubiri
Imiterere yumubiri ya HPMC, nko gukemuka, ubushyuhe bwa gelation, hamwe nubushobozi bwo gufata amazi, nayo iratandukanye nicyiciro cyayo:
Gukemura: HPMC nyinshi zifite imbaraga zo gukonjesha mumazi akonje, ariko gukomera biragabanuka uko mikorobe yiyongera. Ibyiciro bimwe byihariye bya HPMC birashobora kandi gushonga mumashanyarazi kama kubikorwa byihariye byinganda.
Ubushyuhe bwa Gelation: Ubushyuhe bwa HPMC mubisubizo byamazi buratandukanye nubwoko nibirimo. Muri rusange, HPMC ifite vitamine nyinshi ikunda gukora geles ku bushyuhe bwo hejuru, mugihe HPMC ifite hydroxypropoxy nyinshi yerekana ubushyuhe buke.
Hygroscopicity: HPMC ifite hygroscopique nkeya, cyane cyane amanota asimbuwe cyane. Ibi bituma biba byiza mubidukikije bisaba kurwanya ubushuhe.
4. Ahantu ho gusaba
Kuberako amanota atandukanye ya HPMC afite ibintu bitandukanye byumubiri nubumashini, ibyo bakoresha mubice bitandukanye nabyo biratandukanye:
Uruganda rwa farumasi: HPMC isanzwe ikoreshwa mububiko bwa tablet, imyiteguro irekura-irekura, ibifata, hamwe nubunini. Icyiciro cya farumasi HPMC igomba kuba yujuje ubuziranenge bwa farumasi, nka Reta zunzubumwe za Amerika Pharmacopoeia (USP), Pharmacopoeia yu Burayi (EP), nibindi.
Inganda zibiribwa: HPMC ikoreshwa nkibyimbye, emulifier, stabilisateur na firime yahoze. Icyiciro cyibiribwa HPMC isanzwe isabwa kuba idafite uburozi, uburyohe, impumuro nziza, kandi igomba kubahiriza amabwiriza yongeramo ibiryo, nkay'ubuyobozi bushinzwe ibiryo n'ibiyobyabwenge muri Amerika (FDA) hamwe n’ikigo cy’uburayi gishinzwe umutekano w’ibiribwa (EFSA).
Inganda zubwubatsi: Icyiciro cyubwubatsi HPMC ikoreshwa cyane mubikoresho bishingiye kuri sima, ibicuruzwa bya gypsumu hamwe nudukingirizo kugirango tubyibushye, tugumane amazi, amavuta kandi yongere imbaraga. HPMC yo mu byiciro bitandukanye bya viscosity irashobora kugira ingaruka kumikorere yibikoresho byubaka no gukora ibicuruzwa byanyuma.
5. Ibipimo ngenderwaho byubuziranenge
Ibyiciro bitandukanye bya HPMC nabyo bigengwa nubuziranenge bwamabwiriza atandukanye:
Urwego rwa farumasi HPMC: rugomba kuba rwujuje ibyangombwa bya farumasi, nka USP, EP, nibindi. Uburyo bwo kubyaza umusaruro nibisabwa kugenzura ubuziranenge ni byinshi kugirango umutekano wacyo urusheho kuba mwiza mugutegura imiti.
HPMC yo mu rwego rwibiryo: Igomba kubahiriza amabwiriza ajyanye n’inyongeramusaruro kugira ngo irinde umutekano mu biribwa. Ibihugu n'uturere dutandukanye birashobora kugira ibisobanuro bitandukanye kubiribwa byo mu rwego rwa HPMC.
Inganda zo mu rwego rwa HPMC: HPMC ikoreshwa mubwubatsi, gutwikira no mu zindi nzego mubisanzwe ntabwo ikeneye kubahiriza ibipimo byibiribwa cyangwa ibiyobyabwenge, ariko iracyakeneye kuba yujuje ubuziranenge bwinganda, nkibipimo bya ISO.
6. Umutekano no kurengera ibidukikije
HPMC y'ibyiciro bitandukanye nayo itandukanye mumutekano no kurengera ibidukikije. Imiti yo mu rwego rwa farumasi hamwe n’ibiribwa HPMC isanzwe isuzumwa rikomeye ryumutekano kugirango barebe ko ntacyo byangiza umubiri wumuntu. Ku rundi ruhande, HPMC yo mu rwego rw’inganda, yita cyane ku kurengera ibidukikije no kwangirika kwayo mu gihe cyo kugabanya ingaruka ku bidukikije.
Itandukaniro riri hagati y amanota atandukanye ya HPMC rigaragarira cyane cyane muburyo bwa shimi, ubwiza, imiterere yumubiri, ahantu hashyirwa mubikorwa, ubuziranenge numutekano. Ukurikije ibisabwa byihariye bisabwa, guhitamo icyiciro gikwiye cya HPMC birashobora kuzamura cyane imikorere nubuziranenge bwibicuruzwa. Mugihe ugura HPMC, ibi bintu bigomba gusuzumwa byuzuye kugirango harebwe niba ibicuruzwa byakoreshwa neza.
Igihe cyo kohereza: Kanama-20-2024