HydroxyPropyl MethylcellllALese (HPMC) ni polymer itandukanye ibona ibyifuzo byinshi mu nganda zitandukanye, harimo imiti, ibiryo, kubaka, no kwisiga. Umutungo wacyo wihariye utanga ntangarugero mubikorwa bisaba guhindura visositines, gushiraho firime, guhuza, no kuzamura umutekano. Gusobanukirwa ibigize, imikorere yinganda, imitungo, hamwe na HPMC ni ngombwa kugirango bikoreshwe neza.
1.Abavuganyo ya HPMC
HPMC ni polymer ya kimwe cya kabiri yakomotse kuri selile, muburyo busanzwe buboneka mu nkuta zugari ibimera. Inzira yo gukora ikubiyemo kuvura selile hamwe na alkali kugirango itange selile ya alkali, ikurikiwe no guta agaciro hamwe na proglene okiside na methyl chloride. Iyi miti yo guhindura imiti mugutangiza hydroxyproppeproppopy na progaramu ya selile ya selile, atanga hpmc.
Urwego rwo gusimbuza (DS) rwa HydroxyPropyl na Methaxproppopy na Methoxspe igena imitungo ya HPMC, harimo no kwishyurwa, pelation, hamwe nibiranga filmi. Mubisanzwe, amanota ya HPMC afite indangagaciro za DS zisumbuye zimurika kwiyongera mubibazo byamazi no kuzamura ibikorwa bya pelance.
2.Poperties ya HPMC
Amazi yonyine: HPMC irashonje mumazi akonje, ikora ibisubizo bisobanutse, viscous. Kwikeba birashobora gutunganizwa no guhindura urwego rwo gusimbuza, uburemere bwa molekiri, nubushyuhe.
Gushiraho firime: HPMC irashobora gukora firime zitoroshye kandi ziboneye kuruma. Izi firime zifite inzitizi nziza, bigatuma bakwiranye no guhinga muri farumasi n'inganda zibiribwa.
Guhindura vicosity: HPMC yerekana imyitwarire ya pseudoplastique, aho ubuswa bwayo bugabanuka hamwe no kongera umubare munini. Uyu mutungo ukoreshwa muburyo butandukanye kugirango ugenzure imyitwarire yo gutembera no kuranga imiterere.
Umutekano mu bushyuhe: HPMC yerekana ko ituje hejuru yubushyuhe bwinshi, bigatuma habaho gusaba bisaba gutunganya ubushyuhe cyangwa guhura nubushyuhe bwo hejuru.
Impeta za chimique: HPMC ni inert ya chimique, ihujwe nurugero runini rwibishyingo, abababaye, nibikoresho bifatika bikoreshwa mubutaka nibiryo.
3.SYNTHESIS ya HPMC
Synthesis ya HPMC ikubiyemo intambwe nyinshi:
Kuvura alkali: Ubugari bwa Alkali buvurwa na Alkali, nka sodium hydroxide, kugirango utanga selile ya alkali.
Guhangana: Ubugari bwa Alkali bwakozwe hamwe na propaylene oxide kugirango itangire amatsinda ya hydroxyPropyl kuri selile.
Ubwicanyi: HydroxyPropyeepyelatedy irafatwa cyane na methyl chloride kugirango itangire amatsinda, atanga hpmc.
Gusukura: HPMC yavuyemo isukurwa kugirango ikureho ibicuruzwa numwanda, kubungabunga ubuziranenge bwibicuruzwa no guhoraho.
4.Abakiriya ba HPMC
Inganda za farumasi: HPMC ikoreshwa cyane nka farumasi ya farumasi muri tablet itunganijwe, aho ikorera muri binder, idashidikanywaho, kandi igenzurwa-agenzurwa. Irakoreshwa kandi muburyo bwa Ophthalmic, amavuta yo hejuru, hamwe no guhagarikwa mu kanwa bitewe na biocompaStation na mucoadies.
Inganda zibiribwa: Mu nganda zibiribwa, HPMC ikora nk'igituba, stilizer, na emalisarier mubicuruzwa bitandukanye, harimo isosi, imyambarire, nubundi buryo bwamata. Irakoreshwa kandi mu guteka ku buntu ku buntu nk'agatsiko k'amabanga kandi ubuhehere.
Inganda zubwubatsi: HPMC ni ikintu cyingenzi muri minisiteri ishingiye kuri sima, inzarani, hamwe no gucogora. Itezimbere imikorere, ihagarikwa ry'amazi, no kumeneka, kugira uruhare mu mikorere rusange no kuramba by'ibikoresho by'ubwubatsi.
Ibicuruzwa byita ku muntu: HPMC yinjijwe mu kwisiga, ibicuruzwa byo ku buhunyu, n'ibicuruzwa byo mu buhungiro, n'ibikoresho byo kwita ku misatsi kubijyanye na firime, kubyimba, no guhimba imitungo. Itanga imiterere yifuzwa, ituze, hamwe nubwumvikane buranga amavuta, amavuta, na gels.
Guhangana no gupakira: Amavuta ashingiye kuri HPMC akoreshwa mubinini bya farumasi na capsules kugirango bigerweho, mask uburyohe, kandi utange uburinzi buhebuje. Filime ya HPMC nayo ikoreshwa mu gupakira ibiryo nkibirori byoroshye cyangwa inzitizi zo kurwanya ubushuhe na ogisijeni.
HydroxyPropyl MethylcellllAlose (HPMC) ni polymer yo mu mibereho myinshi ifite porogaramu zinyuranye mu nganda. Ubusanzwe guhuza imitungo, harimo no kwishyurwa n'amazi, gushiraho filime, guhinduranya virusi, hamwe no gutandukanya imiti, bituma ntangarugero muri faruceticals, ibiryo, kubaka, hamwe nibicuruzwa byitaweho. Gusobanukirwa ibigize, Synthesis, imitungo, hamwe na HPMC ni ngombwa kugirango abamushite n'abakora bashake gukoresha inyungu zayo mugutezimbere ibicuruzwa no guhanga udushya.
Akamaro ka HPMC iri mubihe bitandukanye, imikorere, nintererano yo kuzamura imikorere, gushikama, hamwe nibiranga ibicuruzwa byinshi mumirenge itandukanye, bikaba ibintu bifite akamaro mubijyanye na porogaramu.
Igihe cyagenwe: Feb-29-2024