Ubushakashatsi bwamagambo ya HydroxyPropyl Methylcellse (HPMC) sisitemu yingenzi yo gusobanukirwa imyitwarire yabo muburyo butandukanye, kuva muri farumasi kubiryo no kwisiga. HPMC ni selile Ether Gusiga Byakoreshejwe cyane nkumukozi wijimye, Stabilizer, na Emulsifier bitewe nubushobozi bwayo bwo guhindura ibintu byimiterere no guhagarikwa.
1.Kupirwa:
Viscosity nimwe mubintu byimiterere yibanze byibasiye muri sisitemu ya HPMC. Ubuhanga butandukanye nka rotaitational viscomettry, capillary villarantry, na oscillatory rhemetry ikoreshwa mugupima viscosiya.
Ubu bushakashatsi bwahinduye ingaruka zibintu nka HPMC yibanda kuri HPMC, uburemere bwa molecular, urwego rwo gusimbuza, ubushyuhe, nubushyuhe, hamwe nigitero cyamashanyarazi kuri vino.
Gusobanukirwa visosity ni ngombwa kuko igena imyitwarire igenda, ituze, hamwe na porogaramu ya sisitemu ya HPMC yihuta.
Imyitwarire yoroheje:
Ibisubizo bya HPMC mubisanzwe byerekana imyitwarire inanutse, bivuze ko viscometike yabo igabanuka hamwe no kongera umubare munini.
Inyigisho zuburyo ujye mu rugero rwo gufungura inkombe no kwishingikiriza ku bintu nka Polymer kwibanda n'ubushyuhe.
Kuranga imyitwarire yoroheje ni ngombwa kubisabwa nkibikoresho no kumeneka, aho bitemba mugihe cyo gusaba no gushikama nyuma yo gusaba.
3.Umurongo:
Thixotropy bivuga kugarura ubushyuhe nyuma yo kuvanaho guhagarika imihangayiko. Sisitemu nyinshi za HPMC zerekana imyitwarire ya Thixotropic, zikaba ari nziza muri porogaramu zisaba igenzurwa no gutuza.
Ubushakashatsi bwamagambo burimo gupima ikirego cya sccosity mugihe nyuma yo kugandukira sisitemu yo guhangayika.
Gusobanukirwa Thixtropy bisobanura mugutegura ibicuruzwa nkamashusho, aho hashingiwe mugihe cyo kubika no koroshya gusaba ari ngombwa.
4.Gusohora:
Mugihe kinini cyangwa hamwe nibishyingo byihariye, ibisubizo bya HPMC birashobora gukorerwa pelation, gukora imiterere.
Inyigisho zuburyo zikora iperereza kumyitwarire ya gelateri yerekeye ibintu nkibitekerezo, ubushyuhe, na pH.
Ubushakashatsi bwa Geelation ni ngombwa mu gushushanya ibiyobyabwenge byakomeje gushishikarizwa no gukora ibicuruzwa bishingiye kuri Gel mu biribwa no kwita ku buryo bwita ku giti cyabo.
IBIKORWA BYANCU:
Tekinike nk'inguni ntoya X-ray itatanye (sax) na rheo-sax itanga ubushishozi mu miterere ya sisitemu ya HPMC.
Ubu bushakashatsi bugaragaza amakuru yerekeye Urunigi rwa Polymer, imyitwarire rusange, n'imikoranire hamwe na molekile.
Gusobanukirwa ibintu byubaka bifasha mu guhanura imyitwarire yubwoko bwa macroscopique no guhitamo imiterere kubintu byifuzwa.
6.Gusinic isesengura rya mashini (DMA):
DMA ipima imitungo ya viscoelastique yibikoresho munsi yuburinganire bwa oscillatory.
Ubushakashatsi bwamagambo akoresheje DMA Elucidate nka Modulus (G '), Gutakaza Modulus (G "), hamwe na virusi itera imikorere nkimikorere.
DMA ni ingirakamaro cyane kubiranga imyitwarire ikomeye na fluid nka gels na paste.
7.Gusaba-Ubushakashatsi bwihariye:
Ubushakashatsi bwamagambo bujyanye nibisabwa byihariye nkibinini bya farumasi, aho hpmc ikoreshwa nka farur, cyangwa mubicuruzwa nkibisobe no kwambara, aho bikora nkumubyimbakazi.
Ubu bushakashatsi bwerekana uburyo bwa HPMC kubikorwa byifuzwa, imiterere, hamwe nubukungu bwa Shelf, kubungabunga ibicuruzwa no kwemerwa nabaguzi.
Inyigisho zuburyo zigira uruhare runini mugusobanukirwa imyitwarire igoye ya sisitemu ya HPMC Thickener. Mu rwego rwo gusenya indwara, yoroheje, thixotropy, pelation ibiranga imiterere, n'imitungo yihariye, ubwo bushakashatsi bworohereza igishushanyo mbonera hamwe n'inganda zishingiye kuri HPMC mu nganda zitandukanye.
Igihe cya nyuma: Gicurasi-10-2024