Ni ubuhe butumwa bwo gushonga bwa HPMC polymer?

HPMC (HydroxyPropyl Methylcellse) ni amazi ya polymer akoreshwa cyane muri farumasi, ibiryo, kubaka, kwisiga nizindi nganda. HPMC ni igice cya seliki-ya selikitike yabonetse kubihindura imiti ya selile karemano, kandi ubusanzwe ikoreshwa nkumubyimba, stabilizer, emalifier no kumenyekana.

Umutungo wa HPMC

Ingingo yo gushonga ya HPMC iragoye kuko ingingo yo gushonga ntabwo igaragara nkibikoresho bisanzwe bya Crystalline. Ingingo yo gushonga yibasiwe n'imiterere ya molekelar, uburemere bwa molekile hamwe na elecration yo gusimbuza hydroxyPropyl na methyl matsinda ya methyl, bityo irashobora gutandukana ukurikije ibicuruzwa byihariye bya HPMC. Mubisanzwe, nka polymer-gushonga amazi, hpmc ntabwo ifite ingingo isobanutse kandi yo gushonga, ariko yoroshye kandi yo kubora mubushyuhe runaka.

Gushonga Ingingo

Imyitwarire yubushyuhe bwamaganya ya Sportsl®hpmc iragoye cyane, kandi imyitwarire yo kubora imiti isanzwe yiga nisesengura rya TherMogravimecc (Tga). Duhereye kubitabo, urashobora kubona ko ingingo ya Huza HPMC iri hagati ya 200°C na 300°C, ariko uru rutonde ntirugaragaza ingingo nyayo yo gushonga yibicuruzwa byose bya HPMC. Ubwoko butandukanye bwibicuruzwa bya HPMC bushobora kugira amanota atandukanye hamwe nubushyuhe bwumuriro kubera ibintu nkibintu bya molekile, urwego rwa ethoxy.

Uburemere buke bwa molecular HPMC: Mubisanzwe bishonga cyangwa byoroshye ku bushyuhe bwo hasi, kandi bushobora gutangira kuri Pyrolyze cyangwa gushonga ahagana mu 200°C.

Uburemere bwo hejuru bwa molekile°C na 300°C.

Ibintu bireba ingingo ishonga ya HPMC

Uburemere bwa molekilar: Uburemere bwa moleki ya HPMC bufite ingaruka zikomeye ku ngingo yo gushonga. Uburemere bwa molekilar busanzwe busobanura ubushyuhe bwo hasi, mugihe uburemere bwiburyo bukomeye bushobora gutuma umuntu ashonga.

Urwego rwo gusimbuza: Urwego rwa Hydroxy oproylelation (ni ukuvuga igipimo cyo gusimburwa cya hydroxyproppofl muri molekile) nurwego rwo gusimbuza methyl muri molekile. Mubisanzwe, urwego rwo hejuru rwo gusimbuza rwongera igisubizo cya HPMC kandi kigabanya ingingo yacyo.

Ibirimo byuzuye: Nkibikoresho byo gusoza amazi, ingingo yo gushonga ya HPMC nayo igira ingaruka kubirimo. HPMC hamwe nibirimo byinshi birashobora guhura na hydtion cyangwa gusenya igice, bikavamo impinduka mubushyuhe bwo kuboramo.

Ubushyuhe bwa Trarmal hamwe n'ubushyuhe bwa HPMC

Nubwo HPMC idafite ingingo ikomeye, ituze ryumuriro ni ikintu cyingenzi kigaragaza. Dukurikije isesengura rya TherMushingc (tga) amakuru, HPMC isanzwe itangira kubora mubushyuhe bwa 250°C kugeza 300°C. Ubushyuhe bwihariye bwo kubora biterwa nuburemere bwa molecular, urwego rwo gusimbuza hamwe nabandi mico yumubiri na shimi ya HPMC.

Kuvura ubushyuhe muri porogaramu ya HPMC

Mu porogaramu, ingingo yo gushonga kandi ituje rya HPMC ni ngombwa. Kurugero, mu nganda za farumasi, HPMC ikunze gukoreshwa nkibikoresho bya capsules, aho bihurira na firime, nabatwara imikino irambye. Muri ibyo bikorwa, gushikama ubushyuhe bwa HPMC bigomba kubahiriza ibisabwa byubushyuhe bwo gutunganya, bityo usobanukirwe nimyitwarire yubushyuhe no gushonga amanota ya HPMC ni ngombwa kugirango igenzure inzira yumusaruro.

Mu rwego rw'ubwubatsi, Slowltl®hpmc ikoreshwa kenshi nkuwijimye muri minisiteri yumye, amababi no kugifatika. Muri ibyo porogaramu, umutekano wa Lurmal wa HPMC ugomba kandi kuba murwego runaka kugirango tumenye neza ko bidatanga umusaruro mugihe cyo kubaka.

Hpmc, nkibikoresho bya polymer, ntabwo bifite ingingo ihamye, ariko yerekana ibiranga byoroheje na pyrolysing muburyo bumwe. Ingingo yacyo irambuye muri rusange iri hagati ya 200°C na 300°C, hamwe nuburyo bwihariye bwo gushonga biterwa nibintu nkuburemere bwa molekile, urwego rwa hydroxy oplelation, urwego rwigicucu, nubushuhe bwa HPMC. Mubice bitandukanye bya porogaramu, kumva iyi miterere yumutima ningirakamaro kugirango yitegure kandi ikoreshe.