Hydroxypropyl methylcellulose ni iki?

Hydroxypropyl methylcellulose (HPMC)ni amazi ashonga polymer yashizwemo na chimique ihindura molekile ya selile. Ihuza imiterere karemano ya selile hamwe nimikorere yahinduwe, ifite amazi meza yo gukemura, guhinduranya ibishishwa hamwe no gukora firime, kandi ikoreshwa cyane mubuvuzi, kwisiga, ubwubatsi, ibiryo nibindi bice. Ikiganiro cyo kumenya niba ari igisubizo gikeneye gutandukanya ibikorwa byihariye hamwe nimiterere mubice bitandukanye.

Imiterere yimiti nibiranga hydroxypropyl methylcellulose

HPMC itegurwa no kwinjiza amatsinda abiri asimbura, hydroxypropyl (–CH2CH (OH) CH3) na methyl (–CH3), mubice bya glucose ya molekile ya selile. Molekile ya selile ubwayo ni polysaccharide yumunyururu muremure igizwe na molekile nyinshi β-D-glucose ihujwe na β-1,4-glycosidic, kandi itsinda ryayo hydroxyl (OH) rishobora gusimburwa nitsinda ryimiti itandukanye, ritezimbere cyane imiterere yaryo.

Mugihe cyo gukora synthesis, methylation ituma molekile ya selile irusha lipofilique, mugihe hydroxypropylation ituma amazi yoroha. Binyuze muri ubwo buryo bubiri, HPMC ihinduka polymer ihindagurika ishobora gushonga mumazi.

Gukemura no gukora bya HPMC

HPMC ifite ubushobozi bwo gukemura neza mumazi, cyane cyane mumazi ashyushye. Mugihe ubushyuhe buzamutse, igipimo cyo gusesa no gukomera biziyongera. Ariko, HPMC ubwayo ntabwo isanzwe "solvent", ariko ikoreshwa nkigishishwa cyangwa ikibyimbye. Mu mazi, irashobora gukora igisubizo cya colloidal binyuze mumikoranire ya molekile y'amazi, bityo igahindura ubwiza na rheologiya yumuti.

Nubwo HPMC ishobora gushonga mumazi, ntabwo ifite imiterere ya "solvent" mubisanzwe. Umuti usanzwe ni amazi ashobora gushonga ibindi bintu, nk'amazi, alcool, ketone cyangwa ibindi bimera. Iseswa rya HPMC ubwaryo mumazi nibyinshi mubikorwa bikora kugirango ubyimbye, gele na firime.

Imirima ikoreshwa ya HPMC

Urwego rwubuvuzi: HPMC ikoreshwa nkibikoresho byangiza imiti, cyane cyane mugutegura impapuro zifatika zo mu kanwa (nka tableti na capsules), zikoreshwa cyane mubyimbye, gufatira hamwe, geli, gukora firime nibindi bikorwa. Irashobora kunoza bioavailable yibiyobyabwenge kandi ikoreshwa no mumyiteguro irekura-irekura kugirango ifashe kugenzura irekurwa ryibiyobyabwenge.

Umwanya wo kwisiga: HPMC ikoreshwa cyane mubicuruzwa byita ku ruhu, shampoo, mask yimisatsi, cream yijisho hamwe nandi mavuta yo kwisiga nkumubyimba, stabilisateur nogukora firime. Uruhare rwayo mu kwisiga ni ukongera cyane ituze hamwe nimiterere yibicuruzwa kandi bikarushaho kuba byiza.

Umwanya wubwubatsi: Mu nganda zubaka, HPMC ikoreshwa nkibyimbye kandi ikwirakwiza muri sima, minisiteri yumye, irangi nibindi bicuruzwa. Irashobora kongera ubwiza bwirangi, kunoza imikorere yubwubatsi no kongera igihe cyo kubaka.

Umwanya wibiribwa: HPMC ikoreshwa nkinyongera yibiribwa, ikoreshwa cyane mubyimbye, emulisation no kunoza uburyohe, kandi ikunze kuboneka mubiribwa birimo amavuta make, bombo na ice cream. Byongeye kandi, irashobora kandi gukoreshwa mugutezimbere uburyohe, uburyohe nuburyohe bwibiryo.

Gusaba nkumuti

Mubikorwa bimwe byihariye byo kwitegura, HPMC irashobora kandi gukoreshwa nkigice cyingirakamaro cyumuti. Kurugero, muruganda rwa farumasi, solubile ya HPMC ituma ishobora gukoreshwa nkumuti cyangwa solubilisateur mugutegura ibiyobyabwenge, cyane cyane mubitegurwa bimwe na bimwe byamazi, aho bishobora gufasha neza gushonga ibiyobyabwenge no kubishakira igisubizo kimwe.

Mu mazi amwe ashingiye ku mazi,HPMCIrashobora kandi gukoreshwa nkigikoresho gifasha igisubizo kugirango gitezimbere imiterere yimiterere nubushobozi bwikibiriti, nubwo igisubizo nyamukuru mumyenda isanzwe ari amazi cyangwa umusemburo kama.

Nubwo HPMC ishobora gushonga mumazi mubikorwa byinshi kugirango ikore colloid cyangwa igisubizo kandi yongere ubwiza nubworoherane bwigisubizo, ubwayo ntabwo ifatwa nkigisubizo mubisanzwe. Ahubwo, irakoreshwa cyane nkibintu bikora nkibibyimbye, ibibyimba, hamwe na firime ikora firime. Ifite uburyo butandukanye bwo gukoresha mubice bitandukanye, cyane cyane mubya farumasi, kwisiga, ibiryo, ninganda zubaka. Kubwibyo, mugihe usobanukiwe uruhare numutungo wa HPMC, bigomba gufatwa nkibikorwa byinshi byamazi-soluber polymer aho kuba byoroshye.