Ni izihe ngaruka za HPMC?

Hydroxypropyl methylcellulose (HPMC)ni imiti isanzwe ikoreshwa cyane munganda nyinshi nkubwubatsi, imiti, ibiryo na cosmetike. Nubwo, nubwo HPMC ifite ibintu byinshi byiza cyane, nko kubyimba, emulisile, gukora firime, hamwe na sisitemu ihagarikwa ihamye, ifite kandi ibibi kandi bigarukira.

1. Ibibazo byo gukemura

Nubwo HPMC ishobora gushonga mumazi hamwe na solge zimwe na zimwe, ibishishwa byayo bigira ingaruka kubushyuhe. Ihita gahoro gahoro mumazi akonje kandi isaba gukurura bihagije kugirango ishonga burundu, mugihe ishobora gukora gel mumazi yubushyuhe bwinshi, bigatuma itatana kimwe. Ibi biranga bishobora kuzana ibintu bimwe na bimwe mubintu bimwe na bimwe byakoreshwa (nk'ibikoresho byo kubaka na farumasi), kandi inzira zidasanzwe zo gusesa cyangwa inyongeramusaruro zirasabwa kugira ngo ingaruka ziseswa.

2. Igiciro kinini

Ugereranije nibintu bisanzwe cyangwa ibihimbano, ikiguzi cya HPMC kiri hejuru. Bitewe nuburyo bugoye bwo gutegura, burimo intambwe nyinshi nka etherification no kwezwa, igiciro cyacyo kiri hejuru yizindi ntera, nka hydroxyethyl selulose (HEC) cyangwa carboxymethyl selulose (CMC). Iyo ushyizwe kumurongo munini, ibiciro bishobora guhinduka impamvu yingenzi yo kugabanya imikoreshereze yabyo.

3. Byatewe nagaciro ka pH

HPMC ifite ituze ryiza mubihe bitandukanye bya pH, ariko irashobora kwangirika mubihe bya pH bikabije (nka acide ikomeye cyangwa base base), bikagira ingaruka kubyimbye no gutuza. Kubwibyo, ikoreshwa rya HPMC rishobora kugarukira mubintu bimwe na bimwe bisaba ibintu bya pH bikabije (nka sisitemu yihariye yo kuvura imiti).

4. Ibinyabuzima bigarukira

Nubwo HPMC ifatwa nkibikoresho bitangiza ibidukikije, biracyatwara igihe kirekire kugirango ibe ibinyabuzima rwose. Mubidukikije, igipimo cyo kwangirika kwa HPMC kiratinda, gishobora kugira ingaruka runaka kubidukikije. Kubisabwa hamwe nibisabwa byo kurengera ibidukikije byinshi, kwangirika kwa HPMC ntibishobora kuba amahitamo meza.

5. Imbaraga nke za mashini

Iyo HPMC ikoreshwa nkibikoresho bya firime cyangwa gel, imbaraga zayo zikoreshwa ni nke kandi byoroshye kumeneka cyangwa kwangiza. Kurugero, muruganda rwa farumasi, mugihe HPMC ikoreshwa mugukora capsules, ifite ubukana buke ugereranije na gelatine capsules, kandi ikibazo cyintege nke gishobora kugira ingaruka kumutekano wo gutwara no guhunika. Mu nganda zubaka, iyo HPMC ikoreshwa nkibyimbye, nubwo ishobora guteza imbere ifatizo rya minisiteri, ifite uruhare ruto mumbaraga zikoreshwa mubicuruzwa byanyuma.

6. Hygroscopicity

HPMC ifite urwego runaka rwa hygroscopicite kandi ikurura byoroshye ubuhehere ahantu h’ubushyuhe bwinshi, bushobora kugira ingaruka kumikorere. Kurugero, mubiribwa cyangwa imyiteguro yibiyobyabwenge, kwinjiza amazi bishobora gutera ibinini byoroshe kandi bigahinduka mubikorwa byo gusenyuka, bityo bikagira ingaruka kumiterere yibicuruzwa. Kubwibyo, mugihe cyo kubika no gukoresha, ubushuhe bwibidukikije bugomba kugenzurwa kugirango imikorere yabyo itangirika.

7. Ingaruka kuri bioavailable

Mu nganda zimiti, HPMC ikoreshwa mugutegura ibinini bisohoka-bigenzurwa-bigasohoka, ariko birashobora kugira ingaruka kumyitwarire yimiti. Kurugero, kumiti ya hydrophobique, kuba HPMC irashobora kugabanya umuvuduko wo gusesa imiti mumubiri, bityo bikagira ingaruka kuri bioavailable. Kubwibyo, mugihe hateguwe imiti, ingaruka za HPMC mugusohora ibiyobyabwenge zigomba gusuzumwa neza, kandi nibindi bisabwa birashobora gusabwa kugirango ibiyobyabwenge bigerweho neza.

8. Guhagarara neza

HPMC irashobora gutesha agaciro cyangwa guhindura imikorere mubushyuhe bwinshi. Nubwo HPMC ihagaze neza mubushyuhe rusange, irashobora gutesha agaciro, guhindura ibara, cyangwa kwangirika mubikorwa byubushyuhe burenze 200 ° C, ibyo bikaba bigabanya imikoreshereze yubushyuhe bwo hejuru. Kurugero, mubikorwa bimwe na bimwe bya plastiki cyangwa reberi, HPMC idahagije yubushyuhe irashobora gutuma igabanuka ryibicuruzwa.

9. Ibibazo byo guhuza nibindi bikoresho

Mugutegura porogaramu, HPMC irashobora kwitwara nabi hamwe na surfactants zimwe na zimwe za cationic cacique cyangwa ion yihariye yicyuma, bikaviramo guhungabana cyangwa guhuza igisubizo. Iki kibazo cyo guhuza gishobora kugira ingaruka kumiterere no kugaragara kwibicuruzwa byanyuma mubisabwa bimwe na bimwe (nka cosmetike, imiti cyangwa ibisubizo byimiti), bisaba kwipimisha guhuza no guhitamo neza.

NubwoHPMCni ibikoresho bikoreshwa cyane hamwe no kubyibuha cyane, gukora firime no gutuza, bifite kandi ibibi nko gukemuka guke, kugiciro cyinshi, ibinyabuzima bigabanuka, imbaraga nke za mashini, hygroscopique ikomeye, ingaruka zo kurekura ibiyobyabwenge, no kurwanya ubushyuhe buke. Izi mbogamizi zishobora kugira ingaruka ku ikoreshwa rya HPMC mu nganda zimwe na zimwe. Kubwibyo, mugihe uhisemo HPMC nkibikoresho fatizo, birakenewe ko dusuzuma byimazeyo ibyiza byayo nibibi byayo hanyuma ukabitezimbere hamwe nibisabwa bikenewe.