Hydroxypropyl Cellulose (HPC) nigikoresho gikoreshwa cyane murwego rwa farumasi hamwe nibikorwa bitandukanye. Ikoreshwa cyane mubitegura bikomeye nka tableti na capsules. Nkibikomoka kuri kimwe cya kabiri cyogukora, HPC ikorwa mugutangiza amatsinda ya hydroxypropyl mumikorere ya selile ya selile, itanga uburyo bwiza bwo gukomera, gufatira hamwe no gukora firime, bigatuma ikora muburyo butandukanye.
1. Inkoko na Binders
HPC, nkibibyimbye kandi bihuza, irashobora gufasha ibice guhuza no gukora mugihe cyogusya cyinshi cyo gutunganya ibinini. Ifite imbaraga zikomeye kandi irashobora gufatisha uduce twiza twa poro hamwe binyuze muri granulation itose kugirango ibe ibice bifite umuvuduko mwiza kandi byoroshye. Ibi bice byoroshye gukora kandi bifite compressible nziza mugihe cyo kumeza, bikavamo ibinini byujuje ubuziranenge. Muburyo bwo gutegura ibinini, kongeramo binders birashobora kwemeza ubukana, kurwanya guhonyora hamwe nubunini buke bwibinini.
2. Kugenzura abakozi barekura
Ingaruka igenzurwa ya HPC muri tableti nimwe mubikorwa byingenzi byingenzi. Bitewe no kubyimba no kwijimye mu mazi, HPC irashobora gukora firime ya hydrata hejuru yibinini, bikagabanya umuvuduko w’ibiyobyabwenge, bityo bikagera ku ngaruka zo gutinda kurekura ibiyobyabwenge. Mu bisate bigenzurwa-bisohoka, HPC irashobora guhindura neza igipimo cyo kurekura ibiyobyabwenge ihindura uburemere bwa molekile n’inyongera, bityo bikongerera igihe imiti ikora, kugabanya inshuro z’imiyoborere y’ibiyobyabwenge, no kunoza iyubahirizwa ry’abarwayi. Igice cyacyo cya hydration igenda ishonga buhoro buhoro mugihe, kandi igipimo cyo gusohora ibiyobyabwenge gihora gihagaze, bigatuma gifite amahirwe menshi yo gukoreshwa mubinini bikomeza kurekurwa.
3. Umukozi ukora firime
Imiterere ya firime ya HPC ituma ikoreshwa cyane mububiko bwa tablet, cyane cyane ibikoresho byo gushiramo amazi. Gupfundikanya ibinini hamwe na firime ya HPC birashobora gukora urwego ruto kandi rwinshi rwo kurinda, ibyo ntibishobora gusa guhisha umururazi wibiyobyabwenge no kunoza uburyohe, ahubwo binarinda ibiyobyabwenge kandi byongera umutekano wibiyobyabwenge. Kuberako HPC ifite gukorera mu mucyo no guhinduka, firime ikora irasa kandi yoroshye, kandi ntigira ingaruka nke kumiterere ya tablet. Byongeye kandi, firime ya HPC ifite imbaraga zo gukemura neza mu nzira ya gastrointestinal kandi ntabwo izagira ingaruka mbi kuri bioavailable ya miti.
4. Stabilisateur
Ingaruka zo gukingira HPC nazo ni ingenzi cyane mugukoresha ibinini, cyane cyane kuri iyo miti yorohereza urumuri nubushuhe. HPC irashobora gutandukanya neza ingaruka zumwuka nubushuhe, kandi ikabuza imiti kwangirika cyangwa kudakora okiside bitewe nubushuhe. Cyane cyane iyo ibinini byateguwe byateguwe mumashanyarazi, ubudahangarwa nubushakashatsi bwimiti ya HPC bikabuza kwifata hamwe nibiyobyabwenge bikora, bityo bikarinda ubuzima bwibi biyobyabwenge.
5. Gutandukana
Nubwo HPC ikoreshwa cyane cyane nkumukozi wo kurekura igenzurwa, irashobora kandi gukoreshwa nkibidahwitse mubisate bimwe na bimwe byasohotse. HPC ifite ubukonje buke HPC irashobora gushonga vuba ikabyimba nyuma yo guhura n’amazi, bigatuma ibinini byangirika vuba, bityo bigatera gusesa no kwinjiza imiti mu nzira ya gastrointestinal. Iyi porogaramu ibereye imiti imwe n'imwe igomba gukurikizwa vuba. HPC irashobora kugera kubintu bitandukanye biranga gusenyuka muburyo butandukanye bwa tableti muguhindura uburemere bwa molekile, umubare wongeyeho nibindi bisohoka.
6. Gushyira mu bisate bisenya umunwa
Amazi meza hamwe nubwiza bwa HPC nabyo byerekana ingaruka nziza mubinini byangiza umunwa (ODT). Muri iki kibaho, HPC irashobora kongera umuvuduko wo gusesa ibinini mu cyuho cyo mu kanwa, bikorohereza abarwayi, cyane cyane abasaza cyangwa abana, kumira. Amazi ya HPC atuma ashobora gushonga no gusenyuka mugihe gito, mugihe ububobere bwayo butuma imbaraga zimiterere yibinini kandi bikayirinda kumeneka mugihe cyo gukora no kubika.
7. Gukorana hamwe nibindi bikoresho
HPC ifite kandi uburyo bwiza bwo guhuza ibintu muburyo bwa tablet kandi irashobora guhuza nibindi bintu (nka microcrystalline selulose, carboxymethyl selulose, nibindi) kugirango byongere imikorere ya tablet. Kurugero, iyo ikoreshejwe ifatanije na microcrystalline selile, HPC irashobora kunoza ubwuzuzanye nuburinganire bwibinini mugihe byemeza ubukana bwibinini; iyo ikoreshejwe ifatanije nibindi bifata, irashobora kurushaho kunaniza ibinini bya tablet, kunoza ubwiza bwa granulation hamwe no guhagarika compression.
8. Ingaruka ziterwa nimbibi
Nubwo HPC ifite ibyiza byinshi mubinini, ingaruka zayo zikoreshwa nazo ziterwa nibintu byinshi, nkuburemere bwa molekile, kwibanda, ubuhehere, nibindi. igipimo cyo kurekura ibiyobyabwenge; icyarimwe, ubuhehere bukabije bwibidukikije bushobora gutuma ibinini byinjira mu kirere, bikagira ingaruka ku ituze ryabyo. Kubwibyo, mugihe ukoresheje HPC, birakenewe guhitamo muburyo bwiza kugirango ubone ingaruka nziza muburyo bwo gukora tablet.
Hydroxypropyl selulose ifite imirimo myinshi mugutegura ibinini, harimo umubyimba, guhuza, kugenzura ibintu bisohora, firime yahoze, stabilisateur na disintegrant, bishobora kuzamura neza ireme ryibinini nibikorwa byo gusohora ibiyobyabwenge. Ukurikije imiterere yihariye yibiyobyabwenge nibisabwa, uburemere butandukanye bwa molekuline hamwe na dosiye ya HPC birashobora guhindura byimazeyo ibishishwa, gusenyuka no kurekura ibinini, bigatuma bifite agaciro gakomeye mubikorwa bya farumasi.
Igihe cyo kohereza: Ugushyingo-04-2024