HydroxyPropyl Methylcellsellse (HPMC) ni polymer itandukanye ifite porogaramu nini mu nganda zinyuranye, zirimo imiti, ibiryo, kubaka, no kwisiga. Mugihe usuzumye imitungo yayo yubushyuhe, ni ngombwa gucengera mu myitwarire yayo kubyerekeye ubushyuhe, ubushyuhe bwumuriro, hamwe nibintu byose bifitanye isano.
Umutekano wubushyuhe: HPMC yerekana umutekano mwiza wubushyuhe hejuru yubushyuhe bugari. Mubisanzwe kubora ubushyuhe bwo hejuru, mubisanzwe hejuru ya 200 ° C, bitewe nuburemere bwayo, urwego rwo gusimbuza, nibindi bintu. Inzira yo gutesha agaciro ikubiyemo ibyatsi bya clavio ya selile ya selile no kurekura ibicuruzwa bihindagurika bihindagurika.
Ubushyuhe bwinzibacyuho (TG): Nka polymers nyinshi, HPMC ihura ninzibacyuho yikirahure kuva ku kigega kuri reberi ya rubbery ifite ubushyuhe. TG ya HPMC iratandukanye bitewe nurwego rwo gusimbuza, uburemere bwa moleki, nubushuhe. Mubisanzwe, ikomoka kuri 50 ° C kugeza 190 ° C. Hejuru ya TG, HPMC ihinduka cyane kandi igaragaza ko yiyongereyeho molecular.
Gushonga Ingingo: HPMC yera ntabwo ifite aho ihindagurika kuko ari polymer. Ariko, yoroshye kandi irashobora gutemba ahantu hazamuwe. Kuba hari inyongera cyangwa umwanda birashobora kugira ingaruka kumyitwarire yayo yashonga.
Imyitwarire yubushyuhe: HPMC ifite imyitwarire miremire ugereranije nubyuma nibindi bindi polymers. Uyu mutungo utuma ukwiranye na porogaramu isaba ubushyuhe, nko mu binini bya farumasi cyangwa ibikoresho byo kubaka.
Kwagura ikirere: Kimwe polymers nyinshi, HPMC yaguye mugihe ashyushye kandi amasezerano mugihe yakonje. Coeefficient yo Kwagura Ubushyuhe (Cte) ya HPMC biterwa nibintu nkibihe bya kumiti no gutunganya. Mubisanzwe, ifite cte mu ntera ya 100 kugeza 300 ppm / ° C.
Ubushobozi bwubushyuhe: Ubushobozi bwubushyuhe bwa HPMC buterwa nuburyo bwa molecular, urwego rwo gusimbuza, nubushuhe. Mubisanzwe bingana na 1.5 kugeza 2.5 j / g ° c. Impamyabumenyi yo hejuru yo gusimbuza no kwishumba zikunda kongera ubushobozi bwubushyuhe.
Ubushyuhe butangaje: Iyo uhuye nubushyuhe bwinshi mugihe kirekire, HPMC irashobora gutesha agaciro ubushyuhe. Iyi nzira irashobora kuvamo impinduka mumiterere ya foto yimiti, biganisha ku gutakaza imitungo nka viscozetity nimbaraga zubukanishi.
Ubushyuhe bworoshye: HPMC irashobora guhindurwa kugirango yongere imishinga yubushyuhe kubisabwa byihariye. Kwinjiza abazunguzi cyangwa inyongeramusaruro, nkibice byamazi cyangwa karubone nanotubes, birashobora guteza imbere imitungo yo kwimura ubushyuhe, bigatuma iba ingirakamaro mu bubiko bwubushyuhe.
Porogaramu: Gusobanukirwa imiterere yubushyuhe bwa HPMC ni ngombwa kugirango utezimbere ikoreshwa muburyo butandukanye. Muri farumasi, ikoreshwa nka bunder, film yabanje, kandi ihamye-irekurwa mu mukozi wa Tablet. Mu kubaka, bikoreshwa mu bikoresho bishingiye ku bya sima kugira ngo binoze ibikorwa, kumenyekana, no kugumana amazi. Mu biryo no kwisiga, bikora nk'igituba, Stabilizer, na Emulsifier.
HydroxyPropyl MethylcellllAlose (HPMC) yerekana imiterere yimiterere yubushyuhe bukwirakwira kubisabwa bitandukanye munganda. Ubushyuhe bwayo, ubushyuhe bwinzibacyuho, imikorere yubushyuhe, nibindi biranga bigira uruhare runini mugukurikiza imikorere yacyo mubidukikije nibidukikije. Gusobanukirwa ibi bintu ni ngombwa kugirango ukore neza HPMC mubicuruzwa nibikorwa bitandukanye.
Igihe cyo kohereza: Gicurasi-09-2024