Hydroxypropyl methylcellulose (HPMC) ni polymer itandukanye kandi ikoreshwa muburyo butandukanye mu nganda zitandukanye, harimo imiti, ibiryo, ubwubatsi, no kwisiga. Iyo usuzumye imiterere yubushyuhe bwayo, ni ngombwa gucengera mu myitwarire yayo yerekeranye n’imihindagurikire y’ubushyuhe, ihindagurika ry’ubushyuhe, hamwe n’ibintu byose bifitanye isano.
Ubushyuhe bwumuriro: HPMC yerekana ubushyuhe bwiza bwubushyuhe hejuru yubushyuhe bwagutse. Mubisanzwe ibora kubushyuhe bwinshi, mubisanzwe hejuru ya 200 ° C, bitewe nuburemere bwa molekile, urugero rwo gusimburwa, nibindi bintu. Igikorwa cyo kwangirika kirimo gukuramo umugongo wa selile no kurekura ibicuruzwa byangirika.
Ubushyuhe bwikirahure (Tg): Kimwe na polymers nyinshi, HPMC ihura nikirahure kiva mubirahuri kijya kuri rubberi hamwe nubushyuhe bwiyongera. Tg ya HPMC iratandukanye bitewe nurwego rwayo rwo gusimbuza, uburemere bwa molekile, hamwe nubushuhe. Muri rusange, kuva kuri 50 ° C kugeza kuri 190 ° C. Hejuru ya Tg, HPMC ihinduka kandi ikagaragaza umuvuduko wa molekile.
Gushonga Ingingo: HPMC itanduye ntabwo ifite aho ishonga kuko ni polymer amorphous. Ariko, iroroshya kandi irashobora gutemba mubushyuhe bwo hejuru. Kuba hari inyongeramusaruro cyangwa umwanda birashobora kugira ingaruka kumyitwarire yayo.
Ubushyuhe bwa Thermal: HPMC ifite ubushyuhe buke ugereranije nubutare hamwe nizindi polymers. Uyu mutungo utuma uboneka mubisabwa bisaba ubushyuhe bwumuriro, nko mubinini bya farumasi cyangwa ibikoresho byubaka.
Kwiyongera k'ubushyuhe: Kimwe na polymers nyinshi, HPMC yaguka iyo ishyushye kandi igasezerana iyo ikonje. Coefficient yo kwagura ubushyuhe (CTE) ya HPMC biterwa nibintu nkibigize imiti nuburyo bwo gutunganya. Mubisanzwe, ifite CTE murwego rwa 100 kugeza 300 ppm / ° C.
Ubushobozi bwubushyuhe: Ubushyuhe bwa HPMC buterwa nuburyo bwimiterere ya molekile, urugero rwo gusimbuza, hamwe nubushuhe. Ubusanzwe iri hagati ya 1.5 na 2,5 J / g ° C. Impamyabumenyi zo hejuru zo gusimbuza hamwe nubushuhe bikunda kongera ubushyuhe.
Kugabanuka k'ubushyuhe: Iyo uhuye n'ubushyuhe bwo hejuru mugihe kirekire, HPMC irashobora kwangirika k'ubushyuhe. Iyi nzira irashobora kuvamo impinduka mumiterere yimiti, biganisha ku gutakaza imitungo nkubukonje nimbaraga za mashini.
Gutezimbere Ubushyuhe Bwubushyuhe: HPMC irashobora guhindurwa kugirango yongere imbaraga zumuriro kubisabwa byihariye. Kwinjizamo ibyuzuza cyangwa inyongeramusaruro, nk'ibice by'ibyuma cyangwa karubone ya karubone, birashobora kunoza uburyo bwo kohereza ubushyuhe, bigatuma bikenerwa no gukoresha amashyanyarazi.
Porogaramu: Gusobanukirwa nubushyuhe bwa HPMC ningirakamaro mugutezimbere imikoreshereze yabyo mubikorwa bitandukanye. Muri farumasi, ikoreshwa nka binder, firime yahoze, hamwe nogukomeza-kurekura muburyo bwa tablet. Mu bwubatsi, bukoreshwa mubikoresho bishingiye kuri sima kugirango bitezimbere imikorere, gufatira hamwe no gufata amazi. Mu biryo no kwisiga, ikora nk'ibyimbye, stabilisateur, na emulifier.
Hydroxypropyl methylcellulose (HPMC) yerekana ibintu bitandukanye byubushyuhe butuma bikoreshwa muburyo butandukanye mu nganda. Ubushyuhe bwumuriro, ubushyuhe bwikirahure, ubushyuhe bwumuriro, nibindi biranga bigira uruhare runini muguhitamo imikorere yabidukikije hamwe nibisabwa. Gusobanukirwa iyi mitungo ningirakamaro mugukoresha neza HPMC mubicuruzwa bitandukanye.
Igihe cyo kohereza: Gicurasi-09-2024