Niki cyahinduwe HPMC? Ni irihe tandukaniro riri hagati ya HPMC yahinduwe na HPMC idasobanutse?

Hydroxypropyl methylcellse. Yahinduwe HPMC yerekeza kuri HPMC yahinduye imiterere yimiti kugirango izamure cyangwa ihindure ibintu biranga imikorere. HPMC idahuye, kurundi ruhande, yerekeza kumiterere yumwimerere ya polymer idafite impingamico yinyongera. Muri iki gisobanuro kinini, tuzasenya mumiterere, imitungo, porogaramu, hamwe nitandukaniro hagati yahinduwe kandi bidafite ishingiro HPMC.

1. Imiterere ya HPMC:

1.1. Imiterere y'ibanze:

HPMC ni polymer ya semisythemer ikomoka kuri selile, insimburangingo isanzwe iboneka kurukuta rw'Akagari y'ibimera. Imiterere y'ibanze ya selile igizwe no gusubiramo ibice bya glucose bihujwe na β - 1,4-Glycosic Bonds. Cekwije ihindurwa no kumenyekanisha amatsinda ya hydroxyProppopy na methyl ku matsinda ya hydroxyl yo mu mitwe ya glucose.

1.2. HydroxyPropyl na methyl amatsinda:

• Amatsinda ya HydroxyPropyle: izi zimenyeshwa kugirango zongere amazi yo kwikeba no kongera hydrofilique ya Polymer.
• Amatsinda ya Methyl: Ibi bitanga inzitizi ya steric, zibangamira urunigi rwa polymer muri rusange guhinduka no kugira ingaruka kumitungo yacyo.

2. Imitungo ya HPMC idasobanutse:

2.1. Amazi yonyine:

HPMC idasobanutse ni ugukemura amazi, gukora ibisubizo bisobanutse mubushyuhe bwicyumba. Urwego rwo gusimbuza HydroxyProppeproppopy na methyl rugira ingaruka kumyitwarire yonyine nubusabane.

2.2. Vicosity:

Viscosiya rya HPMC ziterwa nurwego rwo gusimburwa. Urwego rwo gusimbuza muri rusange ruganisha ku kwiyongera. HPMC idahuye iraboneka murwego rwibimenyetso bya virusi, bituma gusaba bigamije.

2.3. Ubushobozi bwo gukora firime:

HPMC ifite imitungo yo gukora film, bigatuma bikwiranye no guhinga porogaramu. Filime zakozwe zirahinduka kandi zigaragaza ubushishozi bwiza.

2.4. Ingano yubushyuhe:

Bamwe mu mpande zose za HPMC zerekana imyitwarire ya gelation yubushyuhe, ikora geles ku bushyuhe bwo hejuru. Uyu mutungo akenshi ni inyungu muburyo bwihariye.

3. Guhindura HPMC:

3.1. Intego yo guhindura:

HPMC irashobora guhindurwa kugirango iteze imbere cyangwa kumenyekanisha imitungo yihariye, nkibisobanuro byahinduwe, kunoza imbaraga, kurekura bigenzurwa, cyangwa imyitwarire yuburyo bwamanuke.

3.2. Guhindura imiti:

• Hydroxy opperylation: Urwego rwa Hydroxy oplevices rugira ingaruka kumazi yo kwishyurwa namazi.
• Ubwicanyi: Kugenzura urwego rw'ubuhinzi bugira ingaruka ku ruhererekane rwa Polymer rworoheje kandi, kubwibyo, vicosiya.

3.3. Guhangana:

Guhinduka akenshi bikubiyemo imyifatire yo guhagarara kugirango itangire amatsinda ya hydroxyProppopy na methyl kuri selile backdone. Ibi bisubizo bikorwa mubihe byagenzuwe kugirango bigere kubyo byihariye.

4. Yahinduwe HPMC: Porogaramu no Gutandukana:

4.1. Kugenzurwa kurekurwa muri farumasi:

• HPMC idasobanutse: ikoreshwa nkumukozi wa binder hamwe na fating mububiko bwa farumasi.
• Yahinduwe HPMC: Hashobora guhindurwa birashobora kudoda ibiyobyabwenge, bigenzurwa bigenzurwa.

4.2. Kunonosora kunoza mu bikoresho by'ubwubatsi:

• HPMC idasobanutse: ikoreshwa mu mikorere yo kubaka amazi yo kugumana amazi.
• Yahinduwe HPMC: Guhindura birashobora kuzamura imitungo, bigatuma bikwiranye no gukomera.

4.3. Amarangamutima yuburyo budozi mugushushanya:

• HPMC idasobanutse: ikora nkumukozi wijimye mumarangi ya latex.
• Yahinduwe HPMC: Ihinduka ryihariye rirashobora gutanga uburyo bwiza bwo kugenzura uburyo bwo gutahura.

4.4. Guhungabanya umutekano mubicuruzwa byibiribwa:

• HPMC idasobanutse: ikoreshwa nkumukozi wijimye kandi uhagaze mubicuruzwa bitandukanye.
• Yahinduwe HPMC: Hashobora guhindurwa birashobora kuzamura umutekano muburyo bwihariye bwo gutunganya ibiryo.

4.5. Inono-Igenamiterere rya Filime muri kwisiga:

• HPMC idasobanutse: ikoreshwa nkumukozi ushinzwe firime mumato.
• Yahinduwe HPMC: Guhindura birashobora kunoza imitungo yo gukora firime, bitanga umusanzu no kuramba byibicuruzwa byo kwisiga.

5. Itandukaniro ryingenzi:

5.1. Imitungo Yimikorere:

• HPMC idasobanutse: ifite imitungo isanzwe nkamazi yonyine nubushobozi bwo gukora firime.
• Yahinduwe HPMC: Erekana imikorere yinyongera cyangwa yongerewe imikorere ishingiye kumiti yihariye.

5.2. Gutanga ibisobanuro:

• HPMC idasobanutse: ikoreshwa cyane muburyo butandukanye.
• Yahinduwe HPMC: Biteganijwe kubisabwa byihariye binyuze muburyo bugenzurwa.

5.3. Ubushobozi bwo kurekura bwasohoye:

• HPMC idasobanutse: ikoreshwa muri farumasi nta nyungu zigezweho zigenzurwa.
• Yahinduwe HPMC: irashobora gukemurwa kugirango igenzure neza ibiyobyabwenge.

5.4. Igenzura ry'uburyo:

• HPMC idahuye: itanga imitungo yibanze.
• Yahinduwe HPMC: Emerera byinshi muburyo busobanutse neza mumashusho nkamashusho nibindi bihuriye.

6. UMWANZURO:

Muri make, hydroxyPropyl methylcellse (HPMC) ihinduka kugirango ihindure imitungo ya porogaramu yihariye. HPMC idahuye ikora nka polymer itandukanye, mugihe impinduka zifasha guhuza neza ibiranga. Guhitamo hagati yahinduwe kandi bidafite ishingiro HPMC biterwa nibikorwa byifuzwa nibipimo byimikorere muri porogaramu yatanzwe. Ihinduka rishobora guhitamo kwitonda, viccosity, kugenwa, gusohora, hamwe nibindi bipimo, bigahindura HPMC igikoresho cyingirakamaro munganda zitandukanye. Buri gihe reba kubicuruzwa hamwe nubuyobozi butangwa nabakora amakuru yukuri kumitungo na porogaramu ya HPMC.