HydroxyPropyl Cellulose (HPC) ikoreshwa cyane mumwanya wa farumasi hamwe nibintu bitandukanye bikora. Irakoreshwa cyane mugutegura gukomeye nkibinini na capsules. Nk'ibice bya selikitekeri ya selikite, HPC ikorwa no kumenyekanisha amatsinda ya hydroxyProppoyle mumiterere ya selile, bikaduha byinshi byo kwikebanura, kutizera no gushiraho film hamwe numutungo wa firime, uyishushanyijeho ibinini bya tablet.
1. THE THECKER
HPC, nkumubyimba na binder, birashobora gufasha ibice hamwe nuburyo bwo gutunganya granulation ya tablet. Ifite imyitozo ikomeye kandi irashobora gukurikiza uduce twinshi twanyuze kuri granulation itose kugirango dushyireho ibice hamwe no guturika no kubyutsa. Ibice biroroshye gushiraho no kugira ubushake bwiza mugihe cya keza, bikaviramo ibinini byiza. Mubikorwa byo gutegura ibinini bya tablet, hinger of bunders birashobora kwemeza gukomera, kurwanya kwamarika kwamarika no gutontoma bike mubisate.
2. Kugenzurwa Abakozi bashinzwe kurekura
Ingaruka zagenzuwe na HPC mubisate nimwe mubisabwa byingenzi. Kubera ibintu byabyibushye kandi byanduye mumazi, HPC irashobora gukora film ya hydration hejuru yibinini, ikagabanya ibiyobyabwenge byibiyobyabwenge, bityo igera ku ngaruka zo gutinza ibiyobyabwenge. Mu binini bigenzurwa, HPC irashobora guhindura neza igipimo cyo kurekura ibiyobyabwenge mu guhindura uburemere bw'ibiyobyabwenge n'amafaranga y'ibiyobyabwenge, agabanya inshuro z'ubuyobozi bw'ibiyobyabwenge, no kunonosora kubahiriza abarwayi. Igice cya hydration kirangiye buhoro buhoro, kandi igipimo cyo kurekura ibiyobyabwenge gihora gihoraho, bigatuma ifite ibyifuzo byiza byo gusaba mubinini bihamye.
3. Umukozi wa firime
Ibikoresho bya firime ya HPC bikoreshwa cyane mubikoresho bya tablet, cyane cyane ibikoresho byo gufunga amazi. Gutwika ibinini hejuru hamwe na firime ya HPC irashobora gukora urwego ruto kandi rwinshi rudashobora guhisha ibiyobyabwenge no kuzamura uburyohe, ariko kandi bukarinda ibiyobyabwenge kandi byongera umutekano wibiyobyabwenge. Kuberako HPC ifite gukorera mu mucyo kandi ihinduka, filime itunganya ni imwe kandi yoroshye, kandi ifite ingaruka nke kumiterere ya tablet. Byongeye kandi, film ya HPC ifite neza cyane munzira ya gastrointestinal kandi ntazagira ingaruka mbi kuri biowaiailible yibiyobyabwenge.
4. Stabilizer
Ingaruka zo kurinda HPC nazo nazo ni ingenzi cyane mugukoresha ibinini, cyane cyane kuri ibyo biyobyabwenge byumva umucyo nubushuhe. HPC irashobora gutandukanya neza ingaruka zumwuka nubushuhe, kandi wirinde ibiyobyabwenge bidashoboka cyangwa okiside kubera ubushuhe. Cyane cyane iyo igikomambo cya tablet cyateguwe mu mico kama, gushikama no gutandukanya HPC birinda imiti y'ibiyobyabwenge, bityo tugabungabunge imitwaro ikora nabi, ubuzima bw'ibiyobyabwenge.
5. Gutandukanya
Nubwo HPC ikoreshwa cyane nkumukozi ushinzwe kurekurwa, irashobora kandi gukoreshwa nkibintu bisenyutse birekura vuba ibinini. HPC-viccosity HPC irashobora gushonga vuba kandi ikabyimba nyuma yo guhura namazi, bikaviramo gusenyuka byihuse kuri tablet, bityo bigatera ibiyobyabwenge kandi byinjije ibiyobyabwenge munzira ya Gastrointestinal. Iyi porogaramu irakwiriye ibiyobyabwenge bimwe bigomba gukurikizwa vuba. HPC irashobora kugera kubiranga ibishushanyo bitandukanye mubitekerezo bitandukanye muguhindura ibiro byayo bya molekile, umubare wongeyeho hamwe nabandi bibabaye.
6. Gusaba mu magambo asenyuka kumvugo
Amazi yoroheje kandi viscosity ya HPC nayo yerekana ingaruka nziza mu magambo asenyuka kumvugo (ODT). Muri iyi tablet, HPC irashobora kuzamura igipimo cy'ibinyuranye bya tablet mu munwa mu kanwa, byoroshye abarwayi, cyane cyane abasaza cyangwa abana, kumira. Amazi yoroheje ya HPC ituma ishonga no gusenyuka mugihe gito, mugihe ubushyuhe bwayo butuma imbaraga zubaka kandi zikabibuza kumena umusaruro nububiko.
7. Ifashijwe nabandi bibabazwa
HPC ifite kandi ubwinshi bwo guhuza ibinini muri tablet hamwe na hamwe nabandi bibasiwe (nka microboxstathine, nka microboxymethyl selile, nibindi) kuzamura imikorere ya tablet. Kurugero, iyo bikoreshejwe hamwe na microcrystalline selile, HPC irashobora gutera imbere amazi nubwisanzure bwa tablet mugihe cyemeza gukomera kwa tablet; Iyo ikoreshwa hamwe nibindi bihumanya, birashobora kongera amarozi ya tablet, kunoza ubuziranenge bwa granulation nibitekerezo byangiza.
8. Ibyiringiro byagize ingaruka
Nubwo HPC ifite ibyiza byinshi mubisate, ingaruka zayo zigira ingaruka kubintu byinshi, nkuburemere bwa molekile, ubushuhe, nibindi binini bya molekile ya HPC, niko imbaraga zo kugenzura Uwiteka igipimo cyo kurekura ibiyobyabwenge; Muri icyo gihe, ubushuhe bukabije bw'ibidukikije bushobora gutera tablet gukurura ubuhehere, bigira ingaruka ku buhamye. Kubwibyo, mugihe ukoresheje HPC, birakenewe kugirango uhitemo ibipimo bikwiye kugirango habeho ingaruka nziza kuri tablet.
HydroxyPropyl Cellulose ifite imirimo myinshi muri tablet, harimo n'ubugari, bunder, igenzurwa n'umukozi ushinzwe kurekura, uhagaze neza, ni iki gishobora kunoza neza ubwiza bw'ibisate n'ibiyobyabwenge. Ukurikije ibisabwa byihariye by'ibiyobyabwenge n'ibisabwa, uburemere butandukanye bwa molekile na bwo burashobora guhindura ibintu, gusenya no gusohora ibinini, bigatuma ifite agaciro gakoreshwa mu nganda za farumasi.
Igihe cyohereza: Nov-04-2024