HPMC iri mu nganda za farumasi?

HydroxyPropylmethylcellcellCellCellsells (HPMC) ni polymer nyinshi ikoreshwa cyane mubikorwa byimiti. Ni uw'umwirondoro wa selile kandi ukomoka kuri selile karemano. HPMC irimo kuvura selile hamwe na proflene okiside na methyl chloride, bikaviramo ibice byinshi byoroheje nibindi bintu byifuzwa. Iyi mikarasi yimiti ikoreshwa cyane mugutezimbere no gukora impapuro zitandukanye za dosiye, harimo na tablets, captsules, imyiteguro ya Ophthalimic kandi igenzurwa-sisitemu yo gutanga ibiyobyabwenge.

Intangiriro kuri HydroxyPropyl Methylcellse:

Imiterere yimiti numutungo:

HydroxyPropyl MethylcellALese ni igice cya kabiri, inert, polymer-yashonze amazi. Imiterere yayo ya fotoimique ikubiyemo hydroxyPropyl na Methoxspes bifatanye na selile ya selile. Umubare wabasimbuye urashobora gutandukana, bivamo amanota atandukanye ya HPMC ifite ibintu bitandukanye. Uburyo bwo gusimbuza bugira ingaruka ku bipimo nka viscosiya, kukesha, na Gel imitungo.

Inganda Inganda:

Umusaruro wa HPMC urimo gutandukanya selile hamwe na proplene okiside na methyl chloride. Urwego rwo gusimbuza (DS) rwa HydroxyPropyl na Methoxy opexsroppopyle na Methoxy ope muri Synthesi, bemerera ubudozi bwa HPMC ibisabwa byibiyobyabwenge byihariye.

Gusaba mu nganda za farumasi:

Guhuza muri tablet forent:

HPMC ikoreshwa cyane nka bunder muri tablet. Guhuza imiterere yabyo infashanyo igabanya ifu mubisate bikomeye. Kugenzurwa Kurekura Ibikoresho bifatika bya Farumasi (APIS) birashobora kugerwaho ukoresheje amanota yihariye ya HPMC hamwe na viscosity hamwe ninzego zisimburwa.

Umukozi wo gutoranya film:

HPMC ikoreshwa nkumukozi wa firime mubinini bya tableti na granules. Itanga ipfundo riringinga rizamura isura, uburyohe buryohe kandi butuje muburyo bwo gutanga dosiye. Byongeye kandi, amakoti ashingiye kuri HPMC arashobora kunezeza imyirondoro yo kurekura ibiyobyabwenge.

ISOHOTSE KANDI YASUBIZA:

Imiterere ya hydrophilic yiyi polymer ituma ikwiye gukoresha muburyo burambye - kandi igenzurwa-kurekura. Matrix ya HPMC yemerera kurekurwa ibiyobyabwenge hejuru yigihe kinini, kunoza kubahiriza no kugabanya inshuro zangiza.

Imyiteguro ya Ophthalmic:

Mu majwi, HPMC ikoreshwa mu kongera ubuyobe z'ijisho ritonyanga, bityo itanga igihe kirekire cyo gutura kuri ocular. Ibi byongera ibinyabuzima byabatiowayi nubuvuzi.

Stickening Stabilizer:

HPMC ikoreshwa nkuwabyimbye kandi stabilizer mumazi na kimwe cya kabiri nka gels, amavuta no guhagarikwa. Itanga iyerekwa kuri aya mafranga kandi itezimbere ibintu byabo muri rusange.

Ibintu by'ingenzi bya HPMC:

Kudashoboka:

HPMC irashonje mumazi kandi ikora igisubizo gisobanutse, gifite ibara. Igipimo cyo gusesa kigira ingaruka kurwego rwo gusimbuza no gutsinda.

Vicosity:

Ibyamamare bya HPMC ibisubizo birakomeye muguhitamo imikorere yabo muburyo butandukanye. Amanota atandukanye arahari hamwe nisukari zitandukanye, yemerera igenzura neza yimitungo ya motelelogiya.

Ingano yubushyuhe:

Impamyabumenyi zimwe za HPMC yerekana imitungo ya thermogell, ikora geles yubushyuhe bwo hejuru. Uyu mutungo ukoreshwa mugutezimbere ubushyuhe.

Guhuza:

HPMC irahuye nintera nini ya farumasi na apis, bituma bihitamo bwa mbere kubamuburira. Ntabwo yitwara cyangwa ikatesha agaciro ibintu byinshi bikora.

INGORANE n'ibitekerezo:

Hygroscopique:

HPMC ni hygroscopique, bivuze ko ikurura ubushuhe kubidukikije. Ibi bigira ingaruka kumutekano no kugaragara kwa forelation, bityo ibintu bikwiye byo kubika.

Guhuza nabandi bababaye:

Nubwo muri rusange bihuye, abamushinyagurira bakeneye gusuzuma guhuza HPMC hamwe nabandi bantu kugirango birinde imikoranire ishobora kugira ingaruka kumikorere yo kurengera.

Ingaruka kuri umurongo wo gusenyuka:

Guhitamo amanota ya HPMC birashobora guhindura cyane umwirondoro wo gusebanya wibiyobyabwenge. Formulator igomba guhitamo yitonze amanota akwiye kugirango ugere ku biranga wifuza.

Ibitekerezo byo kugenzura:

HPMC yemerwa cyane nkicyicaro cyiza kandi cyiza. Ihura nubuziranenge butandukanye kandi bukubiye muri PharmacoPOEIAs kwisi yose. Abakora bagomba kubahiriza imikorere myiza yo gukora (GMP) kugirango ireme ireme kandi rihuze nibicuruzwa birimo HPMC.

Mu gusoza:

HydroxyPropylmethylcellCellCellsellsellsellsellsells (HPMC), nkigihanganye kandi ikoreshwa cyane cyane, igira uruhare runini mubikorwa byimiti. Umutungo wacyo wihariye utuma ukwiye gukoresha muburyo butandukanye bwo gutanga dosiye, harimo ibinini, capsules no kwitegura. Abashinzwe kungukirwa no gushobora guhuza imiterere ya HPMC kugirango bahuze ibisabwa byihariye, nko kugenzurwa no gutura neza. Nubwo hari ibibazo byinshi, HPMC ikomeje ibintu byingenzi mugutezimbere ibicuruzwa byimiti yo mu rwego rwo hejuru, bigira uruhare mu mutekano ndetse no gukora neza mu biyobyabwenge byinshi.